SARS-CoV-2 infection impacts carbon metabolism and depends on glutamine for replication in Syrian hamster astrocytesArticle Published on 2022-10-012022-11-16 Journal: Journal of neurochemistry [Category] COVID19(2023년), SARS, 치료기술, [키워드] Alpha Alter Astrocyte astrocytes blockade Brain carbon metabolism cause change Cognitive impairment Confusion COVID-19 death evaluated Evidence evidenced Glucose Glutamine Glycolysis hamsters Hyperactivation Immunopathogenesis Impact in vitro in vivo Inflammatory response intranasally ketoglutarate Lung disease memory metabolomics neurological Neurological diseases neurological impairment Neuropathology neurotransmitter olfactory Protein proteomics proteomics. pyruvate reduction Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 synaptic Transmission viral replication [DOI] 10.1111/jnc.15679 PMC 바로가기
Humoral response and neutralising capacity at 6 months post-vaccination against COVID-19 among institutionalised older adults in ArgentinaArticle Published on 2022-09-262022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] affected age aging adults Anti-spike anti-Spike IgG antibody AZD1222 B.1 BBIBP-CorV Buenos Aires Cohort Complete correlation COVID-19 COVID-19 pandemic death different time point dose elicited evaluated Evidence evidenced exhibited Gender highlighting hospitalisation humoral Humoral response IgG titer IgG titers initial management neutralising Neutralising activity Neutralising Antibodies neutralising antibodies. Older omicron pandemic participant Participants plasma sample platform provide public health resulting SARS-CoV-2 significantly higher Sputnik-V Strong vaccination vaccination schedule vaccine platform Volunteer [DOI] 10.3389/fimmu.2022.992370 PMC 바로가기
The Omicron Variant BA.1.1 Presents a Lower Pathogenicity than B.1 D614G and Delta Variants in a Feline Model of SARS-CoV-2 InfectionArticle Published on 2022-09-142022-11-15 Journal: Journal of Virology [Category] SARS, 변종, 치료기술, [키워드] addition B.1 B.1.1.529 B.1.617.2 body temperature cats clinical COVID-19 D614G death Delta delta variant disease severity distribution effective Evidence evidenced histologic Hospitalization immunization immunofluorescence increased risk Infection infections Infectious virus Inflammation inoculated less lethargic log Lower lung Lung pathology Mild Model mutated nasal nasal turbinate observation omicron Pathogenesis pathogenic pathogenicity Pneumonia Postinfection present reduced remained Replication SARS-CoV-2 SARS-CoV-2 D614G SARS-CoV-2 variant secretion significant increase South Africa Spread staining suggested susceptible TCID tissue tissue tropism variant Variant of concern. variants Viral load viral replication Viral RNA viral titer Viral variants Virological virulence virus virus [DOI] 10.1128/jvi.00961-22 PMC 바로가기
Plasma biomarkers for systemic inflammation in COVID-19 survivorsArticle Published on 2022-09-012022-11-15 Journal: Proteomics. Clinical applications [Category] SARS, 바이오마커, [키워드] Asymptomatic Biomarker Biomarkers coronavirus disease COVID-19 COVID-19 patient CXCL10 determine Diagnosis dysregulated evidenced exhibited healthy subject immunoassay Impact IMPROVE Infection Inflammation Inflammatory inflammatory protein long haulers. majority multiplex PASC plasma Post-infection Potential biomarker proportion Protein proteomics SARS-CoV-2 significant changes in significantly survivor Survivors Symptom systemic inflammation target Treatment upregulated while [DOI] 10.1002/prca.202200031 PMC 바로가기
Hydroxypropyl-beta-cyclodextrin (HP-BCD) inhibits SARS-CoV-2 replication and virus-induced inflammatory cytokines하이드록시프로필-베타-사이클로덱스트린(HP-BCD)은 SARS-CoV-2 복제 및 바이러스 유발 염증성 사이토카인을 억제합니다Article Published on 2022-09-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] accompanied ACE2 Affect affected Alter antiviral activity Beta Beta-cyclodextrin Calu Calu-3 Cell cell line cell lines cholesterol COVID-19 COVID-19 disease cyclodextrin Cytokines cytopathic effects demonstrated disease drug Drug repurposing evidenced excipient experimental models expression Human Hyperinflammatory syndrome immunomodulatory effect in vitro in vivo Inflammation Inflammatory cytokine Inflammatory response inhibit inhibited inhibiting investigated microbial products mitigate Monocytes Particles pathophysiology primary human cells Proinflammatory cytokine proinflammatory cytokines protein levels reducing reduction in Replication replication complexes required Respiratory system safety profile SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV2 selected selective significantly systemic manifestations the disease therapeutic therapeutic agent therapeutic strategy These data treating Treatment viral cytopathic effect virus virus virus replication Virus replication. virus RNA [DOI] 10.1016/j.antiviral.2022.105373 PMC 바로가기 [Article Type] Article
Maternal epigenetic responsibility: what can we learn from the pandemic?Article Published on 2022-09-012022-11-16 Journal: Medicine, Health Care, and Philosophy [Category] 유전자 메커니즘, [키워드] changes children complex determinant distress Drawing Effect environmental condition Epigenetic epigenetics evidenced example Factor feasible Gene Expression hazards Health Health status implication increasingly individuals Isolation Maternal Maternal effects mother offspring pandemic physical Pregnancy pregnant women prenatal problem Psychological research finding responsibility responsibility. smoking Stress subsequent women [DOI] 10.1007/s11019-022-10094-z PMC 바로가기
Can we get out of the COVID pandemic without adequate vaccination coverage in the pediatric population?소아 인구에 적절한 예방 접종 범위가 없으면 COVID 전염병에서 벗어날 수 있습니까?Article Published on 2022-08-192022-09-11 Journal: Italian Journal of Pediatrics [Category] SARS, 변종, 치료기술, [키워드] age all subjects approved booster Can children contrary Coverage COVID COVID-19 COVID-19 incidence COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines death delta variant diagnosed diffusion dose epidemiological epidemiological surveillance Epidemiology evidenced explain General population greater groups Hospitalization Infant Infection Infectious diseases Italy lower risk manuscript minor nucleic acid Older pandemic pediatric Pediatric case pediatric cases pediatric cohort Pediatric infectious diseases Population positive prolongation proportion rapid increase real-time reverse-transcriptase polymerase-chain-reaction recorded recruited remained RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleic acid SARS-CoV-2. severe disease significant increase specimen subject Surveillance susceptible vaccination vaccine dose virus [DOI] 10.1186/s13052-022-01339-x PMC 바로가기 [Article Type] Article
Infections with the SARS-CoV-2 Delta variant exhibit fourfold increased viral loads in the upper airways compared to Alpha or non-variants of concernSARS-CoV-2 Delta 변이체 감염은 우려되는 알파 또는 비 변이체에 비해 상기도에서 4배 증가된 바이러스 부하를 나타냅니다.Article Published on 2022-08-172022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age all age group all age groups Alpha Alpha variant B.1.1.7 B.1.617.2 coronavirus Delta delta variant dominant Evidence evidenced genomic Genomic surveillance group groups in viral no difference Older age other variants reported respiratory sample Respiratory samples Sample size SARS-CoV-2 severe acute respiratory syndrome Coronavirus Sex significantly lower suggested Surveillance the SARS-CoV-2 Transmissibility upper airway vaccination variant variants Viral load viral loads Wuhan strain [DOI] 10.1038/s41598-022-18279-5 PMC 바로가기 [Article Type] Article
Remote treatment of pectus carinatum (Telepectus) during the COVID-19 pandemicResearch article Published on 2022-08-012022-10-05 Journal: Journal of pediatric surgery [Category] 치료법, [키워드] addition Analysis analyzed Care Chest Chest wall deformities Cohort COVID-19 outbreak COVID-19 pandemic demonstrated evaluated Evidence evidenced feasibility Frame Frequency highest hospitals incidence Intention Level material Modification pandemic Patient Patient satisfaction patients pectus pectus carinatum performed platform question reduction in remote Result Satisfaction telehealth Telemedicine Treatment Type [DOI] 10.1016/j.jpedsurg.2021.10.048 [Article Type] Research article
Point-of-care COVID-19 testing: colorimetric diagnosis using rapid and ultra-sensitive ramified rolling circle amplification현장 진료 COVID-19 테스트: 신속하고 매우 민감한 분기형 롤링 서클 증폭을 사용한 비색 진단Article Published on 2022-08-012022-09-11 Journal: Analytical and bioanalytical chemistry [Category] COVID19(2023년), SARS, 치료기술, [키워드] amplification color change colorimetric detection Colorimetric sensing Combination COVID-19 Diagnosis diagnosis of SARS-CoV-2 diagnostic displaying DNA amplification evidenced gene amplification Genome isothermal isothermal amplification molecular naked eye nucleotide performed point-of-care polymerase positive Prevent probe Propagation Pyrophosphate Ramified rolling circle amplification (RAM) reaction Reactions released respiratory syncytial virus respiratory viral RHthio-CuSO 4 probe Rolling circle amplification SARS-CoV-2 SARS-CoV-2. selectivity sensitivity simple treatment temperature this system Treatment virus [DOI] 10.1007/s00216-022-04156-7 PMC 바로가기 [Article Type] Article