In silico drug repurposing against SARS-CoV-2 using an integrative transcriptomic profiling approach: Hydrocortisone and Benzhydrocodone as potential drug candidates against COVID-19통합 전사체 프로파일링 접근법을 사용하여 SARS-CoV-2에 대한 인실리코 약물 용도 변경: COVID-19에 대한 잠재적 약물 후보로서 히드로코르티손 및 벤즈히드로코돈Article Published on 2022-09-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] ADAR alveolar cell Analysis Anti-viral antiviral immune response Benzhydrocodone binding affinity CASP1 cellular response Cellular responses Clinical studies clinical study complementary COVID-19 COVID-19 pathogenesis determine drug drug candidate Drug repurposing dysregulated enrichment enrichment analysis evaluated FDA-approved drug FOS hallmark HBEGF Host Hydrocortisone ICAM1 identify IFI35 immune system in silico in silico approaches in viral in vitro in vivo experiment infected with SARS-CoV-2 Infectious disease involved IRF2 JUN management MMP9 molecular molecular docking Pathogenesis pathway Pathways promise Protein protein-protein interaction Proteins Repurposed drug Repurposed drugs SARS-CoV-2 SARS-COV-2 infection Signal transduction STAT3 subject suggested transcriptomic transcriptomic profile transcriptomics up-regulated USP18 viral infectious disease [DOI] 10.1016/j.meegid.2022.105318 PMC 바로가기 [Article Type] Article
Transcriptome Analysis of Peripheral Blood Mononuclear Cells Response in Patients with Severe COVID-19 Reveals Crucial Genes Regulating Protein UbiquitinationArticle Published on 2022-08-292022-11-16 Journal: Medical science monitor : international medical jo [Category] 유전자 메커니즘, [키워드] Analysis ASB16 biological process Cell Characteristics Cluster conducted core gene COVID-19 COVID-19 pandemic DEGs detect differentially expressed gene enrichment evaluate expressed facilitate FBXO11 FOXA1 FOXC1 functional GATA2 Gene expression analysis Genes healthy controls hsa-miR-1-3p identify Interaction ITCH macrophages miRNA molecular mononuclear cell Patient performed peripheral Peripheral blood platform progression protein ubiquitination protein-protein interaction regulate Regulating Regulatory response RNA sequencing RNF130 severe COVID-19 signaling pathways single-cell transcription factors Transcriptome TRIM21 UBE2J1 was used were expressed YY1 [DOI] 10.12659/MSM.937532 PMC 바로가기
Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19COVID-19의 적응 면역 구획 전반에 걸친 항원 수용체 레퍼토리 파괴의 글로벌 패턴Article Published on 2022-08-232022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 치료기술, [키워드] adaptive adaptive immune responses aligned anticipated Antigen antigen-receptor repertoires applied approach B cell Cluster COVID-19 deficiency disease disease severity enrichment genomic Genomic DNA IGH immune immune responses Immunoglobulin immunoPETE individuals Infectious disease loci Next-generation sequencing occurred Older pathogen pathogen-specific Patient primary focus receptor reducing risk factor SARS-CoV-2 sequence Seroconversion T cell T cell receptor T cells TCR variant vulnerability [DOI] 10.1073/pnas.2201541119 PMC 바로가기 [Article Type] Article
Multiomic analysis reveals cell-type-specific molecular determinants of COVID-19 severity다중체 분석은 COVID-19 중증도의 세포 유형별 분자 결정 요인을 나타냅니다.Article Published on 2022-08-172022-10-30 Journal: Cell Systems [Category] COVID-19, MERS, 바이오마커, 변종, 유전자 메커니즘, [키워드] Analysis CD56 Cell cell types COVID-19 COVID-19 severity cytokine determinant determinants dysfunction enrichment functions gene discovery Genes Genetic genetic risk Genetic variation genome-wide association Genome-wide association study genomic GWAS healthy human lung innate immune response Intervention limit machine learning mendelian randomization molecular natural killer network analysis NK cell NK cells NK-cell Pathogenesis potential therapeutic targets provide rare variant analysis reveal risk severe COVID-19 severe disease single-cell single-cell multiomic profiling. Support T cells these cell These cells upstream variant [DOI] 10.1016/j.cels.2022.05.007 PMC 바로가기 [Article Type] Article
SEMgsa: topology-based pathway enrichment analysis with structural equation modelsSEMgsa: 구조 방정식 모델을 사용한 토폴로지 기반 경로 강화 분석Article Published on 2022-08-172022-09-11 Journal: BMC Bioinformatics [Category] 유전자 메커니즘, [키워드] Activation Algorithm coronavirus disease COVID-19 dataset disease DNA methylation dysregulation enrichment enrichment analysis estimate evaluate expression data followed by framework frontotemporal dementia functional Gene Expression generate Genes GEO identify information mechanism metabolites node novel pathway Pathway enrichment analysis Pathway topology Pathways power prioritization Protein R package RNA-seq dataset SEM SEMgsa sensitivity Simulation specific disease Statistical power statistically subset text Topology type I type I error Type I error. were used [DOI] 10.1186/s12859-022-04884-8 PMC 바로가기 [Article Type] Article
SARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicitySARS-CoV-2 스파이크 N-말단 도메인은 TMPRSS2 의존성 바이러스 진입 및 융합원성을 조절합니다Article Published on 2022-08-162022-09-11 Journal: Cell Reports [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 airway B.1.617 cell-cell fusion characterized chimeric spike chimeric spikes coronavirus CP: Microbiology Delta enrichment Entry exhibit function Fusogenicity increase Infection Interaction lentivirus Lineage lung cell lung cells Microbiology modulate Mutation N-terminal domain NTD NTDs omicron Organoid organoids pseudotyped Region S1/S2 cleavage S1/S2 cleavage efficiency SARS-CoV-2 SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus spike TMPRSS2 transfer variants variants of concern viral entry virus entry VOCs wild-type [DOI] 10.1016/j.celrep.2022.111220 PMC 바로가기 [Article Type] Article
The Acid Ceramidase Is a SARS-CoV-2 Host Factor산성 세라미다제는 SARS-CoV-2 숙주 인자입니다Article Published on 2022-08-152022-09-11 Journal: Cells [Category] SARS, 변종, [키워드] accelerated acid acid sphingomyelinase Analysis biochemical ceramidase ceramide Ceramides COVID-19 pandemic deacidify described down-regulate Effects enrichment Factor Fluoxetine fluoxetine. genomic Host hypothese hypotheses infected cells inhibit inhibitor interfere Lower lysosomal mRNA mRNAs Omicron variants ORF3 Protein reduce Replication reported RNA SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 variants shown specific acid Support therapeutic strategy transmission rates Treatment variant viral entry viral gene expression viral replication [DOI] 10.3390/cells11162532 PMC 바로가기 [Article Type] Article
A fast and sensitive absolute quantification assay for the detection of SARS-CoV-2 peptides using parallel reaction monitoring mass spectrometry병렬 반응 모니터링 질량 분석을 사용한 SARS-CoV-2 펩타이드 검출을 위한 빠르고 민감한 절대 정량 분석Article Published on 2022-08-152022-09-11 Journal: Journal of proteomics [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] Absolute quantification Clinical diagnosis clinics COVID-19 Ct values Early detection enrichment heat heat-inactivated high resolution high viral load investigated mass mass spectrometry Nasopharyngeal swab nasopharyngeal swab sample Orbitrap pandemic Patient peptide peptides positive positive patient positive patients PRM Protein quantification required RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 nucleocapsid SARS-CoV-2 peptide sensitivity speed Surveillance swab samples the disease Viral load Viral protein Viral proteins [DOI] 10.1016/j.jprot.2022.104664 PMC 바로가기 [Article Type] Article
Immunogenicity of BNT162b2 COVID-19 vaccine in New Zealand adults뉴질랜드 성인에서 BNT162b2 COVID-19 백신의 면역원성Article Published on 2022-08-122022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] age All participant All participants analysed anti-S IgG Antibody Response baseline Beta BMI BNT162b2 BNT162b2 mRNA vaccine BNT162b2 vaccine Cellular immune response cellular immune responses co-morbidities Cohort COVID-19 COVID-19 disease COVID-19 vaccine declined Delta diabete diabetes diabetics disease dose enrichment Ethnic groups female Gender General population IgG immune response immune responses immunoassay immunogenicity in vitro International Lower Māori median age Microparticle morbidities morbidity naïve neutralise neutralising antibody neutralising response neutralising responses neutralizing capacity New obesity of BNT162b2 Older Older adults omicron other variant other variants Pacific Islander Population prospective cohort study pulmonary disease Quantitative recipient representation response risk robust SARS-CoV-2 vaccine second dose second vaccination serious COVID-19 seroconverted serum sample serum samples strain the vaccine Vaccine variant Viral viral neutralisation Wuhan [DOI] 10.1016/j.vaccine.2022.07.009 PMC 바로가기 [Article Type] Article
MALDI-TOF Mass Spectrometric Detection of SARS-CoV-2 Using Cellulose Sulfate Ester Enrichment and Hot Acid Treatment셀룰로오스 황산염 에스테르 농축 및 고온 산 처리를 사용한 SARS-CoV-2의 MALDI-TOF 질량 분석 검출Article Published on 2022-08-052022-09-11 Journal: Journal of Proteome Research [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] acid acute respiratory syndrome acute respiratory syndrome coronavirus affinity Algorithm approach aspartate cause Cellulose cellulose sulfate enrichment characterized contributing to coronavirus coronavirus disease Coronavirus disease 2019 Coverage COVID-19 COVID-19 diagnosis demonstrated detection enrichment ester flight functional groups hot acid aspartate-selective hydrolysis hydrolysis MALDI-TOF MS marker mass mass spectrometry N protein nasal swabs nucleocapsid pandemic parameter peptide peptides processed proteomics rapid COVID-19 detection. SARS-CoV-2 sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sewage sulfate variety virus virus samples virus variant virus variants [DOI] 10.1021/acs.jproteome.2c00238 PMC 바로가기 [Article Type] Article