Targeting cathepsins: A potential link between COVID-19 and associated neurological manifestationsResearch article Published on 2021-09-292022-10-05 Journal: Heliyon [Category] 신약개발, [키워드] age Analysis binding binding ability Brain cathepsin Cathepsins complexes COVID-19 COVID-19 infection CTSL cyclosporine disorder disorders drug Drug repurposing expression Health host cells Hypothesis identify involved lysosomal cathepsins mitigate molecular molecular docking Neurological disorders neurological manifestation neurological manifestations performed potential therapeutic target Proteases required SARS-CoV-2 SARS-CoV-2 entry shown stability targeting virus entry [DOI] 10.1016/j.heliyon.2021.e08089 [Article Type] Research article
Immunological Response Against SARS-COV-2 After BNT162b2 Vaccine Administration Is Impaired in Allogeneic but Not in Autologous Stem Cell Transplant RecipientsOncology Published on 2021-09-062022-10-31 Journal: Frontiers in Oncology [Category] COVID-19, [키워드] administration Against Allogeneic allogeneic HSCT Antibody Response Antibody titer autologous autologous HSCT B cell B lymphocyte BNT162b2 CD19 CD19+ CD20 CD56+ Cell control group correlated correlation COVID-19 immunity cyclosporine Cytometry develop Efficacy evaluate Flow glycoprotein healthy subjects HSCT HSCT recipients immune response immunosuppressive Impaired mRNA-based natural killer negatively affected NK cell NK cells Patient performed Peripheral blood Pfizer-BioNTech platform Prospective Study recipient response rituximab SARS-CoV-2 IgG SARS-CoV-2 vaccine SARS-CoV2 second dose Seroconversion serum sample STEM Stem cell transplantation submitted T cells tested the antibody response the Spike Transplant vaccination Vaccine [DOI] 10.3389/fonc.2021.737300 PMC 바로가기 [Article Type] Oncology
COVID-19 Disease Leading to Chronic Spontaneous Urticaria Exacerbation: A Romanian Retrospective StudyArticle Published on 2021-09-012022-10-31 Journal: International journal for equity in health [Category] COVID-19, [키워드] AH1 biological profile case sery chronic Chronic diseases chronic spontaneous urticaria correlated COVID-19 COVID-19 disease COVID-19 infection COVID-19 pandemic CRP cyclosporine Department diagnosed Disease activity doctor dose form Hypothesis impacted Infection Inflammation inflammatory markers leading marker Mast cells moderate moderate-severe MOST non-specific nonspecific omalizumab Patient patients positive correlation positively correlated Professor proportion Result retrospective Romania SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severity Spontaneous Symptom the patient the SARS-CoV-2 treated Treatment triggered urticaria Visual Analogue Scale were assessed with COVID-19 [DOI] 10.3390/healthcare9091144 PMC 바로가기 [Article Type] Article
Remdesivir and Cyclosporine Synergistically Inhibit the Human Coronaviruses OC43 and SARS-CoV-2Pharmacology Published on 2021-08-132022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Cell Combination COVID-19 cyclosporine Cytokine storm drug fibroblast HCoV-OC43 HCT-8 Human human coronavirus OC43 human lung IFA IL-6 IL-8 immunofluorescence assay inhibited inhibitor inhibitory activity OC43 reduced Remdesivir SARS-CoV-2 synergistic treatment for COVID-19 [DOI] 10.3389/fphar.2021.706901 PMC 바로가기 [Article Type] Pharmacology
Randomized clinical trial to compare the efficacy of ivermectin versus placebo to negativize nasopharyngeal PCR in patients with early COVID-19 in Peru (SAINT-Peru): a structured summary of a study protocol for randomized controlled trial페루의 초기 COVID-19 환자(SAINT-Peru)에서 비인두 PCR을 무효화하기 위해 이버멕틴 대 위약의 효능을 비교하기 위한 무작위 임상 시험(SAINT-Peru): 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-04-092022-09-01 Journal: Trials [Category] MERS, 임상, 진단, [키워드] 1:1 Administered adverse event allergy Amiodarone Anosmia Antiviral attending physician baseline blinded Blinding block childbearing age clarithromycin clinical clinical and laboratory parameters clinical care clinical trial Cobicistat coin conducted control group correlation cough COVID-19 COVID-19 disease COVID-19 patient COVID-19 pneumonia COVID-19 progression criteria Critical current cyclosporine CYP3A4 daily dose death determine determined by diagnosed diagnostic test Diltiazem dissemination dose drug early treatment Efficacy element Eligible patients emergency services enrolled epidemiologist erythromycin evaluate expected Fever follow-up visits generate hospital Hospitalization IgA IgG IgM IIa immune response immunomodulatory in vivo include inclusion criteria Indinavir Infection Informed consent inhibitor Intervention intestinal investigator investigators involved itraconazole Ivermectin ketoconazole laboratory parameter less list lung magnitude medical staff nasopharyngeal nasopharyngeal specimen Nasopharyngeal swab nasopharyngeal swab PCR nasopharyngeal swabs National negative number objective Older outcome oxygen oxygen saturation Parallel Arm participant Patient patients patients with SARS-CoV-2 PCR PCR cycle Peru Pharmacist phase Placebo placebo group placebo-controlled trial Pneumonia positive positive PCR test positive SARS-CoV-2 PCR pregnancy test pregnant women principal investigator progression proportion protocol quinidine randomization list Randomized Randomized controlled trial Randomly Rapid diagnostic test receive recruited reduce Registered Registration Result risk factor Risk factors Ritonavir Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR SARS-CoV-2 RNA SARS-CoV-2 viral load secondary Secondary objectives Seroconversion Seven severe disease severity spironolactone statistician status study population Study protocol supplementary material Symptom symptomatic Symptomatology Symptoms tacrolimus the patient the placebo group the SARS-CoV-2 threshold Treatment treatment group treatment groups treatment initiation Trial Trial registration two group two groups verapamil Viral Viral load virus Warfarin website with COVID-19 women [DOI] 10.1186/s13063-021-05236-2 PMC 바로가기 [Article Type] Letter
The global impact of the COVID-19 pandemic on the management and course of chronic urticariaMulticenter Study Published on 2021-03-012023-07-13 Journal: Allergy [Category] SARS, [키워드] chronic urticaria COVID-19 cyclosporine omalizumab pandemic SARS-CoV-2 Treatment UCARE [DOI] 10.1111/all.14687 [Article Type] Multicenter Study
Immunosuppressive drugs for patients with psoriasis during the COVID-19 pandemic era. A reviewReview Published on 2021-01-012023-07-11 Journal: Dermatologic therapy [Category] SARS, [키워드] COVID-19 cyclosporine IL12/23 inhibitors IL17-inhibitors immunosuppressive drugs jak inhibitors methotrexate psoriasis review risk of infection TNFα inhibitors [DOI] 10.1111/dth.14498 [Article Type] Review
Dynamic data-driven meta-analysis for prioritisation of host genes implicated in COVID-19COVID-19와 관련된 숙주 유전자의 우선 순위를 지정하기 위한 동적 데이터 기반 메타 분석Meta-Analysis Published on 2020-12-182022-09-10 Journal: Scientific Reports [Category] MERS, 바이오마커, 유전자 메커니즘, 임상, 치료제, [키워드] Algorithm Betacoronavirus CD3E CD4 chromosome chromosome 3 conducted content COVID-19 COVID-19 pathogenesis CXCL10 cyclosporine data-driven datasets described disease-associated dynamic evaluate Evidence experiment Factor Factors FYCO1 GWAS Host host gene host genes human betacoronavirus IL1A Immunogenetics immunology implicated Infection Infectious diseases Interpretation list list of gene locus MERS MERS-CoV Meta-analysis Other PPIA Prognostic factor Prognostic factors resource robust SARS-CoV SARS-CoV-2 seasonal coronaviruses systematic review therapeutic target Therapies viral infection Weighting [DOI] 10.1038/s41598-020-79033-3 PMC 바로가기 [Article Type] Meta-Analysis
Immune Response to Vaccination in Patients with Psoriasis Treated with Systemic TherapiesReview Published on 2020-12-162024-09-02 Journal: Vaccines [Category] 대상포진, [키워드] apremilast biologics cyclosporine dimethyl fumarate methotrexate psoriasis vaccination Vaccine [DOI] 10.3390/vaccines8040769 PMC 바로가기 [Article Type] Review
SARS-CoV2 and immunosuppression: A double-edged swordReview Published on 2020-12-012023-07-13 Journal: Transplant infectious disease : an official journa [Category] SARS, [키워드] coronavirus COVID-19 cyclosporine SARS Steroids tacrolimus [DOI] 10.1111/tid.13404 PMC 바로가기 [Article Type] Review