Evaluating the Neutralizing Ability of a CpG-Adjuvanted S-2P Subunit Vaccine Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants of Concern중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 우려 변종에 대한 CpG-보강 S-2P 소단위 백신의 중화 능력 평가Article Published on 2022-06-102022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 진단, [키워드] Ability acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against Alpha Alpha variant aluminum aluminum hydroxide antibody Antigen Beta Beta variant beta variants breath clinical trial coated with concern coronavirus coronavirus 2 COVID-19 CpG D614G demonstrated dose effective Effectiveness elicit elicited Evaluating High dose Human humans hydroxide immune response immunization immunized immunogenicity medium neutralization neutralization ability neutralization activity Neutralizing antibodies neutralizing antibody neutralizing capacity Neutralizing titer neutralizing titers Phase 1 prefusion pseudovirus pseudoviruses RAT RATs reduced reduction reduction in respiratory retained S-2P SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants serum antibodies serum antibody serum sample serum samples severe acute respiratory syndrome Coronavirus significantly Spike protein subject subunit subunit SARS-CoV-2 vaccine the SARS-CoV-2 Vaccine Vaccines variant variant of concern variants VOCs wild-type [DOI] 10.1093/cid/ciab711 PMC 바로가기 [Article Type] Article
N protein-based ultrasensitive SARS-CoV-2 antibody detection in seconds via 3D nanoprinted, microarchitected array electrodesN 단백질 기반 초고감도 SARS-CoV-2 항체 검출은 3D 나노프린팅된 마이크로아키텍처 어레이 전극을 통해 몇 초 만에 검출됩니다.Article Published on 2022-05-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] 3D printing 3D printing and functional sensors antibody array Biomarker Cell coated with Complete COVID-19 COVID-19 antibody Critical detect diagnostics electrochemical cell epidemiological functional Graphene Infection Interaction limit of detection N protein N proteins nucleocapsid platform Protein provide quantification Rapid reduce Research SARS-CoV-2 SARS-CoV-2 antibody sensor the antibody the N protein vaccination Vaccine [DOI] 10.1002/jmv.27591 PMC 바로가기 [Article Type] Article
D-dimer and CoV-2 spike-immune complexes contribute to the production of PGE2 and proinflammatory cytokines in monocytesD-이량체 및 CoV-2 스파이크-면역 복합체는 단핵구에서 PGE2 및 전염증성 사이토카인 생성에 기여합니다Article Published on 2022-04-062022-09-12 Journal: PLoS Pathogens [Category] 진단, [키워드] accelerate activated antibody binding antibody Calcium signaling chimeric Coagulopathy coated with Combination complexes contribute convalescent plasma correlated COVID-19 cytokine D-dimer dose healthy healthy donors hospitalized COVID-19 patient hospitalized COVID-19 patients human monocyte IL-6 IL-8 immune complex increase in infiltrating monocyte Inflammatory cytokine Inflammatory cytokines inflammatory status inhibitor integrin kinase lung Lung pathology MAPK monoclonal antibody monocyte much lower neutralizing antibody titers overreactive inflammatory response pathway Patient PGE2 plasma produced Proinflammatory cytokine prostaglandin E2 pseudovirus recombinant S protein regions responses S protein SARS CoV-2 significantly Treatment viral particle [DOI] 10.1371/journal.ppat.1010468 PMC 바로가기 [Article Type] Article
Diagnostics of SARS-CoV-2 infection using electrical impedance spectroscopy with an immunosensor to detect the spike protein스파이크 단백질을 검출하기 위해 면역 센서와 전기 임피던스 분광법을 사용하여 SARS-CoV-2 감염 진단Article Published on 2022-03-012022-09-11 Journal: Talanta [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] addition antibody Biomarker change chitosan coated with concentrations control sample country COVID-19 detect detection diagnostics electrical electrical impedance genetic material healthy healthy and infected patients Immunosensors impedance Impedance spectroscopy inactivated infected patients Information visualization Interaction limit of detection linear mass matrix mechanism methodology multidimensional performed point-of-care Protein resources SARS-CoV-2 SARS-COV-2 infection selective species spike Spike protein spike protein of SARS-CoV-2 the spike protein virus [DOI] 10.1016/j.talanta.2021.123076 PMC 바로가기 [Article Type] Article
Quantum optical immunoassay: upconversion nanoparticle-based neutralizing assay for COVID-19양자 광학 면역 분석 : COVID-19에 대한 상향 전환 나노 입자 기반 중화 분석Article Published on 2022-01-242022-09-01 Journal: Scientific Reports [Category] 진단, 치료기술, 치료제, [키워드] a glass ACE-2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody binding domain Biological physics coated with confocal microscope COVID-19 detect dynamic range fluorescent glass high affinity IgG antibody Infection infections Nanoparticles Nanoscale biophysics Neutralizing neutralizing antibody optical Optical sensors pandemic Particle Particles population immunity Prevent Protein quantum reduction in required SARS-CoV-2 receptor SARS-CoV-2 virus sensitivity severity substrate target cells the SARS-CoV-2 virus therapeutic vaccination Viral virion virus was used [DOI] 10.1038/s41598-021-03978-2 PMC 바로가기 [Article Type] Article
Mesenchymal stromal cells coated with anti-ACE2 antibodies might improve efficacy against COVID-19항-ACE2 항체로 코팅된 중간엽 기질 세포는 COVID-19에 대한 효능을 향상시킬 수 있습니다Article Published on 2022-01-012022-09-12 Journal: Human Cell [Category] SARS, 진단, [키워드] anti-ACE2 antibody coated with COVID-19 Efficacy IMPROVE Mesenchymal stromal cell [DOI] 10.1007/s13577-021-00620-1 PMC 바로가기 [Article Type] Article
COVID-19 Antibody Detection and Assay Performance Using Red Cell AgglutinationConference abstract Published on 2021-11-232022-10-05 Journal: Blood [Category] 치료기술, [키워드] acute respiratory syndrome agglutination anti-SARS-CoV-2 anti-SARS-CoV-2 IgG antibodies antibody antibody concentration assays AUC Blood CCP Cell Clinical course clinical evaluation coated with collected commercial immunoassay Concentration convalescent plasma coronavirus correlation COVID-19 COVID-19 disease COVID-19 outbreak current detect detection Donor donors EUA FDA Follow-up healthy hospital IgA IgG IgM IMPROVE Laboratory Longitudinal data Neutralizing nucleocapsid protein peptide performance performed plasma sample plasma samples positive Prognosis ranged Rapid test reached Red Red cell required resource ROC Curve SARS-CoV-2 sensitivity serologic serologic test serology tests Spearman Specificities specificity Spike protein suggested tested Testing the SARS-CoV-2 Total virus was measured was performed was tested [DOI] 10.1182/blood-2021-150795 [Article Type] Conference abstract
Kinetics of antibody response in critically ill patients with Middle East respiratory syndrome and association with mortality and viral clearanceArticle Published on 2021-11-192022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, [키워드] 95% CI Admission admitted to ICU antibody Antibody Response Antigen assessment association blood sample clearance coated with collected Corticosteroids Critically ill Critically ill patient Diseases ELISA enzyme-linked immunosorbent failure faster ICU IgG antibody immunology Immunotherapy implication invasive ventilation Kinetics lower mortality median MERS MERS patient MERS-CoV MERS-CoV RNA MERS-CoV S1 Middle East Mortality onset of symptom optical Pathogenesis Patient renal replacement therapy rRT-PCR significantly increased Signs and symptoms SOFA study cohort syndrome vasopressors viral clearance [DOI] 10.1038/s41598-021-01083-y PMC 바로가기 [Article Type] Article
Rapid Detection and Inhibition of SARS‐CoV‐2‐Spike Mutation‐Mediated MicrothrombosisResearch Article Published on 2021-10-232022-10-28 Journal: Advanced Science [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome adverse outcome age antibodies binding Blood Blood coagulation boost can be used coated with coronavirus coronavirus disease COVID‐19 patients D614G detection Endothelial cell enzyme examined genetic heterogeneity hACE2 Host immune response in viral increasingly Infection Inflammation inhibition Microfluidic chip Microthrombosis outcomes Patient patients platform presence of comorbidity protective mechanism Protein Rapid reduce reported Safe SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 spike SARS‐CoV‐2 sequence spike tested therapy thought thrombosis thrombotic complication thrombotic event Thrombotic events vaccination Vaccine variant vector Whole blood [DOI] 10.1002/advs.202103266 PMC 바로가기 [Article Type] Research Article
Rapid inactivation of SARS-CoV-2 by titanium dioxide surface coatingResearch Article Published on 2021-09-092022-10-28 Journal: Wellcome Open Research [Category] COVID-19, [키워드] acute respiratory syndrome ambient atomic Care coated with coating Complete Contamination coronavirus detectable droplet evaluated flow cytometry had no Health HIV-1 inactivated inactivation infected cell Infection infection control inoculated interval lentiviral system LIGHT live SARS-CoV-2 Live virus magnitude no significant difference Nosocomial infection occur Post-infection Protein pseudotyped pseudotyped virion Rapid reduction in remained SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 spike SARS-CoV-2 virus significant effect significantly spike spray stability surface target cell tested TiO2 titanium dioxide titre Transmissibility Transmission VERO E6 cells viability viral variant virus was determined [DOI] 10.12688/wellcomeopenres.16577.2 PMC 바로가기 [Article Type] Research Article