Effect of Chloroquine and Hydroxychloroquine on Cytokine Release Syndrome in Patients with COVID-19COVID-19 환자의 사이토카인 방출 증후군에 대한 클로로퀸 및 하이드록시클로로퀸의 효과Randomized Controlled Trial Published on 2021-12-012022-09-11 Journal: Clinical medicine & research [Category] SARS, 임상, 치료기술, 치료제, [키워드] Adult patients age blinded Care Chain Reaction Chloroquine conducted coronavirus disease Coronavirus disease 2019 COVID-19 CRS Cytokine release syndrome Department diagnose diagnoses Effect electrochemiluminescence immunoassay Emirate enrolled hospitalized patient Hydroxychloroquine IL-6 interleukin interleukin 6 Medicine Mild mild to moderate mild to moderate symptoms moderate no effect no significant difference onset of symptom Patient patients patients with COVID-19 placebo-controlled polymerase chain polymerase chain reaction randomization randomized study reducing Release Result reverse transcription reverse transcription polymerase chain reaction Roche RT-PCR screened serum sample serum samples significant difference study groups Symptoms the mean the patient three groups Treatment with COVID-19 [DOI] 10.3121/cmr.2021.1659 PMC 바로가기 [Article Type] Randomized Controlled Trial
Seroprevalence of Unidentified SARS-CoV-2 Infection in Hong Kong During 3 Pandemic Waves3번의 유행병 동안 홍콩에서 확인되지 않은 SARS-CoV-2 감염의 혈청 유병률Research Published on 2021-11-152022-09-10 Journal: JAMA Network Open [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% CI adjusted age anti-SARS-CoV-2 anti-SARS-CoV-2 IgG assist be positive city collected Complete conducted confirmation confirmed cases Contact contact with Coverage COVID-19 COVID-19 pandemic COVID-19 testing cross-sectional cross-sectional study diagnosed with COVID-19 electrochemiluminescence immunoassay enrolled enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay estimate female finding followed by gastrointestinal symptoms General population highlighting Hong Kong IgG antibodies illnesses Importance individual Infection information Isolation less lockdown measure median age MOST objective Older outcome pandemic participant Participants Point positive Prevalence Protein quarantine recall Receptor binding domain recorded recruited Relevance reported respiratory respiratory symptoms Result roll S1/S2 SARS-CoV SARS-CoV-2 SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody SARS-COV-2 infection SARS-CoV-2 RNA Seroprevalence setting Sociodemographic Spike protein Symptoms test results Transmission Travel Unidentified vaccination Vaccine Wave [DOI] 10.1001/jamanetworkopen.2021.32923 PMC 바로가기 [Article Type] Research
Prevalence of SARS-CoV-2 Antibody in 2,935 Healthcare Workers at 6 Major Hospitals, Daegu, Korea대구 6대병원 의료진 2,935명의 SARS-CoV-2 항체 유병률Article Published on 2021-11-082022-09-12 Journal: Journal of Korean medical science [Category] MERS, SARS, 진단, [키워드] Abbott acute respiratory syndrome antibody Antibody test blood specimen collected Community coronavirus disease Coronavirus-2 COVID-19 criteria detection diagnosed with COVID-19 Elecsy electrochemiluminescence immunoassay enzyme-linked immunosorbent Genscript HCW HCWs healthcare worker hospital IgG Inc. Major much lower neutralizing antibody occurred outbreak park performed positive positive rate Prevalence Roche Diagnostics SARS-CoV-2 SARS-CoV-2 antibody screening test screening tests specimen subject subjects Switzerland the SARS-CoV-2 USA was determined was performed was tested worker [DOI] 10.3346/jkms.2021.36.e294 PMC 바로가기 [Article Type] Article
Medium-term serostatus in Spanish case series recovered from SARS-CoV-2 infectionSARS-CoV-2 감염에서 회복된 스페인 사례 시리즈의 중기 혈청 상태Article Published on 2021-10-012022-09-11 Journal: Journal of medical virology [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% CI Admission aims anti-SARS-CoV-2 antibody antibodies Antibody Response Antibody responses Antibody test antibody tests carried Case series case sery chemiluminescence chemiluminescence immunoassay Cohort cohort of patient Comorbidity Corticosteroids COVID-19 COVID-19 recovered patients COVID-19 severity detectable develop Elecsys electrochemiluminescence immunoassay Factors Fever form glomerular glomerular filtrate hospital hospitalized patients immunosuppressive therapies immunosuppressive therapy incidence independent predictor individual IQR leukocyte leukocytes Logistic regression median medium Mild mild case mild cases multiple logistic regression outpatients Patient PCR-confirmed Pneumonia risk Risk factors Roche Diagnostics SARS-CoV-2 SARS-COV-2 infection Seroconversion Serologic response serological test seropositive serostatus severe pneumonia Spanish subpopulation Symptom symptom onset tested Tocilizumab was determined [DOI] 10.1002/jmv.27135 PMC 바로가기 [Article Type] Article
Performance of anti-SARS-CoV-2 antibody testing in asymptomatic or mild COVID-19 patients: A retrospective study in outbreak on a cruise ship무증상 또는 가벼운 CovID-19 환자에서 항 -SARS-COV-2 항체 검사의 성능 : 유람선 발병에 대한 후 향적 연구Research Article Published on 2021-09-282022-09-10 Journal: PLoS ONE [Category] SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgM antibody Antibody responses Antibody testing Antibody titer Antibody titers Asymptomatic blood sample Blood samples collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patient Cruise ship Diagnosis electrochemiluminescence immunoassay ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated false-negative Follow-up Genetic Genetic testing IgG antibodies IgG antibody IgM antibodies IgM antibody immunochromatographic assay initial lateral flow lateral flow immunochromatographic assay Mild mild COVID-19 patient mild COVID-19 patients nucleocapsid objective outbreak Patient performance positive result required respiratory responses Result Retrospective study Sample SARS-CoV-2 significantly lower specificity Spike protein Spike proteins the patient titer titers total antibodies total antibody used to evaluate was performed were measured [DOI] 10.1371/journal.pone.0257452 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Antibody Rapid Tests: Valuable Epidemiological Tools in Challenging SettingsResearch Article Published on 2021-09-222022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome addition affecting Analysis analyzed antibody tests carried collected coronavirus country COVID-19 COVID-19 patient cross-reactivity demonstrated detect diagnostic test different time point Diseases dose electrochemiluminescence immunoassay elicited ELISA employment Endemic enzyme-linked immunosorbent Epidemiology evaluated first dose Health care worker identify IgG IgG response Immunological response individual lack large-scale analysis Lateral Lateral flow assays low-middle-income countries Patient performance Perspective Pfizer-BioNTech point-of-care tests Population screening postvaccination provide question Rapid RBD Receptor binding domain response to vaccination risk S protein SARS-CoV-2 SARS-CoV-2 immunology SARS-COV-2 infection sensitivity Sensitivity and specificity setting specificity subjects Support symptom onset the SARS-CoV-2 therapy Treatment Tuberculosis vaccination Vaccine was used [DOI] 10.1128/Spectrum.00250-21 PMC 바로가기 [Article Type] Research Article
Effects of Short-Term Corticosteroid Use on Reactogenicity and Immunogenicity of the First Dose of ChAdOx1 nCoV-19 Vaccine단기 코르티코스테로이드 사용이 ChAdOx1 nCoV-19 백신의 첫 번째 용량의 반응성 및 면역원성에 미치는 영향Comparative Study Published on 2021-09-222022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] anti-SARS-CoV-2 antibody BNT BNT162b2 Cellular immune response ChAdOx1 nCoV-19 Concentration Corticosteroid COVID-19 dose Effect electrochemiluminescence immunoassay evaluated first dose groups HCW HCWs healthcare worker IFN-γ immunogenicity interferon gamma interquartile range IQR low-dose corticosteroid median prednisolone equivalent Quantitative reactogenicity recruited reduce robust significantly significantly higher Spike protein statistical significance steroid total score vaccination Vaccine was measured [DOI] 10.3389/fimmu.2021.744206 PMC 바로가기 [Article Type] Comparative Study
Effect of SARS-CoV-2 mRNA vaccination in MS patients treated with disease modifying therapies질병 변형 요법으로 치료받은 다발성 경화증 환자에서 SARS-CoV-2 mRNA 백신 접종의 효과Observational Study Published on 2021-09-222022-09-12 Journal: EBioMedicine [Category] MERS, 임상, 진단, [키워드] Affect analyzed anti-CD20 therapy anti-CD20 treatment antibody antigens assessments Blood blood collection BNT162b2 BNT162b2 vaccine Cellular immune response contribute coronavirus correlated decrease detectable disease Effect electrochemiluminescence immunoassay elicit evaluate the effect finding Follow-up funding humoral immune response Immunomodulatory therapies interval Italian Linear regression Moderna mRNA vaccination mRNA vaccine mRNA-1273 mRNA-based SARS-CoV-2 vaccines multicenter cohort study Multiple multiple sclerosis multivariable multivariable analysis Patient patients treated reduced SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 vaccine sclerosis second dose serological assessment significantly the vaccine therapy untreated patients vaccination Vaccine vaccine dose Vaccines [DOI] 10.1016/j.ebiom.2021.103581 PMC 바로가기 [Article Type] Observational Study
Differential immunogenicity of BNT162b2 or ChAdOx1 vaccines after extended-interval homologous dual vaccination in older peopleResearch Published on 2021-08-202022-10-30 Journal: Immunity & Ageing : I & A [Category] COVID-19, [키워드] adenovirus vaccine adenovirus-based Analysis antibody Antibody Response Antibody titre blood sample BNT162b2 BNT162b2 mRNA boost cellular Cellular immune response cellular response ChAdOx1 ChAdOx1 vaccine Clinical efficacy clinical risk COVID detectable Donor electrochemiluminescence immunoassay elicited Evidence extended interval extended-interval heterologous vaccine homologous Homologous vaccine Humoral immunity IFN-γ ELISPOT immune response immune senescence induce Infection IQR limit median Meta-analysis mRNA natural infection objective of BNT162b2 offer Older participant Patient platform protocol question recipient regimen regimens reported response Result SARS-CoV-2 SARS-CoV-2 vaccine second dose shown Spike protein Spike-specific antibody stability supplementary material T cell response the median vaccination Vaccine vaccine responses vaccinee were assessed were measured [DOI] 10.1186/s12979-021-00246-9 PMC 바로가기 [Article Type] Research
SARS-CoV-2 Serologic Assays Dependent on Dual-Antigen Binding Demonstrate Diverging Kinetics Relative to Other Antibody Detection Methods이중 항원 결합에 의존하는 SARS-CoV-2 혈청학적 분석은 다른 항체 검출 방법에 비해 발산하는 역학을 보여줍니다Article Published on 2021-08-182022-09-11 Journal: Journal of Clinical Microbiology [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus anti-SARS-CoV-2 Anti-SARS-CoV-2 S antibodies antibody Antibody detection Antibody titer Antibody titers Antigen assays binding Cohort convalescent COVID-19 patients convalescent plasma coronavirus Course COVID-19 cross-sectional demonstrated Dependent dependent on detection Donor drug dual-antigen binding assays eight Elecsy Elecsys electrochemiluminescence immunoassay Emergency use authorization food humoral humoral immune response Humoral response immunoassays implication Kinetics lack longitudinal Longitudinal studies majority Neutralizing nucleocapsid Other Patient populations profile relative respiratory Roche Roche Diagnostics SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody sera serologic serologic assay serologic assays serology study period symptom onset while [DOI] 10.1128/JCM.01231-21 PMC 바로가기 [Article Type] Article