Non-uniform aspects of the SARS-CoV-2 intraspecies evolution reopen question of its originArticle Published on 2022-12-012022-11-16 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome beta-coronavirus Characteristics conducted conserved coronavirus disease Coronavirus-2 COVID-19 distribution Evenly-uneven Evidence Evolution Frequency functional furin cleavage Furin cleavage site (FCS) hypothese Hypothesis Invariant regions Mutation mutations pandemic Pandemics Protein question Region residue residues SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2. Support the SARS-CoV-2 Transmissibility unique variants virulence virus [DOI] 10.1016/j.ijbiomac.2022.09.184 PMC 바로가기
Evaluation of response to different COVID-19 vaccines in vaccinated healthcare workers in a single center in IranArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 진단, [키워드] adenoviral-vectored vaccine Administered administration age anti-SARS-CoV-2 Anti-spike anti-spike antibody antibody Antibody Response average blood sample calculated center coronavirus disease Covaxin COVID-19 COVID-19 infection COVID-19 vaccine Cutoff ELISA evaluated Frequency healthcare worker individual Iran men Neutralizing antibodies neutralizing antibody neutralizing antibody. outcome Oxford/AstraZeneca pandemic participant participated positive proportion second dose significantly higher single center Sinopharm Sputnik V vaccination Vaccine Vaccines [DOI] 10.1002/jmv.28029 PMC 바로가기
Randomized, double-blind, placebo-controlled, crossover trial of oral doxycycline for epistaxis in hereditary hemorrhagic telangiectasiaArticle Published on 2022-11-072022-11-16 Journal: Orphanet Journal of Rare Diseases [Category] 유전자 메커니즘, [키워드] analysis Angiogenesis assigned Biomarkers bleeding Blood center double-blind doxycycline Effectiveness ENG Epistaxis Frequency heart failure help hemorrhage Hemorrhagic Hereditary Hereditary hemorrhagic telangiectasia Hereditary hemorrhagic telangiectasia. HHT IL-6 Inflammatory intravenous limitations Liver disease malformation marker mechanism Michael morbidity no significant difference not significantly different observation pathway Patient Placebo placebo-controlled provided Quality of life Randomized controlled trial Randomly RBC recruited Registered Registration secondary significantly higher stroke telangiectasia therapy Toronto Treatment treatment period Trial VEGF [DOI] 10.1186/s13023-022-02539-8 PMC 바로가기
Induction of pulmonary HLA-G expression by SARS-CoV-2 infectionArticle Published on 2022-11-052022-11-15 Journal: Cellular and Molecular Life Sciences [Category] SARS, 치료기술, 치료제, [키워드] accompanied Antigen Autopsy biopsies CD8 Cell changes in correlated distribution epithelial cell Evidence expressed expression expression level Frequency heart muscle HLA-G Hyperactivation Immune cell Immune cell infiltration immune cells Immune escape immune response induction information kidney leukocyte lung lung alveolar lung epithelia lung epithelial cell lung tissue Macrophage marker microRNA microRNA. miRNA miRNA expression modulating organs other organ patients protein expression SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 nucleocapsid SARS-CoV-2- SARS-CoV-2-infected patient specimen Spike protein surgical T cell responses T cells therapeutic target tissue tissues Treatment Tumor virus-infected cells while [DOI] 10.1007/s00018-022-04592-9 PMC 바로가기
Efficacy and safety of nitazoxanide in treating SARS-CoV-2 infection: a systematic review and meta-analysis of blinded, placebo-controlled, randomized clinical trialsArticle Published on 2022-11-012022-11-15 Journal: European Journal of Clinical Pharmacology [Category] SARS, 치료제, [키워드] 95% CI 95% confidence interval addition anti-inflammatory effect antiparasitic antiviral activity blinded clinical benefit continuous variable COVID-19 D-dimer D-dimer level death dichotomous variable Disease progression Effect effect size Efficacy and safety element eligibility enrolled Evidence Frequency ICU admission in vitro individual Inflammation Invasive mechanical ventilation lactate dehydrogenase LDH magnitude Meta-analysis Mild moderate Moderate COVID-19 nitazoxanide no difference Patient patients peer-reviewed performed Placebo placebo-controlled positive positive RT-PCR Primary outcome randomized clinical trial RCT RCTs receiving reducing reduction in reported risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection. secondary outcome serum biomarker SMD standardized mean difference systematic review tested to define treat treated Viral load WBC were used White blood cell with COVID-19 [DOI] 10.1007/s00228-022-03380-5 PMC 바로가기
Temporal changes in the accessory protein mutations of SARS-CoV-2 variants and their predicted structural and functional effectsArticle Published on 2022-11-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] accessory protein accessory proteins Affect amino acid sequence association bioinformatics candidate changes in contributing to correlation COVID-19 determine domains Effect Factor Frequency functional humans identify Infection Mutation mutations mutations. occur ORF6 ORF8 predicted Protein PROVEAN Q57H SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence spike Spread Temporal variant variants of concern was used [DOI] 10.1002/jmv.27964 PMC 바로가기
Monitoring the evolution of SARS-CoV-2 on a Spanish university campus through wastewater analysis: A pilot project for the reopening strategyArticle Published on 2022-11-012022-11-16 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] addition administration carried Christma collected conducted COVID-19 COVID-19 incidence defined Epidemiology Evolution Evolution of SARS-CoV-2 Frequency implementation improvement knowledge monitoring Mutation occurred outbreak pandemic populations Probability returned SARS-CoV-2 SARS-CoV-2 RNA detection selected Sequencing sewage Spain Spanish Surveillance symptomatic and asymptomatic transmission of SARS-CoV-2 university University campus viral variant virus virus variants wastewater Wastewater-based epidemiology. [DOI] 10.1016/j.scitotenv.2022.157370 PMC 바로가기
Comparative study of the usefulness of risk score assessment in the early stages of COVID-19 affected pregnancies: Omicron variant versus previous variantsArticle Published on 2022-11-012022-11-16 Journal: The journal of obstetrics and gynaecology research [Category] SARS, 변종, 치료기술, [키워드] affected age Blood C-reactive protein Comparative Course COVID-19 D-dimer level Delta Deterioration disease disease onset early stage Epidemic evaluate examination findings Frequency group groups less no significant difference not significantly different omicron Omicron variant parameter Patient Platelet Pneumonia Pregnancy pregnant Prognosis risk risk scoring significantly lower two group utility variant Variant of concern. variants was increased worsening [DOI] 10.1111/jog.15387 PMC 바로가기
Transmission of SARS-CoV-2 by children to contacts in schools and households: a prospective cohort and environmental sampling study in LondonArticle Published on 2022-11-012022-11-16 Journal: The Lancet. Microbe [Category] SARS, 변종, 치료기술, [키워드] acquisition Assessing Asymptomatic children Community Contact Contamination Department eight Evidence FIVE Frequency Genome sequencing Health household contact household contacts IMPROVE incident index case Infection Innovation Laboratory Local London occur PCR testing positive positive PCR positive SARS-CoV-2 PCR Precaution Prevent prospective cohort public health pupil Pupils quantified reduced representing rising SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 transmission School Schools secondary transmission Spread supported symptomatic individual tested Testing throat swab Transmission transmission of SARS-CoV-2 variant Ventilation viral shedding was done Weekly with COVID-19 [DOI] 10.1016/S2666-5247(22)00124-0 PMC 바로가기
Risk of preeclampsia in patients with symptomatic COVID-19 infectionResearch article Published on 2022-11-012022-10-05 Journal: Journal of gynecology obstetrics and human reprodu [Category] SARS, 진단, 치료기술, [키워드] 95% CI Analysis association COVID-19 COVID-19 infection CT scan diagnosed Frequency in both groups management moderate not significant nulliparous objective occurred Patient patients preeclampsia Pregnancy pregnant women Prevent recent Result risk RT-PCR SARS-CoV-2 sensitivity analysis single-center study subject symptomatic Vascular fetal growth restriction Vascular FGR virus was performed [DOI] 10.1016/j.jogoh.2022.102459 [Article Type] Research article