Ursodeoxycholic acid ameliorates cell migration retarded by the SARS-CoV-2 spike protein in BEAS-2B human bronchial epithelial cellsUrsodeoxycholic acid는 BEAS-2B 인간 기관지 상피 세포에서 SARS-CoV-2 스파이크 단백질에 의해 지연된 세포 이동을 개선합니다Article Published on 2022-06-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression airway analyzed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 basal layer BEAS-2B Beas-2B bronchial epithelial cell BEAS-2B cell Beas-2B cells binding bronchial epithelial cell caused Cell Cell migration cell proliferation cells changes in conditions contribute control cells coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 damage damaged differentiation DNA ENhance enzyme epithelial epithelial cell flow cytometry followed by Gene Expression greater HEK293T Hela immunostaining inhibitory Interaction investigated mechanism Migration overexpression Plasmid Prevent Protective RBD receptor Receptor-binding domain reduced repair repair mechanism Repair mechanisms restoration restored RT-PCR SARS- CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein significantly Single Cell SP binding Spike protein syndrome the receptor-binding domain the SARS-CoV-2 the spike protein transfection Treatment Ursodeoxycholic acid Ursodeoxycholic acid (UDCA). virus infection was increased was measured western blotting wound healing [DOI] 10.1016/j.biopha.2022.113021 PMC 바로가기 [Article Type] Article
The effect of prostacyclin infusion on markers of endothelial activation and damage in mechanically ventilated patients with SARS-CoV-2 infectionSARS-CoV-2 감염이 있는 기계 환기 환자의 내피 활성화 및 손상 마커에 대한 프로스타사이클린 주입의 효과Randomized Controlled Trial Published on 2022-06-012022-09-11 Journal: Journal of critical care [Category] COVID19(2023년), SARS, 바이오마커, 임상, [키워드] Activation Adult patients baseline Biomarker Biomarkers blood sample Blood samples CD40L change changes in collected COVID-19 damage decrease endothelial Endothelium glycocalyx groups marker mechanically ventilated mechanically ventilated patient mechanically ventilated patients median medians not differ Organ failure P-selectin Patient pilot study Placebo placebo group plasma Plasma levels prostacyclin protective effect Randomized Randomized controlled trial reduction in SARS-CoV-2 SARS-COV-2 infection selectin significantly syndecan Syndecan-1 the placebo group thrombomodulin with COVID-19 [DOI] 10.1016/j.jcrc.2022.154010 PMC 바로가기 [Article Type] Randomized Controlled Trial
Impact of COVID-19 on Male Fertility남성 불임에 대한 COVID-19의 영향Review Published on 2022-06-012022-09-11 Journal: Urology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Care caused clinical condition COVID-19 Cytokine storm damage dysregulation Evidence Fertility Impact Inflammation male male fertility medical intervention organ systems pandemic reported SARS-CoV-2 virus Testis the SARS-CoV-2 virus [DOI] 10.1016/j.urology.2021.12.025 PMC 바로가기 [Article Type] Review
The COVID-19 pandemic – what have urologists learned?COVID-19 전염병 - 비뇨기과 전문의는 무엇을 배웠습니까?Review Published on 2022-06-012022-09-11 Journal: Nature reviews. Urology [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료법, [키워드] ACE2 Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affecting AKI androgen angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 caused cell damage changes in clinical study Complication complications coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic damage Deprivation Economy expressed genitourinary tract high risk hypogonadism impairment in urine Invasion organ organs outbreak pandemic patients with COVID-19 public health raising receptor reported respiratory tract SARS-CoV-2 secondary hypogonadism Semen severe acute respiratory syndrome Coronavirus spermatogenesis survival Symptom testes Testosterone the WHO therapy tract treating COVID-19 Urine [DOI] 10.1038/s41585-022-00586-1 PMC 바로가기 [Article Type] Review
Intranasal delivery of SARS-CoV-2 spike protein is sufficient to cause olfactory damage, inflammation and olfactory dysfunction in zebrafishSARS-CoV-2 스파이크 단백질의 비강 내 전달은 제브라피쉬에서 후각 손상, 염증 및 후각 기능 장애를 유발하기에 충분합니다Article Published on 2022-05-012022-09-11 Journal: Brain, behavior, and immunity [Category] COVID19(2023년), SARS, 치료기술, [키워드] animal animal models animals Anosmia bind cause Cell characterized cilia Cluster Combined damage Danio direct infection driven by edema endothelial EOG explained expression fish food functional hemorrhage hemorrhages Histopathology implication indicated Infection Inflammation Inflammatory response Inflammatory responses intranasal intranasally Loss of Smell mechanism myeloid cell nasal epithelium non-neuronal cell non-neuronal cells olfactory Olfactory damage olfactory dysfunction olfactory function Olfactory organ olfactory receptor Olfactory receptor expression organ prevalent Protein RBD receptor reduced response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S SARS-CoV-2 spike SARS-CoV-2 spike protein sensory neuron spike Spike protein Symptom treated Vaccine Viral protein Viral proteins widespread zebrafish Zebrafish (Danio rerio). [DOI] 10.1016/j.bbi.2022.03.006 PMC 바로가기 [Article Type] Article
Neuropilin-1-Mediated SARS-CoV-2 Infection in Bone Marrow-Derived Macrophages Inhibits Osteoclast Differentiation골수 유래 대식세포의 뉴로필린-1 매개 SARS-CoV-2 감염은 파골세포 분화를 억제합니다Article Published on 2022-05-012022-09-11 Journal: Advanced Biology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin angiotensin-converting enzyme 2 B.1.351 bone Bone marrow bone marrow-derived macrophages calcium Clinical data Cluster Complication coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients damage dependent on differentiation Evidence expression host cell host cells Human skeleton humans identify impede in vivo Infection inhibit SARS-CoV-2 Interaction investigated knockdown macrophages marrow-derived macrophage metabolism mouse model Mouse models neuropilin Neuropilin-1 neutralization NRP1 organs osteoclast osteoclast differentiation Pathogenesis pathogenesis of SARS-CoV-2 patients phosphorus phosphorus metabolism provide receptor RNA sequencing SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly Single-cell RNA sequencing susceptible tissue tropism various tissue various tissues virus wild-type [DOI] 10.1002/adbi.202200007 PMC 바로가기 [Article Type] Article
Urine sediment findings were milder in patients with COVID-19-associated renal injuries than in those with non-COVID-19-associated renal injuries소변 침전물 소견은 코로나19와 관련되지 않은 신손상 환자보다 코로나19와 관련된 신손상 환자에서 더 경미했습니다.Article Published on 2022-04-012022-09-11 Journal: International Journal of Infectious Diseases [Category] MERS, 바이오마커, [키워드] acetyl Acute kidney injuries acute renal injury addition arising association Characteristics clinical parameter coronavirus disease Coronavirus disease 2019 COVID-19 damage direct infection epithelial Factor Factors fatty Fatty acid granular Injury involved kidney liver marker mechanisms microglobulin neutrophil Non-COVID-19 non-specific Particle Pathogenesis Patient Protein renal renal function renal injuries renal injury Sepsis severity of COVID-19 subject surgery Urine Urine sediment findings. with COVID-19 α1-microglobulin [DOI] 10.1016/j.ijid.2022.02.024 PMC 바로가기 [Article Type] Article
DAMPs/PAMPs induce monocytic TLR activation and tolerance in COVID-19 patients; nucleic acid binding scavengers can counteract such TLR agonistsDAMP/PAMP는 COVID-19 환자에서 단핵구 TLR 활성화 및 내성을 유도합니다. 핵산 결합 스캐빈저는 이러한 TLR 작용제에 대항할 수 있습니다.Article Published on 2022-04-012022-09-12 Journal: Biomaterials [Category] COVID19(2023년), SARS, 진단, [키워드] Activation agonist anti-viral response binding Blood CD16 COVID-19 COVID-19 patient COVID-19 patients damage Deceased Ex vivo hallmark hyperactivate Hyperactivation hyperinflammation Hyperstimulation ICU ICU patient immunopathology induce Infection Inflammation innate immune intensive care unit limit lung Lungs Major-biological sciences Minor-immunology and inflammation. monocyte Monocytes neutralize nucleic acid outcome patients pattern phenotype proteomics receptors RNA-sequencing SARS-CoV-2 Signaling systemic inflammation the patient TLR TLR agonist TLR stimulation Tolerance Toll-like receptor Treatment viruses [DOI] 10.1016/j.biomaterials.2022.121393 PMC 바로가기 [Article Type] Article
Blood Viscosity in COVID-19 Patients With Sudden Deafness급성 난청이 있는 COVID-19 환자의 혈액 점도Article Published on 2022-03-012022-09-11 Journal: Acta otorrinolaringologica española [Category] COVID19(2023년), SARS, 치료기술, [키워드] anamnesis Blood Blood viscosity carried change control group correlated COVID-19 COVID-19 patients Critical critical patients damage deafness diagnosis of COVID-19 Elevation English evaluated Follow-up healthy hearing loss Hipoacusia neurosensorial Hospital admission Hyperviscosity ICU ICU patient ICU Patients incidence Infection Inpatient limitation media normality Patient patients patients with COVID-19 predisposition prospectivo SARS-CoV-2 SARS-COV-2 infection sensorineural Sensorineural hearingloss severe complication severe complications Sordera súbita Spanish statistically significant subjects sudden Sudden deafness Tone Viscosidad sanguínea. viscosity Volume with COVID-19 [DOI] 10.1016/j.otoeng.2022.02.004 PMC 바로가기 [Article Type] Article
Successful Reversal of the 2020 Covid-19 Response Induced Collateral Damage on Malaria Control in Saudi ArabiaConference abstract Published on 2022-03-012022-10-05 Journal: International Journal of Infectious Diseases [Category] 유전자 메커니즘, [키워드] activities analyzed Anophele Can Collateral Control correlated Coverage COVID-19 COVID-19 pandemic damage Environment Epidemic indicated induced lockdown malaria malaria control management material one health outbreak pandemic Patient patients treated platform positive post intervention post-intervention precipitated Program protocol provided recorded reduction reductions in reflected residual response Result reversal Saudi Arabia Support Surveillance Transmission treated water WHO [DOI] 10.1016/j.ijid.2021.12.288 [Article Type] Conference abstract