Targeted escape of SARS-CoV-2 in vitro from monoclonal antibody S309, the precursor of sotrovimabArticle Published on 2022-08-242022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] ACE2 ACE2 binding ACE2 binding site Amino acid angiotensin-converting enzyme 2 antibody Cell cell entry class conserved domain endocytosis Entry epitope escaped Evolution Evolution of SARS-CoV-2 fusion immune Immune escape immunological in vitro infections inhibit SARS-CoV-2 Interaction monoclonal monoclonal antibody not affected pathogenicity plasticity precursor Receptor-binding domain replicated S309 SARS-CoV-2 Sotrovimab susceptible the spike protein vaccination viral strain wild-type SARS-CoV-2 [DOI] 10.3389/fimmu.2022.966236 PMC 바로가기
The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2SARS-CoV와 SARS-CoV-2 사이의 다양한 보존된 에피토프를 표적으로 하는 항체의 중화 폭Article Published on 2022-08-232022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 진단, 치료기술, 치료제, [키워드] antibody Antibody therapeutics Beta Beta variant breadth broad neutralizing antibody Candidates class complex conserved conversed epitopes COVID-19 cross-neutralizing antibody cryo Cryo-electron microscopy defined Delta effective electron microscopy epitope Epitopes evade exhibited hamsters immunization Infection Microscopy NAb NAbs neutralization Neutralizing Neutralizing antibodies neutralizing antibody offer omicron Omicron variant Omicron variants pseudoviruses Receptor-binding domain SARS-CoV SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody Spike proteins Structure the receptor-binding domain the spike protein Treatment treatment of COVID-19 Vaccine variant variants variants of concern variants of SARS-CoV-2 Viral [DOI] 10.1073/pnas.2204256119 PMC 바로가기 [Article Type] Article
Association between HLA-C alleles and COVID-19 severity in a pilot study with a Spanish Mediterranean Caucasian cohort스페인 지중해 백인 코호트를 대상으로 한 파일럿 연구에서 HLA-C 대립형질과 COVID-19 심각성 사이의 연관성Article Published on 2022-08-122022-09-11 Journal: PLoS ONE [Category] SARS, 유전자 메커니즘, [키워드] age allele analyzed antiviral response association Asymptomatic cause Cell cell surface class Clinical characteristics clinical presentation Clinical presentations Cohort Comorbidity contrary COVID-19 COVID-19 severity Critical described determine disease epitope Epitopes expressed Factor fatal disease Gender groups HLA HLA allele HLA alleles HLA class I HLA-A HLA-B HLA-B allele HLA-B alleles HLA-C HLA-C allele HLA-C alleles HLA-C1 Host hyperinflammatory state immune response individual Infection involved KIR gene male management mechanism Mild mild infection no significant difference no significant differences outcomes pandemic peptide peptides pilot study recruited SARS-CoV-2 protein SARS-CoV-2 proteins significant difference significant differences small sample size Spain Spanish T cells β2-microglobulin [DOI] 10.1371/journal.pone.0272867 PMC 바로가기 [Article Type] Article
Modeling SARS-CoV-2 and influenza infections and antiviral treatments in human lung epithelial tissue equivalents인간 폐 상피 조직 동등물에서 SARS-CoV-2 및 인플루엔자 감염 및 항바이러스 치료 모델링Article Published on 2022-08-122022-09-11 Journal: Communications Biology [Category] SARS, 바이오마커, 진단, 치료기술, 치료제, [키워드] alveolar Analysis antiviral drug Antiviral treatment antiviral treatments Biomarker cell type cell types cellular chemokine class Critical CXCL10 cytokine Cytokine storm develop emerging viruses epithelial exhibiting human lung IAV IFN response IL-10 IL-6 in vitro in vivo include infect Infection infections Influenza influenza A influenza A virus influenza infection MHC MHC class I modeling Pathogens peaking pharmacological platform Replication robust SARS-CoV-2 SARS-COV-2 infection severe SARS severe SARS-CoV-2 Single-cell RNA sequencing throughput tissue tissues tracheobronchial Validity Viral viral infection virus viruses [DOI] 10.1038/s42003-022-03753-7 PMC 바로가기 [Article Type] Article
Effects of mild obesity on outcomes in Japanese patients with COVID-19: a nationwide consortium to investigate COVID-19 host genetics Research Published on 2022-08-092022-10-05 Journal: Nutrition & Diabetes [Category] SARS, 바이오마커, 유전자 메커니즘, 치료법, [키워드] adjusted adjusted odds ratio Analysis analyzed benefit BMI body mass index class coronavirus disease COVID-19 COVID-19 patient Critical Critical case critical cases defined died disease severity Effect enrolled force host genetics independent risk factor indicated intensive care Invasive mechanical ventilation Japan Japanese Mild mortality rate multiple logistic regression no difference obesity Odds ratio outcome Oxygen administration Oxygenation Patient patients with COVID-19 reported required Respiratory failure Result risk risk factor severe COVID-19 severe disease severity of COVID-19 stratified the patient treated [DOI] 10.1038/s41387-022-00217-z [Article Type] Research
Predictors of chronic COVID-19 symptoms in a community-based cohort of adults지역사회 기반 성인 코호트의 만성 COVID-19 증상 예측자Observational Study Published on 2022-08-042022-09-11 Journal: PLoS ONE [Category] SARS, 임상, 진단, 치료법, [키워드] acute COVID-19 acute disease ambulatory Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG antibody Antibody testing changes in Chi-square chronic class Cluster Cohort Community-based cohort COVID-19 COVID-19 infection COVID-19 symptom COVID-19 symptoms demographics disease fatigue female Follow-up headache Headaches highest identify IgG antibody IgG levels individual Infection joint Latent less males median muscle nucleocapsid protein IgG observational study Occurrence participant PASC positive predictor proportion Rate responses risk SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV2 infection severity Sex significantly higher Symptom Symptomatology Symptoms Taste was performed was used weakness [DOI] 10.1371/journal.pone.0271310 PMC 바로가기 [Article Type] Observational Study
Examination of SARS-CoV-2 In-Class Transmission at a Large Urban University With Public Health Mandates Using Epidemiological and Genomic Methodology역학 및 게놈 방법론을 사용하여 공중 보건 위임을 받은 대도시 대학에서 SARS-CoV-2 클래스 내 전파 검사Article Published on 2022-08-012022-09-11 Journal: JAMA Network Open [Category] Coronavirus, SARS, 유전자 메커니즘, 치료기술, [키워드] activities activity analyzed average Campus causative agent Chain Reaction class cohort study conducted Contact tracing COVID-19 detectable disease transmission driving Eligible participants event Evidence examination examined faculty Genetic individual Infection instance involved outcome participant Participation physical distancing polymerase chain polymerase chain reaction Polymerase chain reaction testing Positive test Public public health ranged risk robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission Sequencing suggested surveillance testing Transmission transmission of SARS-CoV-2 universities university urban vaccination variety whole genome Whole genome sequencing [DOI] 10.1001/jamanetworkopen.2022.25430 PMC 바로가기 [Article Type] Article
A year in pharmacology: new drugs approved by the US Food and Drug Administration in 2021약리학의 1년: 2021년 미국 식품의약국 승인 신약Review Published on 2022-08-012022-09-11 Journal: Naunyn-Schmiedeberg's Archives of Pharmacology [Category] 신약개발, 유전자 메커니즘, [키워드] aducanumab adverse effect antibody approval approvals approved Cancer cancers class contrary COVID-19 pandemic disease drug drugs Effects Evidence evidence of FDA First-in-class First-in-indication followed by food genetic alterations had no identify indication Innovation molecular mechanism New New drugs Next Next-in-class. small molecule Small molecules target Treatment US Food and Drug Administration [DOI] 10.1007/s00210-022-02250-2 PMC 바로가기 [Article Type] Review
Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeysArticle Published on 2022-07-252022-10-05 Journal: Nature Microbiology [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] class Combination Complete complex Cryo-electron microscopy Donor epitope Fab Human monoclonal antibody identify in vitro less mAb monoclonal antibody Mutation neutralization neutralize Neutralizing activity omicron other variant Prophylactic reported SARS-CoV-2 SARS-CoV-2 mutant sequence spike epitope tested therapeutic therapy Transmission vaccine-mediated immunity variant [DOI] 10.1038/s41564-022-01198-6 [Article Type] Article
SARS-CoV-2 Surveillance in Indoor Air Using Electrochemical Sensor for Continuous Monitoring and Real-Time Alerts지속적인 모니터링 및 실시간 경고를 위한 전기화학 센서를 사용한 실내 공기 SARS-CoV-2 감시Article Published on 2022-07-132022-09-11 Journal: Biosensors [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome addition Air monitoring Air sampling analyzed Antigen aqueous solution class collected Continuous continuous air monitoring coronavirus coronavirus 2 COVID-19 detect diagnostic electrochemical SARS-CoV-2 sensor EUA faster FDA lack less limit limit of detection monitoring provide rapid detection technique. required RT-PCR test sample collection SARS-CoV-2 SARS-CoV-2 air collection SARS-CoV-2 surveillance sensor Severe acute respiratory syndrome significantly lower Spread tested translate while [DOI] 10.3390/bios12070523 PMC 바로가기 [Article Type] Article