Stepwise Evolution and Exceptional Conservation of ORF1a/b Overlap in CoronavirusesDiscoveries Published on 2021-12-102022-10-29 Journal: Molecular Biology and Evolution [Category] COVID-19, SARS, [키워드] Analysis Combination Complete complex conservation Coronaviral Coronaviruses data set detect disrupt elements evolutionary dynamics examined exceptional feature frameshift Genome genomic genomic data nucleotide nucleotide substitution ORF1a ORF1a/b ORF1b overlap performed Phylogenetic provide SARS-CoV-2 SARS-CoV-2 sequencing secondary structure sequence sequencing data specificity translation [DOI] 10.1093/molbev/msab265 PMC 바로가기 [Article Type] Discoveries
Lipopeptides against COVID-19 RNA-dependent RNA polymerase using molecular docking분자 도킹을 사용한 COVID-19 RNA 의존성 RNA 중합효소에 대한 리포펩티드Article Published on 2021-12-012022-09-11 Journal: Biomedical journal [Category] SARS, 변종, 치료제, [키워드] affinities Amino acid amino acids Analysis approach approaches binding Biological functions caused complex conserved Coronaviral coronavirus disease Coronavirus disease 2019 COVID-19 disease drug drug candidate FDA-approved drug fingers free energy hydrogen hydrogen bonds hydrophobic hydrophobic interactions Interaction iron lipopeptide molecular docking Mutation Nsp12 pandemic predict Remdesivir Replication responsible RNA-dependent RNA polymerase Salt Bridge SARS-CoV-2 Seven Spread the disease thumb Transcription Treatment Vaccine virus was used with COVID-19 [DOI] 10.1016/j.bj.2021.11.010 PMC 바로가기 [Article Type] Article
A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein천연물 화합물은 보존된 Nsp9 SARS-CoV-2 단백질에 결합하여 시험관 내 코로나바이러스 복제를 억제합니다Article Published on 2021-12-012022-09-11 Journal: The Journal of Biological Chemistry [Category] SARS, 치료제, [키워드] affinities antiviral activity Antiviral compound approach assays bind binding C-terminal cellular complex Compound conserved Coronaviral crystal structure cytotoxic domain dose facilitate in vitro Infection inhibit kaurane MERS-CoV molecular Nsp12 Nsp9 oridonin predominant preliminary finding Protein purified reduce reducing Replication replication transcription complex. SARS-CoV-2 SARS-CoV-2 protein substrate Transcription viral titer [DOI] 10.1016/j.jbc.2021.101362 PMC 바로가기 [Article Type] Article
A Challenge of COVID—19: Associated Infective Endocarditis with Streptococcus gordonii in a Young Immunocompetent PatientCase Report Published on 2021-11-262022-10-30 Journal: Medicina [Category] COVID-19, MERS, SARS, [키워드] Streptococcus gordonii Antibiotic treatment biologic Blood challenge clinician Coronaviral COVID-19 COVID-19 infection COVID-19 pandemic Culture diagnosed Diagnosis disease disorder Endocarditis febrile Fever headache Infection infectious endocarditis infective investigation Manifestations Microbiome Moderate COVID-19 myalgias Oral microbiome outcomes Pain Pathogenesis Patient Pneumonia positive reported risk factor RT-PCR Streptococcus sweating Symptom syndrome the patient Treatment vegetation virulence weight loss while [DOI] 10.3390/medicina57121298 PMC 바로가기 [Article Type] Case Report
Functional Severe Acute Respiratory Syndrome Coronavirus 2 Virus-Like Particles From Insect CellsMicrobiology Published on 2021-10-202022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome Coronaviral coronavirus coronavirus 2 coronavirus disease COVID-19 disease Epidemic facilitate Heterologous Infection insect insect cell insect cells Particle Particles produced Protein pseudovirus purification purified replicate Research respiratory Safe SARS CoV-2 SARS-CoV-2 SARS-CoV-2 VLP transduction viral genome virus Virus-like particle virus-like particles VLP VLPs [DOI] 10.3389/fmicb.2021.732998 PMC 바로가기 [Article Type] Microbiology
SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagationSARS-CoV-2는 바이러스 전파를 촉진하기 위해 RIPK1 활성화를 촉진합니다Article Published on 2021-10-182022-09-11 Journal: Cell Research [Category] MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 치료기술, [키워드] ACE2 activate Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid amino acid substitution blocked caused Cell Biology cell death cells CNS conserved Coronaviral coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytokine Cytokine storm Cytokines death downregulated EGFR Evidence evidence of examined facilitate Factor global pandemic Host host defense host defense response human lung organoid human lung organoids Inflammation inhibition inhibitor Innate immunity Interaction Italy lead lombardy lung lung viral load Mechanisms of disease mediator Mortality Nsp12 Proinflammatory cytokine proinflammatory cytokines promote promoted public health reduced Replication respiratory RIPK1 RNA-dependent RNA polymerase SARS-CoV-2 SARS-COV-2 infection Serine severe acute respiratory syndrome Coronavirus subset systemic inflammatory response the SARS-CoV-2 therapeutic therapeutic option threonine Transcription transcriptional transgenic mice Treatment treatment of COVID-19 variant Viral viral entry Viral load viral propagation [DOI] 10.1038/s41422-021-00578-7 PMC 바로가기 [Article Type] Article
SARS-CoV-2 specific memory T cell epitopes identified in COVID-19-recovered subjectsSARS-CoV-2 특정 기억 T 세포 에피토프가 COVID-19 회복 대상에서 확인됨Article Published on 2021-10-152022-09-11 Journal: Virus research [Category] SARS, 치료법, [키워드] Activation Analysis B cell caused CD4 CD8 T cell Cell Coronaviral COVID-19 COVID-19 pandemic COVID-19 vaccine design defined ELISPOT enzyme enzyme-linked immunosorbent epitope epitope mapping Epitopes evaluated examined explicit flow cytometry followed by foundation glycoprotein HLA Hope host immunity IgG immune immune responses immunodominant epitopes immunogenic immunogenicity in some individual induce mapped memory T memory T cells mononuclear cell N protein neutralizing antibody Neutralizing antibody response neutralizing antibody responses nucleocapsid nucleoprotein Outbreaks PBMCs peptide peptides Peripheral blood Peripheral blood mononuclear cells positively correlated proportion protective immunity Protein public health RBD receptor Receptor-binding domain Reinfection response robust S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S spike spike glycoprotein stimulate structural proteins subject subjects T cell T cell activation T cell epitope T cell epitopes T cell response T cell responses T cells the receptor-binding domain the S protein Therapeutics vaccination Vaccine Vaccine design virus-specific T cell virus-specific T cell responses were used [DOI] 10.1016/j.virusres.2021.198508 PMC 바로가기 [Article Type] Article
Neuroimmune multi-hit perspective of coronaviral infectionReview Published on 2021-10-132022-10-30 Journal: Journal of Neuroinflammation [Category] COVID-19, MERS, [키워드] ACE2 Anxiety Brain Central nervous system CNS cognitive consequence contribute contributing to Coronaviral COVID-19 pandemic COVID19 Critical Dementia Depression determine Diseases disorder Evidence Factors Genetic global pandemic illnesses individuals Infection Inflammatory factor loneliness microbial infection microglia microglial neurodegeneration neurodegenerative neuronal processe outcome Perspective psychological stressors Psychosocial stress severity Stress Stressor Support Viral virus [DOI] 10.1186/s12974-021-02282-0 PMC 바로가기 [Article Type] Review
Hypericin Inhibit Alpha-Coronavirus Replication by Targeting 3CL ProteaseArticle Published on 2021-09-142022-10-28 Journal: Viruses [Category] COVID-19, [키워드] α-CoV 3CL 3CL Protease 3CLpro alphacoronavirus antiviral activity Antiviral effect binding binding pocket cause conserved Coronaviral docking energy transfer epidemic diarrhea evaluated gastroenteritis high mortality Hypericin infections inhibit inhibitory effect molecular docking mutants PEDV reduced resulting SARS-CoV-2 sequence shown significantly targeting TGEV viral replication virus viruses [DOI] 10.3390/v13091825 PMC 바로가기 [Article Type] Article
Cyanorona-20: The first potent anti-SARS-CoV-2 agentCyanorona-20: 최초의 강력한 항 SARS-CoV-2 제제Article Published on 2021-09-012022-09-11 Journal: International immunopharmacology [Category] SARS, 신약개발, 치료제, [키워드] activity addition advancement Anti-COVID-19 Compound anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Antidote antiviral drugs approach Arbidol biological assay blockade characterized Compound computational studies Coronaviral coronavirus COVID-19 derivative drug drug design Drug Design and Discovery evaluated exhibited Favipiravir hindrance Hydroxychloroquine in vitro lack medication Modification novel nucleoside nucleotide protocol protocols pyrazine Pyrazine Nucleoside/Nucleotide Analog RdRP RdRp inhibitor Remdesivir reported RNA RNA-dependent RNA polymerase RNA-dependent RNA polymerase (RdRp) SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RdRp inhibitor selective synthesis treatment regimen Viral RNA viral RNA-dependent RNA polymerase [DOI] 10.1016/j.intimp.2021.107831 PMC 바로가기 [Article Type] Article