Efficacy of care manager-led support for family caregivers of people with dementia during the COVID-19 pandemic: a randomized controlled studyRandomized Controlled Trial Published on 2022-08-152022-10-05 Journal: BMC Geriatrics [Category] 임상, [키워드] analyzed baseline burden Care Care burden Caregiver changes in cognitive collected conducted control group COVID-19 COVID-19 infection COVID-19 pandemic decrease Dementia Deterioration Effect Efficacy ENhance enrolled evaluated exacerbate examined family fear functions groups IMPROVE Infection infection control Infection control measure Infection prevention information Intervention intervention group interview measure Modification Multiple Older pandemic participant PHQ-9 physical preparedness Primary outcome Psychological outcome randomized controlled study Randomized controlled trial randomly divided Registered regression analysis risk of infection Saliva salivary scale secondary outcome secure Spread Support usual care was measured [DOI] 10.1186/s12877-022-03371-2 PMC 바로가기 [Article Type] Randomized Controlled Trial
Investigating Linkages Between Spatiotemporal Patterns of the COVID-19 Delta Variant and Public Health Interventions in Southeast Asia: Prospective Space-Time Scan Statistical Analysis MethodCOVID-19 델타 변이의 시공간 패턴과 동남아시아의 공중 보건 개입 간의 연관성 조사: 전향적 시공간 스캔 통계 분석 방법Article Published on 2022-08-092022-09-11 Journal: JMIR Public Health and Surveillance [Category] SARS, 변종, 치료기술, [키워드] adopted aligned Analysis analyzed Asia assistance benefit Cluster Clusters collected Continuous continuous surveillance country COVID-19 COVID-19 transmission cumulative Delta delta variant effective Effectiveness Epidemic exacerbate heterogeneity identify increase in Indonesia infection risk Intervention linkage Malaysia measure NPI outbreak pattern progression Propagation Prospective Public public health authorities public health authority Public health intervention reducing Relative risk risk risk of COVID-19 SEA shown Singapore Southeast Asia space-time scan. spatiotemporal Surveillance Transmission Variation variations [DOI] 10.2196/35840 PMC 바로가기 [Article Type] Article
Gasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis Research Published on 2022-08-042022-10-05 Journal: The Pan African Medical Journal [Category] 변종, [키워드] Analysis contributed defined demonstrated DNA dysregulated exacerbate gasdermin D Genetic GSDMD implicated incidence Inflammation inflammatory cell Inflammatory cytokine Inflammatory cytokines mice mitochondrial NET Neutrophil extracellular trap oxidized Paquinimod pathology Patient pharmacological Platelet positive feedback loop promoted proteomic pyroptosis rapid clinical deterioration Sepsis Signaling significantly increased survival TLR4 toll-like receptor 4 triggering upregulation [DOI] 10.1038/s44161-022-00108-7 [Article Type] Research
Anti-cardiolipin IgG autoantibodies associate with circulating extracellular DNA in severe COVID-19항 카디오리핀 IgG 자가항체는 심각한 COVID-19에서 순환하는 세포외 DNA와 연관됩니다Article Published on 2022-07-222022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] analyzed Anticoagulant association autoantibody circulating citrullinated histone citrullinated histones collected COVID-19 COVID-19 severity disease severity exacerbate extracellular DNA glycoprotein IgA IgG IgG and IgM IgM investigated Lupus lupus anticoagulant marker mild patients NET neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Patient patients with COVID-19 positive patient positive patients Prevalence prothrombin SARS-CoV-2 sera severe COVID-19 severe disease Severe patient severe patients severity the disease with COVID-19 [DOI] 10.1038/s41598-022-15969-y PMC 바로가기 [Article Type] Article
Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2바이러스 E 단백질은 SARS-CoV-2의 BET 단백질 매개 진입 후 길항작용을 중화합니다Article Published on 2022-07-192022-09-11 Journal: Cell Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE2 ACE2 expression acetylated acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral antiviral response BET BET inhibitors BET proteins bind BRD2 BRD3 BRD4 bromodomain Cell coronavirus COVID-19 CP: Microbiology Critical Depletion domain downregulate E protein enzyme exacerbate Factor histone histone mimetic inactivated inactivation Infection inhibitor inhibitors interferon interferon response mice Microbiology Mortality neutralization neutralize overexpressing Protein Replication SARS-CoV-2 SARS-COV-2 infection Support suppresse treated Treatment viral replication [DOI] 10.1016/j.celrep.2022.111088 PMC 바로가기 [Article Type] Article
Perceived discrimination as a modifier of health, disease, and medicine: empirical data from the COVID-19 pandemic Research Published on 2022-07-182022-10-05 Journal: Translational Psychiatry [Category] 치료법, [키워드] Analysis association Care cognitive Comorbidities COVID-19 COVID-19 infection COVID-19 pandemic disease evaluated exacerbate examined Factor form Health Illness severity impacted Increasing Infection information Logistic regression mental health problems Mild mild cases neurological outcome outcomes pandemic path Patient Perceived predict predicted Prevalence prevalent problems provide provided recovered COVID-19 patient reported risk secondary Sex significantly social determinant Sociodemographic Sociodemographic factor Stress stress levels Symptom Symptoms tested [DOI] 10.1038/s41398-022-02047-0 [Article Type] Research
Critically ill COVID-19 patients with neutralizing autoantibodies against type I interferons have increased risk of herpesvirus diseaseI형 인터페론에 대한 자가항체를 중화하는 중환자 COVID-19 환자는 헤르페스 바이러스 질병의 위험이 증가했습니다Article Published on 2022-07-052022-09-12 Journal: PLoS Biology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] 95% confidence interval age Analysis anatomical antiviral action autoantibodies autoantibody caused clinical outcomes CMV Cohort coronavirus 2 COVID-19 COVID-19 cohort COVID-19 patient Critically ill critically ill patients deficiency early diagnosis exacerbate Gender healthy donors herpes simplex herpesvirus disease herpesviruses heterogeneity Hospitalization ICU IFN IFNs IgA IgG IgG level IgM increased risk Infection intensive care likelihood longitudinal Neutralizing Odds ratio one patient Patient plasma predict predisposition respiratory SARS-CoV-2 screened steroid treatment Stratification suffered Switzerland tested tracheobronchial secretions Treatment type I interferon virus [DOI] 10.1371/journal.pbio.3001709 PMC 바로가기 [Article Type] Article
Air pollution and COVID-19 mortality and hospitalization: An ecological study in IranResearch article Published on 2022-07-012022-10-05 Journal: Atmospheric Pollution Research [Category] 치료기술, [키워드] 95% CI Air pollution applied association conditions coronavirus COVID-19 COVID-19 hospitalization COVID-19 mortality Daily death death rate ecological Effect exacerbate exposure to function Hospital admission Hospitalization increase in investigated Iran Medical Sciences Mortality National PM10 and PM2.5 Poisson regression model recorded resulting risk severe COVID-19 SO2 sulfur dioxide university was obtained [DOI] 10.1016/j.apr.2022.101463 [Article Type] Research article
Facial dermatoses and use of protective mask during Covid-19 pandemic: A clinical and psychological evaluation in patients affected by moderate-severe atopic dermatitis under treatment with dupilumab코비드-19 대유행 중 안면 피부병 및 보호 마스크 사용: 두필루맙 치료 중 중등도 아토피 피부염에 걸린 환자의 임상 및 심리학적 평가Article Published on 2022-07-012022-09-12 Journal: Dermatologic therapy [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] affected allergic disease Analysis atopic atopic dermatitis calculated contribute COVID-19 Diseases distress Dupilumab Efficacy ENhance evaluate evaluated Evidence exacerbate face Face mask facial facial dermatoses. greater HADS incidence include Inflammatory Italy mandatory Mask Masks Mental moderate-severe Modification Novara pandemic Patient patients Prevalence Protective protective effect Psychological psychological Impact psychological score recorded reducing reduction in severity significantly significantly lower statistically significant difference subject therapy treated Treatment two group two groups [DOI] 10.1111/dth.15573 PMC 바로가기 [Article Type] Article
Bleeding Complications in Patients With Perioperative COVID-19 Infection Undergoing Cardiac Surgery: A Single-Center Matched Case-Control StudyObservational Study Published on 2022-07-012022-10-05 Journal: Journal of cardiothoracic and vascular anesthesia [Category] 임상, [키워드] age bleeding Blood blood component body mass index cardiac Cardiac surgery Cardiopulmonary cardiopulmonary bypass Case-control chest tube Coagulation system Complication complications consecutive patient Control control group coronavirus Coronavirus 2019 correlation COVID-19 COVID-19 infection COVID-19 patient Deleterious described deviate diagnosis of COVID-19 died exacerbate Hemorrhagic Hemostasis incidence increased risk Infection inflammatory reaction intensive care intensive care unit Matched measurement multiple organ failure Non-COVID-19 patients operative risk outcome Patient patients without COVID-19 Perioperative positive postoperative previous study renal reported Respiratory failure retrospective severe respiratory failure Sex Shock significantly higher Society study group study period surgical the study group Thromboembolic events [DOI] 10.1053/j.jvca.2021.11.013 PMC 바로가기 [Article Type] Observational Study