A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate responseArticle Published on 2022-12-212022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] adaptive alveolar alveolar cells antibodies antibody antibody concentration baseline Cell cell death Cellular automaton COVID-19 develop diffusion domain Efficacy Future Gas exchange healthy human lung Immune cell immune protection immune response Immunity infected cell Infection initial Innate innate immune Innate immunity innate response Interaction interferon interferons lung alveolar maintain manuscript mechanism Model multiple mechanism outcome Pneumonia produced profiles progression Result RNA copy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant simulations. Spread Strains submitted switching T cells the SARS-CoV-2 virus two-dimensional type I Viral load virion virions [DOI] 10.1016/j.jtbi.2022.111293 PMC 바로가기
An EUA for anakinra (Kineret) for COVID-19Article Published on 2022-12-122023-07-11 Journal: The Medical letter on drugs and therapeutics [Category] COVID19(2023년), [키워드] actemra adverse effects Anakinra Baricitinib Corticosteroids COVID-19 Dexamethasone dosage Drug interactions Efficacy lactation Olumiant Pregnancy Remdesivir Safety tocilizumab. Veklury PMC 바로가기
Sewage surveillance of SARS-CoV-2 at student campus residences in the Western Cape, South AfricaArticle Published on 2022-12-102022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] activity acute respiratory syndrome Cape collected coronavirus coronavirus disease country COVID-19 defined Delta diagnostic Efficacy Epidemiology evaluated genotyping Infection infections institution management monitoring Near-source WBE omicron outbreak Passive Passive sampling reported RT-qPCR SARS-CoV-2 sewage South Africa Stellenbosch Stellenbosch University student Student campus residences Surveillance Thermo Fisher variant wastewater Wastewater-based epidemiology. [DOI] 10.1016/j.scitotenv.2022.158028 PMC 바로가기
Early treatment of Favipiravir in COVID-19 patients without pneumonia: a multicentre, open-labelled, randomized control studyArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] 95% CI adjusted hazard ratio Antiviral antiviral. ARMS clinical clinical condition Clinical improvement complications control arm COVID-19 COVID-19 patient Day defined early treatment Effect Efficacy enrolled enrolment faster Favipiravir female FPV investigated likelihood median median time mild case mild pneumonia multicentre Patient PCR-confirmed Pneumonia primary endpoint randomized control study RdRP RdRp inhibitor registry risk of COVID-19 SARS-CoV-2-infected patient score significantly higher supportive care sustained symptomatic Thailand Treatment viral clearance Viral detection [DOI] 10.1080/22221751.2022.2117092 PMC 바로가기
Disease severity and efficacy of homologous vaccination among patients infected with SARS-CoV-2 Delta or Omicron VOCs, compared to unvaccinated using main biomarkersArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 바이오마커, 변종, 진단, [키워드] AstraZeneca Biomarker booster case-control study caused Chronic diseases Clinical severity conducted country COVID-19 COVID-19 confirmed patient COVID-19 patient COVID-19 vaccination COVID-19 vaccine CRP level Delta delta variant Delta wave dose doses effective Effectiveness Efficacy expressed females Health homologous homologous vaccination. hospital Hospitalization Hospitalized individual infected with SARS-CoV-2 Iraq Lower males molecular no significant difference no significant effect omicron Omicron variant pandemic Patient patients Pfizer Population Prevent recommendation recorded risk SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 variant severity significantly Symptom the disease the vaccine transmissibility of SARS-CoV-2 vaccination Vaccine variant variants of concern virus VOCs was done WBC [DOI] 10.1002/jmv.28098 PMC 바로가기
NVX-Cov2373 Novavax Covid-19 vaccine: A further analysis of its efficacy using multiple modes of expressionArticle Published on 2022-12-012022-11-16 Journal: Fundamental & clinical pharmacology [Category] 변종, [키워드] absolute risk reduction age analysed Analysis Characteristics clinical trial COVID-19 vaccines description Efficacy Europe expression NNT Novavax number needed to treat NVX-CoV2373 NVX-Cov2373 Covid-19 vaccine parameter parameters reduction Relative risk. risk treat Vaccine variant [DOI] 10.1111/fcp.12794 PMC 바로가기
Efficacy of heterologous boosting against SARS-CoV-2 using a recombinant interferon-armed fusion protein vaccine (V-01): a randomized, double-blind and placebo-controlled phase III trial재조합 인터페론 무장 융합 단백질 백신(V-01)을 사용한 SARS-CoV-2에 대한 이종 부스팅의 효능: 무작위, 이중 맹검 및 위약 대조 3상 시험Clinical Trial Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 임상, 진단, [키워드] adverse event antibody assigned booster clinical trial common adverse event conducted COVID-19 vaccine COVID-19 vaccines dose double-blind dramatic increase Efficacy elicit eligible fatigue Fever fusion protein groups headache healthy Heterologous heterologous boosting Humoral immunity Identifier Immunity inactivated Inactivated vaccine Inactivated Vaccines Inc injection injection site intention-to-treat principle Malaysia Mild-to-moderate Neutralizing Neutralizing antibodies occurred Older omicron Omicron variant over Pain participant Participants Placebo placebo-controlled primary endpoint Randomized Randomly receive regimen robust Safe SARS-CoV-2 SARS-COV-2 infection second dose Serious Adverse Events subunit Subunit vaccine Subunit vaccine. Surveillance symptomatic SARS-CoV-2 infection the epidemic titre Trial Trial registration V-01 Vaccine vaccine efficacy variant virus-neutralizing antibodies was measured were assessed [DOI] 10.1080/22221751.2022.2088406 PMC 바로가기 [Article Type] Clinical Trial
An open, prospective cohort study of VV116 in Chinese participants infected with SARS-CoV-2 omicron variantsSARS-CoV-2 오미크론 변이체에 감염된 중국 참가자의 VV116에 대한 공개, 전향적 코호트 연구Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] adjusted administration adverse event adverse events anti-SARS-CoV-2 antiviral drug baseline characteristics Chinese Cohort cohort study collected conducted control group COVID-19 Cox regression analysis effective Effectiveness Efficacy enrolled evaluate first positive Follow-up Hospitalized infected with SARS-CoV-2 Infection Intervention median time no significant difference omicron Omicron variant participant Patient preclinical studies predominant Prevalence prospective cohort study receive regression analysis reported resolved robust Safe Serious Adverse Event Serious Adverse Events standard treatment Symptom symptomatic treatment group variant variant of SARS-CoV-2 Viral load Viral load. viral shedding VV116 with COVID-19 [DOI] 10.1080/22221751.2022.2078230 PMC 바로가기 [Article Type] Article
The long term vaccine-induced anti-SARS-CoV-2 immune response is impaired in quantity and quality under TNFα blockadeArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Activation acute respiratory syndrome alteration analysed anti-SARS-CoV-2 anti-SARS-CoV-2 IgG anti-TNF-α appear Autoimmune Autoimmune diseases blockade bystander Cell changes in chronic inflammatory disease Cohort comparable Control coronavirus COVID-19 Decline drugs Effect Efficacy ELISA flow cytometry groups healthy humoral immune response IgG immune cell populations immune response immunoblot investigated less Live virus Necrosis Neutralization assay neutralize neutralizing antibody neutralizing capacity Older omicron Patient patients plasma Plasma cell recipient reduced response SARS-CoV-2 second vaccination significantly T cell subset titre TNF-α TNFα tumor necrosis factor inhibitors tumor necrosis factor-α vaccination vaccination. Vaccine variants of concern virus VoC was increased while [DOI] 10.1002/jmv.28063 PMC 바로가기
Ultrarapid and ultrasensitive detection of SARS-CoV-2 antibodies in COVID-19 patients via a 3D-printed nanomaterial-based biosensing platformArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] 3D biosensor 3D printing Additive manufacturing antibody Antibody detection coated with Concentration COVID-19 COVID-19 antibodies COVID-19 patient COVID-19 patients Critical detected antibody disease domain Efficacy Epidemics Epidemiology evaluate Gold nanoparticle Graphene oxide human plasma samples immune response Immunity Infection Interaction manuscript nucleocapsid Outbreaks Patient patients without COVID-19 platform Quantitative Rapid rapid antibody detection. rapid antibody test RBD reported SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antigens serological Spike protein the antibodies the N protein vaccination Vaccine Viral protein were used [DOI] 10.1002/jmv.28075 PMC 바로가기