Integrated hepatic single-cell RNA sequencing and untargeted metabolomics reveals the immune and metabolic modulation of Qing-Fei-Pai-Du decoction in mice with coronavirus-induced pneumonia통합 된 간 단일 세포 RNA 시퀀싱 및 표적화되지 않은 대사체는 코로나 바이러스-유도 폐렴과 마우스에서 Qing-Fei-Pai-Du 달인의 면역 및 대사 조절을 보여준다.Article Published on 2022-03-012022-08-31 Journal: Phytomedicine : international journal of phytother [Category] 유전자 메커니즘, 치료제, [키워드] alteration Analysis attenuate B cells BALB/c mice best CD4 CD8 clinically Cold Cold-damp environment Combination Control control group coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus pneumonia COVID-19 patients Cytokines damp environment disease disease-associated exposure to Gene Expression HCoV HCoV-229E human coronavirus IFN-γ IL-6 immune immune function Immunity immunological IMPROVE indicated infecting Infection Inflammation Inflammatory cytokine Inflammatory cytokines knowledge Liver injury liver tissue Lymphocytes mechanism mechanism of action metabolic function metabolism metabolomics mice Model modulate modulation mouse model Mouse models performed Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes Pneumonia profile purine Qing-Fei-Pai-Du decoction reduce regulated Regulatory reveal RNA RNA sequencing significantly significantly increased Single-cell RNA sequencing status T cells TCM therapy TNF-α transcriptional treat treated Treatment Untargeted metabolomics [DOI] 10.1016/j.phymed.2021.153922 PMC 바로가기 [Article Type] Article
Automatic Segmentation of Novel Coronavirus Pneumonia Lesions in CT Images Utilizing Deep-Supervised Ensemble Learning NetworkMedicine Published on 2022-01-032022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] alleviate annotation annotations assist Automatic Coronavirus pneumonia COVID-19 COVID-19 lesion segmentation dataset deep learning deep-supervised ensemble learning network Diagnosis Effectiveness experiment Experimental result feature Image indicated intersection over union learning lesion living environment Local local and global features network novel coronavirus disease novel coronavirus pneumonia overcome overfitting Quantitative Segmentation Spread transfer transfer learning Treatment under CT imaging [DOI] 10.3389/fmed.2021.755309 PMC 바로가기 [Article Type] Medicine
D2-CovidNet: A Deep Learning Model for COVID-19 Detection in Chest X-Ray ImagesD2-CovidNet: 흉부 X선 이미지에서 COVID-19 감지를 위한 딥 러닝 모델Research Article Published on 2021-12-152022-09-11 Journal: Computational Intelligence and Neuroscience [Category] MERS, SARS, 치료기술, [키워드] Accuracy assist chest X-ray Chest X-ray images computation Convolution Convolutional neural network coronavirus disease Coronavirus disease 2019 Coronavirus pneumonia COVID-19 data sets deep detection diagnose diagnosing effectively controlled help Image IMPROVE information learning Model network network model Novel coronavirus novel coronavirus pneumonia outbreak parameter Pneumonia Precision researcher sensitivity specificity tested [DOI] 10.1155/2021/9952109 PMC 바로가기 [Article Type] Research Article
Surveillance of SARS-CoV-2 in Sewage Treatment Plants between January 2020 and July 2021 in TaiwanArticle Published on 2021-12-102022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] China Chinese New Year collected conducted confirmed COVID-19 case Coronavirus pneumonia COVID-19 epidemiological Laboratory testing microbe monitoring New Taipei City outbreak pandemic pathogen plant Poliovirus positive reported returned SARS-CoV-2 sewage Sewage treatment plants significant increase specimen spread to Surveillance Taipei Taiwan tested Treatment wastewater Wuhan Wuhan, China [DOI] 10.3390/pathogens10121611 PMC 바로가기 [Article Type] Article
A case of xenon inhalation therapy for respiratory failure and neuropsychiatric disorders associated with COVID-19Case Report Published on 2021-10-282022-10-31 Journal: EXCLI Journal [Category] COVID-19, [키워드] alveolar applied approach ARDS biochemical Blood Case report caused change clinical study Computed tomography Coronavirus pneumonia COVID-19 demonstrated develop disorder disrupt distress effective Effectiveness Efficacy evaluated feasibility functional Gas exchange hematological increase Inhaled Intensive Interaction lung Lungs mechanism of action molecular Molecular modeling Neuropsychiatric neuropsychiatric disorders oxygen saturation parameters Patient patients with pneumonia phospholipid Respiratory failure SARS-CoV-2 SARS-COV-2 infection saturated surfactant syndrome tension therapeutic therapy transferred Treatment van der Waal Ventilation with COVID-19 xenon xenon atom [DOI] 10.17179/excli2021-4316 PMC 바로가기 [Article Type] Case Report
The therapeutic promises of Lianhuaqingke in the mice model of coronavirus pneumonia (HCoV-229E and SARS-CoV-2)Research Published on 2021-10-182022-11-01 Journal: Chinese Medicine [Category] COVID-19, [키워드] 16HBE cell acute pneumonia airway alleviate Anti-HCoVs therapy Anti-viral Antiviral effect approved BALB/c mice caused Cell cells ciliary Coronavirus pneumonia COVID-19 dose-dependent Effect ELISA epithelial expression expression level flow cytometry H&E staining hACE2 HCoV-229E human coronaviruses (HCoVs) identify immune response immunofluorescence staining immunomodulation immunomodulatory in vitro in vivo indicated inhibit inhibited inhibiting Injury Lianhuaqingke (LHQK) lung lung tissue lung tissues mice morphological change MUC5AC Peripheral blood Pneumonia positive pro-inflammatory cytokine reduce reduced reducing Replication Result SARS-CoV-2 staining subset Th cell Th1 Th17 Th2 the SARS-CoV-2 virus therapeutic therapeutic effect Therapies TNFα Transgenic mouse treated Treatment Treg Vero E6 viral replication virus virus titer was measured was used weight loss were measured [DOI] 10.1186/s13020-021-00513-3 PMC 바로가기 [Article Type] Research
A hybrid approach to forecast the COVID-19 epidemic trendCovid-19 전염병 추세를 예측하기위한 하이브리드 접근법Research Article Published on 2021-10-042022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료기술, [키워드] approach Coronavirus pneumonia COVID-19 COVID-19 epidemic Critical diagnose disadvantage Disadvantages Effect Epidemic experiments help implementation Infectious disease initial introduced Logistic mean error Novel coronavirus novel coronavirus pneumonia operation overcome parameter Pneumonia predict Public health interventions quarantine recovered SEIR Spread suggested the epidemic the mean Transmission Transmission dynamics tuning parameter [DOI] 10.1371/journal.pone.0256971 PMC 바로가기 [Article Type] Research Article
A phase I/II dose-escalation multi-center study to evaluate the safety of infusion of natural killer cells or memory T cells as adoptive therapy in coronavirus pneumonia and/or lymphopenia: RELEASE study protocol코로나바이러스 폐렴 및/또는 림프구감소증에서 자연살해세포 또는 기억 T 세포 주입의 안전성을 평가하기 위한 1/2상 용량 증량 다기관 연구: RELEASE 연구 프로토콜Study Protocol Published on 2021-10-022022-09-10 Journal: Trials [Category] MERS, SARS, 임상, [키워드] 1:1 administration Allogeneic alloreactivity ARMS assigned Biology can be used Cell clinical trial convalescent Coronavirus pneumonia COVID-19 COVID-19 patient determine Donor dose dose-escalation dysregulated Efficacy evaluate facilitate HLA immune system Immunotherapy lymphopenia mechanical ventilation memory memory T memory T cell memory T cells nasal nasal cannula natural killer natural killer cell NK cell NK cells Open-label oxygen Oxygen requirement oxygen supplementation Patient patients Phase 2 Phase I Pneumonia protocol Randomized receive Safety SOC Standard of care Study protocol supplementary material T cell T cell lymphopenia T cells T-lymphocyte the patient therapeutic window therapy Tolerability treat Treatment Trial Trial registration Viral [DOI] 10.1186/s13063-021-05625-7 PMC 바로가기 [Article Type] Study Protocol
Risk Factors of In-Hospital Mortality in Non-Specialized Tertiary Center Repurposed for Medical Care to COVID-19 Patients in RussiaArticle Published on 2021-09-152022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] 95% CI alcohol analyzed arterial Arterial hypertension Biological body mass index Care center Clinical outcome collected Comorbidities Complication Computed tomography coronavirus disease Coronavirus pneumonia COVID-19 COVID-19 patient CT scan demographic characteristics died disease echocardiographic Factor Gender Hospital stay Hospitalization hospitalized patient hypertension in-hospital mortality increase in Laboratory male Mortality Myocardial infarction Neutrophil-to-lymphocyte ratio Older age Patient prevalent Protective provided Radiographic Result risk factor Risk factors risk of death Russia severe disease significant increase smoking Stratification stroke Support Tertiary the patient transported [DOI] 10.3390/diagnostics11091687 PMC 바로가기 [Article Type] Article
The effectiveness of early colchicine administration in patients over 60 years old with high risk of developing severe pulmonary complications associated with coronavirus pneumonia SARS-CoV-2 (COVID-19): study protocol for an investigator-driven randomized controlled clinical trial in primary health care—COLCHICOVID study코로나바이러스 폐렴 SARS-CoV-2(COVID-19)와 관련된 중증 폐합병증 발병 위험이 높은 60세 이상의 환자에서 조기 콜히친 투여의 효과: 1차 의료에서 연구자 주도 무작위 대조 임상 시험을 위한 연구 프로토콜 —콜치코비드 연구Study Protocol Published on 2021-09-062022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] Activation addition administration age Anti-inflammatory Care clinical effectiveness Clinical practice Clinical research clinical trial clinical trials Coagulation Colchicine collapse Comorbidities Complication Controlled clinical trial coronavirus Coronavirus pneumonia COVID pneumonia COVID-19 COVID-19 infection COVID-19 pandemic death demonstration early administration early treatment Effectiveness Efficacy evaluate Evidence generate Health Health crisis health system high risk hospital Hospital admission Infection inhibitory effect lethality level of care mitigate Mortality multicenter No hospitalized Open-label pandemic parallel group Pathologies Patient pharmacological Pneumonia Pragmatic Prevent primary care Primary Health Care profile Prophylaxis pulmonary complication pulmonary complications Randomized reduce reducing Research SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection serious complication Study protocol successive wave successive waves susceptible target population Treatment Trial registration Viral viral replication Volume vulnerable patients with COVID-19 [DOI] 10.1186/s13063-021-05544-7 PMC 바로가기 [Article Type] Study Protocol