Transmission of SARS-CoV-2 by children to contacts in schools and households: a prospective cohort and environmental sampling study in LondonArticle Published on 2022-11-012022-11-16 Journal: The Lancet. Microbe [Category] SARS, 변종, 치료기술, [키워드] acquisition Assessing Asymptomatic children Community Contact Contamination Department eight Evidence FIVE Frequency Genome sequencing Health household contact household contacts IMPROVE incident index case Infection Innovation Laboratory Local London occur PCR testing positive positive PCR positive SARS-CoV-2 PCR Precaution Prevent prospective cohort public health pupil Pupils quantified reduced representing rising SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 transmission School Schools secondary transmission Spread supported symptomatic individual tested Testing throat swab Transmission transmission of SARS-CoV-2 variant Ventilation viral shedding was done Weekly with COVID-19 [DOI] 10.1016/S2666-5247(22)00124-0 PMC 바로가기
Identification of TCR repertoires in asymptomatic COVID-19 patients by single-cell T-cell receptor sequencingResearch article Published on 2022-11-012022-10-05 Journal: Blood cells, molecules & diseases [Category] COVID19(2023년), SARS, 변종, [키워드] analyzed Asymptomatic Asymptomatic COVID-19 asymptomatic infection cell-mediated immune response Combination COVID-19 COVID-19 patient dominant effective FIVE healthy control help identification identify Immunity Immunopathogenesis Immunotherapy J gene Patient PBMC performed SARS-CoV-2 SARS-COV-2 infection scTCR-seq Sequencing single-cell skewed study groups subjects symptomatic T cell response T-cell receptor TCR TCR repertoires TCR sequencing therapeutic strategy viral infection [DOI] 10.1016/j.bcmd.2022.102678 [Article Type] Research article
Towards Covid-19 TMPRSS2 enzyme inhibitors and antimicrobial agents: Synthesis, antimicrobial potency, molecular docking, and drug-likeness prediction of thiadiazole-triazole hybridsResearch article Published on 2022-11-012022-10-05 Journal: Journal of Molecular Structure [Category] 치료제, [키워드] 1 2 3 3-Triazoles 4-Thiadiazole analogue antimicrobial activity Bacillus subtilis binding affinity Candida albican candidate chalcone chloride Compound COVID-19 drug-likeness enzyme Escherichia coli exhibited FIVE Hydrazonoyl halides identify in silico in vitro inhibitor molecular docking pathogen Prevent proliferation Pseudomonas aeruginosa screened Staphylococcus aureus submitted synthesis synthesised therapeutic activity TMPRSS2 TMPRSS2 enzyme transmembrane serine protease Treatment Vanillin was tested [DOI] 10.1016/j.molstruc.2022.133659 [Article Type] Research article
Evaluation of five immunoassays and one lateral flow immunochromatography for anti-SARS-CoV-2 antibodies detectionArticle Published on 2022-11-012022-11-15 Journal: Enfermedades infecciosas y microbiologia clinica ( [Category] SARS, 진단, 치료기술, [키워드] addition anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody approach caused CLIA CLIA assays Clinical practice complementary coronavirus SARS-CoV-2 COVID-19 COVID-19 patient criteria diagnostic ELISA English evaluated FIVE greater healthcare worker healthy IgG IgM IgM antibody immunoassay immunochromatographic test immunochromatography Inmunocromatografía involved lateral flow Pandemia pandemic para performed Rapid test ROC ROC curves RT-PCR SARS-CoV-2 SARS-CoV-2 coronavirus sensitivity Serología. serological serology serum sample Sin Spanish specificity Support Vaccine [DOI] 10.1016/j.eimce.2020.12.007 PMC 바로가기
Elucidation of the inhibitory activity of ivermectin with host nuclear importin α and several SARS-CoV-2 targetsArticle Published on 2022-11-012022-11-15 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] 3CL pro 3CLpro acting antiviral activity approach approach binding binding free energy complex COVID-19 dimeric docked complexes docking explained FDA-approved drug FIVE heterodimeric Host in vitro activity inhibit inhibitor inhibitory activity Ivermectin MD simulation molecular molecular docking Molecular dynamics simulation molecular dynamics simulation. molecular mechanism nuclear previous study protease Proteins reached Replication responsible SARS-CoV-2 SARS-CoV-2 replication shown Structural analysis structural property target translocation variety virus with COVID-19 [DOI] 10.1080/07391102.2021.1911857 PMC 바로가기
Exploring the anti-SARS-CoV-2 main protease potential of FDA approved marine drugs using integrated machine learning templates as predictive toolsArticle Published on 2022-11-012022-11-15 Journal: International journal of biological macromolecules [Category] SARS, 신약개발, 치료제, [키워드] activity Activity atlas model Activity cliff Algorithm anti-SARS-CoV-2 approved Atla Biological camostat Compound COVID-19 COVID-19 pandemic Cresset data set docked drug drugs effective FDA field Field template FIVE flare group Holichondrin B inactive macromolecules Marine drugs. nafamostat outbreak Predictive protease Protein remained Repurposed drug responsible Safe SARS-CoV-2 Structure structures [DOI] 10.1016/j.ijbiomac.2022.09.086 PMC 바로가기
Comparative epidemiology of five waves of COVID-19 in Mexico, March 2020-August 2022Article Published on 2022-10-312022-11-16 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] 95% CI age analyzed Antigen association average calculated Care case fatality rates Comorbidities Comparative confirmed case confirmed cases COVID-19 COVID-19 case Critical death declined decrease Demographic factors Epidemic epidemic wave epidemiological Epidemiology estimates Factors Fatality rate FIVE Gender Health highest hospital Hospital admission Hospitalization hospitalizations Hospitalized In-hospital In-hospital death in-hospital mortality incidence increase in individual Intubated intubation intubations laboratory-confirmed male Metrics notable omicron pandemic Patient patients with comorbidities recorded reduction in Regression model risk SARS-CoV-2 SARS-CoV-2. second wave security severe disease severity subsequent Surveillance symptoms onset System vaccination variant were recorded [DOI] 10.1186/s12879-022-07800-w PMC 바로가기
Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 SpikeArticle Published on 2022-10-262022-11-15 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acid acute respiratory syndrome addition addressed Amino acid amino acid substitution antigenic Antisera Care caused characterized coronavirus COVID-19 death demonstrated expressing expression level fitness FIVE GISAID globe greater Health highlight host immunity identifying Immune escape immune evasion immunological profile initiative Intervention L452 less lineages maintain mutant Mutation mutational studies Naturally neutralization pandemic phenotypic position promote pseudovirus retrieved SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant selected sensitivity sequence single nucleotide spike Spike protein Substitution substitution. T cell Transmissibility variants of concern viral evolution viral fitness viral infectivity virus VoC [DOI] 10.1128/jvi.01162-22 PMC 바로가기
Accessible and Adaptable Multiplexed Real-Time PCR Approaches to Identify SARS-CoV-2 Variants of ConcernArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome approach collected concern coronavirus COVID-19 COVID-19 pandemic Critical cross-reactivity Delta delta variant detect different time points equipment exhibited FIVE genotyping identify Laboratory lack Limits of detection management melting curve analysis Molecular assay multiplex Multiplex PCR Mutation mutations nine omicron Omicron variant other coronaviruses PCR PCR assay performed platform positive sample Rapid rapid genotyping. Real-time PCR resource RNA SARS-CoV-2 SARS-CoV-2 VOCs selected sensitivity Sequencing signature specificity Spike protein Support Surveillance variant variants variants of concern VoC VOCs WGS [DOI] 10.1128/spectrum.03222-22 PMC 바로가기
Murine Hepatitis Virus, a Biosafety Level 2 Model for SARS-CoV-2, Can Remain Viable on Meat and Meat Packaging Materials for at Least 48 HoursArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료기술, [키워드] biosafety Biosafety Level 2 bottleneck BSL2 Can condition conditions contribute coronavirus Coronaviruses COVID-19 case creating detectable determine Evidence facilitate Factor FIVE highest hour hpi hygiene inoculated involved material meat MHV Model murine hepatitis virus notable outbreak packaging material. Particles persistence physical physical distancing plant provide reduction reduction in reservoir resulting SARS-CoV-2 Spread spread of COVID-19 steadily decreased Styrofoam survival tested unpaired t test viability Viable viral infectivity virus [DOI] 10.1128/spectrum.01862-22 PMC 바로가기