Covariance predicts conserved protein residue interactions important for the emergence and continued evolution of SARS-CoV-2 as a human pathogen공분산은 인간 병원체로서 SARS-CoV-2의 출현과 지속적인 진화에 중요한 보존된 단백질 잔기 상호작용을 예측합니다Article Published on 2022-07-272022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] allele alleles Amino acid amino acid residue amino acid residues Analysis approach caused change Combination comprehensive analysis conserved coronavirus CoV CoV genome covariance CoVs difference dominant Epidemics Evolution Evolution of SARS-CoV-2 exhibited followed by Frequency Genome host adaptation human pathogen implicated incrementally independent Interaction Lineage lineages nucleotide occurred Pandemics Pathogens predict Protein protein sequence Region reservoirs residue SARS-CoV-2 SARS-CoV-2 variants statistically unique Viral protein Viral proteins β-coronavirus β-Coronaviruses [DOI] 10.1371/journal.pone.0270276 PMC 바로가기 [Article Type] Article
COVID-19 vaccination elicits an evolving, cross-reactive antibody response to epitopes conserved with endemic coronavirus spike proteinsCOVID-19 백신 접종은 고유의 코로나바이러스 스파이크 단백질로 보존된 에피토프에 대한 진화하는 교차 반응성 항체 반응을 이끌어냅니다Article Published on 2022-07-052022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] Alanine antibody conserved coronavirus coronavirus spike protein CoV COVID-19 pandemic COVID-19 vaccination CoVs CP: Immunology CP: Microbiology cross-reactive cross-reactive antibody detectable elicit Endemic epitope Epitopes experiments homolog identify Immunity immunology longitudinal samples mechanism Microbiology mRNA mRNA-1273 mRNA-1273 vaccine multiplexed serology observé other coronavirus other coronaviruses phylogenetically reactivity regions residue SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes serology spike subject the vaccine trajectory triggered vaccination vaccine response vaccine-induced antibody response widespread [DOI] 10.1016/j.celrep.2022.111022 PMC 바로가기 [Article Type] Article
A Game of Infection – Song of Respiratory Viruses and Interferons감염의 게임 - 호흡기 바이러스와 인터페론의 노래Review Published on 2022-06-292022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 치료제, [키워드] 2019 coronavirus disease acute respiratory syndrome Antiviral Antiviral strategies antiviral strategy cause caused coronavirus coronavirus – COVID-19 coronavirus disease Coronavirus-2 COVID-19 COVID-19 pandemic CoVs death deaths disease pathogenesis driving effective flu game Health Host Host immune response host immune responses immune responses Infection Influenza influenza A influenza A virus Influenza virus influenza viruses innate immune innate immune response innate immune responses innate immune system Innate immunity mechanism outcome pandemic Pandemics pathogen Pathogenesis Pathogens recorded Research respiratory SARS-CoV-2 Severe acute respiratory syndrome singular Song Spanish flu swine flu therapeutic Topic translated virus virus infection Virus-host interaction Virus-host interactions while writing [DOI] 10.3389/fcimb.2022.937460 PMC 바로가기 [Article Type] Review
Binding and structural basis of equine ACE2 to RBDs from SARS-CoV, SARS-CoV-2 and related coronavirusesSARS-CoV, SARS-CoV-2 및 관련 코로나바이러스의 RBD에 대한 말 ACE2의 결합 및 구조적 기초Article Published on 2022-06-212022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 angiotensin angiotensin converting enzyme binding binding affinity causative agent continuous surveillance coronavirus coronavirus disease Coronavirus disease 2019 CoV COVID-19 CoVs crystal structure crystal structures enzyme equine events highlight host range humans infect Interaction Mutation N501Y omicron Prevent question RaTG13 RBD RBDs Receptor binding domain receptor binding domains residue SARS-CoV SARS-CoV-2 Surveillance target tested the binding affinity variant VOCs [DOI] 10.1038/s41467-022-31276-6 PMC 바로가기 [Article Type] Article
The life cycle and enigmatic egress of coronaviruses코로나바이러스의 수명 주기와 불가사의한 탈출Review Published on 2022-06-012022-09-11 Journal: Molecular microbiology [Category] COVID19(2023년), SARS, 치료법, [키워드] adopted alternative route causative agent Cell cell surface cellular Consensus coronavirus CoV CoV infection CoV replication COVID-19 pandemic CoVs drugs Endoplasmic reticulum expression Extracellular genome replication genomic RNA Golgi Golgi apparatus host cell host cells Interference life cycle lumen membrane envelope mobilization nucleocapsid nucleocapsid protein Nucleocapsid proteins pandemic pathway progeny promote Protein rab1 rab11 respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 shown situation the Golgi apparatus the intermediate compartment (IC) the recycling endosome (RE). therapeutic virion assembly virus [DOI] 10.1111/mmi.14907 PMC 바로가기 [Article Type] Review
IgG targeting distinct seasonal coronavirus- conserved SARS-CoV-2 spike subdomains correlates with differential COVID-19 disease outcomes뚜렷한 계절성 코로나바이러스-보존 SARS-CoV-2 스파이크 하위 도메인을 표적으로 하는 IgG는 차별적인 COVID-19 질병 결과와 상관관계가 있습니다Article Published on 2022-05-312022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] Activation ADE amplification anti-Spike IgG anti-spike IgG levels anti-spike IgG response Anti-spike IgG responses antibody antibody-mediated effector responses Betacoronavirus betacoronaviruses caused conserved convalescent individual coronavirus COVID-19 COVID-19 disease COVID-19 patient COVID-19 severity CoVs CP: Immunology CP: Microbiology cross-reactivity Deleterious disease disease severity Early detection epitope Epitopes Fc-gamma receptor activation FcγR fusion protein fusion protein region greater heptad repeat heptad repeat region human betacoronavirus human betacoronavirus. humoral IgG IgG responses immunodominant epitope immunology lowest memory response Microbiology observé OC43 offer outcome predict profile Protective recall receptor responses SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS1 seasonal coronaviruses severe COVID-19 patient severe COVID-19 patients severe disease significantly Spectrum Spike protein the SARS-CoV-2 virus β-CoVs [DOI] 10.1016/j.celrep.2022.110904 PMC 바로가기 [Article Type] Article
Deep learning based on biologically interpretable genome representation predicts two types of human adaptation of SARS-CoV-2 variants생물학적으로 해석 가능한 게놈 표현에 기반한 딥 러닝은 SARS-CoV-2 변이체의 두 가지 유형의 인간 적응을 예측합니다Article Published on 2022-05-132022-09-11 Journal: Briefings in Bioinformatics [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] 3D convolutional neural networks A570D adaptation adaptive Alpha VOC Analysis applied Beta biological significance CNN Convolutional neural network coronavirus COVID-19 CoVs D1118H DCR deep Delta determinant dinucleotide dinucleotide composition representation distribution DNT dominant feature framework genetic diversity Genome glycoprotein human adaptation introduced linear Local Mutation omicron opposite pathogenicity performed predict predicted RdRP RdRps real time RNA virus RNA viruses RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants single-stranded Spike proteins ssRNA the spike protein Transmissibility Type variant variants variants of concern variants of interest viruses VOCs [DOI] 10.1093/bib/bbac036 PMC 바로가기 [Article Type] Article
Structural mapping of antibody landscapes to human betacoronavirus spike proteins인간 베타 코로나바이러스 스파이크 단백질에 대한 항체 지형의 구조적 매핑Article Published on 2022-05-062022-09-12 Journal: Science Advances [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome Analysis antibody Antibody Response antigenic complexes convalescent CoVs cross-reactive disease severity epitope epitope mapping General population HKU1 human betacoronavirus human CoV Immunity infections molecular OC43 polyclonal reactivity SARS-CoV-2 SARS-CoV-2-infected individuals seasonal coronavirus sera serum antibodies specificity spike Spike protein β-CoV β-CoVs [DOI] 10.1126/sciadv.abn2911 PMC 바로가기 [Article Type] Article
Repurposing dyphylline as a pan-coronavirus antiviral therapy범 코로나 바이러스 항 바이러스 요법으로 디필린 용도 변경Article Published on 2022-05-012022-09-11 Journal: Future Medicinal Chemistry [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] Alpha Antiviral antiviral agent antiviral therapy bind catalytic dyad Cell culture coronavirus COVID-19 pandemic CoVs Cystine Drug discovery dyphylline FDA-approved drug functional enzyme functional enzymes HCoV HCoV-229E HCoV-NL63 HCoV-OC43 HCoVs highly pathogenic histidine Human human coronavirus human coronaviruses human coronaviruses (HCoVs) humans inhibited life cycle Mild MPro NL63 OC43 protease repurposing respiratory diseases SARS-CoV-2 severe respiratory disease severe respiratory diseases structures Support targets therapeutically target viral replication Virtual screening virus Virus life cycle viruses xanthine zoonotic [DOI] 10.4155/fmc-2021-0311 PMC 바로가기 [Article Type] Article
Coronaviruses and SARS-CoV-2 in sewerage and their removal: Step by step in wastewater treatment plants하수도의 코로나바이러스 및 SARS-CoV-2 및 그 제거: 폐수 처리장의 단계별Review Published on 2022-05-012022-09-11 Journal: Environmental research [Category] COVID19(2023년), SARS, 치료기술, [키워드] activated adequate knowledge Adsorption Concentration condition Coronaviruses CoV CoVs debate decrease Detection limit digestion discharged Disinfection ENhance faece Faeces filtration help hydrophobic inactivated knowledge logarithm mesophilic microorganisms occur plant plants predation Prevent reduced required reuse SARS-CoV-2 sedimentation separated sewage significantly Sludge step temperature Transmission Treatment Ultrafiltration UV light Viral load viral loads virus wastewater Wastewater treatment plants [DOI] 10.1016/j.envres.2021.112204 PMC 바로가기 [Article Type] Review