The immune response as a double-edged sword: The lesson learnt during the COVID-19 pandemicArticle Published on 2022-11-012022-11-16 Journal: Immunology [Category] SARS, 변종, [키워드] Asymptomatic breadth cellular Clinical severity COVID-19 COVID-19 pandemic Critical Cross-immunity cytokine Cytokine storm detrimental disease disease severity effort events Evidence feature highlighting immune response Immunopathogenesis Infection Innate immunity pathogen pathogenic processes Protective protective immunity protective role provided public health reducing resulting T-cell immunity the SARS-CoV-2 therapeutic approaches tissue injury Vaccine Viral variants [DOI] 10.1111/imm.13564 PMC 바로가기
Cross-sectional study for COVID-19-related mortality predictors in a Brazilian state-wide landscape: the role of demographic factors, symptoms and comorbiditiesArticle Published on 2022-10-172022-11-15 Journal: BMJ Open [Category] 진단, [키워드] 95% CI Analysis association cardiac epidemiology Clinical severity Comorbidity COVID-19 COVID-19 pandemic criteria criterion cross-sectional study dataset death demographic characteristics Demographic factors diabete diabetes & diagnosed disease disorder Effects electronic medical record endocrinology Epidemiology evaluate Factor health system healthcare highlight hospitalisation hospitalised ICU implementation increased mortality information Intervention kidney kidney & Kidney disease majority measure mitigate Mortality multicollinearity non-hospitalised non-ICU non-ICU patient occurred Patient patients patients older predictor Prevent public health reverse transcription-PCR secondary outcome selected severity Sex state suffered Symptom Urinary tract urinary tract disorders virus [DOI] 10.1136/bmjopen-2021-056801 PMC 바로가기
Global Epidemiology of Human Infections With Variant Influenza Viruses, 1959-2021: A Descriptive StudyArticle Published on 2022-10-122023-06-03 Journal: Clinical Infectious Diseases: An Official Publicat [Category] 조류인플루엔자, [키워드] Clinical severity Epidemiology human-to-human transmissibility pandemic variant influenza virus. [DOI] 10.1093/cid/ciac168
Clinical severity of SARS-CoV-2 Omicron BA.4 and BA.5 lineages compared to BA.1 and Delta in South AfricaArticle Published on 2022-10-042022-11-16 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI clinical Clinical severity COVID-19 COVID-19 case Delta delta variant diagnosed Factor hospitalisation hospitalised individual individuals Infection infections Laboratory Lineage multivariable logistic regression National omicron outcome PCR assay reduced risk S-gene SARS-CoV-2 severe disease severity South Africa TaqPath [DOI] 10.1038/s41467-022-33614-0 PMC 바로가기
Functional limitations 12 months after SARS-CoV-2 infection correlate with initial disease severity: An observational study of cardiopulmonary exercise capacity testing in COVID-19 convalescentsResearch article Published on 2022-10-012022-10-05 Journal: Respiratory medicine [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] Cardiopulmonary changes Clinical course Clinical severity convalescent correlated COVID-19 diffusion capacity disease Dyspnea Efficiency exercise Exercise capacity extracorporeal membrane oxygenation Factor Gas exchange impairment independent initial intensive care treatment Invasive mechanical ventilation limitation lung morbidity muscular offered outcome oxygen uptake parameter parenchymal participant Participants Patient PCR positive performed predicted prospective observational study provide Pulmonary function test Quality of life questionnaire reduced reported Result resulting risk factor SARS-COV-2 infection survivor Testing Treatment ventilatory Ventilatory capacity was reduced [DOI] 10.1016/j.rmed.2022.106968 [Article Type] Research article
Increased percentage of apoptotic and CTLA-4 (CD152) expressing cells in CD4+/CD8+ cells in COVID-19 patientsArticle Published on 2022-09-232022-11-15 Journal: Medicine [Category] 바이오마커, 치료제, [키워드] addition analyzed Apoptosis apoptotic apoptotic cell association blood cell C-reactive protein can be used CD4+ cell CD8+ cell Cell cell count cells characterized Chest CT Clinical severity confirmed case correlated correlation COVID-19 COVID-19 case COVID-19 patient COVID-19 patients CRP CTLA-4 cytotoxic T-lymphocyte antigen-4 detect Diagnosis diagnostic Dyspnea eosinophil expressing expression ferritin flow cytometry healthy control healthy volunteer In-patients Increased Infectious disease lymphocyte Lymphocyte count lymphopenia neutrophil Patient patients Platelet proportion reduced severity significant difference significantly therapeutic targets Total up-regulated WBCs while white with COVID-19 [DOI] 10.1097/MD.0000000000030650 PMC 바로가기
Untargeted saliva metabolomics by liquid chromatography-Mass spectrometry reveals markers of COVID-19 severityArticle Published on 2022-09-222022-11-15 Journal: PLoS ONE [Category] 바이오마커, 변종, [키워드] Amino acid amino acids analysed Analysis C-reactive protein Clinical diagnosis Clinical severity clinical suspicion Clinical tests collected COVID-19 COVID-19 diagnosis COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 severity Diagnosis diagnostic Disease progression driver dysregulation eliminating expand exploratory feature Health hospital hospitalised patient likelihood marker metabolomics Metadata Non-invasive offer outcomes Patient patients peripheral oxygen saturation Prognosis progressed receiver operating characteristics recent Research reservoir respiratory rate resulting reveal RT-PCR testing Saliva saliva sample serum severity shown the disease Treatment Vaccine variants [DOI] 10.1371/journal.pone.0274967 PMC 바로가기
Misclassification bias in estimating clinical severity of SARS-CoV-2 variantsArticle Published on 2022-09-102022-11-16 Journal: Lancet (London, England) [Category] SARS, 변종, [키워드] Clinical severity Misclassification SARS-CoV-2 variant [DOI] 10.1016/S0140-6736(22)01469-6 PMC 바로가기
Misclassification bias in estimating clinical severity of SARS-CoV-2 variants – Authors’ replyArticle Published on 2022-09-102022-11-16 Journal: Lancet (London, England) [Category] SARS, 변종, [키워드] Clinical severity Misclassification SARS-CoV-2 variant [DOI] 10.1016/S0140-6736(22)01432-5 PMC 바로가기
Functional associations between polymorphic regions of the human 3’IgH locus and COVID-19 disease인간 3'IgH 유전자좌의 다형성 영역과 COVID-19 질병 간의 기능적 연관성Article Published on 2022-09-052022-09-11 Journal: Gene [Category] COVID19(2023년), SARS, 변종, [키워드] age allele allelic Allelic polymorphisms Alpha association blood sample Blood samples Clinical outcome clinical outcomes Clinical severity collected coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients diffusion disease severity disequilibrium distribution DNA binding enhancer enhancer region ERα Estrogen Estrogen receptor alpha exhibited explain Genetic genetic background Genetic variant genetic variants genotyped SNP genotyped SNPs haplotypes heavy chain hospital hs1,2 enhancer. humans hypothese IgH locus immune response Immunoglobulin Infection Italy less linkage locus men MOST nine nucleotide Occurrence pandemic Pneumonia produced protective factor receptor Region SARS-COV-2 infection severe disease sex differences Sex-related differences significantly SNPs women [DOI] 10.1016/j.gene.2022.146698 PMC 바로가기 [Article Type] Article