Detection of respiratory viruses directly from clinical samples using next-generation sequencing: A literature review of recent advances and potential for routine clinical useArticle Published on 2022-09-012022-11-15 Journal: Reviews in Medical Virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Acute respiratory infection aetiology barriers characterisation clinical sample Clinical use Cluster database death detection diagnosed Diagnosis English FIVE Illumina IMPROVE Inclusion indicate Infection Influenza literature review majority métapneumovirus Mortality Mutation Next-generation sequencing next-generation sequencing (NGS) NGS other respiratory virus parainfluenza virus platform potential barrier previous study respiratory infection respiratory syncytial virus respiratory virus respiratory viruses SARS-CoV-2 searched Sequencing thought variety virus virus detection were used [DOI] 10.1002/rmv.2375 PMC 바로가기
Repurposing drugs and identification of inhibitors of integral proteins (spike protein and main protease) of SARS-CoV-2SARS-CoV-2의 필수 단백질(스파이크 단백질 및 주요 프로테아제) 억제제의 용도 변경 및 식별Article Published on 2022-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, [키워드] Analysis binding energy Cefoperazone Clinical use Compound Coronavirus infection COVID-19 docked domain drug effort EGCG Emergency exhibited FIVE glycoprotein GRN HCQ Hydroxychloroquine identify Infection inhibitor inhibitors inhibitors of SARS-CoV-2 Inhibitory effects Lopinavir LPV M pro main protease enzyme MDs molecular molecular docking molecular dynamic simulations MPro nelfinavir outbreak predicted protease Protein Public public health emergency RBD RDV Receptor-binding domain recorded Remdesivir repurposing SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein screened spike (S) glycoprotein Spike protein were used WHO World Health Organisation Zafirlukast [DOI] 10.1080/07391102.2021.1886993 PMC 바로가기 [Article Type] Article
Limited Correlation between SARS-CoV-2 Serologic Assays for Identification of High-Titer COVID-19 Convalescent Plasma Using FDA ThresholdsArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibody assay standardization assays authorization can be used CCP clinical trials Clinical use Cohort collected comparable Concordance consequence convalescent convalescent plasma COVID-19 COVID-19 convalescent plasma criteria Cutoff cutoff value Donor drug Emergency Emergency use authorization EUA Expanded Access Program FDA FDA EUA FIVE food high-titer CCP high-titer convalescent plasma highlight hospitalized patients identification identify immunosuppressed patients indicate Limited lowest monoclonal antibody multiple serological assay Pandemics Pathogens positive precluded provided ranged reduce released Roche SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant serologic serologic assay serological Serological assay serological assays serology serum sample significantly Standardization therapeutic therapeutic option therapy threshold Treatment [DOI] 10.1128/spectrum.01154-22 PMC 바로가기
A potent neutralizing antibody provides protection against SARS-CoV-2 Omicron and Delta variants via nasal deliveryArticle Published on 2022-08-302022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome Administered antibody approved B.1.1.529 B.1.617.2 broad-spectrum antivirals characterized circulating Clinical outcome Clinical use coronavirus Delta delta variant dosage drug effective Efficacy ENhance half-maximal inhibitory concentration hamster IC50 inhibit Intravenous injection knowledge Lungs mutants nasal nebulized neutralizing antibody omicron overcome Patient prevented Prophylactic provide Replication SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 variant therapeutic therapeutic efficacy therapy Treatment Vaccine variant virus-neutralizing VoC VOCs [DOI] 10.1038/s41392-022-01135-3 [Article Type] Article
Regulatory considerations to keep pace with innovation in digital health products Reviews Published on 2022-08-192022-10-05 Journal: NPJ Digital Medicine [Category] 바이오마커, [키워드] accelerated approach Clinical use current Evolution Health Medical conditions offer potential benefit proliferation Rapid Regulatory regulatory pathway [DOI] 10.1038/s41746-022-00668-9 [Article Type] Reviews
Cellular senescence and senolytics: the path to the clinic Reviews Published on 2022-08-112022-10-05 Journal: Nature Medicine [Category] 바이오마커, 임상, 진단, 치료제, [키워드] alleviate Cell cell cycle arrest cellular senescence Clinical use condition deleterious effect disease Diseases disorder disorders drug humans Intervention Prevent Protein review secrete senescent cell shown therapeutic target tissue tissue damage [DOI] 10.1038/s41591-022-01923-y [Article Type] Reviews
A CRISPR-based ultrasensitive assay detects attomolar concentrations of SARS-CoV-2 antibodies in clinical samplesCRISPR 기반 초고감도 분석은 임상 샘플에서 SARS-CoV-2 항체의 원자 농도를 감지합니다.Article Published on 2022-08-092022-09-11 Journal: Nature Communications [Category] SARS, 바이오마커, 진단, 치료기술, [키워드] anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody Antibody detection classic clinical clinical sample clinical samples Clinical use clinically collected Concentration CRISPR detect diagnostics General population homogeneous immunoassay immunoassays kidney transplant recipient Laboratory large cohort nucleic acid Nucleic acid detection nucleic acids point-of-care powerful tool Proteins Quantitative analysis SARS-CoV-2 antibody sensitivity serum serum sample serum samples shown simplicity specificity translate [DOI] 10.1038/s41467-022-32371-4 PMC 바로가기 [Article Type] Article
Measurements of SARS-CoV-2 antibody dissociation rate constant by chaotrope-free biolayer interferometry in serum of COVID-19 convalescent patients코로나19 회복기 환자의 혈청 내 무카오트로프 생물층 간섭계를 통한 SARS-CoV-2 항체 해리율 상수 측정Article Published on 2022-08-012022-09-12 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 진단, [키워드] Antibody concentrations avidity binding binding interaction binding kinetics Biolayer interferometry BLI children Clinical use clinical utility coated with convalescent COVID-19 patients COVID-19 COVID-19 convalescent patient COVID-19 convalescent patients COVID-19 patient Critical demonstrated dissociation dissociation rate Dissociation rate constant Efficiency functional intensity Kinetics knowledge Lower measurement non-specific pediatric probe RBD Real-time monitoring Receptor binding domain reduction reported SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 spike protein sera serum serum albumin serum antibody Vaccines were measured [DOI] 10.1016/j.bios.2022.114237 PMC 바로가기 [Article Type] Article
Circulating tumour DNA — looking beyond the blood Reviews Published on 2022-08-012022-10-05 Journal: Nature Reviews Clinical Oncology [Category] 바이오마커, 변종, [키워드] Analysis Biomarkers biopsy Blood cerebrospinal fluid circulating Clinical use complementary DNA majority offer over plasma Research review tissue tissue sample unique Urine [DOI] 10.1038/s41571-022-00660-y [Article Type] Reviews
RNA solutions to treat inborn errors of metabolism신진대사의 선천적 오류를 치료하기 위한 RNA 솔루션Review Published on 2022-08-012022-09-11 Journal: Molecular genetics and metabolism [Category] 유전자 메커니즘, [키워드] activating antisense Antisense oligonucleotides approved Biology Chemistry Clinical efficacy clinical trial clinical trials Clinical use COVID-19 drug drugs effective expression gene silencing help IEM include lncRNA mechanism mechanism of action messenger RNAs metabolism MicroRNAs molecules mRNA mutations New offer overcome Patient pharmacokinetic rare disease rare diseases Research RNA RNA interference RNA vaccine RNA vaccines RNAs siRNA splicing Stage suppress target tissues Therapeutic approach therapy tissues treat [DOI] 10.1016/j.ymgme.2022.07.006 PMC 바로가기 [Article Type] Review