The TLR-NF-kB axis contributes to the monocytic inflammatory response against a virulent strain of Lichtheimia corymbifera, a causative agent of invasive mucormycosisArticle Published on 2022-10-132022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] 24 hours activated Activation Apoptosis apoptotic cascade caused Cell cell damage characterized contribute COVID-19 CTLs Cytokines Diabetes Mellitus Diagnosis Diseases ENhance exhibit fungal Fungal infection fungi Hematological malignancies host cell Host immune response host inflammatory response host-pathogen interactions human monocyte human monocytes IL-1β IL-6 increase in individual Infection Inflammatory Inflammatory response inflammatory signaling Interaction invasive killing life-threatening modulation monocyte mortality rate Mucorales Mucormycosis NF-kB Occurrence organ pathogenic phagocyte phagocytosis priming pro-inflammatory cytokine produced progression PRRs receptor receptors receptors. regulate secreted signaling pathway spore susceptible synergistic therapy TLR TLR4 TLRs TNF-α Toll-like receptor transcription factor virulent [DOI] 10.3389/fimmu.2022.882921 PMC 바로가기
Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low ToxicityArticle Published on 2022-10-132022-11-15 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] anti-SARS-CoV-2 antiviral activity antiviral agent binding caspase 3 cathepsin Critical cytotoxicity derivative direct-acting drug design exhibit inhibit inhibitor interactions M pro piperazine protease SARS-CoV-2 Spread Structure target therapy for COVID-19 variants X-ray [DOI] 10.1021/acs.jmedchem.2c01146 PMC 바로가기
DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2Article Published on 2022-10-062022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] administration animal challenge model antibodies antibody cocktail Antigen antiviral potency binding cryo-EM demonstrated Efficacy effort exhibit forms functional High-resolution in vivo Interaction lineages mAb monoclonal antibody monoclonal antibody therapy omicron performed populations promote Prophylactic Prophylaxis Protective Protein SARS-CoV-2 serum antibody specificity Strategy Support trimeric [DOI] 10.1038/s41467-022-33309-6 PMC 바로가기
Can iron, zinc, copper and selenium status be a prognostic determinant in COVID-19 patients?Review article Published on 2022-10-012022-10-05 Journal: Environmental toxicology and pharmacology [Category] COVID19(2023년), SARS, 바이오마커, 변종, [키워드] Can Concentration Control copper correlated COVID-19 COVID-19 patients death rate deficiency dispersal exhibit facilitate host immune responses increase in independent risk factor Infection Inflammatory cytokine iron modify outcome oxidative stress Patient Prognosis prognostic regulate replication of SARS-CoV-2 risk of infections SARS-CoV-2 Selenium serum serum Cu levels severe COVID-19 significantly higher Spike protein suppress the SARS-CoV-2 viral genome viral replication while worse prognosis Zinc [DOI] 10.1016/j.etap.2022.103937 [Article Type] Review article
Brequinar and dipyridamole in combination exhibits synergistic antiviral activity against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19Research article Published on 2022-10-012022-10-05 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 치료법, 치료제, [키워드] acute respiratory syndrome Antiviral antiviral activity Antiviral treatment B.1.351 B.1.617.2 Beta Brequinar cellular Combination coronavirus coronavirus disease COVID-19 de novo deaths Delta DHODH Dihydroorotate dehydrogenase (DHODH) Dipyridamole drug treatments effective enzyme evade Evolution of SARS-CoV-2 exhibit global pandemic Host host cell in vitro Infection infections inhibitor maintain medical need monoclonal antibody nucleotide pathway rationale Replication required resulting RNA virus SARS-CoV-2 SARS-COV-2 infection selective shown Support synergistic therapy treat Treatment Vaccine variants viral replication [DOI] 10.1016/j.antiviral.2022.105403 [Article Type] Research article
Peimine inhibits variants of SARS-CoV-2 cell entry via blocking the interaction between viral spike protein and ACE2Article Published on 2022-10-012022-11-16 Journal: Journal of food biochemistry [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome addition Analysis binding affinity block Calu-3 caused cell entry complementary coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients docking drug energy transfer evade exhibit Fritillaria functional glycoprotein Hydrogen bond Infection inhibit inhibit SARS-CoV-2 inhibitor Interaction lung cells molecular docking analysis N501Y patients peimine. Protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 viral infection significantly small molecule suggested suppresse the spike protein treatment for COVID-19 Vaccine variant variant spike variants of concern variants of SARS-CoV-2 viral entry viral infection viral infections viral spike viral spike protein VoC VOCs [DOI] 10.1111/jfbc.14354 PMC 바로가기
Clinical efficacy and in vitro neutralization capacity of monoclonal antibodies for severe acute respiratory syndrome coronavirus 2 delta and omicron variants중증급성호흡기증후군 코로나바이러스 2 델타 및 오미크론 변이체에 대한 단일클론항체의 임상적 효능 및 시험관내 중화능Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Casirivimab casirivimab/imdevimab clinical Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient decrease delta variant dosage Efficacy except for exhibit Hospital stay Imdevimab in vitro in vitro data in vivo Infection mAb mAbs monoclonal monoclonal antibodies monoclonal antibody neutralization Neutralization assay neutralization capacity neutralizing capacity neutralizing effect Omicron variant Patient patients treated performed provided receiving respiratory respiratory tract respiratory viral RNA SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus sotromivab Sotrovimab the SARS-CoV-2 therapeutic therapy treated variant Viral Virus neutralization virus neutralization assay. virus neutralization assays [DOI] 10.1002/jmv.27916 PMC 바로가기 [Article Type] Article
(+)-Usnic Acid and Its Derivatives as Inhibitors of a Wide Spectrum of SARS-CoV-2 VirusesArticle Published on 2022-09-292022-11-15 Journal: Viruses [Category] SARS, 치료제, [키워드] acid Antiviral antiviral action antiviral activity Antiviral compound binding site Compound compounds Delta derivative exhibit glycoprotein hemoglobin inhibitory activity main viral protease 3CLPro mechanism metabolite molecular Molecular modeling N-terminal domain omicron performed protease SARS-CoV-2 SARS-CoV-2 virus shown Spectrum strain Strains Surface glycoprotein surface glycoprotein S usnic acid virus virus SARS-CoV-2. Wuhan [DOI] 10.3390/v14102154 PMC 바로가기
Characterizing the Spatiotemporal Heterogeneity of the COVID-19 Vaccination LandscapeArticle Published on 2022-09-282022-11-16 Journal: American journal of epidemiology [Category] SARS, 변종, [키워드] acute respiratory syndrome center Cluster Control coronavirus coronavirus disease Coronavirus disease 2019 Coverage COVID-19 COVID-19 vaccination Critical data accuracy discrepancy effort exhibit foci growth heterogeneity IMPROVE landscape outcome prevention rising SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome coronavirus 2 spatiotemporal Spatiotemporal analysis statistically the SARS-CoV-2 the United State The United States These data Transmission United States vaccination vaccination. variant widespread [DOI] 10.1093/aje/kwac080 PMC 바로가기
Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadthArticle Published on 2022-09-222022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, [키워드] activity antibodies antibody antibody cocktail antibody resistance binding breadth computational simulation costly COVID-19 crosslinking cryo-EM Engineering epitope exhibit IMPROVE Infection mouse model Neutralizing Neutralizing activity parental RBD reduce SARS-CoV-2 SARS-CoV-2 variant the receptor-binding domain therapeutic efficacy therapy variants virus-neutralizing X-ray crystallography [DOI] 10.1038/s41467-022-33284-y PMC 바로가기