Impact of exposure to secondhand smoke on the risk of obesity in early adolescence Research Published on 2022-08-132022-10-05 Journal: Pediatric Research [Category] 변종, [키워드] 95% CI Adachi Analysis association BMI BMI category children city Continuous evaluate exposure to help higher risk Impact investigated Japan Longitudinal data obesity ordinal logistic regression Prevent Result risk risk factor Sex stratified Tokyo [DOI] 10.1038/s41390-022-02231-4 [Article Type] Research
Molecular mechanism of antibiotic resistance induced by mono- and twin-chained quaternary ammonium compounds단쇄 및 쌍쇄 4차 암모늄 화합물에 의한 항생제 내성의 분자 메커니즘Article Published on 2022-08-012022-09-11 Journal: The Science of the total environment [Category] 유전자 메커니즘, [키워드] accelerated Ammonium Antibiotic resistance Antibiotics BAC benzalkonium Benzalkonium chloride Cell chloride Compound Concentration contributed COVID-19 pandemic DDAC Didecyldimethylammonium Didecyldimethylammonium chloride E. coli Evolution exposure to faster FIVE inhibitory inhibitory concentration K-12 mechanism minimum molecular mechanism Multidrug resistance Mutagenesis Mutation outbreak outer membrane phenotypic Protein rifampicin risk RNA polymerase sensitivity Sequencing significantly Usage whole-genome sequencing [DOI] 10.1016/j.scitotenv.2022.155090 PMC 바로가기 [Article Type] Article
Treatment with metformin glycinate reduces SARS-CoV-2 viral load: An in vitro model and randomized, double-blind, Phase IIb clinical trial메트포르민 글리시네이트로 치료하면 SARS-CoV-2 바이러스 부하 감소: 시험관 내 모델 및 무작위, 이중 맹검, IIb상 임상 시험Randomized Controlled Trial Published on 2022-08-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] adaptive aligned Alpha caused Cell Clinical data clinical trial conducted control group coronavirus disease COVID-19 COVID-19 patients COVID-19 treatment dose doses double-blind drug effort Epsilon evaluate exposure to Health Health crisis highlight highlighting identify IIb in vitro in vitro model in vitro result in vitro study in vivo increased survival indicate inhibit metformin Metformin glycinate New coronavirus new coronavirus SARS-CoV-2 new treatment strategy new virus oxygen phase Randomized reduce reduced SARS-CoV-2 SARS-CoV-2 variants SARS-CoV-2 viral SARS-CoV-2 viral load severe disease supplementary oxygen tested the SARS-CoV-2 therapeutic option treated Treatment Treatment effectiveness triggered variant variants of interest Vero E6 VERO E6 cells viral infection Viral load viral replication [DOI] 10.1016/j.biopha.2022.113223 PMC 바로가기 [Article Type] Randomized Controlled Trial
Nonproductive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immune responsesSARS-CoV-2에 대한 PBMC의 비생산적 노출은 세포 고유의 타고난 면역 반응을 유도합니다Article Published on 2022-08-012022-09-11 Journal: Molecular Systems Biology [Category] SARS, 치료기술, [키워드] absence ACE2 receptor analyzed baseline bystander cell bystander cells Cell COVID-19 Culture Cytokines detectable Ex vivo experiment exposure to expression expression profile expression profiles healthy donor healthy donors human PBMC immune responses in vivo induce infected cell Infection innate immune response Interaction interferon interferon-stimulated gene interferon-stimulated genes interferon-stimulated genes. Invasion ISG ISGs Mild monocyte Monocytes mounted Particle Patient PBMC PBMCs physical proinflammatory cytokines respiratory tract response RT-PCR SARS-CoV SARS-CoV-2 severe COVID-19 Single-cell RNA sequencing STAT stimulate susceptibility triggered virus particle virus particles [DOI] 10.15252/msb.202210961 PMC 바로가기 [Article Type] Article
The association of airborne particulate matter and benzo[a]pyrene with the clinical course of COVID-19 in patients hospitalized in PolandResearch article Published on 2022-08-012022-10-05 Journal: Environmental pollution (Barking, Essex : 1987) [Category] 바이오마커, 변종, [키워드] Affect Air pollution association benzo(a)pyrene benzo[a]pyrene Clinical course coronavirus disease COVID-19 COVID-19 in patient death decrease elevated Epidemiology Evidence exposure exposure to higher odd Hospitalization Hospitalized hospitalized patients Hyperinflammatory immune response inflammation marker inflammation markers interleukin-6 limit measure outcome oxygen saturation Oxygen therapy pandemic parameter Particulate matter Patient Poland procalcitonin respiratory symptom severe COVID-19 severity severity of COVID-19 the disease the mean viral disease viral respiratory White blood cell [DOI] 10.1016/j.envpol.2022.119469 [Article Type] Research article
Utility of Newborn Dried Blood Spots to Ascertain Seroprevalence of SARS-CoV-2 Antibodies Among Individuals Giving Birth in New York State, November 2019 to November 20212019년 11월부터 2021년 11월까지 뉴욕주에서 출생한 개인들 사이에서 SARS-CoV-2 항체의 혈청유병성을 확인하기 위한 신생아 건조 혈액 반점의 유용성Article Published on 2022-08-012022-09-11 Journal: JAMA Network Open [Category] SARS, 진단, 치료기술, [키워드] 95% CI age analyzed association Birth Birth weight Blood can be used Characteristics collected conducted correlated COVID-19 COVID-19 case COVID-19 vaccination cross-sectional cross-sectional study cumulative DBS sample detect Dried blood spots exposure to female fluctuation gestational age Giving identify IgG antibodies IgG antibody immunoassay individual individuals Infant Infants Low birth weight Lower male maternal age median microsphere MONITOR Multiple birth New York Newborn Odds ratio Older outcome pregnant Prevalence Program reflected repeated reported S antigen SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 N SARS-CoV-2 nucleocapsid SARS-CoV-2 seroprevalence Screening screening program Seroprevalence Serosurvey Serosurveys significantly lower spot state stratified study period submitted utility vaccination Vaccinations was measured women [DOI] 10.1001/jamanetworkopen.2022.27995 PMC 바로가기 [Article Type] Article
Immunogenicity evaluation after BNT162b2 booster vaccination in healthcare workers의료 종사자의 BNT162b2 추가 접종 후 면역원성 평가Article Published on 2022-07-262022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] BNT162b2 booster booster vaccination Contact contact with exposure to first vaccination followed by HCW healthcare worker Healthcare workers humoral Humoral response IgA IgA antibodies IgA antibody IgA level IgA levels IgG IgG level IgG levels immune response Immunity immunogenicity implementation increase in Infection Measures new virus pandemic patients Registered restored SARS-COV-2 infection significantly statistically subject the antibody vaccination Vaccine variants virus [DOI] 10.1038/s41598-022-16759-2 PMC 바로가기 [Article Type] Article
Emergency department personnel patient care-related COVID-19 risk응급실 직원 환자 치료 관련 COVID-19 위험Multicenter Study Published on 2022-07-222022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI Asymptomatic attributable risk Care Community conducted COVID-19 detect determine emergency department exposure to Factor fraction hcp Health Health care Height higher risk hospital identify incidence increase increased risk Infection information intubation intubations Mask multicenter multivariable Multivariable regression nasal Nurse Nurses occurred over pandemic participant Patient Patient care Personal protective equipment Physicians PPE Probability prospective cohort study provided risk risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection serology specimen vaccine availability with infection [DOI] 10.1371/journal.pone.0271597 PMC 바로가기 [Article Type] Multicenter Study
Rapid, point-of-care antigen tests for diagnosis of SARS-CoV-2 infectionSARS-CoV-2 감염 진단을 위한 신속한 현장 진료 항원 검사Review Published on 2022-07-222022-09-11 Journal: The Cochrane database of systematic reviews [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] 95% CI 95% confidence interval absence access Accuracy age Antigen antigen test antigen tests approach assays Asymptomatic average Bern bioRxiv brand can not carried Chain Reaction Characteristics checked CIs Cohort Compliance conducted COVID-19 COVID-19 pandemic COVID-19 testing criteria criterion Data collection database demonstrated described detect diagnosis of SARS-CoV-2 diagnostic Diagnostic accuracy diagnostic tests Effectiveness eligible epidemiological estimate Europe evaluate evaluated Evidence exposure to False positive False positives global health groups Health Organization healthcare help heterogeneity highest include independent indication Infection Interpretation investigated logistic regression models management Mass screening measure medRxiv molecular test National Open Access Other participant Participants Patient care point-of-care polymerase chain polymerase chain reaction population groups Positive predictive value positive result PPV Predictive value presence or absence Prevalence produced public health QUADAS-2 random-effect ranged Rapid rapid antigen test Rapid antigen tests Rapid diagnostic test reduce reducing reference reference standard Reference standards repeated reported Research respiratory respiratory sample resulting reverse transcription reverse transcription polymerase chain reaction RT-PCR RT-PCR testing SARS-CoV-2 SARS-COV-2 infection Schools screened screening procedure screening programmes searched second Selection sensitivities sensitivity Sensitivity and specificity Seven Signs and symptoms Source Specificities specificity study cohort Study design Symptom symptom onset symptom status symptomatic symptomatic and asymptomatic symptomatic participant symptomatic participants symptomatic people symptoms of COVID-19 test negative test result Testing to define Transmission Triage unique University of Bern variable Viral Viral load viral loads website were used WHO World Health Organization [DOI] 10.1002/14651858.CD013705.pub3 PMC 바로가기 [Article Type] Review
Burden of SARS-CoV-2 infection in healthcare workers during second wave in England and impact of vaccines: prospective multicentre cohort study (SIREN) and mathematical model영국 2차 유행 중 의료 종사자의 SARS-CoV-2 감염 부담과 백신의 영향: 전향적 다기관 코호트 연구(SIREN) 및 수학적 모델Multicenter Study Published on 2022-07-202022-09-11 Journal: The BMJ [Category] COVID19(2023년), SARS, 변종, [키워드] 95% confidence interval adjusted odds ratio assistant booster booster vaccination booster vaccinations burden Chain Reaction clinical Cohort cohort study conducted Coverage COVID-19 pandemic determine Effect emergency department England enrolled Evidence evidence of exposure to Factor first vaccination FIVE greater health organisation healthcare Healthcare provision healthcare worker Healthcare workers help highlight hospital Households incidence indicated infected with SARS-CoV-2 Infection Infection prevention ISRCTN likelihood lockdown Logistic regression maintain mathematical mathematical model multicentre multivariable analysis National National Health Service no evidence of Omicron variant outcome pandemic participant Patient peaked polymerase chain polymerase chain reaction predict Prevention and control proportion prospective cohort study PROTECT responsible risk factor Risk factors SARS-COV-2 infection second wave secondary care SIREN Support susceptible the SARS-CoV-2 time Transmission dynamics vaccination Vaccination Status Vaccine Vaccines variants was obtained was used with infection [DOI] 10.1136/bmj-2022-070379 PMC 바로가기 [Article Type] Multicenter Study