chemokines – Page 2 – Communicable Diseases Research

A Comparative Study of the Plasma Chemokine Profile in COVID-19 Patients Infected with Different SARS-CoV-2 Variants

다양한 SARS-CoV-2 변이체에 감염된 COVID-19 환자의 혈장 케모카인 프로필 비교 연구

Comparative Study

Published on 2022-08-132022-09-11
Journal: International Journal of Molecular Sciences
[Category] SARS, 변종, 유전자 메커니즘,

Circulating microRNA signatures associated with disease severity and outcome in COVID-19 patients

Article

Published on 2022-08-112022-11-15
Journal: Frontiers in Immunology
[Category] SARS, 치료제,

[키워드] 95% CI adaptive immune responses Angiogenesis antiviral response antiviral responses asymptomatic infection AUROC Biomarker Biomarkers chemokines circulating miRNA clinical condition collected Combination COVID-19 COVID-19 pathogenesis COVID-19 patient DE miRNA death differentially expressed disease disease severity downregulation driven by experiment Genes healthy control heart failure highlighting Hospital admission human cell impairment in vitro induce Inflammation inhibit Innate immunity interferon involved leukocyte life threatening Lung disease Lung epithelial cells Lung fibrosis microRNA microRNA. Mild miR-4433b-5p miRNA miRNA signature miRNAs moderate modulated Mortality organ damage outcome Patient predicted pro-inflammatory cytokine pro-inflammatory factors provided RNA-sequencing SARS-CoV-2 SARS-COV-2 infection Sensitivity and specificity serum serum sample severe COVID-19 severe disease severity Stress subset the cytokine storm upregulation Vascular damage was performed with COVID-19
[DOI] 10.3389/fimmu.2022.968991 PMC 바로가기

Maternal vaccination as an additional approach to improve the protection of the nursling: Anti-infective properties of breast milk

Article

Published on 2022-08-102022-11-15
Journal: Clinics
[Category] 진단,

[키워드] anti-SARS-CoV-2 anti-SARS-CoV-2 vaccines antibody Antibody Response approach B lymphocyte bacterial antigen Bioactive factors Breast breast milk Breastfeeding chemokines complement component cytokine elevated Factors fatty acids function Growth factors hormone Human IgA IgA antibodies IgA antibody IgG antibody IMPROVE inactivated induce lactation lactoferrin leukocyte mammary Maternal maternal immunization MicroRNAs nucleic acids oligosaccharides pandemic passive immunity performed Placenta Plasma cell plethora polysaccharide Pregnancy produced Proteins respiratory infections respiratory tracts secretion secretory secretory IgA Secretory IgA antibodies. Specific specific antibody unique vaccination Vaccine Vaccines virus virus-neutralizing viruses
[DOI] 10.1016/j.clinsp.2022.100093 PMC 바로가기

Cell surface SARS-CoV-2 nucleocapsid protein modulates innate and adaptive immunity

세포 표면 SARS-CoV-2 뉴클레오캡시드 단백질은 선천성 및 후천성 면역을 조절합니다

Article

Published on 2022-08-052022-09-11
Journal: Science Advances
[Category] SARS, 변종, 치료기술, 치료법, 치료제,

[키워드] activate adaptive antibody antigenicity bind Cell cell surface cells chemokine chemokines chemotaxis Combination conserved CoVs cross-reactive cytosol detect electrostatic heparan sulfate heparin high affinity high-affinity binding human CoVs immune cells Immunity induce infected cells inhibited Innate immune cells Innate immunity leukocyte leukocytes live cells MERS-CoV modulate neighboring cell neighboring cells nucleocapsid protein Protein released SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2-infected cell SARS-CoV-2-infected cells sequestering Strains sulfate sulfated T cell T cell responses transfected cell Vaccine zoonotic
[DOI] 10.1126/sciadv.abp9770 PMC 바로가기 [Article Type] Article

Platelets in the NETworks interweaving inflammation and thrombosis

염증과 혈전을 뒤섞는 NETworks의 혈소판

Review

Published on 2022-08-012022-09-11
Journal: Frontiers in Immunology
[Category] 치료기술, 치료제,

[키워드] activate Bacterial Capillaries capillary characterized chemokine chemokines chromatin Clinical outcome Coagulation factors contribute contributing to Course COVID-19 COVID-19 pandemic COVID-19 patient Cytokine storm disease DNA engage ENhance Evidence expression Extracellular extracellular space Growth factors hemorrhage Hemostasis histone Histones host innate immunity immune response immunothrombosis IMPROVE increased mortality induce infiltration Inflammation Inflammatory diseases inflammatory signaling Interaction interface kill lesion lung majority mechanism microthrombi molecular mechanism NET NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophil extracellular traps neutrophil infiltration Neutrophils other tissue other tissues pathogen Pathogens Pathways Patient Pattern recognition Pattern recognition receptors Platelet Platelets platelets. procoagulant Protein Proteins provide provided resulting signaling pathway subsequent surface expression survival target thrombi thrombosis thrombotic TLR2 TLR4 Topic TRAP Treatment vascular beds virus
[DOI] 10.3389/fimmu.2022.953129 PMC 바로가기 [Article Type] Review

Human surfactant protein D facilitates SARS-CoV-2 pseudotype binding and entry in DC-SIGN expressing cells, and downregulates spike protein induced inflammation

인간 계면활성제 단백질 D는 DC-SIGN 발현 세포에서 SARS-CoV-2 유사형 결합 및 진입을 촉진하고 스파이크 단백질 유도 염증을 하향 조절합니다

Article

Published on 2022-07-282022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술,

[키워드] ACE2 Analysis Anti-viral binding carbohydrate cause Cell cell interaction cell line cell surface receptor cells chemokine chemokines collectins controls COVID-19 cytokine cytokine response Cytokines DC-SIGN dendritic cell domain downregulate downregulated eight epithelial expressing facilitate fragment of HEK 293T HEK293T cell HEK293T cells help Human IFN-α IL- 6 IL-1β IL-8 immune function immune response immunomodulatory effect increase independent independent of infection assay infection assays Inflammation inhibit SARS-CoV-2 innate immune innate immune system Interaction intercellular involved Macrophage macrophages MHC class MHC class II modulating mRNA expression mRNA level mRNA levels N-terminal naïve T cell naïve T cells NF-κB pathogen Pathogens pro-inflammatory cytokine pro-inflammatory cytokines Protein pseudotype RANTES receptors Replication rfhSP-D. RNA virus RT-qPCR SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 spike protein shown SIGN spike Spike protein surface receptor T cells the Spike THP-1 TNF-α treated Treatment Vero Cell Vero cells viral entry viruses
[DOI] 10.3389/fimmu.2022.960733 PMC 바로가기 [Article Type] Article

Exploring the Immunomodulatory Aspect of Mesenchymal Stem Cells for Treatment of Severe Coronavirus Disease 19

중증 코로나바이러스 질환 치료를 위한 중간엽 줄기세포의 면역조절 측면 탐색 19

Review

Published on 2022-07-122022-09-11
Journal: Cells
[Category] COVID19(2023년), SARS, 치료법,

[키워드] ACE-2 acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 administration affected Alpha alveolar epithelial cell alveolar epithelial cells angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-apoptotic Anti-inflammatory anti-oxidative aspect Asymptomatic average Betacoronavirus breathlessness cause cellular characterized chemokines chest pain Clinical outcome Clinical symptoms colony-stimulating factor coronavirus 2 COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients curative cytokine Cytokine storm Cytokine storms damaged dependent on Deterioration disease severity dry cough Effectiveness Effects elicited endothelial engage enzyme epithelial cells excessive inflammation family Coronaviridae fatigue Fever fibroblast fibroblast growth factor functional GCSF genus genus Betacoronavirus granulocyte granulocyte colony-stimulating factor growth factor Growth factors Health healthy histological IL-6 IL-7 IL-8 IL-9 immune cells immune response immune responses immunomodulation immunomodulatory immunomodulatory capabilities immunomodulatory capability Incubation period individual infected individual infected individuals infiltrating immune cells Inflammatory Inflammatory cytokines inflammatory protein inhalation Injury Intention interferon interleukin intravenous intravenous infusion Invasion IP10 lung Lungs Macrophage majority MCP1 Mesenchymal stem cells mesenchymal stem cells. MIP1A mitigate monocyte monocyte chemotactic protein-1 MSC MSCs multitude myriad Necrosis organ PDGFB persistence Platelet platelet-derived growth factor positioned positive Protein receptor reduce respiratory Respiratory droplets RNA SARS-CoV-2 SARS-COV-2 infection secretion Secretome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sore throat STEM stem cell stem cells subunit supportive therapy symptomatic therapeutic therapy tissue TNF-α translational transmitted Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha undergo Vascular virus widespread
[DOI] 10.3390/cells11142175 PMC 바로가기 [Article Type] Review

mRNA-1273 vaccination protects against SARS-CoV-2-elicited lung inflammation in nonhuman primates

mRNA-1273 백신 접종은 비인간 영장류에서 SARS-CoV-2 유발 폐 염증으로부터 보호합니다

Article

Published on 2022-07-082022-09-11
Journal: JCI Insight
[Category] COVID19(2023년), SARS, 변종,

[키워드] 48 hour 48 hours Antibody Response Antibody responses Antibody titer Bronchoalveolar lavage fluid CCL3 cellular Cellular immune response chemokines collected correlated COVID-19 CXCL10 dissemination dose-dependent manner expression Genes Human IFIT1 immune immunology immunology. independent induction Inflammation Inflammatory ISG15 less limit Lower respiratory tract lung Lung inflammation mRNA mRNA-1273 MX1 observation Pathogenesis profile PROTECT replicated respiratory tract restrict viral replication rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 antibody response SARS-CoV-2 antibody responses SARS-CoV-2 spike SARS-CoV-2 strain serum Support suppressed These data transcriptomic USA-WA1/2020 vaccination Vaccine-induced immunity variant of SARS-CoV-2 viral infection viral replication Viral RNA
[DOI] 10.1172/jci.insight.160039 PMC 바로가기 [Article Type] Article

Transcriptional landscape of human neuroblastoma cells in response to SARS-CoV-2

SARS-CoV-2에 대한 인간 신경모세포종 세포의 전사적 풍경

Article

Published on 2022-07-062022-09-11
Journal: BMC neuroscience
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus analysis applied approach Cell cells Central nervous system changes in chemokines contagious coronavirus Cytokines decrease differentially expressed gene Differentially expressed genes downregulated function functions Gene ontology host mRNA identify Infection Injury involved knowledge Kyoto mechanism mRNA mRNAs Neuroinflammation Neurological symptom Neurological symptoms NF-κB pathogenic Pathways Patient performed receptors reported RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathways significantly SK-N-SH cells. transcriptional profile transcriptional profiles transcriptomic Treatment upregulated
[DOI] 10.1186/s12868-022-00728-6 PMC 바로가기 [Article Type] Article

MicroRNAs in the development of potential therapeutic targets against COVID-19: A narrative review

Review article

Published on 2022-07-012022-10-05
Journal: Journal of infection and public health
[Category] COVID19(2023년), SARS, 바이오마커, 변종, 치료제,

[키워드] ACE2 ACE2 receptor ACE2 receptors Antiviral biogenesis cellular miRNAs change chemokines collected complex conducted consequence COVID-19 cytokine Cytokines database Degradation Deleterious effective evaluate expression Extensive function generate Google help host response immune system include Infection infection process information inhibiting Interaction involved latency microRNA miRNA miRNAs Modification modulate Pathogenesis platform potential therapeutic target Prognosis reduce reduced regimen Regulation Regulatory Result SARS-CoV-2 SARS-COV-2 infection Science Direct Scientific community secretion Side effects Specific the SARS-CoV-2 therapeutic therapeutic target therapeutic targets Therapeutics therapy threat viral infection Viral load viral replication Viral RNA virus website WHO
[DOI] 10.1016/j.jiph.2022.06.012 [Article Type] Review article