epigenomic – Page 2 – Communicable Diseases Research

Management of epigenomic networks entailed in coronavirus infections and COVID-19

Review

Published on 2020-08-052022-10-31
Journal: Clinical Epigenetics
[Category] COVID-19, MERS,

[키워드] acute respiratory syndrome Antiviral approach approved clinical trials clinically combination therapy coronavirus Coronavirus disease 2019 Coronavirus infection Coronavirus infections coronavirus pathogenesis COVID-19 COVID-19 disease CoVs death deaths drug effective emerging disease Epigenetic epigenomic Focusing Gene Expression genomic immune system increase in indicated infected case Inflammation Inflammatory marker MERS-CoV Middle East molecular mechanism Mutation outcome pathogen Patient Recombination Regulation Replication respiratory syndrome coronavirus respiratory tract SARS-CoV SARS-CoV-2 single-stranded RNA virus susceptibility the cytokine storm therapy Transcription viral entry viral replication virus Virus-host interaction worldwide pandemic
[DOI] 10.1186/s13148-020-00912-7 PMC 바로가기 [Article Type] Review

Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure

심부전의 사망률과 관련된 염색체 5q22의 유전적 변이 발견

Research Article

Published on 2016-05-052022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] acting activate addition African allergic allergy applied approach assays association Asthma Blood Cell chemokine chemokines chromosome clinical trial clinical trials cytokine death dendritic cell dendritic cells determinant development DNA methylation ENhance enhancer region epigenomic Evidence evidence of expressing expression Factor failure Follow-up gene encode Genetic Genetic variant Genome-wide association studies Genome-wide association study genotyping heart heart failure HEK293 high mortality human cell human tissues identify increase increased risk independent induce inhibiting knockdown leads maintain Mast cells maturation Meta-analysis molecular Monocytes Mortality multiple tissues NHLH1 Patient performed polymorphism Population populations Positive selection predicted promote replicated reporter reporter gene responses risk allele subject T helper T-cell therapeutic Therapeutics Therapies transcription factor TSLP turn variant Whole blood
[DOI] 10.1371/journal.pgen.1006034 PMC 바로가기 [Article Type] Research Article

Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway

죽상경화증 퇴행 동안 플라크 대식세포의 전사체에 대한 후성유전체 분석은 Wnt 신호 전달 경로의 활성화를 보여줍니다

Research Article

Published on 2014-12-042022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] activated Affect Analysis annotations approach arterial plaque macrophage arteries Atherosclerosis binding site canonical Cell cell motility cell type chromatin circulating condition control group demonstrated detect differentially expressed drug treatments eight element enrichment epigenomic eQTL Evidence expression foam cell functional Gene Expression humans identify in vitro in vivo increase Inflammation inflammatory disease inflammatory state innate immune system less Lipoproteins lowering Macrophage Macrophage response macrophage responses macrophages mice Migration molecular mouse model network overlap plaque plaque macrophage plaque macrophage response plaque macrophage responses plaque macrophages plaque regression plaques plasma lipoprotein plasma lipoproteins power promoter promoters reducing regressing plaque regressing plaques Regression Regression model regression models regulatory region response reversed risk significantly SNPs statins statistically Stimulation Systems biology TCF/LEF therapeutic target transcription factor transcription factors transcriptional change Transcriptome upregulated upregulated gene upregulated genes upstream validation study while Wnt Wnt signaling Wnt signaling pathway β-catenin
[DOI] 10.1371/journal.pgen.1004828 PMC 바로가기 [Article Type] Research Article