Transcriptional landscape of circulating platelets from patients with COVID-19 reveals key subnetworks and regulators underlying SARS-CoV-2 infection: implications for immunothrombosisResearch Published on 2022-02-092022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] acute respiratory syndrome affected aggregation Analysis binding Cell circulating platelet Clinical outcome Coagulopathy coding coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients COVID-19 progression Critical eight energy metabolism feature healthy donors Hemostasis immune response immunothrombosis implication increased mortality Interaction involved mechanism molecular mechanism multiple organ failure Pathways patients with COVID-19 performed Platelet platelet activation Platelets promoted Protein provided regulate Result reveal risk RNA RNA Polymerase II RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease severity significantly subunit supplementary material therapeutic strategy thrombosis thrombotic complication thrombus formation transcription factor transcriptional Transcriptome upstream with COVID-19 [DOI] 10.1186/s13578-022-00750-5 PMC 바로가기 [Article Type] Research
SARS‐CoV‐2 triggered oxidative stress and abnormal energy metabolism in gut microbiotaOriginal Article Published on 2022-01-172022-10-30 Journal: MedComm [Category] COVID-19, [키워드] ABC accompanied Actinomyce alteration Amino acid analyzed annotation Antiviral Bacteria Bacteroide Biomarkers Butyrate characteristic characterized collected controls correlated COVID‐19 COVID‐19 patient COVID‐19 Critical Defense disease severity energy metabolism ENhance Escherichia coli exacerbate expression Fecal sample functions genes encoding Gut gut microbiota indicated Infection inflammation response Inflammatory intestinal flora KEGG Kyoto mechanism metabolism metagenome metagenomic metatranscriptome metatranscriptomic microbe Microbiome Neutral Ontology oxidative stress pathogen pathway positively correlated progression reduced SARS‐CoV‐2 SARS‐CoV‐2 virus SARS‐CoV‐2 selected Sequencing severity significantly Specific sphingolipids Streptococcus sugar suggested triggered upregulated upregulation was performed [DOI] 10.1002/mco2.112 PMC 바로가기 [Article Type] Original Article
SARS-CoV-2 Causes Mitochondrial Dysfunction and Mitophagy ImpairmentMicrobiology Published on 2022-01-062022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome binding cause caused cells co-immunoprecipitation Coronavirus-2 Critical cross cyclosporin A Defense dsRNA early stage energy metabolism expression fluorescent homeostasis host cell increase in inhibited initiated innate immune response Interaction involved knockdown Microscopy Mitochondria mitochondrial mitochondrial accumulation mitochondrial dysfunction mitochondrial membrane mitophagy performed Proteins Quality control reactive oxygen specy recruitment reduced RNA ROS SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selective substrate Tom20 Viral load viral RNA localization virus clearance [DOI] 10.3389/fmicb.2021.780768 PMC 바로가기 [Article Type] Microbiology
Decrease in life expectancy due to COVID-19 disease not offset by reduced environmental impacts associated with lockdowns in ItalyResearch article Published on 2022-01-012022-10-05 Journal: Environmental pollution (Barking, Essex : 1987) [Category] SARS, 유전자 메커니즘, [키워드] Adjusted Life Year Analysis average category complex conducted COVID-19 COVID-19 disease COVID-19 pandemic death decrease disability Disability Adjusted Life Years (DALYs) Endpoint energy metabolism Environmental impact Evolution Future Health Impact impacts Italy life cycle assessment (LCA) lockdown magnitude occurred Occurrence offset recorded reduced reducing reductions in Research Result SARS-CoV-2 the SARS-CoV-2 virus [DOI] 10.1016/j.envpol.2021.118224 [Article Type] Research article
Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and ApoptosisPhysiology Published on 2021-12-202022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] Administered Anti-inflammatory antiapoptotic antioxidant Antioxidative Apoptosis Autoimmunity autophagy cell death cell membrane China chronic inflammatory diseases clinical trials Clinical use coronavirus COVID-19 Diseases Effect Effects Efficacy energy metabolism help hydrogen immune system injection Ischemia mechanism mitochondrial modulating molecular Molecular hydrogen molecular hydrogen (H2) molecule novel Novel coronavirus nuclear penetrate Pneumonia pyroptosis reactive oxygen species reactive oxygen specy Regulation reperfusion injury Respiratory disease Sepsis shown Spread therapeutic effect transcription factor Treatment treatment guideline variety [DOI] 10.3389/fphys.2021.789507 PMC 바로가기 [Article Type] Physiology
Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcomeCOVID-19 환자 혈청의 비표적 대사체학은 심각성과 결과 모두의 잠재적인 예후 마커를 나타냅니다Original Article Published on 2021-12-202022-09-10 Journal: Metabolomics [Category] SARS, 바이오마커, 치료기술, [키워드] among others Analysis approach Bayesian Bayesian logistic regression model blind capture Cohort COVID-19 COVID-19 patient COVID-19 patient serum cross Deceased deoxycytidine diagnosis of COVID-19 discharged energy metabolism high resolution Hospital admission Host host inflammatory response host response include infected individual infected individuals Infection Kynurenine LC–MS/MS Orbitrap logistic regression model marker metabolism metabolite metabolites metabolomics Mild nucleic acid objective outcome Patient patient treatment Planning positive predict predicted Predictive predictor profile Prognostic marker property qualitative detection Result reveal ROC AUC ROC Curve selected serum severity statistical significance subset supplementary material Treatment UHPLC UHPLC-MS/MS uninfected control Untargeted metabolomics validation study Viral Viral load viral nucleic acid was performed [DOI] 10.1007/s11306-021-01859-3 PMC 바로가기 [Article Type] Original Article
Strong relationship between cholesterol, low-density lipoprotein receptor, Na + /H + exchanger, and SARS-COV-2: this association may be the cause of death in the patient with COVID-19Editorial Published on 2021-12-132022-10-29 Journal: Lipids in Health and Disease [Category] COVID-19, SARS, [키워드] accelerated ACE2 activated Activation Ang II angiotensin-converting enzyme-2 association Atherosclerosis cause Cell cell damage cell membrane cholesterol COVID-19 death decrease dysfunction energy metabolism Exchanger Extracellular fat-soluble vitamins fatty functions genetic material high-density increase Increases infect inhibiting interact Ion LDL LDLR limits Lipid lipids low-density Na+/H+ exchanger novel novel coronavirus disease Patient PCSK9 pH value physiological previous study Prolonged receptor replicate RNA SARS-CoV-2 SARS-COV-2 infection severity of COVID-19 shown stimulate Strong susceptibility the patient Transport Treatment treatment regimen variety with COVID-19 [DOI] 10.1186/s12944-021-01607-5 PMC 바로가기 [Article Type] Editorial
The Roles of Dipeptidyl Peptidase 4 (DPP4) and DPP4 Inhibitors in Different Lung Diseases: New EvidencePharmacology Published on 2021-12-092022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Affect approved Asthma Biomarker body fluid cells chronic obstructive clinical trial COPD Coronavirus disease-19 COVID-19 dipeptidyl peptidase 4 (DPP4) Disease progression DPP4 DPP4 inhibitors drug energy metabolism Evidence expressed FDA fibroblast food global pandemic immune function infectious lung disease Inflammation inhibitor lung cancer Lung disease Lung diseases lung parenchyma marker Middle East New non-infectious non-infectious disease organ Pathogenesis peptidase Physicians physiological pulmonary disease pulmonary fibrosis Respiratory disease role shown syndrome therapeutic target transmembrane glycoprotein Treatment type 2 diabete Vascular endothelium [DOI] 10.3389/fphar.2021.731453 PMC 바로가기 [Article Type] Pharmacology
Observational study on the benefit of a nutritional supplement, supporting immune function and energy metabolism, on chronic fatigue associated with the SARS-CoV-2 post-infection progressObservational Study Published on 2021-12-012022-10-05 Journal: Clinical nutrition ESPEN [Category] SARS, 임상, [키워드] affected Amino acid analyzed association benefit characterized chronic Chronic fatigue components conducted discharged disease Dyspnea Effect Effects energy metabolism enrolled evaluate evaluated fatigue general health status headache Health status hospital immune function IMPROVE Infection Italy life long-COVID Mental Mild Minerals negativity Nutritional Supplement observational study participant Patient Post-infection Quality Quality of life questionnaire Questionnaires recent reduce relative SARS-CoV-2 Severe infection severity statistic statistically significant subject subsequent Symptom synergistic the SARS-CoV-2 tiredness vitamins weakness were measured [DOI] 10.1016/j.clnesp.2021.08.031 PMC 바로가기 [Article Type] Observational Study
Blood Transcriptomes of Anti-SARS-CoV-2 Antibody-Positive Healthy Individuals Who Experienced Asymptomatic Versus Clinical InfectionImmunology Published on 2021-10-052022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] ALOX15 analysed Anti-SARS-CoV2 antibody Antibody Response asympomatic Asymptomatic Asymptomatic disease asymptomatic infection baseline baseline expression Bioinformatics analysis CACNA2D2 CLEC12A CLEC1B clinical clinical variability Course decreased expression develop differentially expressed gene ENC1 energy metabolism FOLR3 GCAT gene signature GZMH healthy individuals Hypothesis IFI44L IFIT3 immune immune response implication increased expression individual Infection innate immune response Innate immunity interferons involved lethal disease mRNA translation nine oxidative stress response PCR performed PI3 predicts protein-coding gene Proteins regulated RNA sequencing RNAseq robust RSAD2 SARS-CoV-2 SARS-COV-2 infection significantly transcriptional vaccination Whole-blood [DOI] 10.3389/fimmu.2021.746203 PMC 바로가기 [Article Type] Immunology