SARS-CoV-2 infection in pediatric population before and during the Delta (B.1.617.2) and Omicron (B.1.1.529) variants eraArticle Published on 2022-09-082022-11-16 Journal: Virology Journal [Category] SARS, 변종, [키워드] Affect Asymptomatic available data B.1.1.529 B.1.617.2 caused children clinical manifestation clinical manifestations Complication conditions coronavirus disease country COVID-19 Delta delta variant Direct drastic exacerbating Google Scholar Health highest highlight Hospitalization immune response Immunodepressive incidence Infant Infants infected children Infection Manifestations Mild MIS MIS-C occur omicron Omicron variant pandemic pediatric Prevalence prevalence of COVID-19 proportion reported Risk factors SARS-COV-2 infection Science suggested symptomatic SARS-CoV-2 infection Symptoms. the United State Transmission dynamics vaccination variant variants virulent [DOI] 10.1186/s12985-022-01873-4 PMC 바로가기
Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, BrazilArticle Published on 2022-09-052022-11-16 Journal: BioMed Research International [Category] SARS, 변종, 유전자 메커니즘, [키워드] activated allele association Asymptomatic Brazil CARD8 center clinical clinical evolution Clinical management clinical manifestations contributing to COVID-19 COVID-19 severity death disease disease severity Factors Genetic Genetic variant Genotype group Haplotype Host host cells Inflammasome Inpatient investigated knowledge logistic regression models mechanism moderate NLRP3 NLRP3 inflammasome outcomes Patient performed polymorphism Polymorphisms profile protection Real-time PCR recruited Rio de Janeiro risk risk factor SARS-COV-2 infection SARS-CoV-2-infected individual scale severe symptom severity Significant single-nucleotide SNP SNPs Symptom the WHO two group two groups variants virus was determined WHO with mild disease [DOI] 10.1155/2022/9082455 PMC 바로가기
Clinical manifestations of COVID-19 breakthrough infections: A systematic review and meta-analysisCOVID-19 돌발 감염의 임상 양상: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval Analysis asymptomatic infection Breakthrough infection breakthrough infections clinical manifestation clinical manifestations Clinical outcome Coronavirus 2019 COVID-19 COVID-19 infection COVID-19 infections Delta delta variant Effect Effectiveness examined groups heterogeneity Hospitalization individual individuals Infection Invasive mechanical ventilation Meta-analysis Mortality need for oxygen other variants oxygen oxygen supplementation Patient Relative risk risk Risk factors risk of infection significantly significantly higher statistically statistically significant difference Still study heterogeneity supplemental oxygen systematic review Treatment strategies Vaccine vaccine effectiveness. variant variants Web of Science [DOI] 10.1002/jmv.27871 PMC 바로가기 [Article Type] Meta-Analysis
Clinical manifestations of COVID-19: An overview of 102 systematic reviews with evidence mappingArticle Published on 2022-09-012023-07-10 Journal: Journal of evidence-based medicine [Category] COVID19(2023년), [키워드] clinical manifestations COVID-19 evidence map SARS-CoV-2 systematic review. [DOI] 10.1111/jebm.12483 PMC 바로가기
Discovering common pathogenetic processes between COVID-19 and sepsis by bioinformatics and system biology approachArticle Published on 2022-08-312022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] acute respiratory syndrome addition Analysis approach bioinformatics Biomarker Blood caused clinical manifestations Clinical practice Coagulopathy Corona Coronavirus-2 COVID-19 Critically ill Critically ill patient Cytokine storm database DEGs demonstrated diagnostic differentially expressed differentially expressed gene differentially expressed gene (DEG) disease drug molecule enrichment analysis functional functional enrichment Gene Expression Omnibus gene expression profile Gene ontology gene regulatory network genetic link genetic mechanism GEO high mortality rate hub gene hypercoagulable Inflammatory response Interaction ITGAM molecular docking molecular mechanism multiple organ dysfunction neutrophil dysfunction pandemic Pathogenesis pathogenesis of COVID-19 pathway potential therapeutic agents progesterone protein-protein interaction Protein–protein interaction protein–protein interaction (PPI) receptor Regulatory Research respiratory infectious disease resulting risk SARS-CoV-2 screened Sepsis sepsis patient sepsis. Septic shock severe COVID-19 signaling pathway similarity Spread syndrome System biology Systems biology Treatment were used with COVID-19 [DOI] 10.3389/fimmu.2022.975848 PMC 바로가기
Post-COVID-19 Parkinsonism and Parkinson’s Disease Pathogenesis: The Exosomal Cargo HypothesisArticle Published on 2022-08-282022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, [키워드] accompanied acute respiratory syndrome aggregation alpha-synuclein Brain cargo cascades caused clinical manifestation clinical manifestations complex contributing to Coronavirus disease 2019 Coronavirus-2 correlation COVID-19 Diagnosis disease disease severity Dopaminergic neuron Evidence Exosome Exosomes Extracellular host protein Infection Inflammation Inflammatory Inflammatory mediators Intercellular communication long-lasting modulated molecular neurodegeneration neurodegenerative Neuroinflammation neurological Parkinson’s disease parkinsonian Parkinsonism Pathogenesis pathophysiological conditions pathway phenotype Pneumonia post-COVID-19 Post-infection prevalent promoter Protein reflected SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA similarity substantia Symptoms syndrome Transmission Viral proteins virus virus virus. [DOI] 10.3390/ijms23179739 PMC 바로가기
Clinical manifestations and disease severity of SARS-CoV-2 infection among infants in Canada캐나다 영유아에서 SARS-CoV-2 감염의 임상 증상 및 질병 중증도Article Published on 2022-08-242022-09-11 Journal: PLoS ONE [Category] SARS, 치료기술, [키워드] absence acute COVID-19 age approved Asymptomatic Canada Care Characteristics Clinical management clinical manifestation clinical manifestations clinics Cohort comorbid condition comorbid conditions condition coryza cough COVID-19 criteria defined disease severity Fever help higher odd higher odds Hospitalization Hospitalized identify incidentally detected Infant Infants Infrastructure initial Inpatient Logistic regression main analysis microbiologically Mild moderate moderate or severe disease multivariable logistic regression National oral intake outcome Outpatient outpatients patient with SARS-CoV-2 presenting symptom Program Prospective Study Public health interventions reported SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe disease severity strain Vaccine was performed [DOI] 10.1371/journal.pone.0272648 PMC 바로가기 [Article Type] Article
Multicenter Study on COVID-19 Lung Computed Tomography Segmentation with varying Glass Ground Opacities using Unseen Deep Learning Artificial Intelligence Paradigms: COVLIAS 1.0 Validation보이지 않는 딥 러닝 인공 지능 패러다임을 사용하여 다양한 유리 바닥 불투명도를 사용한 COVID-19 폐 컴퓨터 단층 촬영 분할에 대한 다기관 연구: COVLIAS 1.0 검증Multicenter Study Published on 2022-08-212022-09-12 Journal: Journal of medical systems [Category] 진단, [키워드] adjusted And AI annotations artificial automated automatically blinded clinical manifestations collected conducted consolidations COVID-19 CRO deep deep learning demonstrated GGO glass Glass ground opacities HDL Hounsfield units hybrid Hybrid deep learning hypotheses intelligence Italian learning lesion lung Lung CT multicenter multicenter study opacity Patient Performance metrics predict radiologist Regulatory Segmentation Solo deep learning. unit validation web-based system were used [DOI] 10.1007/s10916-022-01850-y PMC 바로가기 [Article Type] Multicenter Study
Detection of Intestinal Dysbiosis in Post-COVID-19 Patients One to Eight Months after Acute Disease Resolution급성 질환 해결 후 1~8개월 후 코로나19 환자의 장내 세균총 이상 감지Article Published on 2022-08-172022-09-11 Journal: International Journal of Environmental Research an [Category] 치료제, [키워드] acute COVID-19 acute disease acute phase adaptive immune responses addition alopecia anti-SARS-CoV-2 antibody Antibiotic therapy Antibiotics Anxiety bidirectional Bifidobacterium C-reactive protein Clinical data clinical manifestations controls COVID-19 severity Cytokine storm Depression Desulfovibrio detection disease DNA Dysbiosis Dyspnea evaluate fatigue Hypothesis immune response immune responses Immune status Interaction intestinal intestinal microbiota memory memory loss microbes microbiota modulating modulation Month myalgia pandemic Patient post-COVID-19 Post-COVID-19 patients Prevotella quantified reported symptoms Resolution Sequelae. sequenced severity significant difference significant differences Stool stool samples target the patient Therapeutic approach These data use of antibiotics viral infections with COVID-19 [DOI] 10.3390/ijerph191610189 PMC 바로가기 [Article Type] Article
Inactivated vaccines prevent severe COVID-19 in patients infected with the Delta variant: A comparative study of the Delta and Alpha variants from China비활성화된 백신은 Delta 변이에 감염된 환자에서 심각한 COVID-19를 예방합니다: 중국의 Delta 및 Alpha 변이에 대한 비교 연구Article Published on 2022-08-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] addition Alpha variant Antibiotics China Clinical characteristics clinical manifestation clinical manifestations Delta delta variant diagnosed disease dose Efficacy follow-up period generally mild glucocorticoid Glucocorticoids Hospital stay Hospitalization hospitalized patient Inactivated vaccine Inactivated Vaccines Infection information majority Mild MOST outcome Patient Prevent proportion replaced SARS-CoV-2 SARS-COV-2 infection severe COVID-19 vaccination Vaccine vaccine. widespread Zhejiang [DOI] 10.1002/jmv.27759 PMC 바로가기 [Article Type] Article