Developing Computational Thinking Teaching Strategies to Model Pandemics and Containment MeasuresArticle Published on 2021-11-282022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] activity affected Asia-Pacific computational modeling computational thinking Containment cooperation COVID-19 Developing Digital Economy Engineering example feasible help lack lesson study mathematics measure Model pandemic Pandemics problem public health School Science sequence Strategy sustainability Teaching technology thinking virus transmission [DOI] 10.3390/ijerph182312520 PMC 바로가기 [Article Type] Article
Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunityArticle Published on 2021-11-182022-10-04 Journal: Nature Communications [Category] MERS, SARS, 진단, [키워드] acquisition Analysis antibodies antibody Antibody Response Antibody titer Antimicrobial responses circulating computational modeling coronavirus Critical cross-protective Determination disease severity dissect Donor elevated HCoV Hospitalization human coronavirus Humoral response immune response Immunity less MOST multifactorial multiplex negativity neutralization activity Patient pre-existing immunity promote protective immunity reactivity reduced response responses reveal SARS-CoV-2 SARS-CoV-2 antibody response SARS-CoV-2 immunity SARS-CoV-2 positive patients Seroconversion viral infection [DOI] 10.1038/s41467-021-27040-x PMC 바로가기 [Article Type] Article
Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and TherapyReview Published on 2021-11-102022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, MERS, SARS, [키워드] addition Atherosclerosis atherosclerotic atherosclerotic plaque cardiovascular cardiovascular disease cardiovascular system Characteristics clinical Combination computational modeling Concentration coronavirus COVID-19 CVD delivery Diagnosis diagnostic methods Effectiveness Endothelial dysfunction endothelial function flow-mediated dilation homeostasis IMPROVE in vivo Inhaled inhaled NO therapy Laboratory manifestation nitric oxide delivery NO release platform Occurrence Oxide platform progression pulmonary hypertension Raman spectroscopy regulate Stem cell therapy therapy treat Treatment [DOI] 10.3390/ijms222212166 PMC 바로가기 [Article Type] Review
Rapid development of analytical methods for evaluating pandemic vaccines: a COVID-19 perspectiveSpecial Report Published on 2021-10-142022-10-28 Journal: Bioanalysis [Category] COVID-19, MERS, SARS, [키워드] analytical tools assist attribute computational modeling COVID-19 COVID-19 pandemic COVID-19 vaccine dependent on develop highlight In vitro assay in vivo initial Mutation pandemic Perspective preclinical models predict provide Rapid SARS-CoV-2 Vaccine Vaccine design vaccine production vaccine response Viral protein virus viruses [DOI] 10.4155/bio-2021-0096 PMC 바로가기 [Article Type] Special Report
Intelligent health system for investigation and consenting COVID-19 patients and precision medicineCOVID-19 환자 및 정밀 의학 조사 및 동의를위한 지능형 건강 시스템Perspective Published on 2021-10-082022-09-10 Journal: Personalized Medicine [Category] SARS, 치료기술, [키워드] Advancing Analysis artificial intelligence assist best cause clinical decision Clinical research computational modeling continuum COVID-19 COVID-19 patient data analytics Decision making diagnostic Early detection Electronic health records granularity Health health system healthcare identify include information machine learning machine learning algorithm Machine learning algorithms Mortality patients recruitment population studies Precision Predictive prevention of COVID-19 Research risk factor Stratification subgroup Support translational [DOI] 10.2217/pme-2021-0068 PMC 바로가기 [Article Type] Perspective
High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19420 Published on 2021-10-052022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS, [키워드] Activation acute respiratory syndrome alteration basophils CD63 CD69 circulating clinical complication clinical feature Clinical features Clinical outcome collected combined use computational modeling convalescent convalescent phase coronavirus correlated COVID-19 COVID-19 pandemic COVID-19 pathogenesis COVID-19 patient COVID-19 patients COVID-19 severity CXCR4 detrimental dysregulated dysregulation eosinophil eosinophil and basophil activation Evidence expression flow cytometry granulocyte Granulocytic heterogeneity high-dimensional flow cytometry Hospitalization identify immature immune immune response immunotype indicate inflammatory markers inflammatory state innate immune response involved laboratory measurement longitudinal analysis Migration Multiorgan dysfunction neutrophil neutrophil heterogeneity Neutrophils pathophysiologic Patient Peripheral blood phenotypic phenotypic data predict predicted Predictive profiles Protein provide receptor Respiratory function reveal SARS-COV-2 infection selected severity of COVID-19 Significance significantly subset the disease viral immune responses virus clearance with COVID-19 [DOI] 10.1073/pnas.2109123118 PMC 바로가기 [Article Type] 420
Predicting Mechanical Ventilation and Mortality in COVID-19 Using Radiomics and Deep Learning on Chest Radiographs: A Multi-Institutional StudyArticle Published on 2021-09-302022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Analysis analyzed approach artificial intelligence center characteristic Chest Clinical outcome computational modeling coronavirus disease COVID-19 COVID-19 pandemic COVID-19 patient CXR deep deep learning demonstrated evaluated feature IMPROVE Inclusion information instance Interpretation introduced learning machine learning machine learning classifier Mechanical mechanical ventilation Mortality patients predict prognostic Radiography Radiomics random resource Retrospective study sensitivity Severity Score severity scores specificity treated university [DOI] 10.3390/diagnostics11101812 PMC 바로가기 [Article Type] Article
Structural and energetic profiling of SARS-CoV-2 receptor binding domain antibody recognition and the impact of circulating variantsSARS-COV-2 수용체 결합 도메인 항체 인식의 구조적 및 에너지 프로파일 링 및 순환 변이체의 영향Research Article Published on 2021-09-072022-09-10 Journal: PLoS Computational Biology [Category] SARS, 변종, 진단, [키워드] affected Alpha Analysis antibody atomic Author B.1.1.7 B.1.617.2 binding binding domain circulating variant Clustering Community complex computational modeling Contact COVID-19 pandemic dataset Delta described determinant disrupt epitope epitope conservation evade feature group high resolution highlight identify immune response immune responses less molecular monoclonal antibodies monoclonal antibody Mutation mutations natural infection Neutralizing antibodies performed predicted Protective antibody protective antibody responses RBD Receptor binding domain Research residue residues SARS-CoV-2 pandemic SARS-CoV-2 receptor SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus spike glycoprotein Spread Structural analysis Structure structures target the SARS-CoV-2 the SARS-CoV-2 virus therapeutic Unsupervised clustering Vaccine Vaccine design Vaccines variants Viral viral variant Viral variants was used [DOI] 10.1371/journal.pcbi.1009380 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma고도로 중화되는 COVID-19 회복기 혈장에서 SARS-CoV-2 탈출420 Published on 2021-09-072022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody Response binding Brazil change computational modeling convalescent convalescent patient convalescent plasma convalescent sera coronavirus COVID-19 Deletion Donor E484K effective emerging variants evade Evolution generate immune immune evasion immune pressure immune response immune selective pressure Immunity Increases Infection insertion Japan monoclonal antibodies monoclonal antibody Mutation N-terminal domain neutralization neutralized Neutralizing Neutralizing antibodies neutralizing antibody neutralizing responses new virus NTD occurred passages plasma polyclonal predict Prevent RBD Receptor-binding domain respiratory SARS-CoV-2 serum Seven severe acute respiratory syndrome Coronavirus Significance similar changes South Africa susceptibility tested the receptor-binding domain United Kingdom vaccination Vaccine variant virus [DOI] 10.1073/pnas.2103154118 PMC 바로가기 [Article Type] 420
From Infection to Immunity: Understanding the Response to SARS-CoV2 Through In-Silico Modeling감염에서 면역까지: 인실리코 모델링을 통한 SARS-CoV2 대응 이해Immunology Published on 2021-09-072022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] in-silico modeling ACE2 receptor age Antibody titer Biomarker clinical observation Clinical outcome Cohort computational modeling condition Course COVID-19 COVID-19 infection Critical determinant develop Effectiveness epidemiological Evidence Evolution experiments explain Factor humoral Hypothesis identify immune immune response Immune simulation Immunity immunological immunosenescence in-silico infected individual infecting Infection key factor limitation modeling outcome parameter platform population level Prognostic factor provide response Result SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV2 statistical survival the disease the patient Therapies understanding Variability Viral load Viremia virtual cohort [DOI] 10.3389/fimmu.2021.646972 PMC 바로가기 [Article Type] Immunology