A Ligand Selection Strategy Identifies Chemical Probes Targeting the Proteases of SARS‐CoV‐2Research Article Published on 2021-01-282022-10-28 Journal: Angewandte Chemie (International ed. in English) [Category] COVID-19, SARS, [키워드] 3CL pro ABPP approach Cell Chemical chemical probes complementary cysteine protease derivative develop Efficacy electrophilic enzyme Enzyme inhibitors inhibitor inhibitors labeling Ligand probe protease Proteases proteome proteomic resulting SARS‐CoV‐2 Selection specificity Strategy target protein targeting tuning virus [DOI] 10.1002/anie.202016113 PMC 바로가기 [Article Type] Research Article
Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (M pro ) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking StudyResearch Article Published on 2020-12-232022-10-28 Journal: Scientifica [Category] COVID-19, [키워드] acute respiratory syndrome antimalarial antiretroviral drug approach AutoDock binding free energy calculated candidate caused Chloroquine complex Compound compounds coronavirus coronavirus disease COVID-19 criteria determine docking docking score drug drugs electrophilic evaluate evaluated FDA FIVE gallate glycoprotein hesperidin highest affinity humans hydroxychloroquine sulfate in vitro in vivo indicated Infection inhibit inhibitors investigated kaempferol M pro meet molecular docking nucleophilic oral bioavailability outbreak pandemic plant Potential proliferation protease protein-ligand reactivity Region researcher SARS-CoV-2 selected spike spike glycoprotein treat Treatment was performed were used [DOI] 10.1155/2020/6307457 PMC 바로가기 [Article Type] Research Article
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main proteaseArticle Published on 2020-10-072022-10-04 Journal: Nature Communications [Category] SARS, 변종, 신약개발, 치료제, [키워드] antiviral drug approach caused coronavirus COVID-19 COVID-19 therapeutics cysteine develop drug design effective electrophilic Enzymes identify information inhibitor lack mass spectrometry MERS-CoV offer Outbreaks performed progressed protease Proteases reactivity SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 main protease starting point Structure the SARS-CoV-2 Vaccine Viral protein viral replication X-ray X-ray crystallography zoonotic [DOI] 10.1038/s41467-020-18709-w PMC 바로가기 [Article Type] Article