Anti-SARS-CoV-2 Omicron Antibodies Isolated from a SARS-CoV-2 Delta Semi-Immune Phage Display LibraryArticle Published on 2022-02-102022-10-27 Journal: Antibodies [Category] COVID-19, [키워드] ACE2 antibodies antibody B.1.1.529 B.1.617.2 binding blocked convalescent convalescent patient COVID-19 COVID-19 patient COVID-19 symptoms cross-reactive cross-reactive antibody Delta display domain enzyme human IgG1 IGHV immune Inc. infected with SARS-CoV-2 Infection Isolated library neutralize omicron Patient phage phage display profiles PROTECT provide RBD Receptor-binding domain (RBD) SARS-CoV-2 SARS-CoV-2 neutralization scFv Seven single dose the antibody the RBD the SARS-CoV-2 therapeutic therapeutic antibodies unique Vaccine VOCs were used wildtype [DOI] 10.3390/antib11010013 PMC 바로가기 [Article Type] Article
In vitro data suggest that Indian delta variant B.1.617 of SARS-CoV-2 escapes neutralization by both receptor affinity and immune evasion시험관 내 데이터에 따르면 SARS-CoV-2의 인도 델타 변이체 B.1.617은 수용체 친화성과 면역 회피 모두에 의해 중화를 피합니다Article Published on 2022-01-012022-09-11 Journal: Allergy [Category] SARS, 변종, [키워드] ACE2 affinity Anti-RBD IgG antibodies antibody B.1.351 B.1.617 binding binding affinity Binding assays BLI BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine cell receptor convalescent correlated COVID-19 convalescent donor COVID-19 convalescent donors delta variant display E484K ectodomain Effect ELISA glycoprotein higher affinity immune evasion Immunity immunization immunized Inhibition assays Interaction Interferometry L452R less main receptor mRNA vaccine mutant mutated Mutation natural infection neutralization occur P.1 Point mutation produced RBD RBD-ACE2 RBDs receptor Receptor-binding domain recognize reduced SARS-CoV-2 SARS-CoV-2 variant sera shown single mutant subject Substitution substitutions the binding affinity the RBD the receptor-binding domain the Spike Transmissibility vaccination Vaccine variant variants variants of concern Virus neutralization wild-type wild-type virus [DOI] 10.1111/all.15065 PMC 바로가기 [Article Type] Article
Rapid characterization of spike variants via mammalian cell surface displayTechnology Published on 2021-12-162022-10-31 Journal: Molecular Cell [Category] COVID-19, SARS, [키워드] Abstract accelerate ACE2 ACE2 binding Alanine Alpha antibody Antigen antigenicity B.1.1.28 B.1.1.7 B.1.351 B.1.617.2 cell display circulating variant convalescent plasma COVID-19 Critical display ectodomain epitope epitope mapping expression FIVE glycosylated highlight immune system immunogenic mammalian cell Mutagenesis Mutation N-terminal domain neutralizing antibody neutralizing monoclonal antibody NTD peptide platform Proteins Rapid Receptor-binding domain SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein spike spike variant spike variants Threats Vaccine variant variants variants of concern viral glycoproteins [DOI] 10.1016/j.molcel.2021.11.024 PMC 바로가기 [Article Type] Technology
SARS-CoV-2 Delta Variant Displays Moderate Resistance to Neutralizing Antibodies and Spike Protein Properties of Higher Soluble ACE2 Sensitivity, Enhanced Cleavage and Fusogenic ActivityArticle Published on 2021-12-112022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ACE2 activity antibody antigenic distance AY.1 B.1.351 B.1.526 B.1.617 B.1.617 variants B.1.617.1 B.1.617.2 cleavage Complete contribute convalescent sera Delta delta variant display dominant effective enhanced exhibited greater India Infection Lineage mRNA mRNA-based vaccine neutralization neutralization resistance Neutralizing antibodies neutralizing antibody P.1 P681R property pseudovirus Pseudovirus neutralization assay pseudoviruses reduction reduction in resistance SARS-CoV-2 second wave sensitivity sera soluble ACE2 spike spike cleavage Spike protein Spread syncytia formation tested therapeutic variant variants [DOI] 10.3390/v13122485 PMC 바로가기 [Article Type] Article
A Mycobacteriophage-Based Vaccine Platform: SARS-CoV-2 Antigen Expression and DisplayArticle Published on 2021-11-232022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] administration Antigen characterized described display displaying Efficacy infectious agents intravenous mycobacteriophage Neutralizing antibodies phage phage display vaccine platform protein antigens recombinant safety profile SARS-CoV-2 SARS-COV-2 infection spike Vaccine Vaccine development variety [DOI] 10.3390/microorganisms9122414 PMC 바로가기 [Article Type] Article
One dose of COVID-19 nanoparticle vaccine REVC-128 protects against SARS-CoV-2 challenge at two weeks post-immunizationCOVID-19 나노입자 백신 REVC-128의 1회 용량은 면역화 후 2주에 SARS-CoV-2 공격으로부터 보호합니다Research Article Published on 2021-10-312022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 변종, 진단, [키워드] alleviation animals antibody-dependent enhancement (ADE) antigenic binding body weight caused COVID-19 COVID-19 vaccine cross-reactive antibody display dose ectodomain Evidence evidence of glycine golden hamster hamster hamsters immunization immunized indicate induce less mice nanoparticle nanoparticle vaccine Neutralizing one-dose regimen position PROTECT Protein RBD Receptor-binding domain resulting S2 subunit Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus serum Serum neutralizing antibody significantly higher single dose single-shot vaccine Spike protein subunit subunits suppressed the SARS-CoV-2 virus tissue damage titre trimeric spike Trimeric spike protein vaccination Vaccine vaccine candidate vaccine safety vaccine stability Vaccines variants Viral Viral load viral loads viral spread weight loss [DOI] 10.1080/22221751.2021.1994354 PMC 바로가기 [Article Type] Research Article
An outbreak of appreciation: A discursive analysis of tweets of gratitude expressed to the National Health Service at the outset of the COVID‐19 pandemicOriginal Article Published on 2021-09-202022-11-01 Journal: Health Expectations : An International Journal of Public Participation in Health Care and Health Policy [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] Affect Analysis approach Care coronavirus disease corpus COVID‐19 COVID‐19 detrimental effect discursive psychology display driver early stage Effect effort expressed expressing gratitude healthcare implicated lockdown media mental health National Health Service NHS objective outbreak pandemic provided Public receiving Result risk Topic Twitter United Kingdom [DOI] 10.1111/hex.13359 PMC 바로가기 [Article Type] Original Article
Association of Visual Display Terminal Usage with Self-Rated Health and Psychological Distress among Japanese Office Workers during the COVID-19 PandemicArticle Published on 2021-09-062022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] 95% confidence interval activity age Analysis applied association conducted COVID-19 COVID-19 pandemic cross-sectional deteriorate display Health Japan Japanese less mental health moderate multiple logistic regression occupational health Odds ratio office Physical health Psychological distress psychological health reduce screen time terminal Usage Visual was used worker Workplace [DOI] 10.3390/ijerph18179406 PMC 바로가기 [Article Type] Article
Convalescent COVID-19 Patients Without Comorbidities Display Similar Immunophenotypes Over Time Despite Divergent Disease Severities동반 질환이 없는 회복기 COVID-19 환자는 다양한 질병 중증도에도 불구하고 시간이 지남에 따라 유사한 면역 표현형을 나타냅니다Immunology Published on 2021-08-192022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료기술, [키워드] abrogation affected analyzed asymptomatic infection caused Comorbidities convalescence convalescent convalescent COVID-19 patient convalescent COVID-19 patients correlated COVID-19 COVID-19 cohort detectable disease course disease severity disease severity assessment display flow cytometric Host immune response immune immune signature immunological immunomonitoring immunophenotype Infection majority mononuclear cell mononuclear cells over Patient PBMCs Peripheral blood Peripheral blood mononuclear cells phenotype Respiratory failure risk factor SARS-CoV-2 SARS-COV-2 infection serum severe respiratory failure stratified T cells the disease time transcriptomics unique [DOI] 10.3389/fimmu.2021.601080 PMC 바로가기 [Article Type] Immunology
IFN-λ1 Displays Various Levels of Antiviral Activity In Vitro in a Select Panel of RNA VirusesArticle Published on 2021-08-122022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] activity addition administration AdV Antiviral antiviral activity Antiviral effect Attention cells cellular CHIKV Concentration cytokine decrease display epithelial cells examined heterodimeric highlight IFN-lambda IFN-α IFN-λ IFN-λ1 IFNs immune system cells Influenza virus inhibited interferon Level likelihood limit Panel protective effect receptor reducing respiratory RNA viruses restrict RNA SARS-CoV-2 SARS-CoV-2 replication shown Side effect therapeutic Treatment Type I IFN type III interferon Vero Cell viral genome replication viral infection Viral load were used [DOI] 10.3390/v13081602 PMC 바로가기 [Article Type] Article