A Novel Single-Stranded RNA-Based Adjuvant Improves the Immunogenicity of the SARS-CoV-2 Recombinant Protein VaccineArticle Published on 2022-08-242022-11-15 Journal: Viruses [Category] SARS, 진단, [키워드] activate acute respiratory syndrome adjuvant adjuvants aluminum China Combination coronavirus CpG effective elevated Emergency use authorization Genome hydroxide immune immune response immunogenicity Innate immunity levels of antibody mice Neutralizing antibody titer novel novel adjuvant omicron Protein RBD Receptor binding domain recombinant recombinant RBD protein Research SARS-CoV-2 SARS-CoV-2 recombinant protein vaccine signaling pathway single-stranded single-stranded RNA-based adjuvant. subunit Th1 Th2 the antibody response the SARS-CoV-2 Vaccine was used ZF2001 [DOI] 10.3390/v14091854 PMC 바로가기
RelCoVax®, a two antigen subunit protein vaccine candidate against SARS-CoV-2 induces strong immune responses in miceSARS-CoV-2에 대한 2개의 항원 소단위 단백질 백신 후보인 RelCoVax®는 마우스에서 강력한 면역 반응을 유도합니다Article Published on 2022-07-302022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] adjuvant adjuvants Administered alum aluminum aluminum hydroxide Antibody titer Antibody titers Antigen antigen exposure Cell Cellular immune response cellular immune responses Combination contribute COVID-19 pandemic CpG Delta delta variant demonstrated develop dominant dose regimen dual E. coli effective vaccine elicited Emergency use authorization evade evidenced glycoprotein heterologous expression hydroxide IFN-γ immune responses immunize immunized immunized mice in vitro induce mammalian cell mammalian cells mice Mutation N protein N proteins neutralize Neutralizing antibodies neutralizing antibody nucleocapsid prime and boost Protein RBD Receptor binding domain Region RelCoVax® S protein Safe SARS-CoV-2 SARS-CoV-2 viral SARS-CoV-2 virus serum splenocyte splenocytes stimulated strain strong immune response subunit Subunit vaccine Th1 the SARS-CoV-2 virus vaccinated individuals Vaccine vaccine candidate vaccine candidates variants of SARS-CoV-2 viral strains virus entry [DOI] 10.1016/j.vaccine.2022.06.026 PMC 바로가기 [Article Type] Article
Comparative genomic analysis of the human genome and six bat genomes using unsupervised machine learning: Mb-level CpG and TFBS islands비지도 머신 러닝을 사용한 인간 게놈과 6개의 박쥐 게놈 비교 게놈 분석: Mb 수준 CpG 및 TFBS 섬Comparative Study Published on 2022-07-082022-09-11 Journal: BMC Genomics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 3D structure 3D Structures addition Algorithm Analysis artificial artificial intelligence bat bats binding Centromeric heterochromatin characteristic Characteristics chromosomes class Clustering Comparative conducted contributing to CpG diagnostic dinucleotide disease-causing distribution Ebola Emerging infectious disease feature Features function Gene Expression Genome genomes genomic Genomic analysis help hosts Human Human genome humans Infectious disease information Interaction involved knowledge machine machine learning motif natural reservoir nuclear oligonucleotide Oligonucleotide composition oligonucleotides Protein Region regions Regulation reveal RNA viruses SARS-CoV-2 self-organization Self-organizing map Self-organizing map. sequence TFS the SARS-CoV-2 thought transcription factor transcription factors variety virus viruses zoonotic [DOI] 10.1186/s12864-022-08664-9 PMC 바로가기 [Article Type] Comparative Study
Non-glycosylated SARS-CoV-2 RBD elicited a robust neutralizing antibody response in mice글리코실화되지 않은 SARS-CoV-2 RBD는 마우스에서 강력한 중화 항체 반응을 유도했습니다Article Published on 2022-07-012022-09-12 Journal: Journal of Immunological Methods [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] adjuvant Analysis Antibody Response binding activity candidate vaccine CpG Delta domain Efficacy elicited enzyme Escherichia Escherichia coli glycosylated HPLC immune response Inclusion induce mice neutralized Neutralizing activity neutralizing antibody Neutralizing antibody response omicron overexpressed produced protective immunity protective neutralizing antibody Protein provided pseudovirus pseudoviruses purification RBD Receptor-binding domain Receptor-binding domain (RBD) robust SARS-CoV-2 SARS-CoV-2 RBD the RBD Vaccine was obtained wild-type [DOI] 10.1016/j.jim.2022.113279 PMC 바로가기 [Article Type] Article
Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine나노입자 전달 TLR4 및 RIG-I 작용제는 SARS-CoV-2 소단위 백신에 대한 면역 반응을 향상시킵니다Article Published on 2022-07-012022-09-11 Journal: Journal of controlled release : official journal o [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] activated Adaptive immune response adjuvant adjuvants agonist Anti-spike anti-Spike IgG Antibody titer Antibody titers Antigen antigen-presenting cell antigen-presenting cells APC APCS B cell B cells BAL Bcl6 Blood bronchoalveolar CD4 CD44 Cell cell population characterized Combination adjuvant COVID-19 COVID-19 protein subunit vaccine CpG DLNs draining lymph node draining lymph nodes Efficacy ENhance follicular Germinal center GL7 helper cell humoral immune responses IgA IgG immune immune response immune responses Immunity IMPROVE in vitro in vivo Increases increases in Infection intramuscular intramuscular vaccination intranasal Intranasal versus intramuscular vaccination intranasally lead lung Lungs lymphocyte memory T memory T cell mice molecular Monophosphoryl lipid A MPLA Native neutralizing antibody titers Pattern recognition pattern recognition receptor Pattern recognition receptors Polymer Population Proinflammatory cytokine Protein subunit protein subunit vaccine Protein subunit vaccines PRR PRRs PUUC reaction receptor receptors responses against retinoic acid retinoic acid-inducible gene I RIG-I robust S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein secretion spike IgA Spike protein stabilized spike protein stimulate subunit Subunit vaccine T cell T cell proliferation the S1 subunit TLR TLR4 TLR7 TLR7/8 TLR9 TLRs Toll-like receptor Toll-like receptors Transmission unique Vaccine vaccine availability vaccine responses variants [DOI] 10.1016/j.jconrel.2022.05.023 PMC 바로가기 [Article Type] Article
Evaluating the Neutralizing Ability of a CpG-Adjuvanted S-2P Subunit Vaccine Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants of Concern중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 우려 변종에 대한 CpG-보강 S-2P 소단위 백신의 중화 능력 평가Article Published on 2022-06-102022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 진단, [키워드] Ability acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against Alpha Alpha variant aluminum aluminum hydroxide antibody Antigen Beta Beta variant beta variants breath clinical trial coated with concern coronavirus coronavirus 2 COVID-19 CpG D614G demonstrated dose effective Effectiveness elicit elicited Evaluating High dose Human humans hydroxide immune response immunization immunized immunogenicity medium neutralization neutralization ability neutralization activity Neutralizing antibodies neutralizing antibody neutralizing capacity Neutralizing titer neutralizing titers Phase 1 prefusion pseudovirus pseudoviruses RAT RATs reduced reduction reduction in respiratory retained S-2P SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants serum antibodies serum antibody serum sample serum samples severe acute respiratory syndrome Coronavirus significantly Spike protein subject subunit subunit SARS-CoV-2 vaccine the SARS-CoV-2 Vaccine Vaccines variant variant of concern variants VOCs wild-type [DOI] 10.1093/cid/ciab711 PMC 바로가기 [Article Type] Article
Receptor-binding domain recombinant protein on alum-CpG induces broad protection against SARS-CoV-2 variants of concernAlum-CpG의 수용체 결합 도메인 재조합 단백질은 우려되는 SARS-CoV-2 변이체에 대한 광범위한 보호를 유도합니다Article Published on 2022-06-092022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Alpha) (Beta) addition adjuvant Alpha alum aluminum aluminum hydroxide Antibody titer Antibody titers B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 benefit Beta Cellular immune response conducted Controller convalescent plasma Corbevax COVID-19 CpG Delta dose drug Emergency use authorization evaluated exceeded hydroxide immune response immunized induce Infection intramuscularly mice neutralization Neutralizing antibodies neutralizing antibody neutralizing antibody titers omicron other variants preclinical studies preclinical study Protein Receptor-binding domain reported SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variant second dose subunit Subunit vaccine TLR9 TLR9 adjuvant Vaccine vaccine candidate variant variants variants of concern Virus neutralization Wuhan Wuhan isolate yeast [DOI] 10.1016/j.vaccine.2022.05.007 PMC 바로가기 [Article Type] Article
LNP-CpG ODN-adjuvanted varicella-zoster virus glycoprotein E induced comparable levels of immunity with Shingrix™ in VZV-primed miceArticle Published on 2022-06-012022-10-05 Journal: Virologica Sinica [Category] 두창, 비임상, 수두, 진단, 홍역, [키워드] adjuvant adopted Affect approved AS01B carriers CD4+ T cell Cell-mediated immunity Cell-mediated immunity (CMI) CMI comparable component COVID-19 mRNA vaccine CpG CpG oligodeoxynucleotide (CpG ODN) Efficacy ELISA enzyme-linked immunosorbent FDA hepatitis B herpes zoster Humoral immunity IFN-γ IgG antibody IL-2 Immunity Latent Lipid nanoparticle Lipid nanoparticle (LNP) LNP mice MOST motif number preclinical study proportion secreting splenocyte subunit Subunit vaccine T helper Th1 Vaccine Varicella zoster virus (VZV) virus virus glycoprotein [DOI] 10.1016/j.virs.2022.06.002 [Article Type] Article
Partial-Methylated HeyL Promoter Predicts the Severe Illness in Egyptian COVID-19 Patients부분 메틸화된 HeyL 프로모터는 이집트 COVID-19 환자의 심각한 질병을 예측합니다Article Published on 2022-05-312022-09-12 Journal: Disease Markers [Category] MERS, 진단, [키워드] addition alteration America approved Asia association binding Biomarkers Blood blood sample Cell cell proliferation cells clinical outcomes COVID-19 COVID-19 patient COVID-19 patients CpG demethylating agent Diseases DNA DNA sequencing dose downstream dry cough Effect element environmental factor epithelial Europe facilitate Fever Frequency GenBank genetic material Health healthy subject healthy subjects illness IMPROVE incidence methylated Methylation Modification mortality rate Notch PCR Prognostic marker promoter reference sequence Regulation Regulatory severe pneumonia subject therapy transcription factor Treatment protocol unmethylated Vaccine [DOI] 10.1155/2022/6780710 PMC 바로가기 [Article Type] Article
Intranasal Delivery of Thermostable Subunit Vaccine for Cross-Reactive Mucosal and Systemic Antibody Responses Against SARS-CoV-2SARS-CoV-2에 대한 교차 반응성 점막 및 전신 항체 반응을 위한 열안정성 소단위 백신의 비강내 전달Article Published on 2022-05-032022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 addition Against Alpha angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-RBD Anti-RBD antibody antibody Antibody Response Antibody responses Antibody titer Antibody titers approved Beta binding binding domain Breakthrough infection breakthrough infections chitosan circulation COVID-19 COVID-19 vaccines CpG cross-reactive delivery Delta variants domain Efficacy effort enzyme exclusion FIVE genetic material help Hesitancy IgA antibodies IgG1 IgG2a IL-12 Immunity immunization IMPROVE induce inhibited interleukin interleukin-12 intranasal intranasal vaccination intranasally isotype Laboratory mice mucosal mucosal immunity mutant oligonucleotide polypeptide Prevent PROTECT RBD RBD-specific antibodies RBD-specific antibody receptor Receptor binding domain receptor binding domain (RBD) reduce respiratory respiratory viruses response responses room temperature SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants specific antibodies stability subcutaneous vaccination subunit Subunit vaccine systemic temperature the vaccine thermostable upper respiratory tract vaccination Vaccine Vaccine development Vaccine hesitancy vaccine platform variants virus [DOI] 10.3389/fimmu.2022.858904 PMC 바로가기 [Article Type] Article