follicular – Page 2 – Communicable Diseases Research

Metabolic signatures in human follicular fluid identify lysophosphatidylcholine as a predictor of follicular development

Research

Published on 2022-07-292022-10-05
Journal: Communications Biology [Category] 바이오마커,

SARS-CoV-2 epitope-specific CD4 + memory T cell responses across COVID-19 disease severity and antibody durability

COVID-19 질병 중증도 및 항체 내구성 전반에 걸친 SARS-CoV-2 에피토프 특이적 CD4 + 기억 T 세포 반응

Article

Published on 2022-07-222022-09-11
Journal: Science Immunology [Category] COVID19(2023년), SARS, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive anti-S antibody antibody Antibody Response Antibody responses Boston CD4 Cell cells circulating conducted controls convalescent individual convalescent individuals coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 disease severity demonstrated disease disease control disease course early disease epitope Epitopes First wave follicular function functions greater histocompatibility complex Hospitalization Immunity individual longitudinal study major histocompatibility complex memory memory T nucleocapsid pandemic peptide Population predict proportion recognizing response SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes seroconverted severe acute respiratory syndrome Coronavirus subset sustained T cell T cells T cells response T helper USA viral clearance virus
[DOI] 10.1126/sciimmunol.abl9464 PMC 바로가기 [Article Type] Article

Immune responses in Omicron SARS-CoV-2 breakthrough infection in vaccinated adults

백신 접종 성인의 Omicron SARS-CoV-2 돌발성 감염의 면역 반응

Article

Published on 2022-07-182022-09-11
Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술,

[키워드] activated antibody antigens B cell B cell response Breakthrough infection breakthrough infections Cell cells cellular immunity circulation Cytotoxic T cells de novo follicular functional humoral humoral responses Immunity individual Infection memory B cell memory B cells memory T memory T cell Mutation omicron participant plasmablast PROTECT Protein RBD-specific IgG recall Receptor binding domain response robust SARS-CoV-2 significantly increased spike Spike protein T cell T cell response T cell responses T cells the Spike Transmissibility vaccinated individuals vaccine immunity Vaccines variant Viral viral antigens viral escape wild type
[DOI] 10.1038/s41467-022-31888-y PMC 바로가기 [Article Type] Article

Immune dynamics in SARS-CoV-2 experienced immunosuppressed rheumatoid arthritis or multiple sclerosis patients vaccinated with mRNA-1273

SARS-CoV-2의 면역 역학은 면역 억제된 류마티스 관절염 또는 mRNA-1273 예방 접종을 받은 다발성 경화증 환자를 경험했습니다.

Article

Published on 2022-07-152022-09-12
Journal: eLife [Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] absence acute respiratory syndrome affected analyzed anti-CD20 antibody Autoimmune Autoimmune disease Autoimmune diseases B cell response benefit CD4 CD8 Cell cellular cellular immunity central memory circulating condition coronavirus COVID-19 COVID-19 mRNA vaccine development disease Disease activity European European Commission first vaccination flow cytometry follicular HCs healthy control Horizon Human humanized humoral Humoral immunity IgG immune immune response Immunity immunology Immunosuppressant immunosuppressants Immunosuppressed increased risk Infection Inflammation leadership longitudinal marker Medicine methotrexate Moderna monoclonal antibody monotherapy mRNA mRNA-1273 MTX multiple sclerosis Netherland organization outcome Patient patients treated preserved recall Research resulting rheumatoid arthritis SARS-CoV-2 second vaccination shielding significantly supported suppress sustained T cell T cell response T cells T helper the SARS-CoV-2 treated Treatment union vaccination Vaccine vulnerable patients whole blood sample
[DOI] 10.7554/eLife.77969 PMC 바로가기 [Article Type] Article

Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine

나노입자 전달 TLR4 및 RIG-I 작용제는 SARS-CoV-2 소단위 백신에 대한 면역 반응을 향상시킵니다

Article

Published on 2022-07-012022-09-11
Journal: Journal of controlled release : official journal o [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] activated Adaptive immune response adjuvant adjuvants agonist Anti-spike anti-Spike IgG Antibody titer Antibody titers Antigen antigen-presenting cell antigen-presenting cells APC APCS B cell B cells BAL Bcl6 Blood bronchoalveolar CD4 CD44 Cell cell population characterized Combination adjuvant COVID-19 COVID-19 protein subunit vaccine CpG DLNs draining lymph node draining lymph nodes Efficacy ENhance follicular Germinal center GL7 helper cell humoral immune responses IgA IgG immune immune response immune responses Immunity IMPROVE in vitro in vivo Increases increases in Infection intramuscular intramuscular vaccination intranasal Intranasal versus intramuscular vaccination intranasally lead lung Lungs lymphocyte memory T memory T cell mice molecular Monophosphoryl lipid A MPLA Native neutralizing antibody titers Pattern recognition pattern recognition receptor Pattern recognition receptors Polymer Population Proinflammatory cytokine Protein subunit protein subunit vaccine Protein subunit vaccines PRR PRRs PUUC reaction receptor receptors responses against retinoic acid retinoic acid-inducible gene I RIG-I robust S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein secretion spike IgA Spike protein stabilized spike protein stimulate subunit Subunit vaccine T cell T cell proliferation the S1 subunit TLR TLR4 TLR7 TLR7/8 TLR9 TLRs Toll-like receptor Toll-like receptors Transmission unique Vaccine vaccine availability vaccine responses variants
[DOI] 10.1016/j.jconrel.2022.05.023 PMC 바로가기 [Article Type] Article

COVID-19 disease does not cause ovarian injury in women of reproductive age: an observational before-and-after COVID-19 study

Observational Study

Published on 2022-07-012022-10-05
Journal: Reproductive biomedicine online [Category] Coronavirus, COVID19(2023년), SARS, 바이오마커, 임상,

Prolonged shedding of infectious viruses with haplotype switches of SARS-CoV-2 in an immunocompromised patient

면역 저하 환자에서 SARS-CoV-2의 일배체형 스위치로 감염성 바이러스의 장기간 배출

Case Reports

Published on 2022-07-012022-09-11
Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술,

[키워드] accumulated acquired immunity Bendamustine Clinical course Complete Complete Remission convalescent stage COVID-19 COVID-19 case COVID-19 infection COVID-19 pneumonia detectable eight episode episode of follicular Follicular lymphoma Haplotype Host immune Immunity Immunocompromised Immunocompromised host Immunocompromised patient Infectious virus infectiousness Infectivity initial kinetic long-lasting lymphoma management mechanical ventilation Non-synonymous mutation Patient Pneumonia Prolonged raised required Respiratory failure rituximab SARS-CoV-2 SARS-CoV-2 variants spike gene suppressed tested the SARS-CoV-2 variants Viral Viral kinetic. Viral RNA
[DOI] 10.1016/j.jiac.2022.04.004 PMC 바로가기 [Article Type] Case Reports

Severe Acute Respiratory Syndrome Coronavirus 2 Cross-Reactive B and T Cell Responses in Kidney Transplant Patients

Article

Published on 2022-07-012022-11-15
Journal: Transplantation proceedings [Category] COVID19(2023년), SARS, 진단, 치료기술,

The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 Infection

세포 면역의 견고함이 SARS-CoV-2 감염의 운명을 결정합니다

Review

Published on 2022-06-272022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제,

[키워드] addition Administered Analysis antibody secreting cells antiviral cytokine antiviral cytokines antiviral immunity antiviral response appearance approach autosomal recessive axis B cell booster dose breadth CD4+ CD4+ T cell CD8+ Cell cellular Cellular immune response cellular immunity component contribute coordinating correlated COVID-19 COVID-19 patient Critical cross-protection Cytokines cytotoxic lymphocytes cytotoxic T lymphocytes described disease Disease progression disease severity dysregulated evasion Evolution follicular functional Germinal center global pandemic greater helper T cells humoral IFN-γ immune protection immune system Immunity in some infected cells Infection infection control inflammatory cascade innate immune system killing knowledge long-lasting lymphocyte Lymphocytes magnitude memory modulating neutralizing antibody pathogenic inflammation phenotypic pro-inflammatory cytokine pro-inflammatory cytokines protective immunity reported responsible robustness SARS-CoV-2 SARS-CoV-2 virus secreting severe COVID-19 severity Stage stages T cell T cell response T cell responses T cells T helper cell T helper cells Tfh Tfh cells the SARS-CoV-2 virus thought TNF-α vaccination Vaccine viral replication X-linked
[DOI] 10.3389/fimmu.2022.904686 PMC 바로가기 [Article Type] Review

Molecular and cellular immune features of aged patients with severe COVID-19 pneumonia

중증 COVID-19 폐렴 노인 환자의 분자 및 세포 면역 특징

Article

Published on 2022-06-162022-09-12
Journal: Communications Biology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] activated activated macrophage age aging anti-RBD anti-S anti-viral response antibodies CD4 CD56 Cell cellular central memory circulating Clinical outcome collagen concerning Cytokines difference disease severity elderly exacerbate feature fibrosis follicular helper T cell IgG3 immature immune immune characteristics immunological change individuals Infection Inflammation less lung macrophages monocyte mononuclear cells Patient patients percentage Peripheral blood plasma plasmablasts pro-inflammatory cytokines pro-inflammatory monocytes promote proportion reduced reported risk factor SARS-CoV-2 severe COVID-19 Severe COVID-19 pneumonia severe SARS-CoV-2 specific antibody subject T cell T cells Transcriptome transcriptomic profile
[DOI] 10.1038/s42003-022-03537-z PMC 바로가기 [Article Type] Article