DNA replication – Page 2 – Communicable Diseases Research

Profiling Ribonucleotide and Deoxyribonucleotide Pools Perturbed by Remdesivir in Human Bronchial Epithelial Cells

Pharmacology

Published on 2021-05-042022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] Activation acute respiratory syndrome addition Affect antiviral efficacy BEAS-2B BEAS-2B cell bronchial caused cell cycle arrest cellular click chemistry Concentration coronavirus coronavirus disease COVID-19 COVID-19 therapy cytidine Deoxyribonucleotide DNA DNA replication Effect Efficacy ENhance exacerbating hospitalized patient host cells Human implication increase in Infection inhibit inhibition of CTP synthase inhibition of RNA and DNA synthesis limit moderate monophosphate nucleotide nucleotides perturbation of nucleotide pools pool precursor Profiling purine RDV Remdesivir Replication resulting ribonucleotide ribonucleotides RNA SARS-CoV-2 survival rate Transcription Treatment Variation viral nucleic acids Viral RNA virus replication were measured
[DOI] 10.3389/fphar.2021.647280 PMC 바로가기 [Article Type] Pharmacology

Screened antipsychotic drugs inhibit SARS-CoV-2 binding with ACE2 in vitro

Research article

Published on 2021-02-012022-10-05
Journal: Life sciences [Category] SARS, 신약개발,

[키워드] ACE2 ACE2 protein acting Amino acid antipsychotic antipsychotic drug Antipsychotic drugs Antiviral antiviral activity APD applied bind binding binding site cell membrane cells CMC compounds coronavirus coronavirus disease COVID-19 COVID-19 infection demonstrated detect DNA replication drug Drug repurposing drugs effective exhibited FIVE globe Hepatitis B virus HIV infection host cell in vitro inhibit inhibit SARS-CoV-2 MERS-CoV molecular docking pandemic Phenothiazines protective effect pseudotype virus Replication reported SARS-CoV SARS-CoV-2 screened selected Significance significantly subsequent synergistic therapy tiapride virus
[DOI] 10.1016/j.lfs.2020.118889 [Article Type] Research article

Mechanisms of inhibition of viral RNA replication by nucleotide analogs

뉴클레오티드 유사체에 의한 바이러스 RNA 복제 억제 메커니즘

Review

Published on 2021-01-012022-09-11
Journal: The Enzymes [Category] 유전자 메커니즘, 치료제,

An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2

DNA 복구-복제 인터페이스 및 SARS CoV-2를 표적으로 하는 핵산 효소에 대한 구조 기반 억제제에 대한 효율적인 화학적 스크리닝 방법

Article

Published on 2021-01-012022-09-11
Journal: Molecules [Category] Coronavirus, 유전자 메커니즘,

[키워드] Absorption ADME ADP-ribose affinity approach approved Cancer cancer cell Cancer cells Cassandra CASSIE Cell Chemical Chemical library Chemistry classical Compound defined distribution DNA DNA replication DNA replication and repair docking drug drug design Drug discovery effective effort enzyme excretion facilitate human protein human proteins increasingly inhibitor inhibitors iterative Mac1 macrodomain mechanism metabolism molecular nonstructural protein 3 Nsp3 nucleic acid optimization PARG Pathogenesis pathway predicted problem profiles protein 3 Proteins provide repair ribose RNA SARS CoV SARS CoV-2 SARS-CoV2 Screen screening method specific inhibitor specific inhibitors Structure structures target to define
[DOI] 10.1016/bs.mie.2021.09.003 PMC 바로가기 [Article Type] Article

IL-18 variant increases risk of enhanced HBV DNA replication in chronic hepatitis

Article

Published on 2020-12-012023-06-12
Journal: Immunology letters [Category] B형 간염,

[키워드] Chronic HBV infection DNA replication Interleukin-18 polymorphism susceptibility
[DOI] 10.1016/j.imlet.2020.10.002

HMGB1: A pleiotropic activity

HMGB1: 다면발현성 활동

Article

Published on 2020-11-012022-09-11
Journal: Pediatric allergy and immunology : official public [Category] SARS, 진단, 치료기술, 치료제,

Characterization of Streptococcus pneumoniae PriA helicase and its ATPase and unwinding activities in DNA replication restart

스트렙토코쿠스 뉴모니아 프리아 헬리케이스의 특성화 및 DNA 복제 재시작에서의 ATPase 및 풀림 활성을 연구하다

Article

Published on 2020-10-162024-08-24
Journal: Biochemical Journal [Category] 폐렴구균 감염증,

[키워드] DNA helicase DNA replication primosome protein replication restart.

Consensus transcriptional regulatory networks of coronavirus-infected human cells

Analysis

Published on 2020-09-222022-10-29
Journal: Scientific Data [Category] COVID-19, SARS,

A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission

다양한 사이클린/사이클린 의존성 키나제 복합체가 생식세포 형성과 전파 동안 말라리아 기생충의 비정상적인 복제를 조절한다.

Article

Published on 2020-06-222024-08-11
Journal: eLife [Category] 말라리아,

[키워드] cell cycle cyclin-dependent kinase DNA replication gametogenesis Other Plasmodium Transmission
[DOI] 10.7554/eLife.56474 PMC 바로가기

The nucleoid occlusion factor Noc controls DNA replication initiation in Staphylococcus aureus

nucleoid occlusion factor Noc는 황색 포도구균에서 DNA 복제 개시를 조절합니다

Research Article

Published on 2017-07-192022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,