Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variantsSARS-CoV-2 오미크론 및 델타 변이체의 백신 돌발 감염에서 면역 중화Article Published on 2022-04-282022-09-11 Journal: Cell [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibody Antibody neutralization Antibody Response Asymptomatic B.1.1.529 B.1.617.2 boosted breakthrough infection Breakthrough infection COVID-19 cross-neutralizing decrease Decreased Delta delta variant exhibited humoral Humoral immunity Immunity immunogenic individuals Infection less Live virus Mild moderate moderate to severe neutralizing immunity omicron Omicron variant patients proportion pseudovirus pseudovirus infectivity studies Quantitative quantitative antibody assay reduced Reinfection SARS-CoV-2 SARS-CoV-2 variant Severe infection the SARS-CoV-2 titers uninfected vaccinated individuals vaccine breakthrough infection variant variant of concern variant severity variants virus-like particle. VLP were used [DOI] 10.1016/j.cell.2022.03.019 PMC 바로가기 [Article Type] Article
Broad Neutralization of SARS-CoV-2 Variants, Including Omicron, following Breakthrough Infection with Delta in COVID-19-Vaccinated IndividualsCOVID-19 백신을 접종한 개인의 Delta에 대한 획기적인 감염에 따른 오미크론을 포함한 SARS-CoV-2 변이체의 광범위한 중화Article Published on 2022-04-262022-09-11 Journal: mBio [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Antibody Response Antibody responses AZD1222 B.1.1.529 B.1.617.2 BNT162b2 breadth Breakthrough infection COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines cross-neutralizing Delta effective ENhance Evidence evidence of greater hospitalizations IgG immunization Impact in some Including individual Infection magnitude neutralization neutralization breadth neutralizing antibody Neutralizing antibody response neutralizing antibody responses neutralizing antibody. Numerous occur omicron Omicron variant population immunity potency priming provide Rapid reducing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 variant SARS-CoV-2 variants shown the antibody response Transmission vaccinated individuals Vaccine vaccinees variant variants of concern [DOI] 10.1128/mbio.03798-21 PMC 바로가기 [Article Type] Article
Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies알파카 면역 레퍼토리의 다변량 마이닝은 강력한 교차 중화 SARS-CoV-2 나노바디를 식별합니다Article Published on 2022-03-252022-09-11 Journal: Science Advances [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus approach approach Beta Beta variant biochemical conserved Conventional coronavirus cross-neutralize cross-neutralizing deuterium epitope functional half-maximal inhibitory concentration hydrogen identify immune mass spectrometry monomeric multivariate nanobodies nanobody Neutralization assay neutralization assays neutralize Next-generation sequencing Other RBD Receptor binding domain receptor binding motif respiratory SARS-CoV-1 SARS-CoV-2 screening strategy side specificity the RBD the SARS-CoV-2 variant virus [DOI] 10.1126/sciadv.abm0220 PMC 바로가기 [Article Type] Article
Three doses of an inactivation-based COVID-19 vaccine induces cross-neutralizing immunity against the SARS CoV-2 Omicron variant비활성화 기반 COVID-19 백신의 3회 용량은 SARS CoV-2 Omicron 변이체에 대한 교차 중화 면역을 유도합니다Coronaviruses Published on 2022-03-032022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 B.1.1.529 collected coronavirus COVID-19 vaccine cross-neutralizing delta variant demonstrated dose enrolled fold geometric mean geometric mean titer geometric mean titers GMT immune Immunity immunization immunized induce natural infection neutralization activity Neutralizing activity neutralizing antibody omicron Omicron variant positive prototype pseudotyped Pseudotyped virus recipient reported respiratory SARS CoV SARS CoV-2 SARS-CoV-2 sera serum sample serum samples severe acute respiratory syndrome Coronavirus sustained the vaccine vaccination Vaccine variant was determined [DOI] 10.1080/22221751.2022.2044271 PMC 바로가기 [Article Type] Coronaviruses
Cross-Neutralizing Breadth and Longevity Against SARS-CoV-2 Variants After Infections감염 후 SARS-CoV-2 변종에 대한 교차 중화 폭 및 수명Article Published on 2022-02-242022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against Antibody titer Antibody titers B.1.1.7 B.1.351 breadth center convalescent sera coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 cross-neutralizing D614G D614G mutation decrease epitope Epitopes infected with SARS-CoV-2 Infection Longevity maintain neutralization Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers not significantly different P.1 pandemic Patient patients produced Protective public health recognize respiratory responsible SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants selected sera several variant several variants Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly sustained variant variants variants of concern variants. virus Virus neutralization viruses VoC VOCs was performed [DOI] 10.3389/fimmu.2022.773652 PMC 바로가기 [Article Type] Article
A Perspective on the Roles of Adjuvants in Developing Highly Potent COVID-19 VaccinesPerspective Published on 2022-02-142022-10-28 Journal: Viruses [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] acute respiratory syndrome adjuvant caused coronavirus coronavirus disease country COVID-19 COVID-19 vaccine cross-neutralizing develop Developing disadvantage dose effective Efficacy effort IMPROVE Inactivated Vaccines neutralizing activities Occurrence omicron potent reduce required Research role SARS-CoV-2 SARS-CoV-2 variants subunit Vaccine Vaccine development variant variants [DOI] 10.3390/v14020387 PMC 바로가기 [Article Type] Perspective
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection인간 항체는 베타-코로나바이러스 스파이크 단백질의 보존된 부위를 드러내고 SARS-CoV-2 감염에 대한 보호를 제공합니다Research Article Published on 2022-02-082022-09-14 Journal: Science Translational Medicine [Category] MERS, SARS, 진단, 치료기술, [키워드] adopted animal models antibody beta-coronavirus beta-coronavirus conserved controls coronavirus coronavirus coronavirus disease CoV COVID-19 COVID-19 infection CoVs cross-neutralizing described description Donor Efficacy epitope exhibit exhibited Fab facilitate helical structure in vivo less lung viral titer mAb molecular basis neutralizing antibody peptide Prophylactic Protective Protective antibody reactivity reagent reduced residue reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S2 Spike protein target therapeutic treat Vaccine design Vaccines weight loss β-CoV β-CoVs [DOI] 10.1126/scitranslmed.abi9215 PMC 바로가기 [Article Type] Research Article
Sequentially immune-induced antibodies could cross-neutralize SARS-CoV-2 variants순차적으로 면역 유도된 항체는 SARS-CoV-2 변이체를 교차 중화할 수 있습니다Article Published on 2022-02-012022-09-11 Journal: Animal models and experimental medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibody B.1.1.529 collected cross-neutralize cross-neutralize SARS-CoV-2 cross-neutralizing delta variant Delta variants demonstrated dose geometric mean geometric mean titer geometric mean titers GMT GMTs Human human sera Humoral immunity immune Immunity in vitro inactivated Inactivated vaccine lead Mutation neutralization Neutralization antibody neutralization titers Neutralizing activity neutralizing antibody omicron Omicron variant PiCoVacc Protein raised Recombinant protein reduction in SARS-CoV-2 SARS-CoV-2 variant sequentially immune. sera Spike protein target the spike protein vaccination Vaccine variant wild type ZF2001 [DOI] 10.1002/ame2.12216 PMC 바로가기 [Article Type] Article
Inactivated Rabies Virus Vectored MERS-Coronavirus Vaccine Induces Protective Immunity in Mice, Camels, and AlpacasImmunology Published on 2022-01-312022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] accelerated alpaca antibody antigen-specific antibody Camel candidate vaccine caused CD8 clades coronavirus cross-neutralizing domain effective evaluated event highlight immune immunized inactivated MERS-CoV mice Middle East potent Prophylactic protective antibody response Rabies virus rabies virus vector Raby reduce reduced respiratory syndrome coronavirus risk sera T-cell Response the antibody response therapeutic efficacy vaccination Vaccination strategy Vaccine viral replication virus clearance zoonotic [DOI] 10.3389/fimmu.2022.823949 PMC 바로가기 [Article Type] Immunology
Longitudinal Study after Sputnik V Vaccination Shows Durable SARS-CoV-2 Neutralizing Antibodies and Reduced Viral Variant Escape to Neutralization over TimeResearch Article Published on 2022-01-252022-10-29 Journal: mBio [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] addition Analysis anti-spike IgG level antibody Antibody Response B.1 lineage Beta breadth circulating variant collected convalescent individuals coronavirus disease COVID-19 cross-neutralizing Delta escape examined Gamma increase in indicate Lambda Lineage Local longitudinal neutralization neutralizing antibody neutralizing capacity observation postvaccination receiving recent reduction SARS CoV-2 SARS-CoV-2 SARS-CoV-2 variant Serum neutralizing antibody serum sample show shown significantly Sputnik V susceptibility time vaccination Vaccine variant variants variants of concern viral variant Viral variants virus VoC Volunteer were used Wuhan [DOI] 10.1128/mbio.03442-21 PMC 바로가기 [Article Type] Research Article