Surveillance for substandard and falsified medicines by local faith-based organizations in 13 low- and middle-income countries using the GPHF MinilabGPHF Minilab을 사용하여 13개 저소득 및 중간 소득 국가의 현지 신앙 기반 조직에서 표준 이하 및 위조 의약품에 대한 감시Article Published on 2022-07-302022-09-11 Journal: Scientific Reports [Category] MERS, 치료제, [키워드] Analysis API Chloroquine contribute country COVID-19 pandemic deficiency evaluate ingredient International less Local Medicine National organization pandemic product reported screened sensitivity study period substandard Surveillance treatment for COVID-19 WHO [DOI] 10.1038/s41598-022-17123-0 PMC 바로가기 [Article Type] Article
Friend or Foe? Implication of the autophagy-lysosome pathway in SARS-CoV-2 infection and COVID-19친구 또는 적? SARS-CoV-2 감염 및 COVID-19에서 자가포식-리소좀 경로의 의미Review Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] assist autophagy autophagy machinery autophagy marker autophagy markers Chloroquine clinical trial clinical trials COVID-19 COVID-19 patient COVID-19 patients Effect effort Evidence expected Friend global pandemic highlight host cell host cells Hydroxychloroquine increasingly inhibit Interaction lysosome molecular pathogen pathway Prognostic value Replication SARS-CoV-2 SARS-COV-2 infection the SARS-CoV-2 therapeutic strategy Therapeutics Therapeutics. Treatment viral replication while [DOI] 10.7150/ijbs.72544 PMC 바로가기 [Article Type] Review
Safety considerations of chloroquine in the treatment of patients with diabetes and COVID-19Research article Published on 2022-07-012022-10-05 Journal: Chemico-biological interactions [Category] COVID19(2023년), SARS, 신약개발, 치료법, 치료제, [키워드] adverse effect Cardiotoxicity caused changed Chloroquine Chloroquine phosphate coronavirus disease COVID-19 death diabetes Diabetic dosage dose Drug safety effective Electrocardiograms elevated hepatic enzyme High dose High-dose high-dose group humans IL-1β IL-6 levels increased risk intervals kidneys leukocyte liver observation Ocular toxicity Patient patients with diabete produced Protein QTc regimen Safety serum Severe case significantly spleen T2D total mortality treat Treatment type 2 diabete underlying disease [DOI] 10.1016/j.cbi.2022.109954 [Article Type] Research article
Development and optimization of a high-throughput screening assay for in vitro anti-SARS-CoV-2 activity: Evaluation of 5676 Phase 1 Passed Structures시험관내 항SARS-CoV-2 활성에 대한 고처리량 스크리닝 분석의 개발 및 최적화: 5676 1상 통과 구조 평가Clinical Trial Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus African green monkey anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Antiviral Antiviral agents Caco-2 can not cell lines Chloroquine clinical development clinical trials clinically Compound coronavirus coronavirus coronavirus disease Coronavirus disease 2019 coronavirus. COVID-19 COVID-19 pandemic COVID-19 treatment development Doxorubicin drug effective enhanced green fluorescent protein epithelial cell epithelial cells expressing fluorescent green fluorescent protein green monkey Hydroxychloroquine in vitro inhibitor inhibitors itraconazole kidney library nelfinavir outbreak pandemic pharmacokinetic data Phase 1 Protein Remdesivir SARS Coronavirus SARS-CoV-2 SARS-COV-2 infection strain Strains Structure Support these compound these compounds Toxicity Treatment Vaccine Vaccines VeroE6-eGFP cells virus was used [DOI] 10.1002/jmv.27683 PMC 바로가기 [Article Type] Clinical Trial
Curcumin inhibits spike protein of new SARS-CoV-2 variant of concern (VOC) Omicron, an in silico study커큐민, 새로운 SARS-CoV-2 변이체(VOC) Omicron의 스파이크 단백질 억제, in silico 연구Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] Allicin Amino acid amino acid substitution B.1.1.529 Capsaicin change Chloroquine Cinnamaldehyde complex coronavirus COVID-19 Curcumin demonstrated disrupt docked dominant evaluate Gingerol Immunity in silico in silico study inhibit inhibitory molecular multiple mutation multiple mutations Native new SARS-CoV-2 omicron Omicron variant physiological piperine Protein RBD RBD domain Receptor binding domain S protein Seven specific treatment spike Spike protein Spike-RBD. stability suggested the Spike therapeutic therapeutic agent three-dimensional structure Vaccine variant variant of SARS-CoV-2 VoC was performed [DOI] 10.1016/j.compbiomed.2022.105552 PMC 바로가기 [Article Type] Article
Hydroxychloroquine versus placebo in the treatment of non-hospitalised patients with COVID-19 (COPE – Coalition V): A double-blind, multicentre, randomised, controlled trialResearch article Published on 2022-07-012022-10-05 Journal: The Lancet Regional Health - Americas [Category] 신약개발, 임상, 치료법, [키워드] 1:1 Analysis benefit Brazil Chloroquine Clinical deterioration Coalition complement conducted Controlled trial COPE COVID-19 COVID-19 patient did not reduce double-blind Enrollment events finding form funding hospitalisation Hydroxychloroquine Infection intention-to-treat ITT matching placebo Meta-analysis Mild mITT analysis moderate molecular multicenter multicentre no significant difference non-hospitalised Outpatient participants with SARS-CoV-2 Patient patients with COVID-19 Placebo placebo group positive precluded presenting Primary outcome randomised Randomly RCT receive reducing Registered risk risk factor serology testing Seven Statistical power suggested Support Symptom Treatment treatment allocation Trial use of hydroxychloroquine was performed [DOI] 10.1016/j.lana.2022.100243 [Article Type] Research article
Synergistic anti-SARS-CoV-2 activity of repurposed anti-parasitic drug combinations용도 변경 구충제 조합의 상승적 항 SARS-CoV-2 활성Article Published on 2022-06-182022-09-11 Journal: BMC Pharmacology & Toxicology [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] Analysis anti-parasitic drug Anti-parasitic drugs Anti-SARS-CoV-2 Activity antiviral drug antiviral drugs approach benefit Calu Calu-3 calu-3 cells Chloroquine claimed clinical trials Combination combinations country COVID-19 pandemic demonstrated drug drug combination drug combinations drugs Economy effective Effectiveness ENhance epithelial cells evaluated Health Service highest in vitro inhibitory inhibitory concentration Ivermectin Lung epithelial cells niclosamide pandemic reduction in Repurposed drug repurposing resulting SARS-CoV-2 SARS-CoV-2. shown Spread synergistic synergy tested Treatment vaccination Vero E6 Vero E6 cell VERO E6 cells [DOI] 10.1186/s40360-022-00580-8 PMC 바로가기 [Article Type] Article
Clinical update on COVID-19 for the emergency and critical care clinician: Medical management응급 및 중환자 진료의를 위한 COVID-19에 대한 임상 업데이트: 의료 관리Review Published on 2022-06-012022-09-11 Journal: The American journal of emergency medicine [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] 2019 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Admitted Patient antagonists antivirals Aspirin Care caused Chloroquine clinical clinician Clinicians Colchicine concerning convalescent plasma coronavirus coronavirus disease Coronavirus-2019 COVID-19 Critical care demonstrated disease Emergency Famotidine help Hydroxychloroquine IMPROVE interleukin interleukin-6 introduced Ivermectin kinase inhibitors management mineral Minerals monoclonal antibodies morbidity and mortality outcomes Outpatient outpatients pandemic Patient patients progressed prophylactic anticoagulation provide Randomized respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome coronavirus 2. Steroids Therapies therapy utility variety Vitamin vitamins with COVID-19 [DOI] 10.1016/j.ajem.2022.03.036 PMC 바로가기 [Article Type] Review
Computational study on the affinity of potential drugs to SARS-CoV-2 main proteaseArticle Published on 2022-05-182023-07-09 Journal: Journal of physics. Condensed matter : an Institute of Physics journal [Category] COVID19(2023년), [키워드] betamethasone Chloroquine Dexamethasone Hydroxychloroquine molecular docking. SARS-CoV-2 main protease [DOI] 10.1088/1361-648X/ac6c6c PMC 바로가기
Effects of Drugs Formerly Suggested for COVID-19 Repurposing on Pannexin1 Channels이전에 COVID-19 용도 변경을 위해 제안된 약물이 Pannexin1 채널에 미치는 영향Article Published on 2022-05-182022-09-11 Journal: International Journal of Molecular Sciences [Category] 신약개발, 유전자 메커니즘, [키워드] Alter Analysis Anti-inflammatory Anti-inflammatory drugs Antiviral antiviral and anti-inflammatory drugs Azithromycin candidate Chain Reaction channel Chloroquine clinical trial clinical trials Combination COVID-19 COVID-19 patients Dexamethasone Diseases drug drug candidate drug target Effect effort extracellular ATP Favipiravir functional Hydroxychloroquine immune response Immunoblot analysis Inflammation inhibit inhibitor Lopinavir mechanism mRNA expression mRNA levels outcome pandemic pannexin1. Pathogenesis pathogenesis of COVID-19 polymerase chain polymerase chain reaction Protein Quantitative Remdesivir repurposing ribavirin Ritonavir selected tested Treatment viral infections were used without affecting [DOI] 10.3390/ijms23105664 PMC 바로가기 [Article Type] Article