Immunogenicity of Third-dose BNT162b2 mRNA Vaccine Following Two Doses of ChAdOx1 in Health Care Workers: A Prospective Longitudinal StudyArticle Published on 2022-11-012022-11-16 Journal: Annals of laboratory medicine [Category] SARS, 변종, [키워드] acute respiratory syndrome analyzed anti-S antibody BNT162b2 BNT162b2 mRNA ChAdOx1 collected Concentration coronavirus Coronavirus disease-19 COVID-19 delta variant demonstrated dose doses Effectiveness Efficacy eight healthcare worker help immunogenicity longitudinal NAbs Neutralizing neutralizing antibody occurred omicron outbreak pandemic predicted produced Prospective PROTECT reached regimen risk second dose study period the vaccine Three-dose vaccination. university hospital vaccination vaccination rate variant variants of concern Wuhan-Hu-1 [DOI] 10.3343/alm.2022.42.6.688 PMC 바로가기
Transmission of SARS-CoV-2 by children to contacts in schools and households: a prospective cohort and environmental sampling study in LondonArticle Published on 2022-11-012022-11-16 Journal: The Lancet. Microbe [Category] SARS, 변종, 치료기술, [키워드] acquisition Assessing Asymptomatic children Community Contact Contamination Department eight Evidence FIVE Frequency Genome sequencing Health household contact household contacts IMPROVE incident index case Infection Innovation Laboratory Local London occur PCR testing positive positive PCR positive SARS-CoV-2 PCR Precaution Prevent prospective cohort public health pupil Pupils quantified reduced representing rising SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 transmission School Schools secondary transmission Spread supported symptomatic individual tested Testing throat swab Transmission transmission of SARS-CoV-2 variant Ventilation viral shedding was done Weekly with COVID-19 [DOI] 10.1016/S2666-5247(22)00124-0 PMC 바로가기
Neutrophil Extracellular Traps, Local IL-8 Expression, and Cytotoxic T-Lymphocyte Response in the Lungs of Patients With Fatal COVID-19Article Published on 2022-11-012022-11-16 Journal: Chest [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis analyzed association Bacteria bronchiolar CD8+ T-cell chemokine correlated COVID-19 CXCL8 Cytokines cytotoxic death Defense Diseases eight exploratory expression Extracellular fatal COVID-19 function heterogeneity IL-8 immune response immunohistochemistry infiltration Inflammation Inflammatory inherent leukocyte liver tissues Local lung Lungs mechanism Messenger RNA mRNA mRNA levels multiplexed immunofluorescence NET NETosis NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils no correlation pathogenic Patient polymerase chain pulmonary thrombi quantified Respiratory failure response SARS-CoV-2 severe COVID-19 shown T-lymphocyte the SARS-CoV-2 tissue tissue damage tissue viral load validation cohorts viral loads [DOI] 10.1016/j.chest.2022.06.007 PMC 바로가기
Immunological responses following the third dose of the BNT162b2 SARS-CoV-2 vaccine among Japanese healthcare workersArticle Published on 2022-11-012022-11-15 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), SARS, 진단, [키워드] age alcohol all age groups anti-RBD antibody antibody level antibody levels Antibody Response Antibody titer Asian baseline binding domain BNT162b2 BNT162b2 mRNA BNT162b2 vaccine Boosted vaccination booster dose booster vaccination conducted COVID-19 COVID-19 vaccine dose eight elevated Ethnic groups group healthcare worker Healthcare workers healthy IgG information investigated Japan Japanese median median titer of BNT162b2 participant Prevent provided RBD response SARS-CoV-2 vaccine second dose serum shown significant increase the vaccine university vaccination Welfare [DOI] 10.1016/j.jiac.2022.07.006 PMC 바로가기
Covid-MANet: Multi-task attention network for explainable diagnosis and severity assessment of COVID-19 from CXR imagesResearch article Published on 2022-11-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 진단, 치료기술, [키워드] Accuracy approach assigned automated Bacterial chest X-ray CNN conducted COVID-19 COVID-19 case COVID-19 cases COVID-19 diagnosis COVID-19 disease COVID-19 infection Critical CXR dataset deep learning develop Diagnosis disease early diagnosis eight experiment Explainable AI False negative Final first stage Health highlight IMPROVE Infection Infection Segmentation initial Interpretation lung Lung segmentation Lungs measure Mild moderate outbreak outperform Pneumonia predicted proportion quantification radiological examination reduced Region reported Research research finding RT-PCR test scoring system sensitivity sensitivity analysis severity severity of COVID-19 Stage Support transfer learning Tuberculosis Viral pneumonia with COVID-19 [DOI] 10.1016/j.patcog.2022.108826 [Article Type] Research article
Antibody responses and SARS-CoV-2 infection after BNT162b2 mRNA booster vaccination among healthcare workers in JapanArticle Published on 2022-11-012022-11-15 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), SARS, 진단, [키워드] 95% confidence interval 95%CI adjusted odds ratio age analyzed anti-spike antibody Antibody Response BNT162b2 BNT162b2 mRNA booster vaccination Booster vaccine Cohort Coverage COVID-19 decrease dose Effectiveness eight Factor group groups HCW HCWs Health care worker healthcare worker Increased infection control interquartile range introduced IQR Japan median mRNA vaccine multivariate logistic regression no significant difference not significant positive risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections subject university vaccination Vaccine waning immunity [DOI] 10.1016/j.jiac.2022.07.010 PMC 바로가기
Onset and window of SARS-CoV-2 infectiousness and temporal correlation with symptom onset: a prospective, longitudinal, community cohort studyArticle Published on 2022-11-012022-11-15 Journal: The Lancet. Respiratory Medicine [Category] SARS, 변종, 치료기술, [키워드] accelerate Alpha assessment assumption Bayesian Cohort cohort study Community Contact correlation Course COVID-19 COVID-19 case determine diagnosed early diagnosis eight eligible enrolled Evidence Final Guidance Hierarchical High-resolution household index cases Infection infection control Infectious virus initial IQR Isolation kinetic Lateral flow device LFD median Older Onset participant PCR positive PCR-confirmed plaque-forming unit post-symptom onset Probability quantified real-world data recruitment reduced released RT-PCR SARS-CoV-2 Self-isolation sensitivity Seven study population suggested Support survival Symptom symptom onset Symptoms the median the SARS-CoV-2 to define Transmission upper respiratory tract variant viral growth Viral load viral replication Viral RNA viral RNA load viral shedding virus were assessed [DOI] 10.1016/S2213-2600(22)00226-0 PMC 바로가기
Omicron (B.1.1.529) – A new heavily mutated variant: Mapped location and probable properties of its mutations with an emphasis on S-glycoproteinArticle Published on 2022-10-312022-11-16 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 receptor addition Analysis analyzed antibodies antibody Antibody binding B.1.1.529 bioinformatics characterized contribute country D614G eight human ACE2 receptor information investigated K417N mapped molecular mutated Mutation mutations N501Y NAb nAb escape. omicron outcome performed Quotient RBD RBD mutation recorded Region reported Research S477N SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 VoC Seven spike spike mutation Spread statistical the binding affinity the RBD the SARS-CoV-2 variant while ΔΔG [DOI] 10.1016/j.ijbiomac.2022.07.254 PMC 바로가기
Traditional Chinese medicine combined with Moxibustion in the treatment of “long-COVID”: A protocol for systematic review and meta-analysisArticle Published on 2022-10-282022-11-16 Journal: Medicine [Category] meta-analysis, [키워드] benefit carried China Chinese composed COVID-19 database Efficacy and safety eight evaluate evaluated Evidence exclusion criteria Inclusion Infrastructure international public health journal knowledge lack Meta-analysis moxibustion patients with COVID-19 prevalent protocol Randomized controlled trial Research risk Science screened symptoms of COVID-19 systematic review technology Traditional Chinese medicine treat Treatment was used Web of Science [DOI] 10.1097/MD.0000000000031447 PMC 바로가기
The pH Robustness of Bacterial SensingArticle Published on 2022-10-262022-11-16 Journal: mBio [Category] 유전자 메커니즘, [키워드] analyzed appear Bacteria Bacterial bacterial adaptation binding can be used change chaperone chemoreceptor chemotaxis condition conditions COVID-19 pandemic cytosolic demonstrated demonstration determine dimeric domain eight energy Escherichia coli extreme facilitate form Hormones in vivo include information intrinsic isothermal titration calorimetry Ligand ligands mechanism MONITOR Neurotransmitters nine pathway periplasmic pH pH robustness pH value progression Protein Proteins Pseudomonas aeruginosa quorum-sensing receptors recognize reported Research resonance respond response reveal robustness sensing sensor domains signal Signal transduction Signaling TAR tested ultracentrifugation was obtained [DOI] 10.1128/mbio.01650-22 PMC 바로가기