Favipiravir, camostat, and ciclesonide combination therapy in patients with moderate COVID-19 pneumonia with/without oxygen therapy: An open-label, single-center phase 3 randomized clinical trialResearch article Published on 2022-06-032022-10-05 Journal: EClinicalMedicine [Category] 신약개발, 임상, 치료제, [키워드] 95% CI Admission Adverse AMED assigned calculated camostat Characteristics Ciclesonide clinical Clinical finding Clinical management Combination combination therapy comparable COVID-19 COVID-19 infection deaths decrease development discharge Effectiveness enrolled evaluated event Favipiravir finding funding group groups healthcare worker hospital discharge rate Hospital stay Hospitalization Hospitalized Japan Japanese lack less limitation median time Ministry of Health monotherapy no significant difference number Open-label oxygen participant Patient patients patients with moderate Phase 3 phase 3 study Pneumonia positive Primary outcome randomized clinical trial Randomized controlled trial Randomly Registered registry Research SARS-CoV-2 Severe COVID-19 Infection significantly higher significantly lower single-center statistically supported therapy Treatment vaccination Version Welfare [DOI] 10.1016/j.eclinm.2022.101484 [Article Type] Research article
Pearson’s patterns correlational of clinical risks at admissions with hospitalization outcomes during initial COVID-19 outbreakResearch article Published on 2022-05-182022-10-05 Journal: iScience [Category] 바이오마커, 신약개발, 임상, [키워드] absence Admission Analysis Aspartate aminotransferase AST Clinical finding clinical parameter clinical risk Cohort conducted correlated COVID-19 outbreak death dysregulated Guidance Health Sciences healthcare Healthcare systems Hospitalization hospitalized patient independent initial lactate dehydrogenase LDH Mortality neutrophil neutrophil count Outbreaks outcome patients with COVID-19 retrospective cohort study risk factor targeted therapy with COVID-19 [DOI] 10.1016/j.isci.2022.104415 [Article Type] Research article
Acute laryngotracheitis caused by COVID-19: A case report and literature reviewCase report Published on 2022-05-012022-10-05 Journal: International Journal of Surgery Case Reports [Category] 진단, [키워드] acute respiratory syndrome Adults airway Case report caused Chest radiograph Clinical finding coronavirus Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19coronavirus disease 2019 demonstrated Dexamethasone diagnostic edematous EDemergency department emergency department female HPIVhuman parainfluenza virus human parainfluenza virus ICU ICUIntensive Care Unit infections Infectious disease initiated intensive care intensive care unit intubation laryngotracheitis literature review Nasopharyngeal samples nebulized observation outcome Patient pharyngeal polymerase chain positive presentation regimen SARS-CoV-2 SARS-CoV-2severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 Shortness of breath Symptom tested [DOI] 10.1016/j.ijscr.2022.107074 [Article Type] Case report
Assessing clinical applicability of COVID-19 detection in chest radiography with deep learning Research Published on 2022-04-212022-10-05 Journal: Scientific Reports [Category] 치료기술, [키워드] Affect annotation applicability Assessing can be used Chest radiography Clinical finding collected complementary coronavirus disease COVID-19 COVID-19 patients CXR dataset datasets deep learning Disease progression Healthcare system hospital impacted manifestation Mild Multiple studies pandemic positive COVID-19 radiologist recent reported severe COVID-19 patients shown significantly increased subset [DOI] 10.1038/s41598-022-10568-3 [Article Type] Research
Clinicopathologic characteristics of severe COVID-19 patients in Mexico City: A post-mortem analysis using a minimally invasive autopsy approachResearch Article Published on 2022-03-032022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] alteration Analysis approach Autopsies Autopsy Characteristics characterized Clinical finding cohort study cohorts correlation COVID-19 Deceased demonstrated described diagnosis of SARS-CoV-2 diagnostic Diffuse alveolar damage Endothelitis feature hallmark hepatic histologic histological histology Histopathology Inflammation Injury Interstitial nephritis invasive kidney Liver function Liver histology liver tissue lung Lung compliance mechanical ventilation Mexico City Necrosis neutrophilic objective Patient performed Pneumonia Post-mortem predominant reported Result SARS-CoV-2 positivity setting severe COVID-19 patient severe SARS-CoV-2 steatosis the disease thrombosis [DOI] 10.1371/journal.pone.0262783 PMC 바로가기 [Article Type] Research Article
Classification and occurrence of an abnormal breathing pattern during cardiopulmonary exercise testing in subjects with persistent symptoms following COVID‐19 diseaseOriginal Article Published on 2022-02-182022-10-28 Journal: Physiological Reports [Category] COVID-19, MERS, [키워드] abnormal breathing pattern acute respiratory syndrome cardiopulmonary exercise testing Characteristics classification Clinical finding clinical observations COVID COVID‐19 COVID‐19 criteria determine disease Dyspnea Efficiency evaluate Exercise capacity expected explain hyperventilation Infection intensive care medical records occur Occurrence oxygen Patient peak ventilation reduced reported retrospective SARS‐CoV‐2 SARS‐CoV‐2 selected subject Symptom syndrome to define Ventilation ventilatory Volume [DOI] 10.14814/phy2.15197 PMC 바로가기 [Article Type] Original Article
Duodenal tropism of SARS-CoV-2 and clinical findings in critically ill COVID-19 patientsOriginal Paper Published on 2022-02-182022-10-29 Journal: Infection [Category] COVID-19, COVID19(2023년), MERS, SARS, 치료기술, [키워드] ACE2 applied biopsies bleeding cause caused Characteristics clinical Clinical finding Complication consequence COVID-19 COVID-19 patient Critically ill Critically ill patient critically ill patients detect develop diagnosed direct infection duodenal enterocyte Duodenitis histopathological immunohistochemical staining immunohistochemistry In situ hybridization indication intestinal macroscopic mucosal Patient patients positive Protein Replication Result SARS-CoV-2 SARS-CoV-2 pneumonia SARS-CoV-2 spike protein supplementary material tropism of SARS-CoV-2 viral replication was performed [DOI] 10.1007/s15010-022-01769-z PMC 바로가기 [Article Type] Original Paper
COVID-19 and the Vasculature: Current Aspects and Long-Term ConsequencesCell and Developmental Biology Published on 2022-02-152022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] ACE2 addition arrythmia aspect Cardiomyopathy cardiovascular disease cardiovascular event change Clinical finding clinical observation co-morbidity consequence Corona coronavirus 2 COVID-19 COVID-19 pathology COVID-19 patient Critical current CVD develop diabete disease endothelial Endothelial cell Endothelial dysfunction Endothelium Evidence extrapulmonary tissue heart hypertension in vitro study include individual infecting Long COVID-19 syndrome other tissues outcome pandemic Perspective promote provide respiratory respiratory pathogen respiratory tract SARS-CoV-2 SARS-COV-2 infection susceptibility the SARS-CoV-2 vascular inflammation vasculature virus [DOI] 10.3389/fcell.2022.824851 PMC 바로가기 [Article Type] Cell and Developmental Biology
Diagnostic and Prognostic Biomarkers of Coronavirus Disease 2019 in Children코로나 바이러스 질병 2019의 진단 및 예후 바이오 마커Article Published on 2022-02-032022-08-31 Journal: Journal of tropical pediatrics [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Adults age analyzed Biomarker Biomarkers blood sample Blood samples C-reactive protein can be used Chain Reaction chemokine chemokines children children with COVID-19 Clinical data Clinical finding Clinical findings Coagulation coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients cytokine Cytokines D-dimer diagnosed with COVID-19 Diagnosis diagnostic disease severity early diagnosis early treatment examined healthy children Hemogram IL-12 IL-1β Increased inflammatory parameter inflammatory parameters information interferon interferon gamma interleukin IP-10 Lymphocytes Mild moderate Pathogenesis Patient patient group Pediatric patient Pediatric patients pediatrics pediatrics and cytokine. polymerase chain polymerase chain reaction predict Predictive procalcitonin procalcitonin level Prognosis Prognostic factor Protein real-time polymerase chain reaction Serum level serum levels severe group Severe infection severity of COVID-19 significantly higher were measured [DOI] 10.1093/tropej/fmac003 PMC 바로가기 [Article Type] Article
Ocular Surface Infection by SARS-CoV-2 in COVID-19 Pneumonia Patients Admitted to Sub-Intensive Unit: Preliminary ResultsArticle Published on 2022-02-022022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] administration aerosol causal link Clinical data Clinical finding Concentration conjunctival Conjunctival swab consecutive patient Corneal COVID-19 COVID-19 diagnosis epithelial evaluated eye Eye infection eyes facial Italy nasal ocular ocular transmission SARS-CoV-2 oxygen Patient Pneumonia positive reported Result reverse-transcriptase PCR RT-PCR SARS-CoV-2 SARS-CoV-2 RNA Seven supplemental oxygen surface Swab treated Treatment two subject unit university viral infection viral keratoconjunctivitis virus detection [DOI] 10.3390/microorganisms10020347 PMC 바로가기 [Article Type] Article