Borneol Ester Derivatives as Entry Inhibitors of a Wide Spectrum of SARS-CoV-2 Viruses광범위한 SARS-CoV-2 바이러스의 진입 억제제로서의 보르네올 에스테르 유도체Article Published on 2022-06-142022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료제, [키워드] antiviral activity binding site borneol carried Compound conserved coronavirus coronavirus surface protein S-spike Delta derivative domain early stage early stages ester glycoprotein Glycoproteins heptad repeat Ligand ligands molecular molecular docking molecular dynamics nitrogen omicron protein S pseudoviral system Region SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2 virus strains SARS-CoV-2 viruses searched Spectrum strain Strains suggested surface protein terpene the SARS-CoV-2 virus viral replication Wuhan [DOI] 10.3390/v14061295 PMC 바로가기 [Article Type] Article
Promising Therapeutic Approach for SARS-CoV-2 Infections by Using a Rutin-Based Combination Therapy루틴 기반 조합 요법을 사용하여 SARS-CoV-2 감염에 대한 유망한 치료 접근 방식Article Published on 2022-06-032022-09-11 Journal: ChemMedChem [Category] COVID19(2023년), SARS, 치료제, [키워드] Acetylsalicylic acid addition Administered antioxidants Antiviral Antiviral agents Bacterial calcium combating combination therapy components compounds described early stage early stages flavonoids host cell indication Infection inhibit Magnesium molecular molecular recognition natural natural products noncovalent interactions offer prophylactically provide rutin Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe disease progression targets Therapeutic approach therapy viruses Vitamin C Vitamin D vitamins [DOI] 10.1002/cmdc.202200157 PMC 바로가기 [Article Type] Article
Proficiency testing for SARS-CoV-2 in assuring the quality and overall performance in viral RNA detection in clinical and public health laboratories임상 및 공중 보건 실험실에서 바이러스 RNA 검출의 품질 및 전반적인 성능을 보장하기 위한 SARS-CoV-2에 대한 숙련도 테스트Article Published on 2022-06-012022-09-11 Journal: Pathology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus assays assist Australasia change choice college Concordance confidence coronavirus demonstrated diagnostic testing early stage early stages FIVE Genes house improvement in viral Inconclusive increase in initial Laboratory medium New nucleic acid offered pandemic participant Pathologists positive produced proficiency testing Program progressed protocol protocols provided public health Quality Quality assurance Result RNA SARS-CoV-2 selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown specimen specimens Viral detection Viral load viral loads [DOI] 10.1016/j.pathol.2022.01.006 PMC 바로가기 [Article Type] Article
Repair of acute respiratory distress syndrome by stromal cell administration (REALIST): a structured study protocol for an open-label dose-escalation phase 1 trial followed by a randomised, triple-blind, allocation concealed, placebo-controlled phase 2 trial간질 세포 투여에 의한 급성 호흡 곤란 증후군의 회복(REALIST): 공개 라벨 용량 증량 1상 시험에 이어 무작위, 삼중 맹검, 할당 은폐, 위약 대조 2상 시험을 위한 구조화된 연구 프로토콜Article Published on 2022-05-132022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 acute respiratory distress acute respiratory distress syndrome administration allocation ARDS benefit blind causes Cell cells clinical clinical trial Cohort cohort of patient cohorts of patients concealed CONSORT COVID-19 distress dose dose-escalation early stage early stages Efficacy EudraCT Good immunomodulatory incidence include Mesenchymal stem cells Mesenchymal stromal cell Mesenchymal stromal cells moderate to severe MSC MSCs multicentre NHS number Open-label outcome outlined oxygenation index patients patients with moderate Phase 1 phase 1 trial Phase 2 phase 2 trial Placebo placebo-controlled placebo-controlled trial Practice produced protocol randomised rationale receive recruited recruitment repair reported Reporting respiratory distress Respiratory distress syndrome Serious Adverse Events severe ARDS Standard stromal cell stromal cells Study protocol syndrome therapy Trial triple-blind umbilical Umbilical cord [DOI] 10.1186/s13063-022-06220-0 PMC 바로가기 [Article Type] Article
New Psychoactive Substances and receding COVID-19 pandemic: really going back to “normal”?새로운 정신 활성 물질과 코로나19 대유행 퇴조: 정말 "정상"으로 돌아가는가?Article Published on 2022-05-112022-09-11 Journal: Acta bio-medica : Atenei Parmensis [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Abuse agency analogue Analysis appear approach arising available data benzimidazole can not Case report case reports Characteristics check circumvent clonitazene club compounds COVID-19 COVID-19 pandemic criminal criminality Dark Web death deaths derivative detectable detection system disorders diversion dosages drug Drug Abuse early stage early stages ecosystem Effect effective Effects effort Endemic etonitazene European Exacerbation fatality fentanyl FIVE form Health Service Health services healthcare implicated implication increasingly information Interaction involved isotonitazene less magnitude mechanism media metonitazene mistake Mortality New nine NMR NPs opioid opioids Opioids abuse overdose pandemic Probing public health public health emergency Public health responses receptor reduction Reduction potential replicate Research resource rising risk Scientific community seeking selected significantly more social media Still Stress substance substance abuse supply supply and demand Surveillance the SARS-CoV-2 traffickers turn urgency user experience variants web-based platform X-ray diffraction [DOI] 10.23750/abm.v93i2.13008 PMC 바로가기 [Article Type] Article
Efficient Framework for Detection of COVID-19 Omicron and Delta Variants Based on Two Intelligent Phases of CNN ModelsCNN 모델의 두 가지 지능형 단계를 기반으로 하는 COVID-19 오미크론 및 델타 변이체 감지를 위한 효율적인 프레임워크Article Published on 2022-04-212022-09-11 Journal: Computational and Mathematical Methods in Medicine [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Accuracy Algorithm Asia assist caused CNN collapse complex Convolutional neural network COVID-19 COVID-19 diagnosis COVID-19 pandemic CT scan CT scans deep learning Delta delta variant Delta variants detection Detection sensitivity diagnostic Diagnostic method diagnostic methods diagnostic testing dramatic increase early stage early stages efficient evaluated faster feature framework health-care identify less Middle East Model non-COVID-19 case non-COVID-19 cases omicron Pandemics parameter patients phase radiologist Radiologists researcher significantly specificity test dataset the disease transfer variant were used while X-ray [DOI] 10.1155/2022/4838009 PMC 바로가기 [Article Type] Article
IoT-Enabled Framework for Early Detection and Prediction of COVID-19 Suspects by Leveraging Machine Learning in Cloud클라우드에서 기계 학습을 활용하여 COVID-19 의심의 조기 탐지 및 예측을 위한 IoT 지원 프레임워크Article Published on 2022-04-122022-09-11 Journal: Journal of Healthcare Engineering [Category] 치료기술, [키워드] Accuracy advancement Algorithm Algorithms calculated cloud collected conducted COVID-19 COVID-19 virus Data collection dataset Decision tree detect detection diagnostic early stages effective Efficiency experiment FIVE framework globe health parameter health parameters Healthcare system Healthcare systems Internet Logistic regression machine learning naïve Naïve Bayes outbreak Performance metrics Precision prediction reactive real time recall root searched selected shown Support SVM symptomatic Symptoms the disease virus [DOI] 10.1155/2022/7713939 PMC 바로가기 [Article Type] Article
Transmission dynamics of COVID-19 in household and community settings in the United Kingdom, January to March 20202020년 1월부터 3월까지 영국의 가정 및 지역 사회 환경에서 COVID-19의 전파 역학Article Published on 2022-04-012022-09-11 Journal: Eurosurveillance [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] 95% CI age Asia attack attack rate Community confirmed case confirmed cases Contact COVID-19 COVID-19 transmission early stage early stages form Health Organization highest highlight household household contacts household transmission Incubation Incubation period individual interval mean incubation period outcomes pandemic preventative measure preventative measures protocol reported reproduction Reproduction number reproduction numbers risk SAR secondary secondary attack rate secondary cases Serial interval Study design Surveillance symptoms of COVID-19 Transmission dynamics United Kingdom World Health Organization [DOI] 10.2807/1560-7917.ES.2022.27.15.2001551 PMC 바로가기 [Article Type] Article
Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19-convalescent individuals세로 방향 면역 프로파일링은 COVID-19 회복기 개인의 장기 체액성 면역을 매개하는 지배적인 에피토프를 나타냅니다Article Published on 2022-04-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus Analysis antibody Antibody Response caused circulating variants concerning contagious coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients COVID-19-convalescent individual COVID-19-convalescent individuals cytokine cytokine production diagnostic disease onset dissect dominant dominant epitope early stage early stages endemic human coronavirus endemic human coronaviruses epitope Epitopes fatality feature global pandemic highly pathogenic humoral humoral immune responses Humoral immunity immune immune profiling immune response immune responses Immunity individual induce Kinetics long-term immune response long-term immune responses Longevity longitudinal longitudinal analysis mapped moderate moderate symptoms N-terminal domain Neutralizing antibodies neutralizing antibody ORF1ab path patients peptide peptide microarray performed Protein Proteins proteome proteome-wide peptide microarray. reactive respiratory responsible reveal S1 subunit S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein sequence homology sequence identity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown specific antibodies Spike protein sustained symptoms of COVID-19 the early SARS-CoV-2 the S1 subunit the SARS-CoV-2 Vaccine design Wuhan-Hu-1 [DOI] 10.1016/j.jaci.2022.01.005 PMC 바로가기 [Article Type] Article
Automated System for Identifying COVID-19 Infections in Computed Tomography Images Using Deep Learning ModelsArticle Published on 2022-03-302022-11-16 Journal: Journal of Healthcare Engineering [Category] 치료기술, [키워드] Accuracy Affect assist Clinical symptoms CNN Combination complications Contact Coronavirus disease 2019 COVID-19 COVID-19 cases COVID-19 virus criteria dataset deep deep learning determine develop diagnose diagnostic disease domain early stages epidemiological Fatality rate Final healthcare highest identifying Image Incubation period Laboratory test learning Model Modification nucleic acid amplification outcome Patient sensitivity specificity System this system tomography was used [DOI] 10.1155/2022/5329014 PMC 바로가기