UV-C Light Completely Blocks Aerosol Transmission of Highly Contagious SARS-CoV-2 Variants WA1 and Delta in HamstersArticle Published on 2022-09-062022-11-16 Journal: Environmental science & technology [Category] SARS, 변종, [키워드] activities adhere aerosol block COVID COVID19 Delta effective Effectiveness element hamster individual investigated LIGHT measure Population Prevent prevented reduce risk SARS-CoV-2 SARS-CoV-2 transmission Spread susceptible Syrian Golden hamsters Transmission transmission of SARS-CoV-2 ultraviolet light UV-C virus WA1 wavelength [DOI] 10.1021/acs.est.2c02822 PMC 바로가기
Impaired activation of transposable elements in SARS-CoV-2 infectionArticle Published on 2022-09-052022-11-15 Journal: EMBO Reports [Category] SARS, 유전자 메커니즘, 치료제, [키워드] activate activated Activation Cell cellular changes in Chromatin structure correlation COVID-19 Defense drug target element elements Epigenetic epigenetics Evidence explain expression expression level functional Genes Host host immune system identify immune Impaired Infection interferon interferon response mechanism primary cells Proteins provide regulate robust SARS-CoV-2 SARS-COV-2 infection suggested the SARS-CoV-2 Transcription transposable elements. upregulation variable viral infections Viral load viruses [DOI] 10.15252/embr.202255101 PMC 바로가기
Visual diagnosis of COVID-19 disease based on serum metabolites using a paper-based electronic tongueResearch article Published on 2022-09-012022-10-05 Journal: Analytica chimica acta [Category] 진단, 치료기술, [키워드] Accuracy age Array-based sensor calculated caused chemometrics collected colorimetric detection complexes Compound Concentration Control control sample correlation COVID-19 COVID-19 disease COVID-19 patient diagnosis of COVID-19 disease Diseases element human serum information men and women metabolite metabolomics PCR test point-of-care rapid detection response resulting serum serum sample severity statistical the disease tongue Variation viral infection Viral load Visual [DOI] 10.1016/j.aca.2022.340286 [Article Type] Research article
Unique mutations in SARS-CoV-2 Omicron subvariants’ non-spike proteins: Potential impacts on viral pathogenesis and host immune evasionArticle Published on 2022-09-012022-11-16 Journal: Microbial pathogenesis [Category] SARS, 변종, [키워드] Accessory accessory proteins B.1.1.7 B.1.617.2 Beta Cell Characteristics circulating COVID-19 pandemic cumulative Delta dominant Effect effective element epistasis expression FIVE Gamma growth Host host protein immune evasion immune-evasion Impact inactivation Interaction knowledge M protein Mutation mutations natural killer Non-spike mutations non-structural protein NSP6 omicron ORF7b Orf9b outcome P.1 Potential Probability progeny Protein Proteins Region Replication responsible SARS-CoV-2 significant difference Subvariants survival transmission rate unique variant variants of concern variants of interest viral pathogenesis virulence virus VOCs [DOI] 10.1016/j.micpath.2022.105699 PMC 바로가기
Selenium and mercury concentrations in biological samples from patients with COVID-19Research article Published on 2022-09-012022-10-05 Journal: Journal of trace elements in medicine and biology [Category] 변종, 임상, 진단, 치료기술, [키워드] acute respiratory syndrome affecting age atomic absorption spectrophotometry Bacterial biochemical biological sample biological samples Blood changes in collected complex Concentration coronavirus Coronavirus disease 2019 COVID-19 COVID-19 infection deplete disease disorders Effects element elevated evaluated healthy in healthy individuals incidence of COVID-19 infected with COVID-19 male men Mercury Mortality multiple organs nasal fluid objective outcomes Patient patients with COVID-19 physiological positive correlation promote reaction Respiratory disease recurrence Result Saliva Selenium serum smoker sputum Trace element Treatment viral infection virus weakness with COVID-19 [DOI] 10.1016/j.jtemb.2022.127038 [Article Type] Research article
An agent-based transmission model of COVID-19 for re-opening policy designResearch article Published on 2022-09-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] activities adopted agent-based model approach caused complex interaction computer conditions Contagion Contagion risk Containment measure coronavirus country COVID-19 disease Effect effective element exhibiting experiment global pandemic hypothetical implementation individual Infection information Initially Intervention lack new strain provide reduce Safe SARS-CoV-2 social distancing Social distancing measure tested Transmission Transmission model vaccination variant Ventilation [DOI] 10.1016/j.compbiomed.2022.105847 [Article Type] Research article
An online breathing and wellbeing programme (ENO Breathe) for people with persistent symptoms following COVID-19: a parallel-group, single-blind, randomised controlled trialRandomized Controlled Trial Published on 2022-09-012022-10-04 Journal: The Lancet. Respiratory Medicine [Category] Fulltext, MERS, 임상, [키워드] 1:1 adverse event Analysis Anxiety approach approaches assigned Block randomisation breathlessness chronic obstructive clinically clinics complementary computer-generated conducted COVID COVID-19 eight element English Generalised anxiety disorder groups Health Imperial College London IMPROVE improvement individual intention-to-treat population Intervention Mental mental health MHC outcome measure parallel-group participant participated Patient physical potential participant Primary outcome pulmonary disease qualitative data randomisation randomised controlled trial Randomly recovering from COVID-19 recruited Registered reported Research researcher responses responsible secondary secondary outcome single-blind statistically significant Symptom thematic analysis treatment group Trial unique usual care usual care group Visual Analogue Scale was done were excluded were given [DOI] 10.1016/S2213-2600(22)00125-4 PMC 바로가기 [Article Type] Randomized Controlled Trial
Decavanadate interactions with the elements of the SARS-CoV-2 spike protein highlight the potential role of electrostatics in disrupting the infectivity cycleSARS-CoV-2 스파이크 단백질 요소와의 Decavanadate 상호 작용은 감염 주기를 방해하는 정전기의 잠재적 역할을 강조합니다Article Published on 2022-09-012022-09-11 Journal: Journal of inorganic biochemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral antiviral agent approach association binding biological properties biological property carried collected data coronavirus COVID-19 cytotoxicity decrease disrupt disrupting drug design effective Effectiveness effort electrostatic force electrostatic forces element ENhance Evidence furin furin cleavage site highlight Host host cell host cell membrane identify In vitro studies in vitro study infected cells Interaction interactions less mass spectrometry molecular Native Novel coronavirus Polyanion polybasic Polyoxidometalate Protein Protein binding Proteolytic processing provide receptor Receptor-binding domain robust robustness Safe SARS-CoV-2 entry SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-CoV-2 spike protein shown Spike protein the receptor-binding domain the SARS-CoV-2 the spike protein therapeutic therapeutic agent therapeutic agents Therapeutics utility Vanadium variety Viral mutations while [DOI] 10.1016/j.jinorgbio.2022.111899 PMC 바로가기 [Article Type] Article
The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implicationsArticle Published on 2022-08-312022-11-15 Journal: Biochemical Journal [Category] 진단, [키워드] activities amyloid microclots antioxidants biochemical burst Capillaries cell activation conditions COVID disease element Evidence explain hyperinflammation hypoxia implication Inflammatory diseases initiated Injury involved ischaemia–reperfusion injury. Long Long COVID malaise marker mechanism mechanisms metabolite Occurrence oxidative stress pathology produced reactive oxygen specy relapsing reperfusion rheumatoid arthritis Safe therapeutic Therapeutic benefit variety [DOI] 10.1042/BCJ20220154 PMC 바로가기
Metalloproteinase-Dependent and TMPRSS2-Independent Cell Surface Entry Pathway of SARS-CoV-2 Requires the Furin Cleavage Site and the S2 Domain of Spike ProteinArticle Published on 2022-08-302022-11-16 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ADAM10 addition bind Cell cell death cell interaction cleavage cleaved complex condition contributed coronavirus SARS-CoV COVID-19 develop domain effective element endosomal pathway entry pathway evade furin furin cleavage motif highly pathogenic Host host protease human coronaviruses identify Immunity independent Infection infection mechanism inhibitor involved membrane membrane fusion metalloproteinase organ damage Pathogenesis pathogenesis of COVID-19 pathway Prevent priming provide required S1/S2 boundary S2 domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein selective sequence siRNAs Site spike Spread surface surface receptor syncytium formation the spike protein therapeutic agent therapeutic target Therapies TMPRSS2 unique vaccination variants virus entry virus variant [DOI] 10.1128/mbio.00519-22 PMC 바로가기