Ultrastructural examination of lung “cryobiopsies” from a series of fatal COVID-19 cases hardly revealed infected cells일련의 치명적인 COVID-19 사례에서 폐 "냉동생검"의 미세구조 검사는 감염된 세포를 거의 드러내지 않음Article Published on 2022-05-012022-09-11 Journal: Virchows Archiv [Category] COVID19(2023년), SARS, 치료기술, [키워드] accumulation aggregates alveolar alveolar damage alveolar epithelium Analysis Autopsy caused Cell cell types cells coronavirus COVID-19 patient COVID-19 patients death Detachment diffuse Diffuse alveolar damage electron electron microscopy Endothelium erythrocytes Extracellular fatal COVID-19 FIBRIN fixation fixed granulocyte Histopathology hyaline membrane hyaline membranes hyperplasia immune impairment IMPROVE infected cell investigated latency leukocyte leukocytes lung lung damage macrophages mechanisms Microscopy neutrophilic Particle Patient Region Replication respiratory distress Respiratory distress syndrome Sample SARS‐CoV‐2 Stage Stress stress response the disease the patient these cell These cells Thin section thrombocyte Thrombocytes tissue Ultrastructural analysis ventilated patient ventilated patients virus Virus particle. [DOI] 10.1007/s00428-022-03308-5 PMC 바로가기 [Article Type] Article
Associations between hemostatic markers and mortality in COVID-19 – Compounding effects of D-dimer, antithrombin and PAP complexCOVID-19에서 지혈 마커와 사망률 사이의 연관성 - D-dimer, antithrombin 및 PAP 복합체의 복합 효과Article Published on 2022-05-012022-09-11 Journal: Thrombosis research [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] 95% confidence interval Antithrombin applied Coagulation cohort study complex compounding consecutive patient COVID-19 cumulative D-dimer death dimer Effect elevated excess mortality FIBRIN fibrinogen fibrinolysis fibrinolytic fraction hemostatic function incidence increases in Laboratory Linköping marker Mortality Odds ratio Odds ratios Patient patients plasma Plasma levels plasmin Plasmin-antiplasmin complex. positive SARS-CoV-2 single-center tested university Venous Thromboembolism von Willebrand factor [DOI] 10.1016/j.thromres.2022.03.013 PMC 바로가기 [Article Type] Article
Chronic Inflammatory Placental Disorders Associated With Recurrent Adverse Pregnancy Outcome반복적인 임신 부작용과 관련된 만성 염증성 태반 장애Review Published on 2022-04-222022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] accumulate Activation Adverse aetiology Allograft allograft rejection association Autoimmune diseases CD68 CD68+ CD8+ CD8+ T lymphocyte CD8+ T lymphocytes chorionic chronic chronic histiocytic intervillositis chronic placental inflammation clinical consequences death diagnosed Diagnosis diagnostic disorder Disruption early-onset etiology excluded exclusion Features fetal fetal death fetal growth restriction fetus FIBRIN Gas exchange growth hallmark histopathological histopathological examination immune Immune cell immune cells Immunosuppression Infection infiltration Inflammatory inflammatory disorder intervillous space intrauterine fetal death Lymphocytes macrophages massive massive perivillous fibrin deposition miscarriage mother normal pregnancy observation outcome pathology Placenta placental pregnancies Pregnancy Prevalence Prevent Prophylaxis recurrence Recurrent rejection risk SARS-CoV-2 Stillbirth subsequent syndrome T lymphocytes villitis of unknown etiology. [DOI] 10.3389/fimmu.2022.825075 PMC 바로가기 [Article Type] Review
Altered fibrin network structure and fibrinolysis in intensive care unit patients with COVID‐19, not entirely explaining the increased risk of thrombosisOriginal Article Published on 2022-04-012023-06-16 Journal: Journal of thrombosis and haemostasis : JTH [Category] MERS, [키워드] COVID‐19 FIBRIN fibrinolysis Microscopy thrombosis [DOI] 10.1111/jth.15708 PMC 바로가기 [Article Type] Original Article
Plasma D-dimer value corrected by inflammatory markers in patients with SARS-CoV-2 infection: Its prognostic value in the diagnosis of venous thromboembolismSARS-CoV-2 감염 환자의 염증 표지자로 교정된 혈장 D-dimer 값: 정맥 혈전색전증 진단에 대한 예후적 가치Article Published on 2022-03-252022-09-11 Journal: Medicina clínica [Category] MERS, SARS, 바이오마커, 치료기술, [키워드] Acute-phase proteins age analyzed benefit best C-reactive protein case-control study Control COVID 19 COVID-19 cut-off cut-off point cutoff point D-dimer D-dimer level D-dimer levels D-dimer value detect determine diagnosed Diagnosis diagnostic diagnostic testing Diagnóstico dimer elevated English ferritin Ferritina FIBRIN fibrin fragment D fibrinogen Fragmento de fibrina D higher risk hospital Inflammatory marker inflammatory markers linear Linear model Linear regression media men Patient patients with SARS-CoV-2 plasma predicted Predictive Probability Prognostic value Proteínas de fase aguda ROC ROC Curve ROC curves screening method sensitivity Sex Spain Spanish specificity Thromboembolism Tromboembolismo venoso Usando Venous Thromboembolism VTE [DOI] 10.1016/j.medcli.2021.03.034 PMC 바로가기 [Article Type] Article
Inhaled Placental Mesenchymal Stromal Cell Secretome from Two- and Three-Dimensional Cell Cultures Promotes Survival and Regeneration in Acute Lung Injury Model in Mice2차원 및 3차원 세포 배양에서 흡입된 태반 중간엽 간질 세포 Secretome은 마우스의 급성 폐 손상 모델에서 생존 및 재생을 촉진합니다Article Published on 2022-03-222022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration adult stem cells ALI model ARDS Cell cell spheroids cell-free therapy content coronavirus COVID-19 COVID-19 pandemic cultivation damaged death effective Effectiveness exhibited Extracellular Extracellular vesicles FIBRIN fibroblast healthcare histological immunomodulating in some Inflammatory Inflammatory diseases inhalation Inhaled investigated lung Lung inflammation Lung injury lung surfactant lung tissue Lungs management Measures mice Model morbidity and mortality Mortality Patient placental potential therapy problem proteomic regeneration regenerative respiratory distress Respiratory distress syndrome restored SARS-CoV-2 Secretome severe acute respiratory syndrome Coronavirus severe pneumonia stromal cell surfactant survival syndrome Taking therapeutic tissue regeneration [DOI] 10.3390/ijms23073417 PMC 바로가기 [Article Type] Article
Acute SARS-CoV-2 alpha variant infection leading to placental insufficiency and fetal distress태반 기능 부전 및 태아 고통을 유발하는 급성 SARS-CoV-2 알파 변이체 감염Case Reports Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 변종, [키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission age Alpha Alpha variant B.1.1.7 B.1.1.7 lineage Brain Care Cesarean section coronavirus demonstrated distress fetal fetal distress fetal movement FIBRIN gestational age high viral load hospital induce Infection intensive care Ischemic necrosis Maternal Health Medical care Necrosis Neonatal neonatal intensive care unit Neonate Obstetric obstetric infection obstetrics oligohydramnios pathological Pathological examination pathology Placenta placental placental insufficiency placental tissue placentitis positive Pregnancy reduced reduced fetal movement SARS-CoV-2 SARS-CoV-2 infected patient SARS-CoV-2 infected patients seeking severe acute respiratory syndrome Coronavirus subsequent tested the SARS-CoV-2 umbilical umbilical artery variant Viral load VOC 202012/01 was performed [DOI] 10.1002/jmv.27379 PMC 바로가기 [Article Type] Case Reports
A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications긴 코비드/PASC에서 아밀로이드 피브린 마이크로 클로트의 중심 역할 : 기원 및 치료 적 영향Review Published on 2022-02-252022-09-10 Journal: Biochemical Journal [Category] COVID19(2023년), Fulltext, MERS, SARS, 치료기술, 치료제, [키워드] acute COVID-19 amyloid anticoagulant therapy autoantibodies Blood Blood coagulation breathlessness Capillaries chronic fatigue syndrome clotting Coagulation Coagulopathies Coagulopathy COVID COVID-19 demographics disease entity disorders Encephalomyelitis fatigue fatigue syndrome FIBRIN fibrinogen fibrinolysis fluorescence microscope Health implication individual Infection Inflammation initial lead leads limit Long majority manifested Microscope PASC passage phenotype plasma Platelet platelet-poor plasma preliminary report Proteins proteolysis recognize red blood cell red blood cells referred to Regulatory removal SARS-COV-2 infection shown similarities similarity stain Symptom Symptoms syndrome terminology therapeutic these symptoms Thioflavin tissue damage Treatment [DOI] 10.1042/BCJ20220016 PMC 바로가기 [Article Type] Review
Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients호중구는 Covid-19 뇌졸중 환자에서 뇌 혈전의 면역 시그니처를 우세합니다.Multicenter Study Published on 2022-02-012022-09-10 Journal: Acta Neuropathologica Communications [Category] COVID19(2023년), Fulltext, MERS, SARS, 진단, 치료기술, [키워드] ACE2 expression cells Chain Reaction characterized complement complex conducted Control control patients controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients docking Endovascular treatment Evidence expressed expression level Factor Features FIBRIN immune signature increased risk infected with COVID-19 Ischemic Stroke large vessel lymphocyte macrophages molecular Monocytes monocytes/macrophage monocytes/macrophages mortality rates MPO NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils pathological analysis Patient patients Platelet Platelets polymerase chain polymerase chain reaction Ratio receptor ACE2 red blood cells retrieved ROC analysis SARS-CoV-2 SARS-CoV2 Sequencing severity stroke supplementary material the SARS-CoV-2 thrombi thrombosis thrombotic Thrombotic events Thrombus von Willebrand factor [DOI] 10.1186/s40478-022-01313-y PMC 바로가기 [Article Type] Multicenter Study
Increased histone-DNA complexes and endothelial-dependent thrombin generation in severe COVID-19Article Published on 2022-02-012023-07-07 Journal: Vascular pharmacology [Category] COVID19(2023년), [키워드] COVID-19 endothelial cells FIBRIN Histones SARS-CoV-2 thrombin [DOI] 10.1016/j.vph.2021.106950 PMC 바로가기