A Framework for Biosensors Assisted by Multiphoton Effects and Machine LearningArticle Published on 2022-09-012022-11-15 Journal: Biosensors [Category] SARS, 치료기술, [키워드] Analysis biosensor cells complex demonstrated detect determine Effect Effectiveness exhibited expand framework function highlight information Interaction Invasion machine machine learning nonlinear optics optical optical biosensors Organisms Perspective photonics. physical predict responsible SARS-CoV-2 the SARS-CoV-2 virus used to evaluate viruses [DOI] 10.3390/bios12090710 PMC 바로가기
Single cell gene expression profiling of nasal ciliated cells reveals distinctive biological processes related to epigenetic mechanisms in patients with severe COVID-19Research article Published on 2022-09-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, 임상, [키워드] Activation addition analyses biological processe Cell cellular chromatin ciliated cell Clinical course COVID-19 disease DNA downregulation Epigenetic epithelial cell expand explain Gene expression profiling gene expression signature healthy control histone methylation Histones Interaction mechanism mechanisms membrane permeability Methylation miRNA misfolded proteins Mitochondria Mitochondrial function molecular nasal nasopharyngeal objective pathogenic mechanism pathway enrichment Patient patients with COVID-19 Regulation Regulatory Result reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 miRNAs scRNAseq sequence severe COVID-19 Single-cell RNA sequencing Single-cell transcriptomics the patient upregulation were used [DOI] 10.1016/j.compbiomed.2022.105895 [Article Type] Research article
AI-based search for convergently expanding, advantageous mutations in SARS-CoV-2 by focusing on oligonucleotide frequenciesArticle Published on 2022-08-312022-11-16 Journal: PLoS ONE [Category] SARS, 변종, [키워드] amino acids candidate changes in expand Focusing Frequency function identify involved Lineage lineages MOST Mutation mutations Neutral occur omicron phylogenetically SARS-CoV-2 SARS-CoV-2 genome sequence Transmission viral genome viral replication virus [DOI] 10.1371/journal.pone.0273860 PMC 바로가기
A Randomized, Placebo-Controlled Clinical Trial of Bamlanivimab and Etesevimab Together in High-Risk Ambulatory Patients With COVID-19 and Validation of the Prognostic Value of Persistently High Viral Load코로나19 고위험 보행 환자를 대상으로 한 밤라니비맙과 에테세비맙의 무작위 위약 대조 임상 시험 및 지속적으로 높은 바이러스 부하의 예후 가치 검증Randomized Controlled Trial Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age ambulatory ambulatory patient ambulatory patients antibody treatment applicability bamlanivimab baseline characterized clinical clinical status Cohort confidence interval coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 test Day death determine etesevimab expand first positive greater high risk Hospitalization infused Interim analyses interim analysis intravenously investigated load lower dose median median age Mild-to-moderate NCT04427501 occurred optimal dose outcome Patient persistently high viral load. phase Placebo placebo group receiving reduction in respiratory risk factor SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe COVID-19 Support the placebo group These data those receiving placebo Treatment Trial validation value variant Viral Viral load [DOI] 10.1093/cid/ciab912 PMC 바로가기 [Article Type] Randomized Controlled Trial
Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escapeOmicron SARS-CoV-2 돌연변이는 스파이크 업-RBD 형태를 안정화하고 비-RBM-결합 단일클론 항체 탈출을 유도합니다Article Published on 2022-08-242022-09-11 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] Accessibility ACE2 binding analysis antibody complexes conformational change cryo-EM ENhance epitope expand human ACE2 immune evasion mechanism monoclonal antibody Mutation neutralizing antibody omicron performed Prevent prototype Receptor binding restrict S309 SARS-CoV-2 SARS-CoV-2 mutation stability Substitution substitutions target triggered up-RBD variants of concern VOCs [DOI] 10.1038/s41467-022-32665-7 PMC 바로가기 [Article Type] Article
Summary of Guidance for Minimizing the Impact of COVID-19 on Individual Persons, Communities, and Health Care Systems – United States, August 2022Article Published on 2022-08-192022-11-15 Journal: Morbidity and Mortality Weekly Report [Category] SARS, 변종, 치료제, [키워드] acute illness age Antiviral agents approach Care cause CDC changes in circulating variants conditions COVID-19 COVID-19 illness current death effective effort expand exposure Health high risk Hospitalization Immunity Immunocompromised Impact increase individual Infection information Mask measure Measures medical condition monoclonal antibodies nonpharmaceutical intervention Nonpharmaceutical interventions preexposure prophylaxis Prevent PROTECT public health receive recommendation reduce reduced reducing Respirator risk SARS-CoV-2 symptomatic System therapeutic Treatment United States vaccination Vaccine Vaccines Ventilation virus [DOI] 10.15585/mmwr.mm7133e1 PMC 바로가기
Perinatally Human Immunodeficiency Virus-Infected Adolescents and Young Adults Demonstrate Distinct BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccine Immunogenicity주산기 인간 면역결핍 바이러스에 감염된 청소년 및 젊은 성인은 뚜렷한 BNT162b2 메신저 RNA 코로나바이러스 질병 2019 백신 면역원성을 나타냅니다.Article Published on 2022-08-152022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adolescent anti-SARS-CoV-2 humoral antibody Antigen Antigen-specific T cells Antiretroviral therapy ART baseline BNT162b2 BNT162b2 mRNA BNT162b2 mRNA COVID-19 vaccine CD4+ T cell CD4+ T-cell CD40L Cellular responses characterized Cluster collected coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 demonstrated dose Efficacy eligibility evaluated expand feature Follow-up group HCs healthy control HIV HIV-infected patient HIV-infected patients Human Human immunodeficiency virus humoral immune response Immunity immunization immunodeficiency virus immunogenicity involved messenger Messenger RNA molecules mononuclear cell mononuclear cells mounted mRNA of BNT162b2 Olink perinatally HIV-infected patients. Peripheral blood Peripheral blood mononuclear cells plasma samples Population populations profile protein level protein levels proteomic proximity extension assay Regulation respiratory response responses RNA RNA coronavirus Safety Sample SARS-CoV-2 SARS-CoV-2 antibody second dose severe acute respiratory syndrome Coronavirus study groups T cell T cells vaccination Vaccine Vulnerable populations were assessed [DOI] 10.1093/cid/ciac408 PMC 바로가기 [Article Type] Article
Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies Reviews Published on 2022-08-122022-10-05 Journal: Nature reviews. Immunology [Category] 변종, 유전자 메커니즘, 임상, [키워드] acquisition activate B cell complex mechanism Critical effective expand genetic diversity glycoprotein HIV-1 HIV-1 infection immune evasion immune system induce Interaction Lineage mutations neutralizing antibody Research Safe Strategy vaccination Vaccine Vaccine development [DOI] 10.1038/s41577-022-00753-w [Article Type] Reviews
How does age determine the development of human immune-mediated arthritis? Reviews Published on 2022-08-102022-10-05 Journal: Nature reviews. Rheumatology [Category] 유전자 메커니즘, 진단, [키워드] Adults Affect age Arthritis autoantibody children chronic inflammation contribute controls Critical determine develop disease driven by Drivers environmental exposure Epigenetic expand facilitate Factor Factors Genetic genetics hypothese immune immune system immune tolerance Immune-mediated individual Inflammation involved juvenile idiopathic arthritis maturation mechanism mechanisms microbial modulation Numerous Pathogenesis Patient Phenotypes pro-inflammatory similarity tolerogenic [DOI] 10.1038/s41584-022-00814-3 [Article Type] Reviews
Identifying Promising Themes for Adolescent Vaping Warnings: A National ExperimentRandomized Controlled Trial Published on 2022-08-062022-10-04 Journal: Nicotine & tobacco research : official journal of [Category] 임상, [키워드] Adolescent Affect anticipated COVID-19 Effect effective Effectiveness elicited expand FDA FIVE greater Health Health messaging identify identifying interactions lung National outcome participant PME Primary outcome Probability Randomized recruited secondary Secondary outcomes The United States [DOI] 10.1093/ntr/ntac093 PMC 바로가기 [Article Type] Randomized Controlled Trial