CR3022 – Page 2 – Communicable Diseases Research

Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells

423

Published on 2022-01-252022-10-29
Journal: Proceedings of the National Academy of Sciences of
[Category] COVID-19, COVID19(2023년), SARS,

Structure Based Affinity Maturation and Characterizing of SARS-CoV Antibody CR3022 against SARS-CoV-2 by Computational and Experimental Approaches

Article

Published on 2022-01-192022-10-28
Journal: Viruses
[Category] COVID-19, SARS,

[키워드] affinity against SARS-CoV antibody antibody affinity approach Autoimmune binding binding free energy CDRs complementarity-determining region conserved Coronaviruses COVID-19 COVID-19 epidemic CR3022 criteria cross-react cross-reactivity demonstrated drug ELISA enzyme-linked immunosorbent experiments higher affinity hydrophobic interactions IMPROVE in vitro indicate MM/PBSA molecular molecular dynamics (MD) simulation Molecular simulation mutant mutate mutated Mutation neutralizing antibody performed plasma powerful tool provided RBD reactivity Receptor-binding domain (RBD) recognizing residue salt-bridge SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD selected significantly SPR Structure the binding affinity Treatment wild-type
[DOI] 10.3390/v14020186 PMC 바로가기 [Article Type] Article

Development of an In Vivo Probe to Track SARS-CoV-2 Infection in Rhesus Macaques

Immunology

Published on 2021-12-242022-11-01
Journal: Frontiers in Immunology
[Category] COVID-19, SARS,

Functional Trimeric SARS-CoV-2 Envelope Protein Expressed in Stable CHO Cells

Bioengineering and Biotechnology

Published on 2021-12-172022-10-31
Journal: Frontiers in Bioengineering and Biotechnology
[Category] COVID-19,

[키워드] ACE2 acute respiratory syndrome Cell cellular CHO cell coronavirus COVID-19 pandemic COVID–19 CR3022 described docking domain envelope envelope protein expressing expression Extracellular infection mechanism infection with SARS-CoV-2 integrated bioprocessing Interaction mandatory membrane-bound mutant pandemic parameter Perfusion Protein protocol purification Recombinant spike protein responsible robust S-protein SARS CoV-2 SARS-CoV-2 similarity spike (S) glycoprotein Spike protein STABLE surface protein surface proteins the receptor-binding domain the spike protein therapeutic drug trimeric variant viral envelope proteins virus β-coronavirus
[DOI] 10.3389/fbioe.2021.779359 PMC 바로가기 [Article Type] Bioengineering and Biotechnology

Production of scFv, Fab, and IgG of CR3022 Antibodies Against SARS-CoV-2 Using Silkworm-Baculovirus Expression System

누에-배큘로바이러스 발현 시스템을 이용한 SARS-CoV-2에 대한 CR3022 항체의 scFv, Fab 및 IgG 생산

Article

Published on 2021-12-012022-09-11
Journal: Molecular biotechnology
[Category] SARS, 유전자 메커니즘, 진단,

Nanovesicles derived from bispecific CAR-T cells targeting the spike protein of SARS-CoV-2 for treating COVID-19

COVID-19 치료를 위한 SARS-CoV-2의 스파이크 단백질을 표적으로 하는 이중특이성 CAR-T 세포에서 유래한 나노소포

Research

Published on 2021-11-252022-09-10
Journal: Journal of Nanobiotechnology
[Category] MERS, 진단, 치료제,

[키워드] ADE Adverse drug reactions Antibody-dependent enhancement Antibody-mediated neutralization Antiviral antiviral drug antiviral drugs binding ability CAR-T CAR-T cell caused Cell co-expression COVID-19 COVID-19 pandemic CR3022 develop dilemma drug drugs effective Effects epitope Epitopes Express facilitate Fc fragment help incidence Infection inhibiting lack nanovesicles neutralization neutralize Neutralizing antibodies neutralizing antibody overexpressing present Prevent problem Pseudotyped virus reduce reducing Remdesivir Result SARS-CoV-2 SARS-CoV-2 spike protein scFv selective single antibody Spike protein spike protein of SARS-CoV-2 supplementary material T cells Targeted delivery the spike protein Therapeutic approach toxic effect treat treating COVID-19 Treatment treatment of COVID-19 variable Viral viral infection viral replication Viral resistance virus
[DOI] 10.1186/s12951-021-01148-0 PMC 바로가기 [Article Type] Research

Development of a SARS-CoV-2 Vaccine Candidate Using Plant-Based Manufacturing and a Tobacco Mosaic Virus-Like Nano-Particle

Article

Published on 2021-11-172022-10-28
Journal: Vaccines
[Category] COVID-19,

[키워드] ACE2 antibody Antibody Response assays association binding block C57BL/6 candidate candidate vaccine coronavirus SARS-CoV-2 COVID-19 COVID-19 pandemic CpG CR3022 Critical development domain effective Epitopes fused Host human IgG1 Fc identity immunogenicity mice monoclonal antibody mosaic nanoparticle neutralizing antibody plant-based manufacturing RBD Receptor-binding domain resulting retained S protein S1 domain SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 vaccine spike glycoprotein STABLE the SARS-CoV-2 These data Tobacco Vaccine vaccine candidate virus virus neutralizing titer virus receptor
[DOI] 10.3390/vaccines9111347 PMC 바로가기 [Article Type] Article

Plant-produced SARS-CoV-2 receptor binding domain (RBD) variants showed differential binding efficiency with anti-spike specific monoclonal antibodies

Research Article

Published on 2021-08-112022-10-28
Journal: PLoS ONE
[Category] COVID-19, MERS, SARS,

[키워드] ACE2 acute respiratory syndrome Anti-spike Beta binding binding affinity binding domain binding efficiency characterized contrary convalescent coronavirus disease Coronavirus-2 COVID-19 CR3022 death ELISA enzyme exhibited Host host cell receptor increase in mAb mAbs monoclonal antibody Mutation neutralization neutralizing antibody Nicotiana benthamiana other variants pandemic produced raise RBD RBD-Fc receptor reported required Respiratory illness responsible SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 RBD protein SARS-CoV-2 receptor sera severe pneumonia South Africa strain suggested the spike protein transient expression United Kingdom vaccinated individual variant
[DOI] 10.1371/journal.pone.0253574 PMC 바로가기 [Article Type] Research Article

CAR-NK Cells Effectively Target SARS-CoV-2-Spike-Expressing Cell Lines In Vitro

CAR-NK 세포, 시험관 내에서 SARS-CoV-2-스파이크 발현 세포주를 효과적으로 표적화

Immunology

Published on 2021-07-232022-09-11
Journal: Frontiers in Immunology
[Category] MERS, SARS, 변종, 진단,

[키워드] acute respiratory syndrome coronavirus addition adverse effect Anticoagulants antigen receptor antivirals approach Cancer CAR CAR (chimeric antigen receptor) Cell cells chimeric antigen receptor conserved conserved region contagious convalescent plasma coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 CR3022 current cytokine cytokine production D614G domain E484K E484K variant effective Emergency use escape mutant escape mutants Evidence expressing glycoprotein hematologic immune pressure immune response Immunity immunocompromised condition immunodeficient patients immunomodulators Immunotherapy IMPROVE in vitro include individual isolates kill killing LINE Moderna monoclonal antibody monoclonal antibody therapies mutants N501Y N501Y variant NAbs natural killer neutralizing antibody NK cells off-the-shelf Patient Pfizer Population pseudotyped SARS-CoV-2 virus public health recognize reported respiratory S protein S309 SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolates SARS-CoV-2 neutralizing antibody SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 virus scFv Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown Side effect target target cell target cells the vaccines Therapies therapy treat treating COVID-19 Treatment Vaccine Vaccines variants of SARS-CoV-2
[DOI] 10.3389/fimmu.2021.652223 PMC 바로가기 [Article Type] Immunology

Electrostatic Interactions Explain the Higher Binding Affinity of the CR3022 Antibody for SARS-CoV-2 than the 4A8 Antibody

정전기 상호작용은 4A8 항체보다 SARS-CoV-2에 대한 CR3022 항체의 더 높은 결합 친화도를 설명합니다

Article

Published on 2021-07-062022-09-12
Journal: The journal of physical chemistry. B
[Category] SARS, 진단,