conserved
[대역어] None
[용어속성] Term
[용어속성] Term
Bioinformatics pipeline unveils genetic variability to synthetic vaccine design for Indian SARS-CoV-2 genomes
Article
[키워드] aligned
amino acid change
antigenic
antigenic epitopes
B-cell epitope
bioinformatics
bioinformatics pipeline
can be used
clade
clades
conserved
conserved regions
criteria
epitope
Evolution
genetic variability
genomic
HLA allele
identify
immunogenic
MAFFT
MHC-I
MHC-II
Multiple sequence alignment
Mutation
Nextstrain
Non-synonymous
Non-Synonymous Signature SNP
performed
Phylogenetic analysis
primer
probe
Protein
Region
regions
reported
resulting
SARS-CoV-2
SARS-CoV-2 genome
SARS-CoV-2 pandemic
selected
SNP
SNPs
T-cell
T-cell epitope
T-cell epitopes
T-cell epitopes.
unique
Vaccine
Vaccine design
virus
virus detection
virus genome
[DOI] 10.1016/j.intimp.2022.109224 PMC 바로가기
[DOI] 10.1016/j.intimp.2022.109224 PMC 바로가기
A Meta-summary and Bioinformatic Analysis Identified Interleukin 6 as a Master Regulator of COVID-19 Severity Biomarkers
Research article
[키워드] addition
approach
Bioinformatic
Bioinformatics analysis
Biomarker
Biomarkers
candidate
Compound
conserved
COVID-19
COVID-19 disease
COVID-19 disease severity
COVID-19 severity
Cytokine storm
Cytokines
dataset
datasets
disease severity
enriched biological processe
extreme
highlight
Identified
identify
IL6
immunological reaction
include
Inflammatory biomarker
Inflammatory response
interleukin 6
Isolation
neurological
Patient
physiological system
Prognosis
Prognostic markers
progression
Protein
proteomics
regulator
rising
robust
screening methods
severity
therapeutic approach
Therapeutic approach
treating COVID-19
Treatment
upstream
validation study
[DOI] 10.1016/j.cyto.2022.156011 [Article Type] Research article
[DOI] 10.1016/j.cyto.2022.156011 [Article Type] Research article
Potential of antibody pair targeting conserved antigenic sites in diagnosis of SARS-CoV-2 variants infection
Article
[키워드] antibody
Antibody pair
Antigen
antigenic site
antigenic sites
binding domain
candidate
caused
clinical samples
Clusters
complex
conformational
conserved
Coronavirus disease 2019
COVID-19
COVID-19 pandemic
demonstrated
determine
develop
diagnosis of SARS-CoV-2
diagnostic
early diagnosis
ELISA
Infection
mAb
mAbs
monoclonal antibody
pandemic
Potential
pseudovirus
RBD
RBD-specific mAbs
recognizing
residue
SARS-CoV
SARS-CoV S protein
SARS-CoV-2
SARS-CoV-2 receptor
SARS-CoV-2 S protein
SARS-CoV-2 variant
selected
Sensitivity and specificity
spike
Spike antigen.
Spike protein
substitutions
Treatment
variant
VOCs
[DOI] 10.1016/j.jviromet.2022.114597 PMC 바로가기
[DOI] 10.1016/j.jviromet.2022.114597 PMC 바로가기
Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern Humans
Article
[키워드] affected
analysis
Ape
apes
azoospermia
Brain
brain regions
Cancer
Cell
cell type
cells
Central nervous system
cognitive
Consensus
conserved
coronavirus
COVID-19
COVID-19 pandemic
database
defined
disorders
DNA sequence
dominant
element
embryogenesis
event
Evidence
Evolution
expressed
expression
fetal
functional
gene signature
Genes
genes encoding
Genome
genomic
germline
global pandemic
Glutamatergic
GSEA
HERV
HERVs
Human
human cell
Human embryogenesis
human endogenous retrovirus
Human endogenous retrovirus type H (HERVH)
Human endogenous retrovirus type K (HERVK)
human physiology
Human spermatogenesis
identification
Impact
implicated
include
Infection
inheritance
insertion
Interaction
Lineage
loci
LTR
LTR5_Hs
LTR7 subfamilies
majority
mammalian
Mammalian offspring survival genes
marker
Metastasis
Monkey
morphological feature
morphologically
MOS
naïve
neoplasm
Neoplasm metastasis
Neural
Neuron
neurons
New World
non-human primates
observation
offspring
Oligospermia
pathogen
pathology
pathophysiology
Phenotypes
phenotypic
physiological
Pleiotropy
Population
population-level effect
primate
Primate evolution
promoter
protein-protein interaction
Protein–protein interactions at synapses
proteomics
Quantitative
Radial
rare disease
recessive
regulated
Regulatory
regulatory element
regulatory sequence
Release
replicate
representing
Retrotransposition
retroviral
retrovirus
SARS-CoV-2
SARS-CoV-2 coronavirus
Schizophrenia
sequence
significantly
Spread
Stage
survival
synaptic
Synaptic transmission
Synaptic transmission.
target
the SARS-CoV-2
timeline
traits
Transmission
trigeminal
undergo
viral genome
viral infection
viral infections
virus
viruses
[DOI] 10.1007/s00438-022-01954-7 PMC 바로가기
[DOI] 10.1007/s00438-022-01954-7 PMC 바로가기
Biochemical Characterization of Emerging SARS-CoV-2 Nsp15 Endoribonuclease Variants
Article
[키워드] Affect
analysis
analyzed
biochemically
bioinformatics
catalytic
caused
changed
characterization
characterized
cleavage
Combination
conserved
coronavirus
Coronaviruses
Course
COVID-19 pandemic
domain
drug design
effort
endoribonuclease
endoribonuclease.
EndoU
evade
Evolution
facilitate
Genome
help
Host immune response
in vivo
inactive
increase in
innate immune response
middle
monomeric
Mutation
N-terminal
nonstructural proteins
novel coronavirus SARS-CoV-2
Nsp15
oligomerization
pandemic
Patient
prevalent
Protein
residue
RNA
SARS-CoV-2
SARS-CoV-2 sequence
Sequencing
Transcription
triggering
understanding
variant
viral genome
Viral protein
viral replication
virus
wild type
[DOI] 10.1016/j.jmb.2022.167796 PMC 바로가기
[DOI] 10.1016/j.jmb.2022.167796 PMC 바로가기
An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif
Article
[키워드] ACE2 receptor
acute respiratory syndrome
antibody
Beta
binding
conserved
coronavirus
cryo-EM structure
Delta
delta variant
demonstrated
develop
DNA
epitope
Evolution
glycosylation site
identify
immune
lung
mice
neutralize
neutralizing activities
omicron
RBD
Receptor binding domain
receptor binding motif
reduced
SARS coronavirus
SARS coronaviruses
SARS-CoV-1
SARS-CoV-2
SARS-CoV-2 variant
SARS-CoV-2-specific B cell
sequenced
single-cell
the RBD
therapeutic
variant
Viral load
viral spike protein
were infected
[DOI] 10.1126/sciimmunol.abp9962 PMC 바로가기
[DOI] 10.1126/sciimmunol.abp9962 PMC 바로가기
Hybrid Immunity Shifts the Fc-Effector Quality of SARS-CoV-2 mRNA Vaccine-Induced Immunity
Article
[키워드] accelerate
antibody
antibody function
Antibody Response
Antibody titer
Antigen
binding antibody
Combination
comparable
conserved
COVID-19
cross-reactivity
disease
dose
expected
Fc-receptors
first dose
function
functional
functions
humoral immune response
hybrid
Hybrid immunity
immune
immune priming
Immunity
immunization
immunodominance
increases in
indicate
individual
individuals
Infection
magnitude
modify
mRNA
mRNA vaccination
mRNA vaccine
mRNA vaccines
neutralizing antibody
offer
Quality
receive
recent
Region
remained
resulting
robust
SARS-CoV-2
second dose
selective
serology
shift
spike
subsequent
symptomatic
T cell
the SARS-CoV-2
the Spike
unique
vaccination
Vaccine
vaccine-induced immune response
vaccinee
Vaccines
Vaccines.
variants of concern
virus
while
[DOI] 10.1128/mbio.01647-22 PMC 바로가기
[DOI] 10.1128/mbio.01647-22 PMC 바로가기
Protection from COVID-19 with a VSV-based vaccine expressing the spike and nucleocapsid proteins
Article
[키워드] acute respiratory syndrome
addition
Administered
caused
conserved
coronavirus
COVID-19
COVID-19 pandemic
disease
Efficacy
effort
expressing
Hamster model
highlighting
intranasal
intranasal vaccination
memory
morbidity and mortality
nucleocapsid
nucleocapsid protein
pandemic
PROTECT
protection
Protective
Protein
reduce
reduced
resulting
SARS-CoV-2
severe acute respiratory syndrome coronavirus 2
single dose
the N protein
the SARS-CoV-2
vaccination
Vaccine
variants of concern
vesicular stomatitis virus
Vesicular stomatitis virus.
Viral antigen
viral shedding
VoC
with COVID-19
[DOI] 10.3389/fimmu.2022.1025500 PMC 바로가기
[DOI] 10.3389/fimmu.2022.1025500 PMC 바로가기
Two Ligand-Binding Sites on SARS-CoV-2 Non-Structural Protein 1 Revealed by Fragment-Based X-ray Screening
Article
Published on
Journal: International Journal of Molecular Sciences
[Category] COVID19(2023년), SARS, 치료제,
Journal: International Journal of Molecular Sciences
[Category] COVID19(2023년), SARS, 치료제,
[키워드] affinity
Antiviral
antiviral drug
applicability
assays
atomic resolution
caused
consequence
Consequences
conserved
coronavirus
CoV
COVID-19
cross-binding effects
Degradation
drug design
effective
Efficiency
expression
fragment-based X-ray screening
functional
Health
Host
host mRNA
IFN
infection rate
inhibitor
interferon
ligands
limitation
MERS coronaviruses
mortality rate
N-terminal domain
non-structural protein
non-structural protein 1
outbreak
pandemic
Pathways
Protein
provide
Replication
respiratory
Revealed
Safe
SARS-CoV-2
Screening
Site
starting point
structure-based drug design.
unique
vaccination
Vaccines
variety
virulence
virus
X-ray
X-ray crystallography
[DOI] 10.3390/ijms232012448 PMC 바로가기
[DOI] 10.3390/ijms232012448 PMC 바로가기