Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variantsSARS-CoV-2 변종을 차단하는 범용 약제로서의 임상 등급 ACE2Article Published on 2022-08-082022-09-11 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 Alpha analyzed Beta binding affinity caused clinical clinical trial COVID-19 Delta develop Efficacy epithelial cell epithelial cells Gamma human lung human lung epithelial cells independent Infection inhibit inhibited neutralized neutralizing antibody omicron Phase 2 principle proof reduced SARS-CoV-2 isolates SARS-CoV-2 variant SARS-CoV-2 variants several variant several variants soluble ACE2 strain tested therapeutic Therapeutic strategies therapeutic strategy These data Treatment Vaccine vaccine. variants variants of concern VeroE6 cell VeroE6 cells VoC [DOI] 10.15252/emmm.202115230 PMC 바로가기 [Article Type] Article
USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STINGUSP22는 STING의 활성화를 통해 III형 인터페론 신호 전달 및 SARS-CoV-2 감염을 제어합니다Article Published on 2022-08-062022-09-11 Journal: Cell Death & Disease [Category] SARS, 유전자 메커니즘, 치료제, [키워드] absence Activation Antiviral basal causative agent Control COVID-19 pandemic de novo Defense enzyme epithelial cells exogenous IFN expression function Host identify IFN IFN signaling IFN-stimulated gene IFN-stimulated genes IFN-λ IFNs implication interferons interferons (IFNs interferons (IFNs) intestinal epithelial cell involved ISG ISGs long-lasting Particles pattern Pattern recognition Pattern recognition receptors PRRs receptor reversed SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections secretion Signaling STAT Stat1 STING tumorigenesis Type Type III IFN Type III IFNs type III interferon USP22 viral infection viral replication [DOI] 10.1038/s41419-022-05124-w PMC 바로가기 [Article Type] Article
In-silico screening and in-vitro assay show the antiviral effect of Indomethacin against SARS-CoV-2In-silico 스크리닝 및 in-vitro assay는 SARS-CoV-2에 대한 Indomethacin의 항바이러스 효과를 보여줍니다Article Published on 2022-08-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analysis analyzed anti-inflammatory drug Antiviral effect applied can be used caused cellular Comparative Compound compounds Computational drug coronavirus coronavirus disease COVID-19 CTD death Differential gene expression drug drug candidate drug candidates Drug repurposing epithelial cell epithelial cells Gene Expression Host host response human cell human cells human lung human lung epithelial cells humans in-silico In-vitro in-vitro assay indomethacin Infection investigated moderate molecules mRNA expression profile nonsteroidal anti-inflammatory drug Perspective Protein responsible SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread tested the SARS-CoV-2 therapeutic Toxicogenomics treat Treatment Vaccine Vero CCL-81 cell Vero CCL-81 cells viral infection Virtual screening virtual screening. Vitamin was performed [DOI] 10.1016/j.compbiomed.2022.105788 PMC 바로가기 [Article Type] Article
Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies마비 관련 키나아제는 SARS-CoV-2 감염에 필요하며 항바이러스 전략의 세포 표적입니다Article Published on 2022-08-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 치료제, [키워드] AAK1 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral strategy approach approaches approved caused cellular combination treatment coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated drugs epithelial cells Erlotinib experiment expression functional GAK Genetic global health Health Host-targeted antivirals human lung human lung epithelial cells implication in vitro inhibited kinase kinase inhibitors kinases late stage life cycle multiple RNA viruses multiple RNA viruses Numb Numb-associated kinases other coronaviruses pandemic pharmacological principle probe reported required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro SARS-CoV-2 life cycle SARS-CoV-2 pseudovirus SARS-CoV-2. severe acute respiratory syndrome Coronavirus siRNA small molecule STK16 sunitinib suppressed synergistic synergistic effect target the SARS-CoV-2 threat treat viral entry wild type [DOI] 10.1016/j.antiviral.2022.105367 PMC 바로가기 [Article Type] Article
Cell tropism and viral clearance during SARS-CoV-2 lung infectionSARS-CoV-2 폐 감염 중 세포 친화성 및 바이러스 제거Article Published on 2022-08-012022-09-11 Journal: Pathology, research and practice [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Alpha alveolar macrophage Alveolar macrophages autopsy studies B.1.1.529 B.1.1.7 B.1.617.2 capillary microthrombosis caused Cellular target COVID-19 debate Delta detect driving Endothelial cell endothelial cells Endothelialitis epithelial cells fatal COVID-19 high viral load identify In situ hybridization infected cell key factor Lung infection lung tissue macrophages Microthrombosis omicron original virus strain Patient protein-coding RNA pulmonary reported RNA SARS-CoV-2 SARS-COV-2 infection severe COVID-19 spike Spike protein Time-course. variants variants of concern viral clearance viral infection Viral load Viral RNA was used [DOI] 10.1016/j.prp.2022.154000 PMC 바로가기 [Article Type] Article
Allelic imbalance of HLA-B expression in human lung cells infected with coronavirus and other respiratory viruses코로나바이러스 및 기타 호흡기 바이러스에 감염된 인간 폐 세포에서 HLA-B 발현의 대립형질 불균형Article Published on 2022-08-012022-09-11 Journal: European Journal of Human Genetics [Category] SARS, 변종, 유전자 메커니즘, [키워드] accompanied allelic analysis Analysis Antigen Antiviral association cells characterized contribute coronavirus cytokine Diseases epithelial cells experimental evidence expression genotypes heterozygous HLA HLA allele HLA alleles HLA-B human lung human lung cell human lung epithelial cells IFNβ in silico independent data set infected with SARS-CoV-2 less leucocyte loci lung cell lung cells other respiratory virus overexpression performed predicted respiratory viral infection respiratory viral infections respiratory virus RNA-seq data SARS-CoV-2 tissues viral infectious disease viral infectious diseases with COVID-19 [DOI] 10.1038/s41431-022-01070-5 PMC 바로가기 [Article Type] Article
Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection게놈 전체에 걸친 양방향 CRISPR 스크린은 뮤신을 SARS-CoV-2 감염을 조절하는 숙주 인자로 식별합니다Article Published on 2022-08-012022-09-11 Journal: Nature Genetics [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] ACE2 Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus airway Antiviral bidirectional cause clathrin conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CRISPR CRISPR screen Critical Defense defense mechanism Epigenetic epithelial cell epithelial cells expression Factor family functional highlight Highlights Host host defense human lung human lung epithelial cells identify in vitro infected individuals Infection inflammatory signaling inhibit mechanism mild respiratory modulating molecular weight mucin mucins murine models Pathways progression provide Regulation respiratory respiratory distress Respiratory illness respiratory viruses SARS-CoV-2 SARS-CoV-2 entry factors SARS-COV-2 infection SARS-CoV-2-host interaction SARS-CoV-2-host interactions severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 starting point Symptom syndrome the SARS-CoV-2 TMPRSS2 transcriptional Transport Viral viral infection [DOI] 10.1038/s41588-022-01131-x PMC 바로가기 [Article Type] Article
Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cellsOmicron이 아닌 조상 SARS-CoV-2는 일차 소아 비강 상피 세포에서 덜 효율적으로 복제합니다Article Published on 2022-08-012022-09-11 Journal: PLoS Biology [Category] Coronavirus, SARS, 변종, [키워드] acute respiratory syndrome Adults Air-liquid interface antiviral response Biology biology of SARS-CoV-2 changes in children coronavirus 2 coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 Delta delta variant epithelial cells Evidence Infection infections less Mild symptom nasal epithelial cell nasal epithelium NEC NECs omicron pediatric replicate replicated Replication respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly lower Support susceptible These data vaccination Viral RNA virus VOCs widespread [DOI] 10.1371/journal.pbio.3001728 PMC 바로가기 [Article Type] Article
The green tea catechin EGCG provides proof-of-concept for a pan-coronavirus attachment inhibitor녹차 카테킨 EGCG는 범 코로나바이러스 부착 억제제에 대한 개념 증명을 제공합니다Article Published on 2022-07-282022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Antiviral antiviral activity attachment block catechin caused Cell conserved coronavirus Coronavirus-2 Coronaviruses CoV CoV infection COVID-19 pandemic CoVs EGCG Endemic epigallocatechin epigallocatechin gallate epithelial cells gallate glycans green tea HCoV-OC43 Health heparan sulfate heparin highlight highly pathogenic CoVs Infection inhibitor inhibitors Lentiviral particle lentiviral particles Lung epithelial cells mechanism murine Prevent PROTECT Proteoglycan provide pseudotyped rapid response reduce remained required SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown Spike protein Spike proteins sulfate target cell Treatment Vaccine development virion binding virus [DOI] 10.1038/s41598-022-17088-0 PMC 바로가기 [Article Type] Article
SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl – accumulation in respiratory epitheliumSARS-CoV-2 뉴클레오캡시드 단백질은 단백질-단백질 상호작용 매개 세포내 Cl-호흡 상피에서의 축적을 통해 과염증을 유발합니다Article Published on 2022-07-272022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 신약개발, 치료법, [키워드] abrogated Airway inflammation CAMP cell lines cells CFTR Concentration COVID-19 cystic fibrosis Cytokine storms Defense demonstrated depleting downregulated elicit epithelial epithelial cell epithelial cells expression fibrosis glucocorticoid Host host defense human airway epithelial hyperinflammation immune response immune responses Inflammatory response Inflammatory responses inhibition inhibitor Intracellular knockout microRNA modulating murine model murine models N protein pathogen phosphodiesterase Phosphorylation promoted Protein pulmonary inflammation raised reducing regulated respiratory epithelium resulting robust Rolipram SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid second messenger selective serum SGK1 signaling pathway Smad3 structural protein suggested sustained targeting therapeutic strategy transmembrane Trigger upregulation [DOI] 10.1038/s41392-022-01048-1 PMC 바로가기 [Article Type] Article