CircTHBS1 drives gastric cancer progression by increasing INHBA mRNA expression and stability in a ceRNA- and RBP-dependent manner Research Published on 2022-03-252022-10-05 Journal: Cell Death & Disease [Category] 바이오마커, [키워드] activated Analysis applied backbone Beta Cancer cancer progression cancers cells Circular Diagnosis ENhance expression expression pattern facilitated feasible immunoprecipitation in vitro in vivo INHBA inhibin investigated loss-of-function malignancy mechanism mRNA expression mRNA stability oncogenic pathway performed poor prognosis progression promote pull-down Regulatory reporter Research RNA screened significantly increased stability TGF-β Transcriptome Treatment [DOI] 10.1038/s41419-022-04720-0 [Article Type] Research
WWP1 upregulation predicts poor prognosis and promotes tumor progression by regulating ubiquitination of NDFIP1 in intrahepatic cholangiocarcinomaArticle Published on 2022-03-092022-10-04 Journal: Cell Death Discovery [Category] 바이오마커, [키워드] Bile duct cancer Biological functions CCK-8 Cell Cholangiocarcinoma chromatin immunoprecipitation Clinical prognosis correlated detect Effect expressed expression expression pattern facilitate Hepatocellular carcinoma ICC IHC immunofluorescence immunohistochemistry intrahepatic investigated Mechanisms of disease Metastasis molecular mechanism MYC NDFIP1 Oncogenes overexpression Patient performed poor prognosis potential mechanisms potential therapeutic target predict progression proliferation promote promoter region Protein protein level reduce reported rescued reveal target tissue tissues Transwell tumor progression Ubiquitylation upregulated upregulation were used WWP1 [DOI] 10.1038/s41420-022-00882-0 PMC 바로가기 [Article Type] Article
Sexual dimorphism in COVID-19: potential clinical and public health implicationsCOVID-19의 성 이형성: 잠재적인 임상 및 공중 보건 영향Review Published on 2022-03-012022-09-12 Journal: The lancet. Diabetes & endocrinology [Category] Fulltext, MERS, 임상, 진단, [키워드] Acute stress binding chromosome Comorbidities complement COVID COVID-19 current difference disease Endocrine Evidence explain expression pattern Follow-up help immune implication increased risk Infectious disease mechanism men Mortality outcomes pandemic Patient patients with COVID-19 progression Protein public health public health measures reaction Reinfection SARS-CoV-2 infections severity severity of COVID-19 Sex Sex difference Sex hormones sexual dimorphism Stratification Surveillance Treatment Vaccines View virus women [DOI] 10.1016/S2213-8587(21)00346-6 PMC 바로가기 [Article Type] Review
Exploration of the ocular surface infection by SARS-CoV-2 and implications for corneal donation: An ex vivo studySARS-COV-2에 의한 안구 표면 감염의 탐색 및 각막 기증에 대한 시사점 : 생체 외 연구Research Article Published on 2022-03-012022-09-10 Journal: PLoS Medicine [Category] MERS, SARS, 치료기술, [키워드] 24 hour 24 hours ACE-2 acute respiratory syndrome aims Algorithms angiotensin angiotensin-converting enzyme 2 bulbar conjunctiva cathepsin cellular entry Conjunctiva Contamination contraindication contraindications Cornea Corneal Corneal Graft Corneal transplantation coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 crisis Ct value Culture culture media decrease diagnosed diagnosed with COVID-19 Donor Donor selection donors enzyme epithelial cell epithelial cells epithelium evaluate Evidence Ex vivo exacerbated exploration expresse expressed expression expression of SARS-CoV-2 expression pattern female genetic material healthy donor immunohistochemistry implication IMPROVE increase in Infection infectious dose inoculation involved lack limbus limited sample size mandatory media median moderate molecular mRNA level nasopharyngeal Nasopharyngeal swab nasopharyngeal swabs Not contaminated Ocular surface organ organ culture pandemic pathway Patient PCR positive Positive test Postinfection promote promoted Protein qPCR quantified quantitative PCR question RdRP receptor Replication researcher respiratory respond retrieved reverse transcription Reverse transcription quantitative PCR risk risk of transmission RNA RNA copy RNA sequence RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 receptors SARS-CoV-2 RNA SARS-CoV-2 viral SARS-CoV-2 virus Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant increase Support TCID tested tissue tissue culture tissues TMPRSS2 Transmission utility Viral Viral detection Viral RNA was tested were infected worsened [DOI] 10.1371/journal.pmed.1003922 PMC 바로가기 [Article Type] Research Article
Cancer and COVID-19 Susceptibility and Severity: A Two-Sample Mendelian Randomization and Bioinformatic AnalysisCell and Developmental Biology Published on 2022-01-242022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] addition Affect alteration Analysis analyzed anticancer approach association Bioinformatic Cancer cancer progression cancer type cancers Chemotherapy Clinical management Consensus COVID-19 COVID-19 disease severity COVID-19 severity COVID-19 susceptibility death demonstrated Deterioration differential expression ERAP2 example expression pattern Genetic Genetic predisposition GWAS heterogeneity implication information introduced involved less lung lung adenocarcinoma mendelian randomization Mutation outlier Patient patients patients with COVID-19 Pleiotropy Prognosis prognostic reached reduce reliability risk factor severity SNP SNPs statistical significance supported Surveillance susceptibility Treatment upregulated with COVID-19 [DOI] 10.3389/fcell.2021.759257 PMC 바로가기 [Article Type] Cell and Developmental Biology
Regulation of gliotoxin biosynthesis and protection in Aspergillus species아스 페르 길 루스 종에서의 글리 톡신 생합성 및 보호의 조절Research Article Published on 2022-01-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis approach aspergillosis Aspergillus Aspergillus fumigatus Aspergillus oryzae best cause colonisation component conserved disease Disease progression enzyme expresse expression expression of gene expression pattern facilitate fungal Genes genetic determinant genetic determinants Genome Glia homolog homologs human immune response identify Immune cell impair include involved kojic acid mechanism metabolism modulated mycotoxin negative regulation neutralising nidulan nidulans observé occur Occurrence pathogenicity producing regulate required responses RNA-sequencing screened secrete secretion sensitivity significantly sulfur Taking TFS toxic effect toxic effects transcription factor transcription factors transcriptional transcriptional response virulence [DOI] 10.1371/journal.pgen.1009965 PMC 바로가기 [Article Type] Research Article
Anti-SARS-CoV-2 Immunoglobulin Isotypes, and Neutralization Activity Against Viral Variants, According to BNT162b2-Vaccination and Infection HistoryBNT162b2-백신 접종 및 감염 이력에 따른 Anti-SARS-CoV-2 면역글로불린 아이소타입 및 바이러스 변이체에 대한 중화 활성Immunology Published on 2021-12-172022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, 치료기술, 치료법, [키워드] activity Against anti-RBD Anti-RBD IgG antigen-specific antibody assays B.1 bead BNT162b2 BNT162b2 vaccine both group both groups coronavirus COVID-19 COVID-19 disease COVID‐19 cytopathic delta variant Delta variants disease domain dose expression pattern Fluorescence followed by Gamma highest history IgA IgG IgG levels IgM immunoassay Immunoglobulin immunoglobulins individual maximum mRNA vaccine multiplex immunoassay naïve neutralization Neutralization assay Neutralizing activity neutralizing capacity neutralizing titers Nucleocapsid proteins plasma post-symptom onset provided RBD Result SARS-CoV-2 SARS-CoV-2 antigen Serological assay single vaccine subject subjects suggested Support symptom onset three groups vaccination Vaccine variants Vero E6 Viral Viral antigen was determined [DOI] 10.3389/fimmu.2021.793191 PMC 바로가기 [Article Type] Immunology
Severe Acute Respiratory Syndrome Coronavirus 2 ACE2 and TMPRSS2 Receptor Protein Expression Patterns Throughout Gestation임신 기간 동안의 중증 급성 호흡기 증후군 코로나바이러스 2 ACE2 및 TMPRSS2 수용체 단백질 발현 패턴Article Published on 2021-12-082022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus apical surface Blood cellular coronavirus coronavirus 2 demonstrated detectable developmental early gestation Endothelium expressed expression expression pattern gestation immunohistochemistry Infection late gestation maternal blood pattern placental placental expression. pregnancies Pregnancy protein expression proteinase receptor required respiratory SARS-CoV-2 TMPRSS2 TMPRSS2 expression trophoblast [DOI] 10.1093/infdis/jiab164 PMC 바로가기 [Article Type] Article
Distinct Disease Severity Between Children and Older Adults With Coronavirus Disease 2019 (COVID-19): Impacts of ACE2 Expression, Distribution, and Lung Progenitor Cells코로나바이러스 질환 2019(COVID-19)가 있는 어린이와 노인 사이의 뚜렷한 질병 심각도: ACE2 발현, 분포 및 폐 전구 세포의 영향Article Published on 2021-12-062022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] 진단, [키워드] ACE2 ACE2 expression ACE2 expression and distribution acute respiratory syndrome Adults airway alveolar analyzed angiotensin-converting enzyme 2 biopsies caused cell marker children clinical feature Cohort Combination coronavirus coronavirus disease COVID-19 data sets develop discharged patient disease disease severity distribution ex vivo infection examined expression expression level expression pattern Follow-up Impact Infection Inflammatory response lung lung progenitor cells lung tissue lymphocyte Older older patient older patients Patient patients with COVID-19 patients’ ages. Pneumonia positive cell positive cells progenitor progenitor cell pulmonary tract receptor reduced Region risk factor SARS-CoV-2 SARS-CoV-2 pseudovirus SFTPC single-cell RNA-seq [DOI] 10.1093/cid/ciaa1911 PMC 바로가기 [Article Type] Article
Single cell atlas for 11 non-model mammals, reptiles and birdsArticle Published on 2021-12-062022-10-04 Journal: Nature Communications [Category] SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome Analysis anatomical Animal physiology Cell Cell signalling co-expression conserved coronavirus Critical Cross-species transmission developmental Evolutionary developmental biology expression pattern Factor gene expression profile highlighting hosts identify investigated lung cell mammals molecular evolution provide regulatory circuit reservoirs reveal RNA sequencing SARS-CoV-2 SARS-CoV-2 entry factor single-cell target cell TMPRSS2 transcriptomics viral entry zoonotic [DOI] 10.1038/s41467-021-27162-2 PMC 바로가기 [Article Type] Article