Update on Innate Immunity in Acute Kidney Injury-Lessons Taken from COVID-19Review Published on 2022-10-192023-07-10 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), [키워드] coagulation cascade complement system immunothrombosis necroinflammation Neutrophil extracellular traps tubular epithelial cells vascular endothelial damage. [DOI] 10.3390/ijms232012514 PMC 바로가기 [Article Type] Review
Targeting thromboinflammation in COVID-19 – A narrative review of the potential of C1 inhibitor to prevent disease progressionReview Published on 2022-10-012022-10-05 Journal: Molecular immunology [Category] COVID19(2023년), SARS, 신약개발, 임상, 진단, 치료제, [키워드] Activation addition Anti-inflammatory anticoagulation Antiviral Asymptomatic carrier C1 inhibitor cascade cascades caused Clinical practice complement complement system Complication Contact contact activation system Coronavirus disease 2019 COVID-19 Critically ill patient death disease driver drug Endothelial cell Evidence Inflammatory inhibitor introduced kallikrein-kinin Kallikrein-kinin system monoclonal antibodies multisystemic myocardial injury pandemic potential benefit prevent disease progression randomized study randomized trials SARS-CoV-2 severe COVID-19 syndrome targeting the disease therapeutic option Thromboembolic events Thromboinflammation Treatment Trial [DOI] 10.1016/j.molimm.2022.08.008 [Article Type] Review
CXCL8, CCL2, and CMV Seropositivity as New Prognostic Factors for a Severe COVID-19 CourseArticle Published on 2022-09-262022-11-15 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, 진단, [키워드] C4BPA C5aR1 CCL2 CCL3 CCR1 CFD chemokine chemokines CMV CMV status complement complement system component Concentration contribute correlated Course courses COVID-19 COVID-19 patient CR1 CXCL10 CXCL8 Cytokine storm enrolled examined Factor groups healthy control Hyperinflammatory response ICU mechanisms molecular mRNA mRNA expression New non-ICU non-ICU patients pathogenesis and development pathophysiology plasma profile Prognostic factor protein level proteomic reduced Research SARS-CoV-2 Seropositivity severe COVID-19 significant difference time intervals [DOI] 10.3390/ijms231911338 PMC 바로가기
Complement and endothelial cell activation in COVID-19 patients compared to controls with suspected SARS-CoV-2 infection: A prospective cohort studyArticle Published on 2022-09-202022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, [키워드] 30-Day mortality Activation Admission Analysis Bacterial Biomarker blood sample C5a cascade clinically suspected comparable complement complement system Concentration Control control group controls COVID-19 COVID-19 patient disease E-selectin elevated endothelial Endothelial cell endothelial cells Endothelium evaluate excluded females galectin-3 galectin-3. ICAM-1 ICU Inflammatory inflammatory condition Inpatient male non-infectious nonspecific occurred outcome Outpatient Patient Pneumonia presenting prospective cohort study recruited respiratory viral infections SARS-CoV-2 SARS-COV-2 infection SC5b-9 significantly significantly higher single-center study VCAM-1 [DOI] 10.3389/fimmu.2022.941742 PMC 바로가기
Contribution of Coronavirus-Specific Immunoglobulin G Responses to Complement Overactivation in Patients with Severe Coronavirus Disease 2019Article Published on 2022-09-132022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, [키워드] Activation acute respiratory syndrome addition Analysis and antibodies antibody C1q circulating classical classical pathway common cold common cold coronavirus common cold Coronaviruses complement complement system coronavirus coronavirus disease correlated COVID-19 Critical demonstrated develop disease disease severity greater healthy control hospitalized patient IgG response immune complex Immunoglobulin Immunoglobulin G implicated mechanism moderate modify outcome overactivation Pathogenesis Patient patients with COVID-19 plasma response responsible RNA SARS-CoV-2 severe COVID-19 severe patients severity systemically therapeutic strategy with COVID-19 [DOI] 10.1093/infdis/jiac091 PMC 바로가기
Dysregulated miRNAs network in the critical COVID-19: An important clue for uncontrolled immunothrombosis/thromboinflammation중요한 COVID-19에서 조절되지 않는 miRNA 네트워크: 통제되지 않는 면역혈전증/혈전염증에 대한 중요한 단서Review Published on 2022-09-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] accompanied activated Activation adenine affecting anti-inflammatory factors Anticoagulant cause clinical complication Coagulation Coagulation system complement complement system Complication components conserved coronavirus disease Coronavirus disease 2019 COVID-19 Critical Cytokine storm Defensive mechanism deviation diffusion Effect expression expression level facilitate Factor function Genetic higher risk homeostasis hyperinflammation immune immunothrombosis incidence Interaction involved life-threatening mechanism microRNA MicroRNAs miRNA miRNAs miRNAs-based therapy. molecules Mortality NADPH nicotinamide nicotinamide adenine dinucleotide Nicotinamide adenine dinucleotide phosphate Non-coding RNAs nucleotide oxygen Pathogens Patient phosphate reactive oxygen species reactive oxygen specy reduction response restrict SARS-CoV-2 severe complications Therapeutic approach therapy Thromboinflammation thrombotic underlie vicious cycle [DOI] 10.1016/j.intimp.2022.109040 PMC 바로가기 [Article Type] Review
C5a elevation in convalescents from severe COVID-19 is not associated with early complement activation markers C3bBbP or C4dArticle Published on 2022-08-242022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, [키워드] Activation Alternative pathway Analysis anaphylatoxin C4d C5a Clinical course clinical risk clinical risk score collected complement Complement pathway complement system convalescent correlation Course COVID-19 disease severity elevated evaluated Follow-up groups highest hospital discharge Hospitalization infected with SARS-CoV-2 marker Numerous pathway Patient positive correlation reported severe COVID-19 severely ill patient severity soluble fraction suffered the disease the patient upstream were assessed [DOI] 10.3389/fimmu.2022.946522 PMC 바로가기
Efficacy and safety of the investigational complement C5 inhibitor zilucoplan in patients hospitalized with COVID-19: an open-label randomized controlled trialRandomized Controlled Trial Published on 2022-08-092022-10-04 Journal: Respiratory Research [Category] SARS, 임상, [키워드] 95% CI 95% confidence interval age Antibiotic prophylaxis assigned baseline Clinical outcome complement Complement 5 complement system Concentration control group COVID-19 COVID-19 patient Day Efficacy and safety Hypoxemia Inflammation inhibitor long-term follow up mean difference men Mortality MOST multicenter Odds ratio Open-label Oxygenation PaO Patient patients hospitalized primary analysis Primary outcome Randomized Randomized controlled trial randomized studies randomized trial Randomly receive Research Respiratory function serum Standard of care statistical significance systemic systemic inflammation the median Trial while zilucoplan [DOI] 10.1186/s12931-022-02126-2 PMC 바로가기 [Article Type] Randomized Controlled Trial
Germline rare variants of lectin pathway genes predispose to asymptomatic SARS-CoV-2 infection in elderly individuals렉틴 경로 유전자의 생식선 희귀 변이체는 노인에서 무증상 SARS-CoV-2 감염을 일으키기 쉽습니다.Article Published on 2022-08-012022-09-11 Journal: Genetics in medicine : official journal of the Ame [Category] COVID19(2023년), SARS, 변종, [키워드] allelic variant allelic variants Asymptomatic Asymptomatic COVID-19 asymptomatic individual Asymptomatic individuals asymptomatic subject Cohort COLEC10 COLEC11 Collapsing complement complement system COVID-19 decreased activity decreased expression enrichment ES European Evidence exome sequencing data Genes Genetic genetic data Genome Aggregation Database germline Hospitalized hospitalized patient Hyperactivation individual individuals investigated lectin lectin pathway lung tissue MASP1 outcome performed phenotype predicted PROTECT prothrombin rare variant replicated SARS-CoV-2 SARS-COV-2 infection serum severe COVID-19 severe disease susceptible variant with COVID-19 [DOI] 10.1016/j.gim.2022.04.007 PMC 바로가기 [Article Type] Article
Complement inhibition: A possible therapeutic approach in the fight against Covid-19Review Published on 2022-07-012023-07-07 Journal: Reviews in Medical Virology [Category] COVID19(2023년), [키워드] C5 complement system COVID-19 membrane attack complex. SARS-CoV-2 [DOI] 10.1002/rmv.2316 [Article Type] Review