Inhibitors of endosomal acidification suppress SARS-CoV-2 replication and relieve viral pneumonia in hACE2 transgenic mice엔도솜 산성화 억제제는 SARS-CoV-2 복제를 억제하고 hACE2 형질전환 마우스에서 바이러스성 폐렴을 완화합니다Research Published on 2021-02-272022-09-10 Journal: Virology Journal [Category] MERS, 치료기술, 치료제, [키워드] 293T 293T-ACE2 cells acidic pH alveolar Analysis Antiviral effect antiviral effects bafilomycin Bafilomycin A1 caused CCK-8 CCK-8 assay Cell Chloroquine Clinical use coronavirus disease Coronavirus disease 2019 COVID-19 detect distribution Drug development Endosomal acidification endosome Endosomes eosin evaluate global pandemic hACE2 hematoxylin Huh-7 In situ hybridization Infection infiltration Inflammatory inhibitor inhibitors investigated lung tissue lung tissues pathological change peribronchiolar perivascular tissues Pneumonia proliferation provide reduced Replication Research Result RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication significantly staining Structure suppress the SARS-CoV-2 transgenic mice used to evaluate Vero E6 Vero E6 cell VERO E6 cells viability Viral Viral pneumonia viral replication was used [DOI] 10.1186/s12985-021-01515-1 PMC 바로가기 [Article Type] Research
Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2SARS-CoV-2 진입의 Hydroxychloroquine 매개 억제는 TMPRSS2에 의해 약화됩니다Research Article Published on 2021-01-192022-08-13 Journal: PLoS Pathogens [Category] COVID-19, Medicine and Health Sciences, [키워드] ablated activate activated activating antiviral activities antiviral activity Autoimmune disorders block cathepsin L Cathepsins cause Cell cell entry cell surface cell-culture studies cell-culture systems Chloroquine cleave clinically Combination combinations coronavirus COVID-19 COVID-19 patient dependent on Efficacy endocytosis Endosomal acidification endosomal protease explain functional furin furin cleavage site furin-cleavage site global public health human clinical trial human clinical trials Hydroxychloroquine identify in vivo Infection inhibit inhibit SARS-CoV-2 interfere introduced lack malaria membrane fusion observé pathogenic coronavirus pathway plasma plasma membrane Prevent protease TMPRSS2 Protein Proteins proteolytic activity Receptor binding reversed S protein S proteins SARS Coronavirus SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 S protein SARS-CoV-2 spike shown target cell target cells tested the cell the SARS-CoV-2 these compounds TMPRSS2 TMPRSS2 expression TMPRSS2 inhibitor TMPRSS2 pathway treat treated treatment for COVID-19 utility Viral viral entry viral infection [DOI] 10.1371/journal.ppat.1009212 PMC 바로가기 [Article Type] Research Article
A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2Article Published on 2020-08-252022-10-04 Journal: Nature Communications [Category] 치료제, [키워드] active against alkaline Antiviral antiviral activity antivirals binding broad-spectrum antivirals cause combating coronavirus COVID-19 disease Drug discovery drug-resistant Endosomal acidification exhibited healthcare highlight Influenza Influenza virus inhibit interfere MERS-CoV mice outbreak pandemic peptide pH-dependent virus pH-dependent viruses PROTECT provide respiratory virus respiratory virus respiratory viruses rhinovirus SARS-CoV SARS-CoV-2 significantly subsequent virus virus virus infection [DOI] 10.1038/s41467-020-17986-9 PMC 바로가기 [Article Type] Article
Nanoparticulate vacuolar ATPase blocker exhibits potent host-targeted antiviral activity against feline coronavirusArticle Published on 2017-10-122022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] addition administration Alter Antibody-dependent enhancement antiviral activity Antiviral effect ATPase caused cells cellular coronavirus cytoplasmic disease downstream effective Endosomal acidification exhibit Experimental result Feline infectious peritonitis High-dose highlight in vitro model incurable Infection inhibit inhibitory activity intravenous investigated mechanism mice mutated pathogenic safety profile susceptibility therapeutic potential Treatment Vaccine vacuolar viral disease virus virus replication [DOI] 10.1038/s41598-017-13316-0 PMC 바로가기 [Article Type] Article
A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory virusesArticle Published on 2016-02-252022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] Amino acid Antiviral antiviral activities antiviral activity Antiviral effect binding blocked Cell emerging respiratory viruses Endosomal acidification exhibited H1N1 H3N2 H5N1 H7N9 high-affinity binding in vitro in vivo influenza A virus membrane fusion MERS-CoV peptide prevented Prophylactic respiratory virus Safe SARS-CoV subsequent tested therapeutic agent viral glycoproteins viral particle Viral RNA viral surface virus [DOI] 10.1038/srep22008 PMC 바로가기 [Article Type] Article