Mycophenolate mofetil decreases humoral responses to three doses of SARS-CoV-2 vaccine in liver transplant recipientsMycophenolate mofetil은 간 이식 수혜자의 SARS-CoV-2 백신 3회 투여에 대한 체액 반응을 감소시킵니다.Article Published on 2022-08-012022-09-11 Journal: Liver international : official journal of the Inte [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] 95%CI Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody anti-SARS-CoV-2 vaccination antibody Antibody titre appear booster dose consultation decrease defined determine develop dose doses Efficacy enrolled Factor failure French Gender humoral Humoral response identify independent independent risk factor liver liver transplant male MMF mRNA mRNA vaccine mycophenolate mycophenolate mofetil Patient patients Predictive receiving recipient recipients responders response rate response to vaccination responsiveness risk factor Risk factors SARS-CoV-2 SARS-CoV-2 vaccine Serious Adverse Events Seroconversion Serologic response solid organ solid organ transplant the patient the vaccine Treatment vaccination Vaccine [DOI] 10.1111/liv.15258 PMC 바로가기 [Article Type] Article
Effect of early nutrition support on length of stay, mortality, and extubation in patients with COVID-19Observational Study Published on 2022-08-012022-10-04 Journal: Nutrition in clinical practice : official publicat [Category] 임상, [키워드] assessment banner coronavirus disease COVID-19 decrease Effect Enteral enteral nutrition extubation failure group hospital ICU Inpatient intensive care intensive care unit Intubated intubation Length of stay median Medicine Mortality Multicenter trial nutrition observé outcome outlined Parenteral Patient patients with COVID-19 Prospective released retrospective significant difference Society statistically significant statistically significant difference Support the timing with COVID-19 [DOI] 10.1002/ncp.10868 PMC 바로가기 [Article Type] Observational Study
Semiquantitative Chest CT Severity Score Predicts Failure of Noninvasive Positive-Pressure Ventilation in Patients Hospitalized for COVID-19 PneumoniaObservational Study Published on 2022-08-012022-10-04 Journal: Journal of cardiothoracic and vascular anesthesia [Category] 임상, [키워드] Analysis calculated Care Chest Chest computed tomography Chest CT confidence interval COVID-19 effective Endpoint Factor failure group Hospital admission In-hospital In-hospital death independent intubation measurement Mortality nine Non-invasive non-invasive ventilation observational study other variables oxygen Patient patients with COVID-19 Pneumonia primary endpoint receiver operator characteristics reported Respiratory Support responding poorly score secondary endpoint Treatment Ventilation [DOI] 10.1053/j.jvca.2021.09.010 PMC 바로가기 [Article Type] Observational Study
Compassionate use of Pulmonary Vasodilators in Acute Severe Hypoxic Respiratory Failure due to COVID-19COVID-19로 인한 급성 중증 저산소성 호흡부전에서 폐혈관 확장제의 자비로운 사용Article Published on 2022-08-012022-09-11 Journal: Journal of Intensive Care Medicine [Category] COVID19(2023년), SARS, 신약개발, [키워드] acute hypoxic respiratory failure Adult patients analysed ARDS changes in Cohort cohort of patient collected data commenced COVID-19 death Evidence failure feasible Gradient hospital hypoxaemia hypoxic respiratory failure ICU ICU admission Iloprost implementation Inhaled intensive care intensive care unit lack less median nitric oxide non-survivor Non-survivors offer outcome Oxygenation PaO Patient patients with COVID-19 patients with SARS-CoV-2 PF ratio Potential treatment Primary outcome protocol pulmonary Pulmonary vasodilators. randomised receiving reduction in respiratory Respiratory failure robust severe COVID-19 significantly study period Support survivor the median therapeutic option therapeutic options therapy trials vasodilator [DOI] 10.1177/08850666221086521 PMC 바로가기 [Article Type] Article
Prognostic Role of sST2 in Acute Heart Failure and COVID-19 Infection-A Narrative Review on Pathophysiology and Clinical Prospective급성 심부전 및 COVID-19 감염에서 sST2의 예후 역할 - 병태생리학 및 임상 전망에 대한 내러티브 검토Review Published on 2022-07-262022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Acute heart failure acute infection adverse outcome adverse outcomes Biomarker Biomarkers cardiovascular diseases clinical Clinical practice clinical setting COVID-19 COVID-19 infection Diagnosis early diagnosis failure heart heart disease heart failure IL33 interleukin involved ischemic heart disease mechanism molecular mechanisms narrative prognostic Prospective receptor review risk risk stratification role SARS-CoV-2 Signaling signaling pathway specific treatment sST2. ST2 therapy [DOI] 10.3390/ijms23158230 PMC 바로가기 [Article Type] Review
Noninvasive ventilation in COVID-19 patients aged ≥ 70 years-a prospective multicentre cohort studyObservational Study Published on 2022-07-222022-10-05 Journal: Critical Care [Category] 임상, [키워드] 30-Day mortality 95% CI Admission age assessment Care CFS clinical cohort study COVID-19 COVID-19 pandemic COVID-19 patient Critically ill death defined elderly Endotracheal intubation enrolled Europe European European country evaluate Factor failure frailty Frequency ICU ICU admission IMV intensive care intensive care unit International Invasive mechanical ventilation male multicentre NIV Noninvasive ventilation occurred Older outcome Patient patients patients treated primary endpoint prospective observational study Registered Registration risk scale severity SOFA the mean treated Ventilation with COVID-19 [DOI] 10.1186/s13054-022-04082-1 PMC 바로가기 [Article Type] Observational Study
Whole-genome sequencing reveals host factors underlying critical COVID-19전체 게놈 시퀀싱은 중요한 COVID-19의 기저에 있는 숙주 요인을 밝힙니다Article Published on 2022-07-012022-09-11 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 임상, 진단, 치료기술, 치료제, [키워드] Adhesion Molecule Antigen association associations ATP11A BCL11A caused CD209 Coagulation coagulation factor Colocalization Control COVID-19 Critical Critical care Critical disease Critical illness Critically ill disease disease severity Evidence expression Factor failure FUT2 Gene Expression Genetic variation genetics Genome genomes GenOMICC Hospitalization Host ICAM5 identify IL10RB Immune-mediated increased expression independent individual infection with SARS-CoV-2 inflammatory lung injury influence interferon intravascular coagulation involved leucocyte life-threatening Lung injury mechanism mechanisms membrane mendelian randomization MUC1 mucin myeloid cell pathophysiology PLSCR1 provide pulmonary inflammation reduced replicate reveal SELE Sequencing significantly Support targets transcriptome-wide underlying disease variant variants Viral viral replication whole-genome sequencing [DOI] 10.1038/s41586-022-04576-6 PMC 바로가기 [Article Type] Article
Major candidate variables to guide personalised treatment with steroids in critically ill patients with COVID-19: CIBERESUCICOVID studyObservational Study Published on 2022-07-012022-10-04 Journal: Intensive care medicine [Category] 임상, [키워드] Administered administration affected age Analysis assessment Bacterial baseline benefit Care clinically Corticosteroid corticosteroid treatment Corticosteroids covariate COVID-19 COVID-19 patient Critically ill Critically ill patient Dexamethasone dosage dose doses of corticosteroid early administration Evidence failure higher risk hospitalisation ICU ICU admission ICUs Illness severity in-hospital mortality increased risk Inflammation information intensive care interaction term Invasive mechanical ventilation investigated Laboratory lower risk Major mechanical ventilation Modification Mortality multivariable analysis no effect nosocomial Observational cohort study organ damage Patient patients with COVID-19 performed personalised Pneumonia potential benefit Primary outcome Protective receiving severe coronavirus disease severity Significant SOFA Spanish steroid subgroup subgroups subgroups of patient symptom onset systemic corticosteroid Treatment use of corticosteroid variable with COVID-19 [DOI] 10.1007/s00134-022-06726-w PMC 바로가기 [Article Type] Observational Study
Meaningful Use of Pathogen Genomic Data병원체 게놈 데이터의 의미 있는 사용Comment Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis bioinformatics Characteristics collected contributing to epidemiological Factor failure genomic Genomic analysis genomic data genomic databases Genomic epidemiology Gill Health Hedge implication instances limitations lineages mBio methicillin methicillin-resistant Staphylococcus aureus MRSA pathogen Pathogens phenotypic Population population genomics powerful tool SARS-CoV-2 Staphylococcus Staphylococcus aureus term These data utility Wilson [DOI] 10.1128/mbio.00311-22 PMC 바로가기 [Article Type] Comment
Partial ORF1ab Gene Target Failure with Omicron BA.2.12.1Omicron BA.2.12.1을 사용한 부분적 ORF1ab 유전자 표적 실패Article Published on 2022-06-152022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] Affect assays benefit cycle threshold cycle threshold (CT) value defined diagnostic E-gene failure faster Genome immune evasion in some Increasing Laboratory Local molecular Mutation omicron ORF1 ORF1ab ORF1ab gene Partial partial ORF1ab gene target failure (pORF1ab) provide RT-PCR S-gene SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant sequence Sequencing target the United State Transmission unique United States variant WGS whole-genome sequencing Whole-genome sequencing (wgs) [DOI] 10.1128/jcm.00600-22 PMC 바로가기 [Article Type] Article