Treatment provider perceptions of take-home methadone regulation before and during COVID-19Research article Published on 2021-11-012022-10-05 Journal: Drug and alcohol dependence [Category] SARS, 치료법, [키워드] Access to care adopted Analysis applied Care change coding Community COVID-19 COVID-19 pandemic deregulation disorder distribution dose effort expressed form iterative looser medication methadone maintenance treatment Opioid treatment program Other participant Patient Patient care patient safety professional Regulation response Result Substance use suggested supported Take-home medication Treatment was used while [DOI] 10.1016/j.drugalcdep.2021.109100 [Article Type] Research article
The cardiac molecular setting of metabolic syndrome in pigs reveals disease susceptibility and suggests mechanisms that exacerbate COVID-19 outcomes in patients돼지에서 대사 증후군의 심장 분자 설정은 질병 감수성을 나타내며 환자에서 Covid-19 결과를 악화시키는 메커니즘을 제안합니다.Article Published on 2021-10-052022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] aggregation Analysis animal model Arterial thrombosis association Blood blood test blood tests capture cardiovascular disease cardiovascular diseases change Comorbidity Complement pathway component components computational analysis COVID-19 CVD deregulation develop diabete diabetes disease elevated enriched pathway enzyme exacerbate expressed greater hallmark hallmarks hypertension identity immune response investigated mechanism metabolic syndrome metabolite metabolites metabolomics molecular Myocardial Myocardium obese obesity outcome overexpressed pathophysiology Patient patients patients with COVID-19 PIGS Platelet platelet aggregation pro-inflammatory pro-inflammatory markers Protein proteomics reveal risk risk factor Risk factors RNA methylation susceptibility syndrome Therapeutic approach thrombosis transcriptomics virus viruses while [DOI] 10.1038/s41598-021-99143-w PMC 바로가기 [Article Type] Article
CD99 and polymeric immunoglobulin receptor peptides deregulation in critical COVID-19: A potential link to molecular pathophysiology?중요한 COVID-19에서 CD99 및 고분자 면역글로불린 수용체 펩티드 규제 완화: 분자 병태생리학에 대한 잠재적 연결?Multicenter Study Published on 2021-10-012022-09-11 Journal: Proteomics [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] affected alpha-1-antitrypsin analysed antitrypsin capillary electrophoresis CD99 change changes collagen collected comparable Course COVID-19 COVID-19 disease Critical deregulation disease disease severity effective endothelial endothelial disease endothelial integrity Europe heart failure hypothese hypotheses identification Immunoglobulin induce Inflammation Kidney disease kidney disease. mass spectrometry mechanisms molecular Molecular Disease molecular mechanisms multicentre pathophysiological mechanism pathophysiology Patient PCR-confirmed COVID-19 patient PCR-confirmed COVID-19 patients peptide peptides PIGR Prospective Study receptor Restoring significant changes in significantly similarities similarity specific inflammation Stage Therapeutic approach tissue Urine WHO [DOI] 10.1002/pmic.202100133 PMC 바로가기 [Article Type] Multicenter Study
Autoimmune Disorders & COVID-19Opinion Published on 2021-09-282022-10-29 Journal: Medicines [Category] COVID-19, [키워드] addition autoantibody Autoimmune Autoimmune disease Autoimmunity children condition coronavirus disease 19 Coronavirus disease 2019 COVID-19 COVID-19 complications COVID-19 infection deregulation Diseases excessive inflammation genetics higher risk Host immune system immunological mechanism increase Inflammatory instance MIS-C Neutralizing question raising Respiratory failure severe pneumonia susceptibility syndrome the cytokine storm the disease the SARS-CoV-2 virus Type I IFN viral infections virus [DOI] 10.3390/medicines8100055 PMC 바로가기 [Article Type] Opinion
Structural Analysis of SARS-CoV-2 ORF8 Protein: Pathogenic and Therapeutic ImplicationsGenetics Published on 2021-09-062022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] Activation approach contributing to COVID-19 COVID-19 mortality COVID-19 therapeutics current deregulation example function growth host cell IFN-I signaling Immunity immunological Impact MAPK mTORC1 ORF8 pathogenicity pathway Protein protein kinase reduce SARS-CoV-2 similarity structural biology the Spike therapeutic strategy Vaccine Viral protein [DOI] 10.3389/fgene.2021.693227 PMC 바로가기 [Article Type] Genetics
Nervous System-Systemic Crosstalk in SARS-CoV-2/COVID-19: A Unique Dyshomeostasis SyndromeNeuroscience Published on 2021-08-272022-10-31 Journal: Frontiers in Neuroscience [Category] COVID-19, [키워드] accelerated Atypical autonomic Autonomic nervous system brain region Cancer cellular combinatorial therapeutics component COVID-19 COVID-19 sequelae Critical care Crosstalk deregulation evolutionary processes FDA-approved drug fibrosis functional functions homeostasis homeostatic impairment in-hospital mortality Interaction manifestation nervous nervous system neurological organ parameter Phenotypes predicted Premature premature aging promote Regulatory renin-angiotensin system SARS-COV-2 infection SARS-CoV-2-host interactions subset syndrome systemic manifestation tissue tissue degeneration to define unique [DOI] 10.3389/fnins.2021.727060 PMC 바로가기 [Article Type] Neuroscience
COVID-19 Immunobiology: Lessons Learned, New Questions AriseImmunology Published on 2021-08-262022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Activation Adaptive immune response adaptive immune system Asymptomatic autoantibody Autoimmune Autoimmunity cellular cellular senescence complement COVID-19 COVID-19 patient cytokine deregulation disease Diseases driven by endothelial Endothelitis Evidence Factor heterogeneity immune immune deregulation immunothrombosis Inflammation Inflammatory cell death Inflammatory response interferon lesson Mortality NET New offer pathophysiology phenotypic platelet activation responses SARS-CoV-2 senescence severe COVID-19 severe disease spatiotemporal subsequent the disease Treatment variety [DOI] 10.3389/fimmu.2021.719023 PMC 바로가기 [Article Type] Immunology
Transcriptomic Analysis of HCN-2 Cells Suggests Connection among Oxidative Stress, Senescence, and Neuron Death after SARS-CoV-2 InfectionHCN-2 세포의 전사체 분석은 SARS-CoV-2 감염 후 산화 스트레스, 노화 및 신경 세포 사멸 간의 연관성을 시사합니다Article Published on 2021-08-252022-09-11 Journal: Cells [Category] MERS, SARS, 유전자 메커니즘, [키워드] analysis antioxidant Apoptosis blocking caspase caspase 3 CDK4 CDK6 CDKN2A Cell cell cycle cells cortical cell death decrease deregulation evaluate the effect explain followed by functions HCN-2 impairment increase in indicated KAT5 mechanism nervous system Neurological symptom Neurological symptoms Neuron neuronal neurons outcome oxidative stress pediatric PMAIP1 Potential treatment potential treatments Prevent PROTECT r death reduction reported required resulting ROS homeostasis SARS-CoV-2 SARS-COV-2 infection senescence SOD1 supported the cell Transcriptome transcriptomic analysis TXN upregulation virus western blot Western blot analysis [DOI] 10.3390/cells10092189 PMC 바로가기 [Article Type] Article
HMGB1-TIM3-HO1: A New Pathway of Inflammation in Skin of SARS-CoV-2 Patients? A Retrospective Pilot StudyArticle Published on 2021-08-162022-10-28 Journal: Biomolecules [Category] COVID-19, MERS, [키워드] Activation addition affected affecting CD4 CD8 COVID-19 deregulation develop expression greater health system heme HMGB1 HO-1 immune immunohistochemistry immunolabeling immunopathology increasingly Lungs manifestation marker morphology New not differ other organ patients positive reduced Result SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 positive patient SARS-CoV-2 positive patients significantly skin statistically subject Support T lymphocyte TIM-3 upper airway [DOI] 10.3390/biom11081219 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Infected Pediatric Cerebral Cortical Neurons: Transcriptomic Analysis and Potential Role of Toll-like Receptors in PathogenesisSARS-CoV-2에 감염된 소아 대뇌 피질 뉴런: 전사체 분석 및 병인에서 유료 유사 수용체의 잠재적 역할Article Published on 2021-07-282022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] ACE2 caspase caspase 8 cells cerebral changes in chemokine chemokines children cortical COVID-19 neurological symptom COVID-19 neurological symptoms deregulation downregulated downregulation downstream ERK expression genes encoding human neuronal cells IKKε increase in increased expression infect infected with SARS-CoV-2 IRF3 JNK mechanism medium nervous system Neurological involvement Neurological symptoms Neuron neuronal next generation sequencing NF-κB Nod-like receptors not express Pathogenesis Pattern recognition pattern recognition receptor pediatric Potential receptor receptors replicate responsible role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins scavenger receptors Sequencing Signaling TLR TLR1 TLR4 TLR6 TLRs TMPRSS2 Toll-like receptor Toll-like receptors TRAF3 transcriptomic analysis transcriptomic profile upregulated upregulation Viral Viral RNA western blot [DOI] 10.3390/ijms22158059 PMC 바로가기 [Article Type] Article