Phytochemical Discrimination, Biological Activity and Molecular Docking of Water-Soluble Inhibitors from Saussurea costus Herb against Main Protease of SARS-CoV-2SARS-CoV-2의 주요 프로테아제에 대한 Saussurea costus Herb의 수용성 억제제의 식물화학적 판별, 생물학적 활성 및 분자 도킹Article Published on 2022-08-012022-09-11 Journal: Molecules [Category] SARS, 변종, [키워드] activity andrographolide ATCC Bacterial binding affinity Bioavailability Biological biological activity carbohydrate carbohydrates carboxylic acid catalytic dyad Cell cell entry Compound coronavirus coronavirus SARS-CoV-2 costus COVID-19 Cys145 D614G variant Delta discrimination docked Escherichia coli event Fatty acid fatty acids FIVE followed by Gamma gas chromatography Gas Chromatography-Mass Spectrometry GC-MS GC-MS profiling Herb His41 HSV-1 virus inhibit inhibitor inhibitory effect investigated M pro main protease mass spectrometry medical system molecular docking phytochemical preference prevalent protease Protein pseudovirus ranged residue room temperature SARS-CoV-2 SARS-CoV-2 entry Saussurea Saussurea costus Siddha spike Spike proteins Staphylococcus aureus Sterol Strains tannin tannins temperature these compounds variant virucidal virus VoC water [DOI] 10.3390/molecules27154908 PMC 바로가기 [Article Type] Article
The SARS-CoV-2 helicase as a target for antiviral therapy: Identification of potential small molecule inhibitors by in silico modelling항바이러스 치료의 표적으로서의 SARS-CoV-2 헬리카제: in silico 모델링을 통한 잠재적인 소분자 억제제 식별Article Published on 2022-07-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] Acetylcysteine active site acute respiratory syndrome addition anti-inflammatory property Antiviral antiviral activity antiviral therapeutics antivirals binding free energy clavulanic acid Compound coronavirus coronavirus disease COVID-19 DHX9 DNA DNA2 expected Fatty acid fatty acids free energies Helicase Hepatitis hepatitis C highlighting identification identify in silico include inhibitor inhibitory activity initial lead leads Ligand MERS-CoV molecular dynamics Molecular dynamics simulation molecular dynamics simulations non-structural protein nsp13 nucleoside performed reported Research respiratory SARS-CoV SARS-CoV-2 SARS-CoV-2 nsp13 selected sequence Severe acute respiratory syndrome small molecule inhibitor specific inhibitor specific inhibitors strain structural homology structural proteins Structure structures synthetic the SARS-CoV-2 utilised Vaccine variant was performed were used [DOI] 10.1016/j.jmgm.2022.108193 PMC 바로가기 [Article Type] Article
Long COVID and long chain fatty acids (LCFAs): Psychoneuroimmunity implication of omega-3 LCFAs in delayed consequences of COVID-19Review article Published on 2022-07-012022-10-05 Journal: Brain, behavior, and immunity [Category] COVID19(2023년), SARS, 바이오마커, [키워드] accelerate accumulating acute respiratory syndrome addition Brain changes in chronic inflammation CNS Coagulation system Cognition Complication consequence coronavirus coronavirus disease COVID COVID-19 Depression disorder dysfunction dysregulated Effect EPA Evidence Fatty acid favorable effect heterogeneous HPA Immunity Impact Inflammation Intervention Long Long COVID mechanism metabolite metabolites modulating molecular mechanism mood multifactorial n-3 PUFAs Neuropsychiatric neurotransmitter offer omega-3 omega-3 PUFA Omega-3 PUFAs oxidative stress pandemic Polyunsaturated pro-inflammatory cytokines Prophylaxis Psychosocial stress PUFAs reducing SARS-CoV-2 SARS-COV-2 infection shown Sickness Spread Stage systematic review systemic inflammation tissue damage tissue homeostasis [DOI] 10.1016/j.bbi.2022.04.001 [Article Type] Review article
An insight to the therapeutic potential of algae-derived sulfated polysaccharides and polyunsaturated fatty acids: Focusing on the COVID-19Review article Published on 2022-06-012022-10-05 Journal: International journal of biological macromolecules [Category] 변종, 치료제, [키워드] addition affected Algae candidate Compound coronavirus COVID-19 COVID-19 case Critical Effectiveness fatty Fatty acid Focusing Gut gut microbiome Health immune regulation immune system immunomodulatory activities immunomodulatory property Infection infections intestine Microbiome microbiota modulate modulating modulation Mutation nutritional intervention other organ pandemic Polyunsaturated Polyunsaturated fatty acids Prevent produced Research resources response sulfated polysaccharide sulfated polysaccharides the vaccine therapeutic therapeutic potential these compound Treatment Vaccine viral infections virus virus pathogenesis [DOI] 10.1016/j.ijbiomac.2022.03.063 [Article Type] Review article
The effect of polyunsaturated fatty acids on the severity and mortality of COVID patients: A systematic reviewReview article Published on 2022-06-012022-10-05 Journal: Life sciences [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acid article conducted COVID COVID-19 COVID19 critical cases Cytokine storm deficiency demonstrated disease effective elevated evaluate the effect fatty Fatty acid fatty acids Fatty Acids, Omega-3 finding High-dose Hospitalization immune pathway increase in increased mortality Infection Inflammatory Inflammatory cytokine investigated lung mechanical ventilation modulating Mortality MOST Omega omega-3 omega-3 supplement Patient patients Polyunsaturated Prognosis PUFAs reduce reducing Result retrieved risk Safe SARS-CoV-2 searched severity systematic review the disease was done was performed was used Web of Science [DOI] 10.1016/j.lfs.2022.120489 [Article Type] Review article
Palmitoylethanolamide (PEA) Inhibits SARS-CoV-2 Entry by Interacting with S Protein and ACE-2 Receptor팔미토일에탄올아미드(PEA)는 S 단백질 및 ACE-2 수용체와 상호작용하여 SARS-CoV-2 진입을 억제합니다Article Published on 2022-05-172022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE-2 activate activated adjuvant therapy Antiviral antiviral agent antiviral drug antiviral drugs antiviral potency binding bioactive lipids cascade cause cellular clinical test Clinical tests clinical trial connection Coronaviruses counteract Course COVID-19 COVID-19 pandemic Degradation derangement Disruption drop droplets energy entry receptor event Evidence fatty Fatty acid generate glycoprotein Glycoproteins highlight Huh-7 cells humans in viral Infection Inflammation inflammatory stimuli lack life cycle Lipid lipid droplets lipid metabolism lipids mechanism of action mechanisms membrane metabolism nutraceutical palmitoylethanolamide Pathways PEA Prevent protective effect Protective effects recent replicate Replication Research RNA virus S protein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 S protein second significantly Spike protein the SARS-CoV-2 therapy Toxicity transcription factor Treatment Usage viral infection viral life cycle virus viruses VSV [DOI] 10.3390/v14051080 PMC 바로가기 [Article Type] Article
Adaptation of gut microbiome and host metabolic systems to lignocellulosic degradation in bamboo rats Research Published on 2022-05-142022-10-05 Journal: The ISME Journal [Category] 바이오마커, [키워드] adaptation aerobe Ailuropoda Amino acid Analysis Bacteria Bacteroidaceae Bacteroidale Bamboo circulating composed Concentration conducted Degradation elevated enzyme facultative Fatty acid fatty acid metabolism Giant Gut Host host gene expression Interaction mammal mechanism metabolite metabolome microbial Microbiome SCFAs serum significantly vitamins [DOI] 10.1038/s41396-022-01247-2 [Article Type] Research
Nutritional Modulation of Gut Microbiota Alleviates Severe Gastrointestinal Symptoms in a Patient with Post-Acute COVID-19 Syndrome장내 미생물총의 영양 조절은 급성 COVID-19 증후군 환자의 심각한 위장 증상을 완화합니다Case Reports Published on 2022-04-262022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] 16S rRNA 16S rRNA gene acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alleviate alleviation alleviation of symptoms Anxiety Appetite arising ASV Bacteria baseline Care Case report change coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 pandemic COVID-19-related symptom COVID-19-related symptoms defined dosage Dysbiosis Expanded access fatty Fatty acid feasibility Gastrointestinal Gastrointestinal symptom gastrointestinal symptoms Gut gut microbiota Health IMPROVE in sight increase increase in IND indicate Infection insulin Intervention life long-hauler. long-lasting loss of appetite medication microbial microbiota modulating modulation nausea nutritional intervention palpitation Patient patient population patients with COVID-19 problem provided public health Quality of life reduce reduced rRNA SARS-CoV-2 SARS-CoV-2 detection sequence serum sight Significant significantly small intestine Symptom symptom severity syndrome target the patient variant [DOI] 10.1128/mbio.03801-21 PMC 바로가기 [Article Type] Case Reports
Inhalation of nebulized omega-3 fatty acids mitigate LPS-induced acute lung inflammation in rats: Implications for treatment of COPD and COVID-19Research article Published on 2022-04-012022-10-05 Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids [Category] 치료법, [키워드] acute lung inflammation acute respiratory distress Administered alveolar Anti-inflammatory Antithrombotic Asthma Budesonide cannabidiol chronic obstructive COPD COVID-19 cytokine determine distress docosahexaenoic acid (DHA) Docosapentaenoic acid (DPA) effective Effects Eicosapentaenoic acid (EPA) Fatty acid free fatty acid group groups histology IL-10 IL-1β IL-6 inhalation injection intravenous investigated less LPS lung cancer lung disorders Lung inflammation male mitigate Montelukast nebulized no evidence of omega-3 Omega-3 fatty acids Pneumonia preclinical data pulmonary disease Severity Score Side effects TGF-β the disease thrombosis TNF-α treated Treatment triggered [DOI] 10.1016/j.plefa.2022.102426 [Article Type] Research article
Urine sediment findings were milder in patients with COVID-19-associated renal injuries than in those with non-COVID-19-associated renal injuries소변 침전물 소견은 코로나19와 관련되지 않은 신손상 환자보다 코로나19와 관련된 신손상 환자에서 더 경미했습니다.Article Published on 2022-04-012022-09-11 Journal: International Journal of Infectious Diseases [Category] MERS, 바이오마커, [키워드] acetyl Acute kidney injuries acute renal injury addition arising association Characteristics clinical parameter coronavirus disease Coronavirus disease 2019 COVID-19 damage direct infection epithelial Factor Factors fatty Fatty acid granular Injury involved kidney liver marker mechanisms microglobulin neutrophil Non-COVID-19 non-specific Particle Pathogenesis Patient Protein renal renal function renal injuries renal injury Sepsis severity of COVID-19 subject surgery Urine Urine sediment findings. with COVID-19 α1-microglobulin [DOI] 10.1016/j.ijid.2022.02.024 PMC 바로가기 [Article Type] Article