Epitope profiling of monoclonal antibodies to the immunodominant antigen BmGPI12 of the human pathogen Babesia microtiarticle Published on 2022-11-302024-09-01 Journal: Frontiers in Cellular and Infection Microbiology [Category] 말라리아, [키워드] antibodies antigen capture apicomplexan parasite Babesia microti BmGPI12 ELISA epitope mapping Human babesiosis [Article Type] article
Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen testsArticle Published on 2022-09-152022-11-15 Journal: Cell [Category] SARS, 변종, 진단, 치료기술, [키워드] antibodies antibody Antibody binding Antigen Complete COVID-19 patient deep deep mutational scanning diagnostic Effect Emergency use authorization epitope epitope mapping escape mutation evaluate identify mammalian mammalian surface-display Mutation platform Point mutation predict profile public health rapid antigen test Rapid antigen tests Rapid diagnostic tests SARS-CoV-2 SARS-CoV-2 nucleocapsid protein susceptibility the antibody utility valuable resource variants variants of concern variants of SARS-CoV-2 [DOI] 10.1016/j.cell.2022.08.010 PMC 바로가기
Epitope mapping of neutralising anti-SARS-CoV-2 monoclonal antibodies: Implications for immunotherapy and vaccine designArticle Published on 2022-09-012022-11-15 Journal: Reviews in Medical Virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome affected anti-SARS-CoV-2 coronavirus coronavirus disease COVID-19 COVID-19 infection death disease drug Emergency use epitope epitope mapping Epitope-based vaccine food Immunotherapy individuals Medicine monoclonal monoclonal antibody neutralising neutralising MAb neutralising monoclonal antibody. pandemic RBD reactivity reported SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 virus the SARS-CoV-2 virus Vaccine design virus [DOI] 10.1002/rmv.2347 PMC 바로가기
Characterization of Functional B-Cell Epitopes at the Amino Terminus of Shigella Invasion Plasmid Antigen B (IpaB)시겔라 침입 플라스미드 항원 B (IpaB)의 아미노 말단에서 기능적 B-세포 에피토프의 특성화Article Published on 2022-08-092024-08-22 Journal: Applied and Environmental Microbiology [Category] 세균성이질, [키워드] epitope mapping invasion plasmid antigen B (IpaB) polyvalent immunogen Shigella Vaccine
ORFeome Phage Display Reveals a Major Immunogenic Epitope on the S2 Subdomain of SARS-CoV-2 Spike ProteinORFeome 파지 디스플레이, SARS-CoV-2 스파이크 단백질의 S2 하위 도메인에 대한 주요 면역원성 에피토프 공개Article Published on 2022-06-172022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Amino acid amino acid sequence anti-SARS-CoV-2 antibodies antibodies antibody Antibody Response Antibody responses applied approved binding binding site blocking cell entry cleave COVID-19 COVID-19 pandemic COVID-19 patients Diseases display Efficacy epitope epitope mapping Epitopes fusion peptide genomic genomic library Host host cell identify immunogenic library Major mechanism monoclonal antibody mutate Mutation neutralization neutralize NGS Open reading frame open reading frames ORFeome ORFs Particle peptide phage phage display RBD RBD region Receptor binding domain representing SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant SARS-CoV-2 variants sequence Serine serine protease serine protease TMPRSS2 spike the cell the RBD the SARS-CoV-2 genome therapeutic therapy TMPRSS2 Vaccine virus variants [DOI] 10.3390/v14061326 PMC 바로가기 [Article Type] Article
Induction of high affinity monoclonal antibodies against SARS-CoV-2 variant infection using a DNA prime-protein boost strategyDNA 프라임-단백질 부스트 전략을 이용한 SARS-CoV-2 변이체 감염에 대한 고친화성 단일클론항체 유도Article Published on 2022-06-092022-09-11 Journal: Journal of Biomedical Science [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Alpha alpha and delta variants angiotensin angiotensin-converting enzyme 2 animals Antibody titers approach approved best Beta Beta variant binding ability binding affinity boost broad spectrum clone coronavirus Coverage COVID-19 COVID-19 vaccination D614G Delta delta variant DNA ELISA Emergency use Endemic epitope epitope mapping Epitopes evaluated exhibit flu Gamma generate high affinity Human angiotensin-converting enzyme 2 include induction Infection Lambda monoclonal antibodies monoclonal antibody monoclonal antibody combination Multiple neutralization neutralization potency neutralize Neutralizing antibody titer neutralizing capacity neutralizing epitope neutralizing epitopes Outbreaks PROTECT RBD Receptor-binding domain regions SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant selected Spike protein the receptor-binding domain the spike protein therapeutic drug therapeutic effect therapeutic effects treat treated Treatment variant variants VoC VOCs were used Wuhan strain [DOI] 10.1186/s12929-022-00823-0 PMC 바로가기 [Article Type] Article
Epitope Mapping of an Anti-Chinese/Golden Hamster Podoplanin Monoclonal AntibodyArticle Published on 2022-06-012023-07-09 Journal: Monoclonal antibodies in immunodiagnosis and immunotherapy [Category] COVID19(2023년), [키워드] enzyme-linked immunosorbent assay epitope mapping hamster podoplanin monoclonal antibody [DOI] 10.1089/mab.2022.0014
Structural mapping of antibody landscapes to human betacoronavirus spike proteins인간 베타 코로나바이러스 스파이크 단백질에 대한 항체 지형의 구조적 매핑Article Published on 2022-05-062022-09-12 Journal: Science Advances [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome Analysis antibody Antibody Response antigenic complexes convalescent CoVs cross-reactive disease severity epitope epitope mapping General population HKU1 human betacoronavirus human CoV Immunity infections molecular OC43 polyclonal reactivity SARS-CoV-2 SARS-CoV-2-infected individuals seasonal coronavirus sera serum antibodies specificity spike Spike protein β-CoV β-CoVs [DOI] 10.1126/sciadv.abn2911 PMC 바로가기 [Article Type] Article
High Titers of Low Affinity Antibodies in COVID-19 Patients Are Associated With Disease SeverityCOVID-19 환자에서 낮은 친화도 항체의 높은 역가는 질병 중증도와 관련이 있습니다Article Published on 2022-04-132022-09-12 Journal: Frontiers in Immunology [Category] Coronavirus, COVID19(2023년), SARS, 진단, [키워드] addition Affect affinity analyzed antibodies antibody production Antibody Response Antibody titer Antigen association binding clinical information coronavirus disease COVID COVID-19 COVID-19 patient Critically ill critically ill patients disease Disease progression disease severity domain epitope mapping humoral IgA IgA antibody IgG IgG antibody titer IgM immunoassay Infectious diseases Interaction investigated isotype material maturation pandemic Patient peptide positive Prognostic marker Protein Proteins RBD SARS-CoV2 sera severity specific antibody SPRi (surface plasmon resonance imagery) the RBD titer viral infection [DOI] 10.3389/fimmu.2022.867716 PMC 바로가기 [Article Type] Article
A broad-spectrum nanobody targeting the C-terminus of the hepatitis B surface antigen for chronic hepatitis B infection therapyArticle Published on 2022-03-012023-06-12 Journal: Antiviral Research [Category] B형 간염, [키워드] Broad-spectrum therapeutic antibody Chronic hepatitis B virus epitope mapping Heavy chain antibody hepatitis B surface antigen Immunotherapy [DOI] 10.1016/j.antiviral.2022.105265