Cryo-EM structure of a SARS-CoV-2 omicron spike protein ectodomainSARS-CoV-2 오미크론 스파이크 단백질 엑토도메인의 Cryo-EM 구조Article Published on 2022-03-032022-09-11 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] cell entry conformations Critical cryo-EM structure ectodomain globe immune immune evasion immune surveillance mechanism mixture Mutation Neutralizing antibodies neutralizing antibody Omicron variant open RBD RBD region Receptor binding Receptor-binding domain SARS-CoV-2 Spike protein standing up Surveillance the cell the receptor-binding domain the spike protein viral strain [DOI] 10.1038/s41467-022-28882-9 PMC 바로가기 [Article Type] Article
Structural basis for SARS-CoV-2 Delta variant recognition of ACE2 receptor and broadly neutralizing antibodiesACE2 수용체 및 광범위 중화 항체의 SARS-CoV-2 Delta 변이체 인식을 위한 구조적 기반Article Published on 2022-02-152022-09-10 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 binding ACE2 receptor affinity Antibody neutralization antigenic binding circulating complex conformational conformational state contribute cryo-EM Cryo-EM analysis cryo-EM structure cryo-EM structures Cryoelectron microscopy Delta delta variant destabilized dominant effective Engagement FIVE identify immune induce Interaction lead mAbs mechanism Mutation Neutralizing neutralizing antibody pathogenicity RBD RBM receptor SARS-CoV-2 sensitivity shedding Spread T478K tested Transmission Viral proteins [DOI] 10.1038/s41467-022-28528-w PMC 바로가기 [Article Type] Article
Cryo-EM structures of human bradykinin receptor-G q proteins complexesArticle Published on 2022-02-072022-10-04 Journal: Nature Communications [Category] 변종, [키워드] acting Activation agonist binding cardiovascular system complex complexes conformational change conserved Cryo-electron microscopy cryo-EM cryo-EM structure Cryoelectron microscopy determine dysfunction G protein-coupled receptor G protein-coupled receptors Glutamate induce Inflammation Interaction Ligand mechanism molecular mechanism motifs Pain peptide peptides PROTECT Protein Proteins receptor Receptor pharmacology Structure Type [DOI] 10.1038/s41467-022-28399-1 PMC 바로가기 [Article Type] Article
A dual mechanism of action of AT-527 against SARS-CoV-2 polymeraseArticle Published on 2022-02-022022-10-04 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] 3′ end acting active site AT-527 binding cells clinical trial complex coronavirus COVID-19 cryo-EM structure Cryoelectron microscopy guanine inhibit inhibiting mechanism of action Multienzyme complexes N-terminal domain Nsp12 NTP nucleotide polymerase Prevent RdRP Replication Research respiratory RNA RNA synthesis RNA-dependent RNA polymerase SARS-CoV-2 target the SARS-CoV-2 Treatment Viral RNA [DOI] 10.1038/s41467-022-28113-1 PMC 바로가기 [Article Type] Article
Coronaviral RNA-methyltransferases: function, structure and inhibitionAcademicSubjects/SCI00010 Published on 2022-01-252022-10-31 Journal: Nucleic Acids Research [Category] COVID-19, [키워드] Activation antiviral immunity complex Coronaviral COVID cryo-EM structure cytoplasm Degradation enzyme inhibitor inhibitors innate immune system Innate immunity methyltransferase nsp14 pandemic RNA scrutiny stability viral replication Viral RNA X-ray [DOI] 10.1093/nar/gkab1279 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Biophysical and structural characterizations of the effects of mutations on the structure-activity relationships of SARS-CoV-2 spike proteinArticle Published on 2022-01-012022-11-16 Journal: Molecules [Category] 변종, [키워드] ACE2 addition analysis Analysis Antibody binding Antibody neutralization atomic binding binding kinetics change changes complement COVID-19 Cryo-electron microscopy cryo-EM cryo-EM structure Effect ENhance enzyme expression Folding stability functional help host receptor host-pathogen interactions Impact in vitro induce information investigated kinetic mammalian cell Microscopy molecular molecular basis morphological change Mutation mutations Protein provide Receptor binding recombinant S protein robust SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 spike protein. stability staining Structure the S protein thermodynamic Transmissibility variant [DOI] 10.1016/bs.mie.2022.07.013 PMC 바로가기
Conformational dynamics of the Beta and Kappa SARS-CoV-2 spike proteins and their complexes with ACE2 receptor revealed by cryo-EMArticle Published on 2021-12-202022-10-04 Journal: Nature Communications [Category] SARS, 변종, [키워드] ACE2 ACE2 binding ACE2 receptor Analysis association Beta biochemical Combination Combined complex complexes Complexes conformational conformational state COVID-19 pandemic cryo-EM cryo-EM structure cryo-EM structures Cryoelectron microscopy distribution domain immune evasion IMPROVE mechanism modify Mutation Neutralizing neutralizing antibody pathogenicity Protein RBD Receptor binding recognize S protein SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein spike spikes Structure the S protein Transmissibility understanding variant variant spike variants virus wild-type [DOI] 10.1038/s41467-021-27350-0 PMC 바로가기 [Article Type] Article
A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants비 ACE2 경쟁 인간 단일 도메인 항체는 SARS-CoV-2 및 순환 변이체에 대한 광범위한 중화를 제공합니다Article Published on 2021-11-032022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 진단, [키워드] ACE2 affinity Alpha angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody B.1.1.7 B.1.351 B.1.617.2 Beta bind binding circulating variant clinical development competing complex conformation COVID-19 COVID-19 pandemic cryo-EM structure cryo-EM structures crystal structure Delta effective epitope exhibit Gamma global public health host cell host cell receptor humanized Immune escape Infectious diseases inhibit lineages membrane fusion mice Mutation neutralization Neutralizing P.1 prevalent Prophylactic Pseudovirus neutralization assay RBD Receptor-binding domain reveal SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 S SARS-CoV-2 variants structural biology the receptor-binding domain therapeutic therapeutic antibodies treat Vaccine variant [DOI] 10.1038/s41392-021-00810-1 PMC 바로가기 [Article Type] Article
Stabilized coronavirus spike stem elicits a broadly protective antibodyArticle Published on 2021-10-162023-06-15 Journal: Cell Reports [Category] MERS, SARS, [키워드] coronaviruses (CoV) cross-reactivity cryo-EM structure protective antibodies protective antigens spike (S) glycoprotein stem stabilization stem-helix antibodies [DOI] 10.1016/j.celrep.2021.109929 PMC 바로가기 [Article Type] Article
Structures of synthetic nanobody–SARS-CoV-2 receptor-binding domain complexes reveal distinct sites of interactionResearch Article Published on 2021-09-162022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, MERS, SARS, [키워드] accompanied ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome angiotensin-converting enzyme 2 antibody BSA, buried surface area CCs, correlation coefficients CDR1, complementarity-determining region 1 CDR2, complementarity-determining region 2 CDR3, complementarity-determining region 3 complementarity-determining region complexes conformational coronavirus cryo-EM cryo-EM structure crystal structure Crystallography CTF, contrast transfer function difference domain enzyme explained FIVE indicate interact Interaction PDB, Protein Data Bank RBD RBD variant RBD, receptor-binding domain S-6P, HexaPro S S, spike SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SEC, size-exclusion chromatography single-domain antibody (sdAb, nanobody) Spike protein SPR, surface plasmon resonance Spread Structure structures surface plasmon resonance (SPR) sybody synthetic nanobodies the RBD the SARS-CoV-2 Trimeric spike protein unliganded variant X-ray [DOI] 10.1016/j.jbc.2021.101202 PMC 바로가기 [Article Type] Research Article