Effectiveness and safety of fibrinolytic therapy in critically ill patients with COVID-19 with ARDS: protocol for a prospective meta-analysisArticle Published on 2022-09-262022-11-16 Journal: BMJ Open [Category] meta-analysis, SARS, [키워드] acute respiratory distress anticoagulation ARDS bleeding disorder bleeding disorders & bleeding event clinical trial clinical trials Coagulopathies COVID-19 COVID-19 pandemic Critical care critical care. Critically ill patient Efficacy and safety eligibility criteria eligible Evidence fibrin deposit fibrinolytic FIVE Gas exchange identify IMPROVE include Intensive intensive & lung Meta-analysis microthrombi Mortality other organs outcome Oxygenation Patient patients patients with COVID-19 peer-reviewed performed PROSPERO protocol quantitative synthesis randomised controlled trial Registered Safety secondary outcome Standard of care syndrome therapy Trial ventilation/perfusion with COVID-19 [DOI] 10.1136/bmjopen-2022-063855 PMC 바로가기
Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injuryArticle Published on 2022-09-092022-11-15 Journal: Genome Medicine [Category] 유전자 메커니즘, 진단, [키워드] Acute kidney injury adverse outcomes affected AKI Cell cell type changes in characterized Control COVID-19 criteria Critical Critical illness Critically ill patient diagnosed with COVID-19 disease disease-associated distal epithelial Gene Expression heterogeneity highlighting histology human kidney humans hypoxia Improving individual Injury inter-individual interferon response KDIGO kidney Kidney injury kidney tissue limbs mechanism molecular molecular responses occur oxidative stress performed Post-mortem provide proximal resource respiratory infections response reveal Sequencing single-cell sequencing. Single-cell transcriptomics subtype Therapies Transcriptome transcriptomic transcriptomics [DOI] 10.1186/s13073-022-01108-9 PMC 바로가기
Acute kidney injury in critically ill COVID-19 infected patients requiring dialysis: experience from India and PakistanArticle Published on 2022-09-082022-11-16 Journal: BMC Nephrology [Category] SARS, 치료기술, [키워드] Acute kidney injury age AKI analysed Cohort collected Continuous Continuous renal replacement therapy COVID 19 patient COVID-19 COVID-19 infected patient Critically ill Critically ill patient critically ill patients detect dialysis died Efficiency form Hemodialysis high mortality hospital ICU India kidney Kidney injury laboratory parameter men Mortality outcome pandemic Patient patients died patients with COVID-19 renal renal replacement therapy required RRT serum albumin slow Slow low efficiency dialysis. the mean therapeutic intervention variable ventilatory support [DOI] 10.1186/s12882-022-02931-3 PMC 바로가기
Right dose, right now: bedside, real-time, data-driven, and personalised antibiotic dosing in critically ill patients with sepsis or septic shock-a two-centre randomised clinical trialRandomized Controlled Trial Published on 2022-09-052022-10-05 Journal: Critical Care [Category] 임상, [키워드] Acute kidney injury Adequate Adult patient antibiotic Antibiotics clinical Clinical decision support clinical trial control group COVID-19 pandemic Critically ill patient critically ill patients data-driven dose Efficacy eligible Endpoint EudraCT European evaluate faster feasibility feasible for inclusion ICU implementation IMPROVE incidence Inclusion increased mortality Infection intervention group Lactate Mortality Netherland not significantly different outcome patients personalised pharmacokinetic pharmacokinetics Primary outcome randomisation randomised Registered renal right Safe Sepsis Septic shock significantly Support Therapeutic Drug Monitoring Therapeutic drug monitoring. Trial was obtained [DOI] 10.1186/s13054-022-04098-7 PMC 바로가기 [Article Type] Randomized Controlled Trial
SARS-CoV-2 Spike and Nucleocapsid Antibody Response in Vaccinated Croatian Healthcare Workers and Infected Hospitalized Patients: A Single Center Cohort StudyArticle Published on 2022-09-042022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, 치료기술, [키워드] antibodies binding antibody Antibody detection Antibody Response BNT162 vaccine center clinical Cohort cohort of patient contribute correlated COVID-19 COVID-19 patient COVID-19 patients COVID-19 vaccine Critically ill Critically ill patient decrease disease ELISA assay group HCW HCWs health-care healthcare Healthcare workers hospitalized patients hospitalized patients. Humoral response invasive ventilation management Non-invasive nucleocapsid omicron outcome oxygen supplementation Pandemics Protein response Rijeka risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant Seroconversion significant difference significantly spike Spread Support sustained tested vaccination vaccination schedule vaccinee VoC VOCs worker [DOI] 10.3390/v14091966 PMC 바로가기
Reactivation of EBV and CMV in Severe COVID-19-Epiphenomena or Trigger of Hyperinflammation in Need of Treatment? A Large Case Series of Critically ill Patients심각한 COVID-19-Epiphenomena에서 EBV 및 CMV의 재활성화 또는 치료가 필요한 Hyperinflammation의 트리거? 중환자의 대규모 사례 시리즈Article Published on 2022-09-012022-09-11 Journal: Journal of Intensive Care Medicine [Category] 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed ARDS Chain Reaction Characteristics Clinical deterioration CMV cohort study comparable connection control group coronavirus Corticosteroid Course COVID-19 Critically ill Critically ill patient critically ill patients cytomegalovirus decrease described Diagnosis disease EBV Epstein-Barr virus Follow-up analysis Ganciclovir high risk hyperinflammation ICU in viral incidence increased mortality initiation of treatment intensive care intensive care unit intensive care unit. majority Non-COVID-19 non-COVID-19 patient Non-COVID-19 patients outcome Patient polymerase chain polymerase chain reaction Reactivation remains uncertain retrospective rituximab SARS-CoV-2 screened Sepsis sepsis patient Sery severe acute respiratory syndrome Coronavirus severe COVID-19 single-center survived systemic corticosteroid treated Treatment Trigger Viral load viral reactivation virus virus with COVID-19 [DOI] 10.1177/08850666211053990 PMC 바로가기 [Article Type] Article
The safety and effectiveness of tocilizumab in older adult critically ill patients with COVID-19: a multicenter, cohort studyMulticenter Study Published on 2022-09-012022-10-05 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] 1:1 95% CI benefit cohort study Complication Confirmed COVID-19 infection COVID-19 criteria Critically ill Critically ill patient Effectiveness elderly evaluate ICU ICUs in-hospital mortality intensive care unit mechanical ventilation Mortality multicenter objective Older older adult P-value Patient patients with COVID-19 Primary outcome Propensity score Respiratory failure Result Retrospective study safety profile SARS-CoV-2 selected severe COVID-19 statistically significant difference Support TCZ Tocilizumab two group Ventilator-free days was used with COVID-19 [DOI] 10.1016/j.ijid.2022.05.038 [Article Type] Multicenter Study
Discovering common pathogenetic processes between COVID-19 and sepsis by bioinformatics and system biology approachArticle Published on 2022-08-312022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] acute respiratory syndrome addition Analysis approach bioinformatics Biomarker Blood caused clinical manifestations Clinical practice Coagulopathy Corona Coronavirus-2 COVID-19 Critically ill Critically ill patient Cytokine storm database DEGs demonstrated diagnostic differentially expressed differentially expressed gene differentially expressed gene (DEG) disease drug molecule enrichment analysis functional functional enrichment Gene Expression Omnibus gene expression profile Gene ontology gene regulatory network genetic link genetic mechanism GEO high mortality rate hub gene hypercoagulable Inflammatory response Interaction ITGAM molecular docking molecular mechanism multiple organ dysfunction neutrophil dysfunction pandemic Pathogenesis pathogenesis of COVID-19 pathway potential therapeutic agents progesterone protein-protein interaction Protein–protein interaction protein–protein interaction (PPI) receptor Regulatory Research respiratory infectious disease resulting risk SARS-CoV-2 screened Sepsis sepsis patient sepsis. Septic shock severe COVID-19 signaling pathway similarity Spread syndrome System biology Systems biology Treatment were used with COVID-19 [DOI] 10.3389/fimmu.2022.975848 PMC 바로가기
Epicardial adipose tissue volume and CT-attenuation as prognostic factors for pulmonary embolism and mortality in critically ill patients affected by COVID-19 Research Published on 2022-08-262022-10-05 Journal: European journal of clinical nutrition [Category] 바이오마커, 치료법, [키워드] adipose affected age and gender approach Biomarkers Blood BMI Computed tomography confounder consequence COVID-19 COVID-19 patient Critically ill Critically ill patient D-dimer died evaluate evaluated hospital ICU ICU admission IL-6 IL-6 level increased risk information intensive care LDH life-threatening Logistic regression men Mortality Older participant Patient post-hoc analysis Prevalence Prevent Prognostic factor Result risk severe COVID-19 significantly higher subject subjects survival tissue Treatment Volume women [DOI] 10.1038/s41430-022-01197-0 [Article Type] Research
Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational studyResearch article Published on 2022-08-242022-10-05 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 진단, [키워드] admitted to ICU Affect affecting Analysis Antwerp Aspergillus autophagy Belgium Bronchoalveolar lavage fluid bronchoalveolar lavage sample bronchoalveolar lavage samples calculate Cell chemokines collected Concentration conidia COVID-19 Critically ill patient Cytokines development diagnose differentially expressed disrupting downregulated downregulation elevated Eligible patients encoding protein enrichment analysis epithelial European expression expression data finding foundation fraction France function funding Gene expression analysis growth factor Horizon hospital hyphae ICU IFNγ IL-1β Immunity in vivo increased mortality Influenza Influenza virus Innate immunity intensive care invasive invasive ventilation investigated kill killing lung epithelial Max Planck Society network neutrophil Neutrophils Non-invasive pathophysiology pathway Pathway analysis Pathways Patient patients patients with COVID-19 patients with influenza performed phagocytosis Protein recruited Regional retrieved SARS-COV-2 infection SARS-CoV-2 RNA several gene significantly significantly lower spores TNF-α tracheobronchial transcriptomics Treatment Type I IFN type II IFN university University Hospitals Leuven were used [DOI] 10.1016/S2213-2600(22)00259-4 [Article Type] Research article