Anti-Inflammatory Activity of CIGB-258 against Acute Toxicity of Carboxymethyllysine in Paralyzed Zebrafish via Enhancement of High-Density Lipoproteins Stability and FunctionalityArticle Published on 2022-09-042022-11-15 Journal: International Journal of Molecular Sciences [Category] 진단, [키워드] activity aggregation ameliorated anti-inflammatory activity Autoimmune disease carboxymethyllysine (CML) cascade caused cholesterol CIGB-258 (Jusvinza) CML co-injection coronavirus disease COVID-19 cytokine Cytokine storm death death rate decrease developmental Efficacy Embryo enhancement exhibited faster ferrous ion Final HDL Heat shock high-density high-density lipoproteins (HDL) highest Hsp60 hyperinflammation infiltration Inflammation Inflammatory inflammatory cells infliximab inhibit injected injection kDa Ligand lipoprotein lowest mechanism neutrophil Pain paralysis Particle peptide plasma protective effect Protein resulting stability Stress Survivability systemic inflammation tissue treated Triglyceride was tested zebrafish zebrafish. [DOI] 10.3390/ijms231710130 PMC 바로가기
Hydroxypropyl-beta-cyclodextrin (HP-BCD) inhibits SARS-CoV-2 replication and virus-induced inflammatory cytokines하이드록시프로필-베타-사이클로덱스트린(HP-BCD)은 SARS-CoV-2 복제 및 바이러스 유발 염증성 사이토카인을 억제합니다Article Published on 2022-09-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] accompanied ACE2 Affect affected Alter antiviral activity Beta Beta-cyclodextrin Calu Calu-3 Cell cell line cell lines cholesterol COVID-19 COVID-19 disease cyclodextrin Cytokines cytopathic effects demonstrated disease drug Drug repurposing evidenced excipient experimental models expression Human Hyperinflammatory syndrome immunomodulatory effect in vitro in vivo Inflammation Inflammatory cytokine Inflammatory response inhibit inhibited inhibiting investigated microbial products mitigate Monocytes Particles pathophysiology primary human cells Proinflammatory cytokine proinflammatory cytokines protein levels reducing reduction in Replication replication complexes required Respiratory system safety profile SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV2 selected selective significantly systemic manifestations the disease therapeutic therapeutic agent therapeutic strategy These data treating Treatment viral cytopathic effect virus virus virus replication Virus replication. virus RNA [DOI] 10.1016/j.antiviral.2022.105373 PMC 바로가기 [Article Type] Article
Persistence, prevalence, and polymorphism of sequelae after COVID-19 in unvaccinated, young adults of the Swiss Armed Forces: a longitudinal, cohort study (LoCoMo)Research article Published on 2022-08-262022-10-05 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 진단, [키워드] Administered Adults aerobic age asymptomatic infection base Blood BMI cardiovascular complications cholesterol cohort study Concentration control group COVID-19 COVID-19 group criteria defined Diagnosis diagnostic dyslipidaemia enrolled fatigue Fatigue scale female finding Follow-up force funding Health healthy higher risk individual Intensive IQR Laboratory Laboratory parameters LDL longitudinal cohort study male management median men metabolic disorder negative RT-PCR neurological no symptoms non-hospitalised organ systems outcomes participant Participants persistent physical polymorphism positive positive PCR test presenting Prevalence Psychological public health quantified questionnaire Registered renal reported reproductive RT-PCR test SARS-CoV-2 SARS-COV-2 infection Serologically serologically positive significant difference study groups Switzerland Symptom the median threshold were excluded with COVID-19 [DOI] 10.1016/S1473-3099(22)00449-2 [Article Type] Research article
The Function behind the Relation between Lipid Metabolism and Vimentin on H9N2 Subtype AIV ReplicationArticle Published on 2022-08-182023-06-22 Journal: Viruses [Category] 조류인플루엔자, [키워드] AMPK cholesterol H9N2 subtype AIV HMGCR Lipid rafts vimentin. [DOI] 10.3390/v14081814 PMC 바로가기
Potential of Egg as Complementary Food to Improve Nutrient Intake and Dietary DiversityRandomized Controlled Trial Published on 2022-08-182022-10-04 Journal: Nutrients [Category] 임상, [키워드] adjusted allergy cholesterol Community complementary contribute control group COVID-19 determine dietary dietary diversity dietary intake Diversity Effect Egg egg allergy egg consumption eight Endpoint feasibility Follow-up food Frequency growth incidence Infants infants. intake lockdown nutrient Potential Randomized controlled trial regression analysis remained South Africa Symptoms vitamin B6 [DOI] 10.3390/nu14163396 PMC 바로가기 [Article Type] Randomized Controlled Trial
Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19 (PASC)COVID-19의 긴 COVID/급성 후유증(PASC)을 가진 개인의 증상, 동반질환, 섬유소 아밀로이드 미세응고 및 혈소판 병리의 유병률Article Published on 2022-08-062022-09-11 Journal: Cardiovascular Diabetology [Category] SARS, 진단, 치료기술, [키워드] accompanied acute COVID-19 African amyloid Amyloid fibrin(ogen) analysed Atypical balance blood sample Blood samples Brain capillary cardiovascular disease cholesterol Clinical studies clinical study Clinical treatment co-morbidities Comorbidities Comorbidity comparable Concentration controlled clinical studies coronavirus coronavirus 2019 disease COVID-19 COVID-19 severity determine diabetes Diabetes Mellitus Diagnostic method Diversity dyslipidaemia Early detection effective Efficacy endotheliopathy fatigue female FIBRIN Fluorescence fluorescence microscopy foci Gender Hyperactivated platelets hypertension individual inhibit joint Long Long COVID/PASC morbidities muscle pains ogen PASC pathology Patient patients Platelet platelet hyperactivation Platelets platform provide reducing registry removal reported reversal SARS-COV-2 infection scoring system Shortness of breath South Symptom Symptoms Symptoms. tissues Transport Treatment type 2 diabete Type 2 diabetes mellitus [DOI] 10.1186/s12933-022-01579-5 PMC 바로가기 [Article Type] Article
Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics Reviews Published on 2022-08-022022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 치료제, [키워드] atherosclerotic atherosclerotic lesion benefit Cancer cancers cardiovascular disease cardiovascular diseases cardiovascular event cardiovascular system Cell cholesterol cholesterol homeostasis cholesteryl esters clinics Critical CVD diabetes disease Diseases Disturbed endothelial events Health inhibiting Intervention Lipid Low-Density Lipoprotein cholesterol maintaining mechanism molecular neurodegenerative nonalcoholic fatty liver obesity Osteoporosis pathway preclinical study Prevent PROTECT Regulation regulatory pathways Research shown target Transport Treatment virus infection [DOI] 10.1038/s41392-022-01125-5 [Article Type] Reviews
Monkeypox is a global public health emergency: The role of repurposing cholesterol lowering drugs not to be forgottenCorrespondence Published on 2022-08-012022-10-05 Journal: Journal of clinical lipidology [Category] 신약개발, 원숭이두창, [키워드] cholesterol Cholesterol lowering drugs drug Fibrates global public health Monkeypox PCSK9 inhibitors statins [DOI] 10.1016/j.jacl.2022.08.003 [Article Type] Correspondence
Are lipid ratios and triglyceride-glucose index associated with critical care outcomes in COVID-19 patients?지질 비율과 트리글리세리드-글루코스 지수는 COVID-19 환자의 중환자 치료 결과와 관련이 있습니까?Article Published on 2022-08-012022-09-11 Journal: PLoS ONE [Category] 바이오마커, [키워드] adjusted age Analysis biochemical marker biochemical markers BMI carried cholesterol coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 COVID-19 mortality COVID-19 patient Critical care demonstrated evaluate Glucose HDL-C high-density insulin insulin resistance LDL-C Lipid lipoprotein Logistic regression analysis low-density Low-density lipoprotein Mortality multivariate multivariate logistic regression analysis outcome performed predictor Prognosis Regression regression models Research severe coronavirus disease Severe patient severe patients severity Sex significantly higher significantly lower statistically survivor Total cholesterol Triglyceride with COVID-19 [DOI] 10.1371/journal.pone.0272000 PMC 바로가기 [Article Type] Article
APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patientsAPOE는 ACE2와 상호작용하여 COVID-19 환자에서 SARS-CoV-2 세포 진입 및 염증을 억제합니다Article Published on 2022-08-012022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 치료기술, 치료법, [키워드] ACE2 addition Affect allele ApoE APOE4 Apolipoprotein Apolipoprotein e assays binding binding affinity cardiovascular diseases carrier carriers cells cellular entry chemokine cholesterol cholesterol metabolism clinically comparable Concentration COVID-19 infection COVID-19 patient COVID-19 patients disease severity docking domain elevated explain genetic risk factor Infection Inflammation Inflammatory factor inhibit inhibiting interact Interaction isoform Lipid mechanism metabolism Protein receptor reduce Regulatory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike protein serum serum concentrations spike Spike protein susceptibility the SARS-CoV-2 transmission electron microscopy viral entry viruses Zinc [DOI] 10.1038/s41392-022-01118-4 PMC 바로가기 [Article Type] Article