Control of CDH1/E-Cadherin Gene Expression and Release of a Soluble Form of E-Cadherin in SARS-CoV-2 Infected Caco-2 Intestinal Cells: Physiopathological Consequences for the Intestinal Forms of COVID-19SARS-CoV-2에 감염된 Caco-2 장 세포에서 CDH1/E-Cadherin 유전자 발현 및 가용성 형태의 E-Cadherin 방출 제어: COVID-19의 장 형태에 대한 생리병리학적 결과Article Published on 2022-05-042022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술, 치료제, [키워드] 24 hour 24 hours 48 hour 48 hours ACE2 ACE2 mRNA Affect AT1 Caco-2 Caco-2 cell Caco-2 cells cadherin CDH1 Cell cell line cells Co-receptor connexin consequence contributing to Control COVID-19 Culture culture supernatant diarrhoea diarrhoea) digestive tract Disruption dissemination down-regulated dysregulation E-cadherin ENCODE epithelial exposure to expresse expression form Gastrointestinal symptom gastrointestinal symptoms gastrointestinal tract HCoV HCoV-OC43 HLA class I human ACE2 illnesses in viral induce infected with SARS-CoV-2 Infection intestinal Intestinal barrier intestinal cells intestinal tissue intranasal involved JAMA junctions leads membrane mRNA mRNA expression OC43 occludin pandemic Patient Physiopathological Post-infection Protein receptor receptor ACE2 Release remained reported respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection significant increase significantly lower Symptom the disease these symptoms TMPRSS2 Transcription transgenic mice Trigger Viral viral entry virus [DOI] 10.3389/fcimb.2022.798767 PMC 바로가기 [Article Type] Article
Ruxolitinib in addition to standard of care for the treatment of patients admitted to hospital with COVID-19 (RUXCOVID): a randomised, double-blind, placebo-controlled, phase 3 trialResearch article Published on 2022-05-012022-10-05 Journal: The Lancet Rheumatology [Category] 임상, 치료법, [키워드] 95% CI acute respiratory distress addition Adverse age analysed assigned baseline benefit clinical status composite endpoint Concentration covariates COVID-19 Cytokine dysregulation Cytokine release syndrome death determine diarrhoea died disease disorder double-blind Efficacy event Exploratory analysis faster female finding funding hazard ratio headache hospital hospitalised ICU care Incyte Inflammatory cytokine inhibitor intensive care International invasive ventilation JAK1/JAK2 inhibitor Janus kinase Logistic regression male median time myelofibrosis nine Novartis occurred Odds ratio on mechanical ventilation Patient patients patients with COVID-19 per day phase 3 trial Placebo placebo-controlled primary endpoint randomised Randomly reduce Registered required Respiratory failure ruxolitinib secondary hemophagocytic lymphohistiocytosis Sex Standard of care study population subgroups the mean Treatment Trial with COVID-19 [DOI] 10.1016/S2665-9913(22)00044-3 [Article Type] Research article
Diarrhoeal pathogenesis in Salmonella infection may result from an imbalance in intestinal epithelial differentiation through reduced Notch signallingarticle Published on 2022-04-302024-09-01 Journal: Translational Neuroscience [Category] 살모넬라증, [키워드] diarrhoea down-regulated in adenoma enteroid foodborne illness intestinal transport Salmonella [Article Type] article
Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study Research Published on 2022-04-272022-10-05 Journal: Scientific Reports [Category] 유전자 메커니즘, 진단, 치료법, [키워드] 30-Day mortality affecting Analysis applied approach association clinical Clinical data clinical symptom clinically Clustering Community Confusion cough COVID-19 determine diagnostic diarrhoea disease duration of symptom Dyspnoea fatigue female Fever Gastrointestinal symptom granular hospitalised hospitalised patient identify in-hospital mortality Interpretation ISARIC Mild Mortality no symptoms observation Older organ system Patient pauci-symptomatic presentation presenting prospective cohort recruited recruitment Replication replication analysis reported robust self-reported symptom Symptom Symptoms therapeutic Unsupervised clustering utility vomiting with COVID-19 [DOI] 10.1038/s41598-022-08032-3 [Article Type] Research
Gastrointestinal, hepatic and pancreatic manifestations of COVID-19 in children소아에서 COVID-19의 위장, 간 및 췌장 발현Review Published on 2022-04-012022-09-11 Journal: Clinics and research in hepatology and gastroenter [Category] COVID19(2023년), SARS, 치료기술, [키워드] abdominal pain acute respiratory syndrome acute respiratory syndrome coronavirus analysed Asymptomatic children coronavirus disease Coronavirus disease-19 Coronavirus-19 Coronavirus-2 COVID-19 diarrhoea Evidence faece Faeces Gastrointestinal Inflammatory liver manifestation nausea pancreas pancreatic pathogen Patient recent respiratory sample Respiratory samples respiratory tract SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 shown syndrome tested Transmission vomiting [DOI] 10.1016/j.clinre.2021.101818 PMC 바로가기 [Article Type] Review
The repurposing of Tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug-resistant Shigella spp테비페넴 피복실을 광범위 약물 내성 시겔라 spp.에 의해 유발된 중증 위장관 감염에 대한 대체 요법으로 재목적화하기Article Published on 2022-03-152024-07-30 Journal: eLife [Category] 세균성이질, [키워드] carbapenems diarrhoea Drug discovery dysentery multi-drug resistance Other Shigella spp [DOI] 10.7554/eLife.69798 PMC 바로가기
Harnessing the Natural Toxic Metabolites in COVID-19Review Article Published on 2022-03-072022-10-31 Journal: Evidence-based Complementary and Alternative Medicine : eCAM [Category] COVID-19, [키워드] ACE2 receptor acute respiratory distress ARDS caused Cell China city cough COVID-19 COVID-19 disease COVID-19 symptoms diarrhoea disease Dry Effect evaluated fatigue Fever headache lung natural Novel coronavirus Pain pathophysiology pharmacological SARS-CoV-2 sore throat syndrome toxic toxins Transmission Treatment Wuhan [DOI] 10.1155/2022/3954944 PMC 바로가기 [Article Type] Review Article
Adverse effects of remdesivir, hydroxychloroquine and lopinavir/ritonavir when used for COVID-19: systematic review and meta-analysis of randomised trialsCOVID-19에 렘데시비르, 하이드록시클로로퀸 및 로피나비르/리토나비르를 사용할 때의 부작용: 무작위 시험의 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-03-022022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] 95% CI Acute kidney injury Adverse adverse effect adverse events approach cardiac toxicity certainty certainty of evidence cognitive conducted COVID-19 database delirium diarrhoea Diseases drug Effect enrolled Evidence Hydroxychloroquine increase Infectious diseases information Intervention Lopinavir Lopinavir/ritonavir management Meta-analysis moderate nausea outcome pairwise meta-analysis patients patients with COVID-19 Placebo Randomised trial randomised trials recommendation Remdesivir risk risk difference Ritonavir searched standard care Support systematic review vomiting [DOI] 10.1136/bmjopen-2020-048502 PMC 바로가기 [Article Type] Meta-Analysis
SARS-CoV-2 seroprevalence in children and their family members, July-October 2020, Brussels아동 및 가족 구성원의 SARS-CoV-2 혈청 유병률, 2020년 7월-10월, 브뤼셀Article Published on 2022-03-012022-09-12 Journal: European journal of pediatrics [Category] MERS, SARS, 진단, [키워드] 95% CI Adults Anosmia antibody Asymptomatic Belgium blood sample children Clusters comparable COVID-19 infection diarrhoea ELISA Familial Familial transmission Fever Final General population generally mild identify Immunoglobulin infected children Mild p-value < 0.01 pandemic parent Patient pediatric questionnaire responsible SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 seroprevalence second wave serological serological results Seroprevalence severe disease source of infection Symptom symptomatic Symptoms tested their family members Transmission with COVID-19 [DOI] 10.1007/s00431-021-04284-9 PMC 바로가기 [Article Type] Article
Associations Between Symptoms, Donor Characteristics and IgG Antibody Response in 2082 COVID-19 Convalescent Plasma Donors2082년 COVID-19 회복기 혈장 기증자의 증상, 기증자 특성 및 IgG 항체 반응 간의 연관성Observational Study Published on 2022-02-282022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] age Anosmia antibodies antibody Antibody Response association average body mass index CCP Characteristics concentrations convalescent plasma COVID COVID-19 COVID-19 symptom diarrhoea disease Donor donors dry cough Dyspnoea faster fatigue female Fever headache IgG IgG antibody less linear longitudinal male mixed-effects model MOST nasal outcome Patient performed questionnaire reported response retrospective SARS-CoV-2 antibody severity of COVID-19 Symptom Symptoms the SARS-CoV-2 unique weakness [DOI] 10.3389/fimmu.2022.821721 PMC 바로가기 [Article Type] Observational Study